Mutagenetix > Incidental Mutation

Incidental Mutation 'R1389:Ceacam15'

162528

Institutional Source

Beutler Lab

Gene Symbol

Ceacam15

Ensembl Gene

ENSMUSG00000078795

Gene Name

CEA cell adhesion molecule 15

Synonyms

C430002N04Rik

MMRRC Submission

039451-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R1389 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

16405256-16409630 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 16405988 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 188 (R188G)

Ref Sequence

ENSEMBL: ENSMUSP00000104138 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108498]

AlphaFold

A0A0B4J1L0

Predicted Effect

probably damaging
Transcript: ENSMUST00000108498
AA Change: R188G

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000104138
Gene: ENSMUSG00000078795
AA Change: R188G

Domain	Start	End	E-Value	Type
IG	39	140	1.28e-1	SMART
IGc2	156	220	2.68e-4	SMART

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.7%
20x: 90.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abtb3	A	G	10: 85,476,460 (GRCm39)	T914A	possibly damaging	Het
Acsl3	A	C	1: 78,665,999 (GRCm39)	I142L	probably benign	Het
Adgra2	C	T	8: 27,601,116 (GRCm39)	P252L	probably damaging	Het
Akap6	A	G	12: 53,186,303 (GRCm39)	E1239G	probably benign	Het
Arhgef17	TGGAGGAGGAGGAGGAGG	TGGAGGAGGAGGAGG	7: 100,580,244 (GRCm39)		probably benign	Het
Calml4	A	T	9: 62,778,548 (GRCm39)	D12V	probably damaging	Het
Car9	G	T	4: 43,512,439 (GRCm39)		probably null	Het
Ccar2	C	A	14: 70,377,558 (GRCm39)	V699L	possibly damaging	Het
Ccdc27	T	C	4: 154,126,226 (GRCm39)	M88V	unknown	Het
Dcaf8	G	A	1: 172,001,619 (GRCm39)	R272H	probably benign	Het
Dchs1	A	G	7: 105,404,778 (GRCm39)	V2588A	probably benign	Het
Dst	G	A	1: 34,250,313 (GRCm39)	R1749H	probably damaging	Het
Exog	A	G	9: 119,291,572 (GRCm39)	Q283R	probably benign	Het
Fmnl1	A	T	11: 103,077,535 (GRCm39)		probably null	Het
Gramd1c	T	C	16: 43,811,085 (GRCm39)	D213G	probably damaging	Het
Iqgap1	A	G	7: 80,409,504 (GRCm39)		probably null	Het
Itgae	A	G	11: 73,016,188 (GRCm39)	Y799C	probably damaging	Het
Kalrn	T	C	16: 33,809,173 (GRCm39)	I903V	probably benign	Het
Kcnh1	A	G	1: 192,188,071 (GRCm39)	E844G	probably benign	Het
Khdc1a	A	T	1: 21,420,251 (GRCm39)	D3V	probably damaging	Het
Ly6g	T	C	15: 75,028,615 (GRCm39)	F25S	probably benign	Het
Mapk1ip1	G	A	7: 138,438,456 (GRCm39)		probably benign	Het
Mfsd3	A	G	15: 76,586,889 (GRCm39)	H243R	probably benign	Het
Mms22l	T	A	4: 24,591,076 (GRCm39)	Y1016N	probably damaging	Het
Mrgprb5	A	T	7: 47,818,078 (GRCm39)	V219E	probably damaging	Het
Nars2	G	A	7: 96,652,036 (GRCm39)	S209N	probably benign	Het
Nckap5	T	C	1: 125,954,447 (GRCm39)	T702A	probably damaging	Het
Or1e26	T	C	11: 73,480,369 (GRCm39)	N65S	possibly damaging	Het
Paf1	A	G	7: 28,098,257 (GRCm39)		probably benign	Het
Prl3d1	A	T	13: 27,282,693 (GRCm39)	R145*	probably null	Het
Rasl10b	G	A	11: 83,308,665 (GRCm39)		probably null	Het
Rnf13	T	A	3: 57,686,917 (GRCm39)	N103K	probably damaging	Het
Senp1	T	C	15: 97,973,734 (GRCm39)	S170G	probably benign	Het
Slc46a2	A	G	4: 59,914,620 (GRCm39)	L101P	probably damaging	Het
Tmem123	C	T	9: 7,791,107 (GRCm39)	T136M	probably damaging	Het
Tpo	T	A	12: 30,153,109 (GRCm39)	H415L	probably damaging	Het
Vipr2	A	G	12: 116,100,950 (GRCm39)	I255V	probably benign	Het
Zc3h11a	A	T	1: 133,561,541 (GRCm39)	V310E	probably damaging	Het
Zfp3	T	A	11: 70,663,462 (GRCm39)	C474S	probably damaging	Het
Zfp707	T	A	15: 75,846,465 (GRCm39)	C99S	probably damaging	Het
Zranb1	C	T	7: 132,573,062 (GRCm39)	P410S	probably damaging	Het
Zswim8	G	T	14: 20,760,816 (GRCm39)	R30L	probably damaging	Het

