Incidental Mutation 'R1387:Vmn2r59'
| ID |
162425 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r59
|
| Ensembl Gene |
ENSMUSG00000092032 |
| Gene Name |
vomeronasal 2, receptor 59 |
| Synonyms |
EG628444 |
| MMRRC Submission |
039449-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R1387 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
41661216-41708405 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 41695521 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 297
(V297A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131856
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168489]
|
| AlphaFold |
E9PUT5 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000121359
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000168489
AA Change: V297A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000131856
Gene: ENSMUSG00000092032
AA Change: V297A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
1.8e-44 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
4.3e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
5.4e-53 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 97.9%
- 10x: 95.1%
- 20x: 88.4%
|
| Validation Efficiency |
99% (82/83) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610303G11Rik |
T |
A |
9: 98,068,812 (GRCm39) |
|
noncoding transcript |
Het |
| 4930447C04Rik |
C |
A |
12: 72,962,208 (GRCm39) |
R52L |
probably benign |
Het |
| Abca13 |
C |
T |
11: 9,632,085 (GRCm39) |
Q5002* |
probably null |
Het |
| Acacb |
T |
C |
5: 114,338,573 (GRCm39) |
I761T |
probably benign |
Het |
| Acap3 |
G |
T |
4: 155,983,937 (GRCm39) |
L134F |
probably benign |
Het |
| Adamtsl1 |
T |
C |
4: 86,293,230 (GRCm39) |
|
probably benign |
Het |
| Adgrv1 |
A |
G |
13: 81,641,295 (GRCm39) |
V3278A |
possibly damaging |
Het |
| Agxt2 |
T |
C |
15: 10,380,696 (GRCm39) |
Y196H |
probably damaging |
Het |
| Akap13 |
T |
C |
7: 75,235,941 (GRCm39) |
V172A |
probably damaging |
Het |
| Aqp8 |
A |
G |
7: 123,065,891 (GRCm39) |
I229V |
probably benign |
Het |
| Atp8a2 |
T |
C |
14: 60,097,719 (GRCm39) |
K770E |
probably benign |
Het |
| Brd10 |
A |
G |
19: 29,700,853 (GRCm39) |
I812T |
probably benign |
Het |
| Cacng8 |
T |
C |
7: 3,463,672 (GRCm39) |
S275P |
possibly damaging |
Het |
| Catsperg1 |
T |
C |
7: 28,906,289 (GRCm39) |
Y138C |
probably damaging |
Het |
| Ccdc93 |
T |
G |
1: 121,418,918 (GRCm39) |
L491R |
probably damaging |
Het |
| Cntnap2 |
T |
C |
6: 47,084,848 (GRCm39) |
V1103A |
probably benign |
Het |
| Col12a1 |
C |
T |
9: 79,588,657 (GRCm39) |
|
probably benign |
Het |
| Col6a3 |
A |
G |
1: 90,750,138 (GRCm39) |
|
probably benign |
Het |
| Csf2rb2 |
C |
T |
15: 78,182,414 (GRCm39) |
A6T |
probably damaging |
Het |
| Cyp2j5 |
T |
A |
4: 96,522,522 (GRCm39) |
S351C |
probably damaging |
Het |
| Cyth1 |
A |
G |
11: 118,073,172 (GRCm39) |
|
probably benign |
Het |
| Dock2 |
A |
G |
11: 34,223,309 (GRCm39) |
|
probably benign |
Het |
| Duoxa1 |
T |
A |
2: 122,134,468 (GRCm39) |
I262F |
possibly damaging |
Het |
| Dync2h1 |
T |
C |
9: 7,125,816 (GRCm39) |
D1930G |
probably benign |
Het |
| Eeig1 |
T |
C |
2: 32,455,635 (GRCm39) |
S254P |
possibly damaging |
Het |
| Eno1 |
C |
T |
4: 150,332,590 (GRCm39) |
|
probably benign |
Het |
| Fam98a |
T |
A |
17: 75,845,264 (GRCm39) |
H494L |
unknown |
Het |
| Fcamr |
C |
A |
1: 130,732,379 (GRCm39) |
T122K |
possibly damaging |
Het |
| Foxq1 |
A |
G |
13: 31,743,288 (GRCm39) |
D130G |
probably damaging |
Het |
| Glb1 |
T |
A |
9: 114,249,431 (GRCm39) |
W5R |
probably damaging |
Het |
| Gm17661 |
GA |
GAA |
2: 90,917,709 (GRCm38) |
|
noncoding transcript |
Het |
| Gm5431 |
T |
A |
11: 48,785,842 (GRCm39) |
