Incidental Mutation 'R1389:Arhgef17'
ID 162533
Institutional Source Beutler Lab
Gene Symbol Arhgef17
Ensembl Gene ENSMUSG00000032875
Gene Name Rho guanine nucleotide exchange factor 17
Synonyms
MMRRC Submission 039451-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1389 (G1)
Quality Score 110
Status Not validated
Chromosome 7
Chromosomal Location 100518959-100581314 bp(-) (GRCm39)
Type of Mutation small deletion (1 aa in frame mutation)
DNA Base Change (assembly) TGGAGGAGGAGGAGGAGG to TGGAGGAGGAGGAGG at 100580244 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000102647 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107032]
AlphaFold Q80U35
Predicted Effect probably benign
Transcript: ENSMUST00000107032
SMART Domains Protein: ENSMUSP00000102647
Gene: ENSMUSG00000032875

DomainStartEndE-ValueType
low complexity region 65 74 N/A INTRINSIC
low complexity region 160 175 N/A INTRINSIC
low complexity region 196 209 N/A INTRINSIC
low complexity region 227 255 N/A INTRINSIC
low complexity region 282 297 N/A INTRINSIC
low complexity region 314 323 N/A INTRINSIC
low complexity region 507 526 N/A INTRINSIC
low complexity region 559 572 N/A INTRINSIC
low complexity region 828 842 N/A INTRINSIC
low complexity region 970 984 N/A INTRINSIC
RhoGEF 1063 1246 9.56e-61 SMART
Blast:PH 1281 1466 4e-88 BLAST
low complexity region 1582 1595 N/A INTRINSIC
low complexity region 1630 1642 N/A INTRINSIC
low complexity region 1646 1657 N/A INTRINSIC
low complexity region 1661 1701 N/A INTRINSIC
low complexity region 1708 1719 N/A INTRINSIC
low complexity region 2033 2040 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb3 A G 10: 85,476,460 (GRCm39) T914A possibly damaging Het
Acsl3 A C 1: 78,665,999 (GRCm39) I142L probably benign Het
Adgra2 C T 8: 27,601,116 (GRCm39) P252L probably damaging Het
Akap6 A G 12: 53,186,303 (GRCm39) E1239G probably benign Het
Calml4 A T 9: 62,778,548 (GRCm39) D12V probably damaging Het
Car9 G T 4: 43,512,439 (GRCm39) probably null Het
Ccar2 C A 14: 70,377,558 (GRCm39) V699L possibly damaging Het
Ccdc27 T C 4: 154,126,226 (GRCm39) M88V unknown Het
Ceacam15 T C 7: 16,405,988 (GRCm39) R188G probably damaging Het
Dcaf8 G A 1: 172,001,619 (GRCm39) R272H probably benign Het
Dchs1 A G 7: 105,404,778 (GRCm39) V2588A probably benign Het
Dst G A 1: 34,250,313 (GRCm39) R1749H probably damaging Het
Exog A G 9: 119,291,572 (GRCm39) Q283R probably benign Het
Fmnl1 A T 11: 103,077,535 (GRCm39) probably null Het
Gramd1c T C 16: 43,811,085 (GRCm39) D213G probably damaging Het
Iqgap1 A G 7: 80,409,504 (GRCm39) probably null Het
Itgae A G 11: 73,016,188 (GRCm39) Y799C probably damaging Het
Kalrn T C 16: 33,809,173 (GRCm39) I903V probably benign Het
Kcnh1 A G 1: 192,188,071 (GRCm39) E844G probably benign Het
Khdc1a A T 1: 21,420,251 (GRCm39) D3V probably damaging Het
Ly6g T C 15: 75,028,615 (GRCm39) F25S probably benign Het
Mapk1ip1 G A 7: 138,438,456 (GRCm39) probably benign Het
Mfsd3 A G 15: 76,586,889 (GRCm39) H243R probably benign Het
Mms22l T A 4: 24,591,076 (GRCm39) Y1016N probably damaging Het
Mrgprb5 A T 7: 47,818,078 (GRCm39) V219E probably damaging Het
