Incidental Mutation 'R1432:Incenp'
ID 162352
Institutional Source Beutler Lab
Gene Symbol Incenp
Ensembl Gene ENSMUSG00000024660
Gene Name inner centromere protein
Synonyms 2700067E22Rik
MMRRC Submission 039487-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1432 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 9849659-9876853 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 9862890 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 388 (T388M)
Ref Sequence ENSEMBL: ENSMUSP00000025562 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025562]
AlphaFold Q9WU62
Predicted Effect unknown
Transcript: ENSMUST00000025562
AA Change: T388M
SMART Domains Protein: ENSMUSP00000025562
Gene: ENSMUSG00000024660
AA Change: T388M

DomainStartEndE-ValueType
Pfam:INCENP_N 6 41 1.9e-18 PFAM
low complexity region 83 94 N/A INTRINSIC
low complexity region 123 145 N/A INTRINSIC
low complexity region 308 314 N/A INTRINSIC
low complexity region 350 367 N/A INTRINSIC
low complexity region 434 447 N/A INTRINSIC
low complexity region 517 553 N/A INTRINSIC
low complexity region 557 573 N/A INTRINSIC
SCOP:d1f5na1 631 739 7e-3 SMART
Pfam:INCENP_ARK-bind 789 846 1.5e-22 PFAM
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.4%
  • 20x: 86.1%
Validation Efficiency 98% (90/92)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygous mutant embryos die before E8.5. Embryonic cells exhibit abnormal nuclei and abberent mitosis. [provided by MGI curators]
Allele List at MGI

All alleles(12) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(9)

Other mutations in this stock
Total: 88 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik A G 12: 71,217,361 (GRCm39) probably null Het
9130401M01Rik A T 15: 57,892,256 (GRCm39) L117Q probably damaging Het
Abcb1b A G 5: 8,887,771 (GRCm39) K886E possibly damaging Het
Acaa2 A T 18: 74,920,198 (GRCm39) I9F probably damaging Het
Acap2 A T 16: 30,929,901 (GRCm39) S386T probably damaging Het
Acsm2 A T 7: 119,172,798 (GRCm39) I138F possibly damaging Het
Agl T C 3: 116,540,342 (GRCm39) Y1424C probably damaging Het
Aoc1l1 T A 6: 48,952,588 (GRCm39) F171Y probably damaging Het
Apc2 T C 10: 80,148,183 (GRCm39) V1079A probably benign Het
Arhgef6 T C X: 56,383,922 (GRCm39) M5V probably benign Het
Armc8 C T 9: 99,405,185 (GRCm39) probably benign Het
Catsperb A G 12: 101,588,476 (GRCm39) Y953C probably damaging Het
Cdk13 G A 13: 17,893,001 (GRCm39) A720V probably damaging Het
Chka T C 19: 3,924,809 (GRCm39) probably benign Het
Clcc1 T C 3: 108,575,418 (GRCm39) I165T probably benign Het
Cndp1 G A 18: 84,652,777 (GRCm39) probably benign Het
Dip2c C A 13: 9,603,340 (GRCm39) P297Q probably damaging Het
Dnah17 A T 11: 117,914,153 (GRCm39) W4429R probably damaging Het
Dram2 T C 3: 106,478,082 (GRCm39) V138A possibly damaging Het
Dus4l T C 12: 31,698,770 (GRCm39) N78S probably benign Het
Dync1h1 G A 12: 110,602,943 (GRCm39) E2195K probably benign Het
Ebf1 T C 11: 44,895,533 (GRCm39) probably benign Het
Epm2a T A 10: 11,266,587 (GRCm39) Y111N probably damaging Het
Gm773 T C X: 55,247,377 (GRCm39) T52A probably benign Het
Gpam C A 19: 55,067,693 (GRCm39) M483I probably damaging Het
Gpr12 T C 5: 146,520,235 (GRCm39) H229R probably damaging Het
Gpr149 T C 3: 62,438,439 (GRCm39) T573A probably damaging Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Hells T A 19: 38,945,628 (GRCm39) probably null Het
