Incidental Mutation 'R1395:Vmn2r15'
ID 162792
Institutional Source Beutler Lab
Gene Symbol Vmn2r15
Ensembl Gene ENSMUSG00000091375
Gene Name vomeronasal 2, receptor 15
Synonyms EG211223
MMRRC Submission 039457-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R1395 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 109434135-109445422 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 109442014 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 140 (I140L)
Ref Sequence ENSEMBL: ENSMUSP00000128333 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167133]
AlphaFold L7N2A0
Predicted Effect probably benign
Transcript: ENSMUST00000167133
AA Change: I140L

PolyPhen 2 Score 0.435 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000128333
Gene: ENSMUSG00000091375
AA Change: I140L

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 75 472 1e-29 PFAM
Pfam:NCD3G 514 568 5.8e-18 PFAM
Pfam:7tm_3 601 836 9.1e-55 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 92.0%
Validation Efficiency 99% (70/71)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik A G 5: 113,249,362 (GRCm39) Y122H probably damaging Het
A330070K13Rik A G 5: 130,407,982 (GRCm39) probably benign Het
Abcc2 A G 19: 43,822,379 (GRCm39) R1406G probably benign Het
Adgrv1 G T 13: 81,534,907 (GRCm39) T5786K probably benign Het
Ankrd27 T C 7: 35,315,294 (GRCm39) F481S possibly damaging Het
Arhgap11a C T 2: 113,663,467 (GRCm39) V939I probably benign Het
Arhgap12 T C 18: 6,037,058 (GRCm39) N561S probably benign Het
Arhgef12 T C 9: 42,917,166 (GRCm39) H391R probably damaging Het
Asb3 T C 11: 31,051,032 (GRCm39) probably benign Het
C2cd5 T C 6: 143,007,464 (GRCm39) probably benign Het
Ccdc85a T C 11: 28,533,412 (GRCm39) K44R possibly damaging Het
Cep128 C T 12: 91,233,754 (GRCm39) R438Q probably benign Het
Cep192 A G 18: 67,991,992 (GRCm39) T1957A probably damaging Het
Col20a1 T A 2: 180,640,400 (GRCm39) V519E probably damaging Het
Cylc2 A G 4: 51,228,366 (GRCm39) K146E possibly damaging Het
Drgx C T 14: 32,330,326 (GRCm39) P148S probably benign Het
Dst T C 1: 34,204,236 (GRCm39) probably null Het
Eef1a1 C T 9: 78,386,300 (GRCm39) V402I probably benign Het
Esyt3 T C 9: 99,198,835 (GRCm39) probably benign Het
Extl3 A G 14: 65,314,945 (GRCm39) V79A possibly damaging Het
Fat3 C T 9: 16,158,212 (GRCm39) V1133I probably benign Het
Fcgbp A G 7: 27,792,804 (GRCm39) H936R probably damaging Het
Fdxacb1 TAGAC T 9: 50,683,796 (GRCm39) probably null Het
Fryl T C 5: 73,230,255 (GRCm39) H1634R probably damaging Het
Gm44511 G A 6: 128,797,293 (GRCm39) S32L possibly damaging Het
Gm8374 G T 14: 18,537,058 (GRCm39) N55K probably benign Het
Gria1 T A 11: 57,174,392 (GRCm39) I558N probably damaging Het
Gse1 G T 8: 121,301,738 (GRCm39) probably benign Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Hectd4 T C 5: 121,466,576 (GRCm39) probably null Het