Other mutations in Ceacam15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03367:Ceacam15	APN	7	16,409,512 (GRCm39)	missense	possibly damaging	0.47
R0144:Ceacam15	UTSW	7	16,407,116 (GRCm39)	missense	probably benign	0.32
R0517:Ceacam15	UTSW	7	16,407,445 (GRCm39)	nonsense	probably null
R0612:Ceacam15	UTSW	7	16,407,445 (GRCm39)	nonsense	probably null
R0697:Ceacam15	UTSW	7	16,407,445 (GRCm39)	nonsense	probably null
R1077:Ceacam15	UTSW	7	16,406,000 (GRCm39)	missense	probably benign	0.03
R1257:Ceacam15	UTSW	7	16,405,949 (GRCm39)	missense	possibly damaging	0.73
R4602:Ceacam15	UTSW	7	16,405,906 (GRCm39)	missense	probably damaging	1.00
R4623:Ceacam15	UTSW	7	16,407,391 (GRCm39)	missense	probably damaging	0.97
R4674:Ceacam15	UTSW	7	16,407,410 (GRCm39)	missense	probably benign	0.09
R4675:Ceacam15	UTSW	7	16,407,410 (GRCm39)	missense	probably benign	0.09
R4745:Ceacam15	UTSW	7	16,407,259 (GRCm39)	missense	probably benign
R5296:Ceacam15	UTSW	7	16,407,121 (GRCm39)	missense	probably benign	0.09
R5510:Ceacam15	UTSW	7	16,406,024 (GRCm39)	missense	probably damaging	1.00
R6210:Ceacam15	UTSW	7	16,407,214 (GRCm39)	missense	probably damaging	0.99
R7414:Ceacam15	UTSW	7	16,407,235 (GRCm39)	missense	probably benign	0.24
R8110:Ceacam15	UTSW	7	16,407,334 (GRCm39)	missense	probably benign	0.00
R8341:Ceacam15	UTSW	7	16,405,928 (GRCm39)	missense	probably benign	0.17
R9553:Ceacam15	UTSW	7	16,407,316 (GRCm39)	missense	probably damaging	1.00
X0020:Ceacam15	UTSW	7	16,409,531 (GRCm39)	start codon destroyed	probably null	0.00
Z1176:Ceacam15	UTSW	7	16,409,508 (GRCm39)	missense	possibly damaging	0.83

Predicted Primers

PCR Primer
(F):5'- CCGCAAAGCTCTGGGTATAGGAAG -3'
(R):5'- GCTCCTTGTTCCAAGGTCAGGTTC -3'

Sequencing Primer
(F):5'- GCTCTGGGTATAGGAAGAGAGG -3'
(R):5'- CGTCCTATTATAGGGAAACTGAGACC -3'

Posted On

2014-03-17