Herc1 T A 9: 66,372,751 (GRCm39) N3102K probably benign Het
Herc3 A T 6: 58,893,827 (GRCm39) T968S possibly damaging Het
Ift88 A G 14: 57,674,736 (GRCm39) Y69C probably benign Het
Jrkl A G 9: 13,245,337 (GRCm39) F108S probably benign Het
Khdc1a A G 1: 21,420,542 (GRCm39) E54G possibly damaging Het
Kif6 T A 17: 49,927,728 (GRCm39) F58L probably damaging Het
Klk14 T C 7: 43,344,342 (GRCm39) S218P probably damaging Het
Kmt2e T C 5: 23,655,319 (GRCm39) M19T probably benign Het
Llgl1 G T 11: 60,599,380 (GRCm39) G454C probably damaging Het
Lyrm4 A G 13: 36,276,898 (GRCm39) V33A probably benign Het
Mcam C T 9: 44,052,588 (GRCm39) R606C probably damaging Het
Mgam T A 6: 40,733,301 (GRCm39) M692K probably damaging Het
Mmp28 C T 11: 83,333,765 (GRCm39) R392H probably damaging Het
Mpdz G A 4: 81,210,788 (GRCm39) T1699M probably damaging Het
Mrps11 T C 7: 78,433,310 (GRCm39) probably benign Het
Mrtfb A G 16: 13,218,866 (GRCm39) N504S probably benign Het
Msmo1 A G 8: 65,180,650 (GRCm39) probably benign Het
Mst1 A G 9: 107,961,403 (GRCm39) E571G probably benign Het
Myh14 T C 7: 44,265,723 (GRCm39) E1585G probably damaging Het
Myrfl A G 10: 116,613,332 (GRCm39) C824R probably damaging Het
Ncapd3 C T 9: 26,981,168 (GRCm39) probably benign Het
Nlrp4a G GGTTCTTC 7: 26,163,622 (GRCm39) probably null Het
Nos1 C T 5: 118,087,684 (GRCm39) probably benign Het
Notch3 T C 17: 32,383,198 (GRCm39) S47G probably benign Het
Npsr1 A G 9: 24,221,371 (GRCm39) Y122C probably damaging Het
Or10ak12 T C 4: 118,666,435 (GRCm39) M209V probably benign Het
Or1j11 C T 2: 36,311,655 (GRCm39) L82F probably damaging Het
Or5a1 G T 19: 12,097,603 (GRCm39) R158S possibly damaging Het
Or6c1b C T 10: 129,272,807 (GRCm39) T42I probably damaging Het
Or6k2 T A 1: 173,986,483 (GRCm39) V48E possibly damaging Het
Or8b9 T A 9: 37,766,548 (GRCm39) L145M possibly damaging Het
Otog G T 7: 45,950,007 (GRCm39) V2490F probably damaging Het
Pibf1 T C 14: 99,350,425 (GRCm39) V191A probably benign Het
Pip A G 6: 41,826,852 (GRCm39) M66V probably benign Het
Plxna2 C T 1: 194,449,771 (GRCm39) R830C probably benign Het
Prkca A T 11: 107,830,346 (GRCm39) V248E probably benign Het
Prmt7 T A 8: 106,963,916 (GRCm39) L253* probably null Het
Prrc2a G T 17: 35,372,888 (GRCm39) probably benign Het
Rasgrf1 A G 9: 89,894,853 (GRCm39) D1091G probably benign Het
Rbm7 C A 9: 48,401,245 (GRCm39) G161V probably benign Het
Scn1a A T 2: 66,152,773 (GRCm39) I736N probably damaging Het
Skint6 A G 4: 112,726,721 (GRCm39) probably benign Het
Slc22a2 C T 17: 12,803,195 (GRCm39) H10Y possibly damaging Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Stam2 A G 2: 52,604,821 (GRCm39) probably benign Het
Stk40 T C 4: 126,030,626 (GRCm39) L282P probably damaging Het
Tas2r110 A G 6: 132,845,331 (GRCm39) N121D probably damaging Het
Tbc1d32 A G 10: 55,893,758 (GRCm39) Y1272H probably damaging Het
Thoc2l T C 5: 104,665,970 (GRCm39) F164S probably damaging Het
Tmem131l T C 3: 83,836,021 (GRCm39) D696G probably damaging Het
Trdmt1 T C 2: 13,524,657 (GRCm39) Y266C probably damaging Het
Trim5 G T 7: 103,928,726 (GRCm39) H72N probably benign Het
Trim5 A C 7: 103,928,728 (GRCm39) L71R probably benign Het
Twf2 T A 9: 106,092,012 (GRCm39) probably benign Het
Ubap2l T C 3: 89,926,635 (GRCm39) T580A probably benign Het