R178W |
possibly damaging |
Het |
| Gys2 |
C |
T |
6: 142,407,009 (GRCm39) |
V116M |
probably benign |
Het |
| Hif1a |
C |
T |
12: 73,989,066 (GRCm39) |
T651I |
possibly damaging |
Het |
| Itgb5 |
T |
A |
16: 33,720,885 (GRCm39) |
Y3* |
probably null |
Het |
| Kank3 |
A |
G |
17: 34,035,205 (GRCm39) |
N7S |
possibly damaging |
Het |
| Kdm2b |
G |
T |
5: 123,018,331 (GRCm39) |
H981Q |
probably damaging |
Het |
| Kdm6a |
C |
T |
X: 18,120,235 (GRCm39) |
|
probably benign |
Het |
| Kif1a |
A |
T |
1: 92,983,672 (GRCm39) |
|
probably benign |
Het |
| Knl1 |
T |
A |
2: 118,901,211 (GRCm39) |
S971T |
possibly damaging |
Het |
| Lcn6 |
T |
C |
2: 25,567,149 (GRCm39) |
V50A |
possibly damaging |
Het |
| Llgl2 |
G |
T |
11: 115,743,958 (GRCm39) |
V762F |
probably damaging |
Het |
| Lpcat4 |
T |
C |
2: 112,075,021 (GRCm39) |
F342L |
probably benign |
Het |
| Lrp2 |
C |
A |
2: 69,287,262 (GRCm39) |
G3725V |
probably damaging |
Het |
| Map1b |
T |
C |
13: 99,569,158 (GRCm39) |
T1188A |
unknown |
Het |
| Mecp2 |
G |
A |
X: 73,079,394 (GRCm39) |
P362S |
possibly damaging |
Het |
| Mideas |
C |
A |
12: 84,199,705 (GRCm39) |
R1005L |
probably damaging |
Het |
| Mmp13 |
T |
A |
9: 7,282,033 (GRCm39) |
F445Y |
possibly damaging |
Het |
| Myo5b |
G |
T |
18: 74,777,272 (GRCm39) |
|
probably benign |
Het |
| Myo7b |
A |
G |
18: 32,116,805 (GRCm39) |
|
probably benign |
Het |
| Nadk2 |
C |
A |
15: 9,106,870 (GRCm39) |
L384I |
possibly damaging |
Het |
| Napg |
A |
G |
18: 63,119,283 (GRCm39) |
I98V |
possibly damaging |
Het |
| Ncoa1 |
G |
T |
12: 4,324,790 (GRCm39) |
N1041K |
probably benign |
Het |
| Nmu |
A |
T |
5: 76,497,992 (GRCm39) |
C64* |
probably null |
Het |
| Nobox |
T |
A |
6: 43,284,132 (GRCm39) |
K13M |
probably damaging |
Het |
| Nos1 |
T |
C |
5: 118,091,848 (GRCm39) |
|
probably benign |
Het |
| Nrg2 |
A |
G |
18: 36,329,792 (GRCm39) |
V141A |
probably damaging |
Het |
| Or1b1 |
T |
G |
2: 36,994,880 (GRCm39) |
I261L |
probably benign |
Het |
| Or2aj5 |
T |
C |
16: 19,424,777 (GRCm39) |
I214V |
probably damaging |
Het |
| Or55b4 |
T |
A |
7: 102,133,911 (GRCm39) |
I139L |
probably benign |
Het |
| Phldb2 |
C |
T |
16: 45,646,357 (GRCm39) |
E71K |
possibly damaging |
Het |
| Pik3r4 |
T |
A |
9: 105,521,490 (GRCm39) |
Y19N |
probably damaging |
Het |
| Pkhd1 |
A |
C |
1: 20,625,447 (GRCm39) |
|
probably benign |
Het |
| Pogk |
G |
T |
1: 166,227,707 (GRCm39) |
P148Q |
possibly damaging |
Het |
| Pten |
G |
T |
19: 32,775,496 (GRCm39) |
A79S |
probably benign |
Het |
| Ptpdc1 |
A |
T |
13: 48,739,796 (GRCm39) |
V545E |
possibly damaging |
Het |
| Qdpr |
G |
C |
5: 45,607,480 (GRCm39) |
|
probably benign |
Het |
| Rhbdd3 |
T |
A |
11: 5,054,121 (GRCm39) |
H83Q |
probably damaging |
Het |
| Rnf6 |
A |
G |
5: 146,148,055 (GRCm39) |
V321A |
probably benign |
Het |
| Rtf1 |
T |
A |
2: 119,536,126 (GRCm39) |
|
probably null |
Het |
| Serpina10 |
C |
T |
12: 103,594,500 (GRCm39) |
V240I |
probably benign |
Het |
| Siah2 |
A |
G |
3: 58,598,935 (GRCm39) |
V101A |
possibly damaging |
Het |
| Taok3 |
A |
G |
5: 117,344,720 (GRCm39) |
K46R |
probably damaging |
Het |
| Tcaf2 |
A |
C |
6: 42,601,512 (GRCm39) |
L849R |
probably damaging |
Het |
| Upf3a |
T |
C |
8: 13,842,118 (GRCm39) |
F178S |
probably damaging |
Het |
| Vmn1r218 |
G |
A |
13: 23,321,478 (GRCm39) |
G195D |
probably damaging |
Het |
| Vmn2r70 |
T |
A |
7: 85,207,969 (GRCm39) |
Q836L |
probably benign |
Het |
| Zfp473 |
A |
G |
7: 44,382,365 (GRCm39) |
V655A |
probably benign |
Het |
| Zic5 |
A |
G |
14: 122,696,897 (GRCm39) |
S573P |
unknown |
Het |
|
| Other mutations in Vmn2r59 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00088:Vmn2r59
