Incidental Mutation 'R1389:Or1e26'
ID 162546
Institutional Source Beutler Lab
Gene Symbol Or1e26
Ensembl Gene ENSMUSG00000095095
Gene Name olfactory receptor family 1 subfamily E member 26
Synonyms Olfr385, GA_x6K02T2P1NL-3760313-3759375, MOR135-3
MMRRC Submission 039451-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.166) question?
Stock # R1389 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 73479624-73480562 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 73480369 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 65 (N65S)
Ref Sequence ENSEMBL: ENSMUSP00000149293 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071553] [ENSMUST00000215689]
AlphaFold Q8VGT1
Predicted Effect possibly damaging
Transcript: ENSMUST00000071553
AA Change: N65S

PolyPhen 2 Score 0.882 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000071484
Gene: ENSMUSG00000095095
AA Change: N65S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.1e-55 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.7e-6 PFAM
Pfam:7tm_1 41 290 2.2e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215689
AA Change: N65S

PolyPhen 2 Score 0.882 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb3 A G 10: 85,476,460 (GRCm39) T914A possibly damaging Het
Acsl3 A C 1: 78,665,999 (GRCm39) I142L probably benign Het
Adgra2 C T 8: 27,601,116 (GRCm39) P252L probably damaging Het
Akap6 A G 12: 53,186,303 (GRCm39) E1239G probably benign Het
Arhgef17 TGGAGGAGGAGGAGGAGG TGGAGGAGGAGGAGG 7: 100,580,244 (GRCm39) probably benign Het
Calml4 A T 9: 62,778,548 (GRCm39) D12V probably damaging Het
Car9 G T 4: 43,512,439 (GRCm39) probably null Het
Ccar2 C A 14: 70,377,558 (GRCm39) V699L possibly damaging Het
Ccdc27 T C 4: 154,126,226 (GRCm39) M88V unknown Het
Ceacam15 T C 7: 16,405,988 (GRCm39) R188G probably damaging Het
Dcaf8 G A 1: 172,001,619 (GRCm39) R272H probably benign Het
Dchs1 A G 7: 105,404,778 (GRCm39) V2588A probably benign Het
Dst G A 1: 34,250,313 (GRCm39) R1749H probably damaging Het
Exog A G 9: 119,291,572 (GRCm39) Q283R probably benign Het
Fmnl1 A T 11: 103,077,535 (GRCm39) probably null Het
Gramd1c T C 16: 43,811,085 (GRCm39) D213G probably damaging Het
Iqgap1 A G 7: 80,409,504 (GRCm39) probably null Het
Itgae A G 11: 73,016,188 (GRCm39) Y799C probably damaging Het
Kalrn T C 16: 33,809,173 (GRCm39) I903V probably benign Het
Kcnh1 A G 1: 192,188,071 (GRCm39) E844G probably benign Het
Khdc1a A T 1: 21,420,251 (GRCm39) D3V probably damaging Het
Ly6g T C 15: 75,028,615 (GRCm39) F25S probably benign Het
Mapk1ip1 G A 7: 138,438,456 (GRCm39) probably benign Het
Mfsd3 A G 15: 76,586,889 (GRCm39) H243R probably benign Het
Mms22l T A 4: 24,591,076 (GRCm39) Y1016N probably damaging Het
Mrgprb5 A T 7: 47,818,078 (GRCm39) V219E probably damaging Het
Nars2 G A 7: 96,652,036 (GRCm39) S209N probably benign Het
Nckap5 T C 1: 125,954,447 (GRCm39) T702A probably damaging Het
Paf1 A G 7: 28,098,257 (GRCm39) probably benign Het
Prl3d1 A T 13: 27,282,693 (GRCm39) R145* probably null Het
Rasl10b G A 11: 83,308,665 (GRCm39) probably null Het
Rnf13 T A 3: 57,686,917 (GRCm39) N103K probably damaging Het
Senp1 T C 15: 97,973,734 (GRCm39) S170G probably benign Het
Slc46a2 A G 4: 59,914,620 (GRCm39) L101P probably damaging Het
Tmem123 C T 9: 7,791,107 (GRCm39) T136M probably damaging Het