Ugt1a10 C T 1: 88,143,982 (GRCm39) R201C probably damaging Het
Unc5a A G 13: 55,152,285 (GRCm39) probably benign Het
Vmn2r85 T C 10: 130,261,155 (GRCm39) N394S possibly damaging Het
Wrn A T 8: 33,809,169 (GRCm39) probably benign Het
Other mutations in Incenp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01324:Incenp APN 19 9,861,092 (GRCm39) missense unknown
IGL01717:Incenp APN 19 9,870,629 (GRCm39) splice site probably benign
IGL02485:Incenp APN 19 9,870,732 (GRCm39) missense unknown
IGL02488:Incenp APN 19 9,870,771 (GRCm39) missense unknown
B5639:Incenp UTSW 19 9,871,182 (GRCm39) missense unknown
R0060:Incenp UTSW 19 9,862,823 (GRCm39) splice site probably benign
R0164:Incenp UTSW 19 9,872,243 (GRCm39) missense probably benign 0.23
R0164:Incenp UTSW 19 9,872,243 (GRCm39) missense probably benign 0.23
R0242:Incenp UTSW 19 9,871,114 (GRCm39) missense unknown
R0242:Incenp UTSW 19 9,871,114 (GRCm39) missense unknown
R0284:Incenp UTSW 19 9,871,357 (GRCm39) missense unknown
R1264:Incenp UTSW 19 9,861,379 (GRCm39) missense unknown
R1679:Incenp UTSW 19 9,872,778 (GRCm39) missense unknown
R1827:Incenp UTSW 19 9,850,093 (GRCm39) missense possibly damaging 0.94
R1970:Incenp UTSW 19 9,862,851 (GRCm39) missense unknown
R3082:Incenp UTSW 19 9,861,143 (GRCm39) missense unknown
R3083:Incenp UTSW 19 9,861,143 (GRCm39) missense unknown
R4062:Incenp UTSW 19 9,861,142 (GRCm39) missense unknown
R4063:Incenp UTSW 19 9,861,142 (GRCm39) missense unknown
R4534:Incenp UTSW 19 9,861,303 (GRCm39) missense unknown
R4535:Incenp UTSW 19 9,861,303 (GRCm39) missense unknown
R4536:Incenp UTSW 19 9,861,303 (GRCm39) missense unknown
R4709:Incenp UTSW 19 9,853,964 (GRCm39) missense unknown
R4785:Incenp UTSW 19 9,855,054 (GRCm39) missense unknown
R4785:Incenp UTSW 19 9,855,055 (GRCm39) missense unknown
R5179:Incenp UTSW 19 9,872,273 (GRCm39) missense unknown
R5282:Incenp UTSW 19 9,855,770 (GRCm39) missense unknown
R5400:Incenp UTSW 19 9,855,039 (GRCm39) critical splice donor site probably null
R5502:Incenp UTSW 19 9,870,728 (GRCm39) missense unknown
R5608:Incenp UTSW 19 9,871,232 (GRCm39) small insertion probably benign
R6033:Incenp UTSW 19 9,850,061 (GRCm39) missense probably damaging 0.99
R6033:Incenp UTSW 19 9,850,061 (GRCm39) missense probably damaging 0.99
R6807:Incenp UTSW 19 9,855,120 (GRCm39) missense unknown
R6885:Incenp UTSW 19 9,852,496 (GRCm39) missense unknown
R6959:Incenp UTSW 19 9,854,134 (GRCm39) missense unknown
R7033:Incenp UTSW 19 9,870,736 (GRCm39) missense unknown
R8258:Incenp UTSW 19 9,871,005 (GRCm39) missense unknown
R8258:Incenp UTSW 19 9,870,993 (GRCm39) missense unknown
R8259:Incenp UTSW 19 9,871,005 (GRCm39) missense unknown
R8259:Incenp UTSW 19 9,870,993 (GRCm39) missense unknown
R8293:Incenp UTSW 19 9,852,497 (GRCm39) nonsense probably null
R9005:Incenp UTSW 19 9,855,088 (GRCm39) nonsense probably null
R9491:Incenp UTSW 19 9,854,141 (GRCm39) missense unknown
R9665:Incenp UTSW 19 9,871,329 (GRCm39) missense unknown
Z1176:Incenp UTSW 19 9,855,051 (GRCm39) missense unknown
Z1177:Incenp UTSW 19 9,876,728 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- GCAACCTCTAGCCAAGATCATGGAC -3'
(R):5'- CTGGCCGCCTAATATCAGAGGAAAC -3'

Sequencing Primer
(F):5'- TAGCCAAGATCATGGACTCTTCAG -3'
(R):5'- TTTCAGCCTGGAGCAGGAG -3'
Posted On 2014-03-14