|
APN |
7 |
41,661,488 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL01432:Vmn2r59
|
APN |
7 |
41,661,983 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02119:Vmn2r59
|
APN |
7 |
41,695,593 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02216:Vmn2r59
|
APN |
7 |
41,661,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02327:Vmn2r59
|
APN |
7 |
41,661,655 (GRCm39) |
missense |
probably benign |
|
|
IGL03346:Vmn2r59
|
APN |
7 |
41,693,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03411:Vmn2r59
|
APN |
7 |
41,708,340 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03412:Vmn2r59
|
APN |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
|
PIT4366001:Vmn2r59
|
UTSW |
7 |
41,695,205 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0068:Vmn2r59
|
UTSW |
7 |
41,695,725 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0094:Vmn2r59
|
UTSW |
7 |
41,661,722 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0179:Vmn2r59
|
UTSW |
7 |
41,696,432 (GRCm39) |
nonsense |
probably null |
|
|
R0370:Vmn2r59
|
UTSW |
7 |
41,662,150 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0412:Vmn2r59
|
UTSW |
7 |
41,695,916 (GRCm39) |
splice site |
probably benign |
|
|
R0465:Vmn2r59
|
UTSW |
7 |
41,696,332 (GRCm39) |
missense |
probably benign |
|
|
R0487:Vmn2r59
|
UTSW |
7 |
41,696,528 (GRCm39) |
nonsense |
probably null |
|
|
R0576:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0632:Vmn2r59
|
UTSW |
7 |
41,708,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1356:Vmn2r59
|
UTSW |
7 |
41,661,218 (GRCm39) |
makesense |
probably null |
|
|
R1388:Vmn2r59
|
UTSW |
7 |
41,695,133 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1435:Vmn2r59
|
UTSW |
7 |
41,695,629 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1750:Vmn2r59
|
UTSW |
7 |
41,695,251 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2020:Vmn2r59
|
UTSW |
7 |
41,693,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2249:Vmn2r59
|
UTSW |
7 |
41,708,326 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2256:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
|
R2257:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
|
R2441:Vmn2r59
|
UTSW |
7 |
41,695,570 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2511:Vmn2r59
|
UTSW |
7 |
41,693,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2860:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2861:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3690:Vmn2r59
|
UTSW |
7 |
41,661,370 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3912:Vmn2r59
|
UTSW |
7 |
41,695,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4167:Vmn2r59
|
UTSW |
7 |
41,670,732 (GRCm39) |
intron |
probably benign |
|
|
R4357:Vmn2r59
|
UTSW |
7 |
41,661,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4445:Vmn2r59
|
UTSW |
7 |
41,691,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4542:Vmn2r59
|
UTSW |
7 |
41,695,497 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4587:Vmn2r59
|
UTSW |
7 |
41,695,648 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4616:Vmn2r59
|
UTSW |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
|
R4653:Vmn2r59
|
UTSW |
7 |
41,693,228 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4703:Vmn2r59
|
UTSW |
7 |
41,661,686 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4895:Vmn2r59
|
UTSW |
7 |
41,695,218 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4910:Vmn2r59
|
UTSW |
7 |
41,693,077 (GRCm39) |
missense |
probably benign |
|
|
R5045:Vmn2r59
|
UTSW |
7 |
41,695,496 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5105:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5153:Vmn2r59