Tpo T A 12: 30,153,109 (GRCm39) H415L probably damaging Het
Vipr2 A G 12: 116,100,950 (GRCm39) I255V probably benign Het
Zc3h11a A T 1: 133,561,541 (GRCm39) V310E probably damaging Het
Zfp3 T A 11: 70,663,462 (GRCm39) C474S probably damaging Het
Zfp707 T A 15: 75,846,465 (GRCm39) C99S probably damaging Het
Zranb1 C T 7: 132,573,062 (GRCm39) P410S probably damaging Het
Zswim8 G T 14: 20,760,816 (GRCm39) R30L probably damaging Het
Other mutations in Or1e26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01570:Or1e26 APN 11 73,480,209 (GRCm39) missense probably benign 0.34
IGL02045:Or1e26 APN 11 73,480,058 (GRCm39) missense probably damaging 1.00
IGL02324:Or1e26 APN 11 73,480,081 (GRCm39) missense probably benign 0.02
IGL02328:Or1e26 APN 11 73,480,081 (GRCm39) missense probably benign 0.02
IGL02562:Or1e26 APN 11 73,480,237 (GRCm39) missense probably benign
IGL02715:Or1e26 APN 11 73,479,947 (GRCm39) missense probably benign 0.00
IGL03182:Or1e26 APN 11 73,480,268 (GRCm39) missense probably benign 0.04
IGL03048:Or1e26 UTSW 11 73,479,831 (GRCm39) missense possibly damaging 0.56
R0346:Or1e26 UTSW 11 73,480,283 (GRCm39) missense probably damaging 1.00
R0675:Or1e26 UTSW 11 73,480,078 (GRCm39) missense probably damaging 1.00
R0751:Or1e26 UTSW 11 73,479,970 (GRCm39) missense probably benign 0.02
R1220:Or1e26 UTSW 11 73,480,203 (GRCm39) nonsense probably null
R1484:Or1e26 UTSW 11 73,480,187 (GRCm39) missense possibly damaging 0.91
R1619:Or1e26 UTSW 11 73,480,118 (GRCm39) missense probably damaging 1.00
R2290:Or1e26 UTSW 11 73,479,745 (GRCm39) missense probably benign 0.37
R3713:Or1e26 UTSW 11 73,479,731 (GRCm39) missense probably damaging 1.00
R3781:Or1e26 UTSW 11 73,480,194 (GRCm39) nonsense probably null
R3781:Or1e26 UTSW 11 73,479,839 (GRCm39) missense probably damaging 1.00
R3782:Or1e26 UTSW 11 73,480,194 (GRCm39) nonsense probably null
R3782:Or1e26 UTSW 11 73,479,839 (GRCm39) missense probably damaging 1.00
R4402:Or1e26 UTSW 11 73,480,081 (GRCm39) missense probably benign 0.02
R4721:Or1e26 UTSW 11 73,480,273 (GRCm39) missense probably damaging 1.00
R5157:Or1e26 UTSW 11 73,480,549 (GRCm39) missense probably damaging 1.00
R5995:Or1e26 UTSW 11 73,480,076 (GRCm39) missense probably benign
R6373:Or1e26 UTSW 11 73,479,724 (GRCm39) missense probably benign 0.42
R6658:Or1e26 UTSW 11 73,479,874 (GRCm39) missense probably damaging 0.99
R7046:Or1e26 UTSW 11 73,480,558 (GRCm39) missense probably benign
R7096:Or1e26 UTSW 11 73,480,463 (GRCm39) missense probably benign 0.03
R7238:Or1e26 UTSW 11 73,480,561 (GRCm39) start codon destroyed probably null 0.99
R7537:Or1e26 UTSW 11 73,480,094 (GRCm39) missense probably benign 0.04
R7548:Or1e26 UTSW 11 73,479,802 (GRCm39) missense possibly damaging 0.56
R7888:Or1e26 UTSW 11 73,480,354 (GRCm39) missense probably damaging 0.99
R7968:Or1e26 UTSW 11 73,480,154 (GRCm39) missense probably benign 0.05
R8923:Or1e26 UTSW 11 73,480,076 (GRCm39) missense probably benign
R9006:Or1e26 UTSW 11 73,480,036 (GRCm39) missense probably benign 0.40
R9281:Or1e26 UTSW 11 73,480,133 (GRCm39) missense probably benign
R9689:Or1e26 UTSW 11 73,479,686 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCGGTCATAGGCCATGAACATAAG -3'
(R):5'- TGACCCAGGATGAGCACATAGCAG -3'

Sequencing Primer
(F):5'- GCCATGAACATAAGAAGAAAGTTCTC -3'
(R):5'- GGAGTTTTGGCATCATAACCAC -3'
Posted On 2014-03-17