Herc1 T C 9: 66,346,463 (GRCm39) I1943T probably benign Het
Ift172 T C 5: 31,442,582 (GRCm39) probably benign Het
Ift81 G T 5: 122,706,986 (GRCm39) D485E probably benign Het
Lactb T C 9: 66,878,661 (GRCm39) probably benign Het
Map1a C T 2: 121,134,406 (GRCm39) H1741Y probably benign Het
Map1lc3b T C 8: 122,323,459 (GRCm39) Y110H probably benign Het
Mlh1 T C 9: 111,076,445 (GRCm39) D304G probably damaging Het
Myo1f A G 17: 33,802,714 (GRCm39) D386G probably damaging Het
Ncoa4 T A 14: 31,894,798 (GRCm39) probably null Het
Neto1 T C 18: 86,416,144 (GRCm39) probably benign Het
Nf1 T C 11: 79,426,809 (GRCm39) V1741A possibly damaging Het
Nkain2 C A 10: 32,766,185 (GRCm39) probably benign Het
Obsl1 T C 1: 75,469,309 (GRCm39) S109G probably damaging Het
Or51ah3 T C 7: 103,210,326 (GRCm39) L214P possibly damaging Het
Or51f23 G A 7: 102,453,414 (GRCm39) C243Y possibly damaging Het
Or6z6 T A 7: 6,491,361 (GRCm39) T171S probably damaging Het
Or9s13 T A 1: 92,548,267 (GRCm39) I213N probably benign Het
Phlpp1 T C 1: 106,278,348 (GRCm39) V920A possibly damaging Het
Psen1 G A 12: 83,771,346 (GRCm39) G209R probably damaging Het
Ralgapa2 T G 2: 146,230,420 (GRCm39) K963N probably damaging Het
Rdh12 A G 12: 79,255,839 (GRCm39) T9A probably benign Het
Rgma G T 7: 73,067,542 (GRCm39) A360S probably benign Het
Sag G A 1: 87,756,163 (GRCm39) V257I probably benign Het
Scaf1 T C 7: 44,657,721 (GRCm39) E386G probably damaging Het
Slc4a10 A G 2: 62,143,630 (GRCm39) E1055G probably benign Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Spata31e5 T C 1: 28,815,890 (GRCm39) E714G possibly damaging Het
Spata46 A G 1: 170,139,573 (GRCm39) T191A probably benign Het
Tgm2 T A 2: 157,966,172 (GRCm39) H494L probably benign Het
Tub C T 7: 108,620,161 (GRCm39) R102* probably null Het
Ugt3a1 T G 15: 9,306,378 (GRCm39) L176V possibly damaging Het
Wdr44 T G X: 23,662,298 (GRCm39) C645G probably damaging Het
Wdr87-ps T A 7: 29,230,812 (GRCm39) noncoding transcript Het
Zfp322a C T 13: 23,540,945 (GRCm39) V266I probably benign Het
Zfp663 T C 2: 165,194,492 (GRCm39) R576G probably damaging Het
Other mutations in Vmn2r15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01335:Vmn2r15 APN 5 109,434,602 (GRCm39) missense possibly damaging 0.70
IGL01367:Vmn2r15 APN 5 109,441,075 (GRCm39) missense probably damaging 0.99
IGL01844:Vmn2r15 APN 5 109,434,135 (GRCm39) makesense probably null
IGL02190:Vmn2r15 APN 5 109,441,240 (GRCm39) missense probably damaging 1.00
IGL02754:Vmn2r15 APN 5 109,441,134 (GRCm39) nonsense probably null
IGL02797:Vmn2r15 APN 5 109,445,250 (GRCm39) missense probably benign 0.18
IGL03301:Vmn2r15 APN 5 109,445,221 (GRCm39) critical splice donor site probably null
IGL03407:Vmn2r15 APN 5 109,434,185 (GRCm39) nonsense probably null
BB001:Vmn2r15 UTSW 5 109,434,254 (GRCm39) missense probably damaging 1.00
BB011:Vmn2r15 UTSW 5 109,434,254 (GRCm39) missense probably damaging 1.00