Nars2 G A 7: 96,652,036 (GRCm39) S209N probably benign Het
Nckap5 T C 1: 125,954,447 (GRCm39) T702A probably damaging Het
Or1e26 T C 11: 73,480,369 (GRCm39) N65S possibly damaging Het
Paf1 A G 7: 28,098,257 (GRCm39) probably benign Het
Prl3d1 A T 13: 27,282,693 (GRCm39) R145* probably null Het
Rasl10b G A 11: 83,308,665 (GRCm39) probably null Het
Rnf13 T A 3: 57,686,917 (GRCm39) N103K probably damaging Het
Senp1 T C 15: 97,973,734 (GRCm39) S170G probably benign Het
Slc46a2 A G 4: 59,914,620 (GRCm39) L101P probably damaging Het
Tmem123 C T 9: 7,791,107 (GRCm39) T136M probably damaging Het
Tpo T A 12: 30,153,109 (GRCm39) H415L probably damaging Het
Vipr2 A G 12: 116,100,950 (GRCm39) I255V probably benign Het
Zc3h11a A T 1: 133,561,541 (GRCm39) V310E probably damaging Het
Zfp3 T A 11: 70,663,462 (GRCm39) C474S probably damaging Het
Zfp707 T A 15: 75,846,465 (GRCm39) C99S probably damaging Het
Zranb1 C T 7: 132,573,062 (GRCm39) P410S probably damaging Het
Zswim8 G T 14: 20,760,816 (GRCm39) R30L probably damaging Het
Other mutations in Arhgef17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00844:Arhgef17 APN 7 100,578,656 (GRCm39) missense probably benign
IGL01071:Arhgef17 APN 7 100,534,907 (GRCm39) missense probably damaging 0.99
IGL01882:Arhgef17 APN 7 100,527,787 (GRCm39) nonsense probably null
IGL01995:Arhgef17 APN 7 100,577,862 (GRCm39) missense probably benign 0.02
IGL02213:Arhgef17 APN 7 100,539,633 (GRCm39) missense probably benign
IGL02380:Arhgef17 APN 7 100,578,650 (GRCm39) missense possibly damaging 0.60
IGL02551:Arhgef17 APN 7 100,579,553 (GRCm39) missense probably damaging 1.00
IGL02613:Arhgef17 APN 7 100,578,103 (GRCm39) missense probably damaging 1.00
IGL02643:Arhgef17 APN 7 100,533,089 (GRCm39) missense possibly damaging 0.95
IGL02798:Arhgef17 APN 7 100,578,833 (GRCm39) missense probably benign 0.00
IGL03113:Arhgef17 APN 7 100,578,938 (GRCm39) missense probably benign 0.00
IGL03264:Arhgef17 APN 7 100,529,220 (GRCm39) missense probably benign 0.00
G1Funyon:Arhgef17 UTSW 7 100,528,866 (GRCm39) missense probably benign 0.00
R0064:Arhgef17 UTSW 7 100,530,561 (GRCm39) missense probably benign 0.00
R0189:Arhgef17 UTSW 7 100,578,057 (GRCm39) missense probably damaging 1.00
R0482:Arhgef17 UTSW 7 100,529,828 (GRCm39) missense probably damaging 1.00
R0826:Arhgef17 UTSW 7 100,579,950 (GRCm39) missense probably benign 0.01
R1295:Arhgef17 UTSW 7 100,530,476 (GRCm39) nonsense probably null
R1296:Arhgef17 UTSW 7 100,530,476 (GRCm39) nonsense probably null
R1466:Arhgef17 UTSW 7 100,578,866 (GRCm39) missense possibly damaging 0.48
R1466:Arhgef17 UTSW 7 100,578,866 (GRCm39) missense possibly damaging 0.48
R1513:Arhgef17 UTSW 7 100,580,069 (GRCm39) missense probably benign
R1539:Arhgef17 UTSW 7 100,539,680 (GRCm39) missense probably damaging 1.00
R1644:Arhgef17 UTSW 7 100,578,711 (GRCm39) missense probably damaging 1.00
R1789:Arhgef17 UTSW 7 100,579,077 (GRCm39) missense probably damaging 1.00
R1861:Arhgef17 UTSW 7 100,531,475 (GRCm39) missense probably damaging 1.00
R1868:Arhgef17 UTSW 7 100,528,184 (GRCm39) missense probably benign
R2009:Arhgef17 UTSW 7 100,530,988 (GRCm39) missense probably damaging 0.98