|
UTSW |
7 |
41,691,834 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5566:Vmn2r59
|
UTSW |
7 |
41,696,247 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5586:Vmn2r59
|
UTSW |
7 |
41,695,105 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5606:Vmn2r59
|
UTSW |
7 |
41,695,318 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5616:Vmn2r59
|
UTSW |
7 |
41,708,191 (GRCm39) |
splice site |
probably null |
|
|
R5625:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5696:Vmn2r59
|
UTSW |
7 |
41,695,468 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5982:Vmn2r59
|
UTSW |
7 |
41,695,491 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6106:Vmn2r59
|
UTSW |
7 |
41,661,749 (GRCm39) |
nonsense |
probably null |
|
|
R6196:Vmn2r59
|
UTSW |
7 |
41,661,679 (GRCm39) |
missense |
probably benign |
0.36 |
|
R6228:Vmn2r59
|
UTSW |
7 |
41,691,835 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6590:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6625:Vmn2r59
|
UTSW |
7 |
41,693,177 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6690:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6768:Vmn2r59
|
UTSW |
7 |
41,661,392 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6830:Vmn2r59
|
UTSW |
7 |
41,693,171 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6859:Vmn2r59
|
UTSW |
7 |
41,693,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7034:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7036:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7145:Vmn2r59
|
UTSW |
7 |
41,695,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7556:Vmn2r59
|
UTSW |
7 |
41,695,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7733:Vmn2r59
|
UTSW |
7 |
41,661,443 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7770:Vmn2r59
|
UTSW |
7 |
41,708,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7812:Vmn2r59
|
UTSW |
7 |
41,695,196 (GRCm39) |
nonsense |
probably null |
|
|
R7867:Vmn2r59
|
UTSW |
7 |
41,661,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7975:Vmn2r59
|
UTSW |
7 |
41,693,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Vmn2r59
|
UTSW |
7 |
41,696,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Vmn2r59
|
UTSW |
7 |
41,661,521 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8367:Vmn2r59
|
UTSW |
7 |
41,661,247 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9106:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,127 (GRCm39) |
missense |
|
|
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,125 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9234:Vmn2r59
|
UTSW |
7 |
41,661,907 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9273:Vmn2r59
|
UTSW |
7 |
41,695,286 (GRCm39) |
nonsense |
probably null |
|
|
R9432:Vmn2r59
|
UTSW |
7 |
41,696,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9433:Vmn2r59
|
UTSW |
7 |
41,695,590 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9616:Vmn2r59
|
UTSW |
7 |
41,661,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9654:Vmn2r59
|
UTSW |
7 |
41,693,217 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9741:Vmn2r59
|
UTSW |
7 |
41,708,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0025:Vmn2r59
|
UTSW |
7 |
41,695,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r59
|
UTSW |
7 |
41,661,838 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1176:Vmn2r59
|
UTSW |
7 |
41,691,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATTGGGTTGGCAGTTCTCCAAAAG -3'
(R):5'- TCTGATCCTCCCAGATGACCACAG -3'
Sequencing Primer
(F):5'- GCAGTTCTCCAAAAGTTGACAATC -3'
(R):5'- GAATCATGGCATCTGCATAGC -3'
|
| Posted On |
2014-03-17 |
Incidental Mutation