R2095:Arhgef17 UTSW 7 100,530,470 (GRCm39) missense probably damaging 1.00
R2311:Arhgef17 UTSW 7 100,578,111 (GRCm39) missense probably benign 0.35
R3607:Arhgef17 UTSW 7 100,580,379 (GRCm39) missense probably damaging 1.00
R3882:Arhgef17 UTSW 7 100,525,661 (GRCm39) missense possibly damaging 0.70
R4089:Arhgef17 UTSW 7 100,533,006 (GRCm39) missense probably damaging 1.00
R4420:Arhgef17 UTSW 7 100,531,515 (GRCm39) splice site probably benign
R4536:Arhgef17 UTSW 7 100,579,061 (GRCm39) missense probably damaging 1.00
R4548:Arhgef17 UTSW 7 100,580,336 (GRCm39) missense possibly damaging 0.60
R4616:Arhgef17 UTSW 7 100,531,692 (GRCm39) missense probably damaging 1.00
R5040:Arhgef17 UTSW 7 100,526,032 (GRCm39) missense probably benign 0.17
R5100:Arhgef17 UTSW 7 100,530,963 (GRCm39) missense possibly damaging 0.90
R5233:Arhgef17 UTSW 7 100,530,576 (GRCm39) missense possibly damaging 0.61
R5307:Arhgef17 UTSW 7 100,578,635 (GRCm39) missense probably benign 0.00
R5313:Arhgef17 UTSW 7 100,578,131 (GRCm39) missense probably damaging 0.99
R5643:Arhgef17 UTSW 7 100,529,218 (GRCm39) missense probably damaging 1.00
R5704:Arhgef17 UTSW 7 100,530,548 (GRCm39) missense probably damaging 1.00
R6166:Arhgef17 UTSW 7 100,525,699 (GRCm39) missense probably damaging 1.00
R6417:Arhgef17 UTSW 7 100,579,269 (GRCm39) missense probably damaging 1.00
R6420:Arhgef17 UTSW 7 100,579,269 (GRCm39) missense probably damaging 1.00
R6510:Arhgef17 UTSW 7 100,527,743 (GRCm39) missense probably damaging 0.97
R6877:Arhgef17 UTSW 7 100,530,548 (GRCm39) missense probably damaging 1.00
R6888:Arhgef17 UTSW 7 100,580,027 (GRCm39) missense possibly damaging 0.74
R7016:Arhgef17 UTSW 7 100,528,184 (GRCm39) missense probably benign
R7073:Arhgef17 UTSW 7 100,579,198 (GRCm39) nonsense probably null
R7322:Arhgef17 UTSW 7 100,527,004 (GRCm39) missense probably benign 0.01
R7691:Arhgef17 UTSW 7 100,578,849 (GRCm39) missense probably damaging 1.00
R7724:Arhgef17 UTSW 7 100,529,816 (GRCm39) missense probably damaging 1.00
R7728:Arhgef17 UTSW 7 100,579,275 (GRCm39) missense probably benign 0.00
R7829:Arhgef17 UTSW 7 100,526,052 (GRCm39) missense probably benign 0.03
R8036:Arhgef17 UTSW 7 100,579,062 (GRCm39) missense probably damaging 1.00
R8072:Arhgef17 UTSW 7 100,531,004 (GRCm39) missense probably benign 0.04
R8301:Arhgef17 UTSW 7 100,528,866 (GRCm39) missense probably benign 0.00
R8935:Arhgef17 UTSW 7 100,527,324 (GRCm39) missense probably benign 0.03
R8958:Arhgef17 UTSW 7 100,579,019 (GRCm39) missense probably damaging 0.98
R9221:Arhgef17 UTSW 7 100,528,818 (GRCm39) missense possibly damaging 0.78
R9362:Arhgef17 UTSW 7 100,580,165 (GRCm39) missense probably benign 0.12
R9499:Arhgef17 UTSW 7 100,526,102 (GRCm39) missense possibly damaging 0.52
R9593:Arhgef17 UTSW 7 100,532,009 (GRCm39) missense probably damaging 1.00
X0012:Arhgef17 UTSW 7 100,578,111 (GRCm39) missense probably benign 0.35
Predicted Primers PCR Primer
(F):5'- CAGCCGTGAACCAACTGAGAGC -3'
(R):5'- ACGACCCAGTATGGACTCTGAGG -3'

Sequencing Primer
(F):5'- CAACTGAGAGCGTCCAGG -3'
(R):5'- AGTATGGACTCTGAGGCCCTG -3'
Posted On 2014-03-17