PIT4445001:Vmn2r15 UTSW 5 109,435,008 (GRCm39) missense probably damaging 0.99
PIT4520001:Vmn2r15 UTSW 5 109,434,871 (GRCm39) missense probably damaging 1.00
R0038:Vmn2r15 UTSW 5 109,441,010 (GRCm39) missense possibly damaging 0.46
R0111:Vmn2r15 UTSW 5 109,435,022 (GRCm39) missense possibly damaging 0.56
R0379:Vmn2r15 UTSW 5 109,434,344 (GRCm39) missense probably damaging 1.00
R0427:Vmn2r15 UTSW 5 109,434,953 (GRCm39) missense probably damaging 1.00
R0639:Vmn2r15 UTSW 5 109,440,881 (GRCm39) missense probably benign 0.22
R0964:Vmn2r15 UTSW 5 109,445,401 (GRCm39) missense probably benign 0.34
R1147:Vmn2r15 UTSW 5 109,441,072 (GRCm39) missense probably damaging 1.00
R1147:Vmn2r15 UTSW 5 109,441,072 (GRCm39) missense probably damaging 1.00
R1232:Vmn2r15 UTSW 5 109,441,168 (GRCm39) missense probably benign 0.39
R1241:Vmn2r15 UTSW 5 109,440,770 (GRCm39) missense probably damaging 1.00
R1244:Vmn2r15 UTSW 5 109,441,092 (GRCm39) nonsense probably null
R1394:Vmn2r15 UTSW 5 109,442,014 (GRCm39) missense probably benign 0.44
R1423:Vmn2r15 UTSW 5 109,441,093 (GRCm39) missense probably damaging 1.00
R1439:Vmn2r15 UTSW 5 109,441,953 (GRCm39) missense probably damaging 1.00
R1513:Vmn2r15 UTSW 5 109,441,195 (GRCm39) missense probably damaging 1.00
R1777:Vmn2r15 UTSW 5 109,442,136 (GRCm39) missense possibly damaging 0.79
R1844:Vmn2r15 UTSW 5 109,434,860 (GRCm39) nonsense probably null
R2072:Vmn2r15 UTSW 5 109,434,619 (GRCm39) missense possibly damaging 0.65
R2074:Vmn2r15 UTSW 5 109,434,619 (GRCm39) missense possibly damaging 0.65
R2122:Vmn2r15 UTSW 5 109,434,322 (GRCm39) missense probably damaging 1.00
R2208:Vmn2r15 UTSW 5 109,445,309 (GRCm39) missense possibly damaging 0.64
R2268:Vmn2r15 UTSW 5 109,441,073 (GRCm39) missense probably benign 0.31
R2831:Vmn2r15 UTSW 5 109,434,458 (GRCm39) missense probably damaging 1.00
R3848:Vmn2r15 UTSW 5 109,445,312 (GRCm39) missense probably benign 0.00
R4058:Vmn2r15 UTSW 5 109,441,312 (GRCm39) missense probably damaging 0.99
R4615:Vmn2r15 UTSW 5 109,441,348 (GRCm39) missense possibly damaging 0.91
R4663:Vmn2r15 UTSW 5 109,441,940 (GRCm39) missense probably benign
R4681:Vmn2r15 UTSW 5 109,434,488 (GRCm39) missense probably damaging 0.97
R4751:Vmn2r15 UTSW 5 109,434,620 (GRCm39) missense probably benign 0.01
R5095:Vmn2r15 UTSW 5 109,436,317 (GRCm39) critical splice acceptor site probably null
R5300:Vmn2r15 UTSW 5 109,441,974 (GRCm39) missense probably damaging 0.99
R5309:Vmn2r15 UTSW 5 109,440,956 (GRCm39) missense probably damaging 0.99
R5335:Vmn2r15 UTSW 5 109,434,673 (GRCm39) missense probably damaging 0.99
R5421:Vmn2r15 UTSW 5 109,434,401 (GRCm39) missense probably damaging 1.00
R5805:Vmn2r15 UTSW 5 109,434,806 (GRCm39) missense possibly damaging 0.88
R6280:Vmn2r15 UTSW 5 109,441,291 (GRCm39) missense possibly damaging 0.65
R6324:Vmn2r15 UTSW 5 109,434,137 (GRCm39) makesense probably null
R6383:Vmn2r15 UTSW 5 109,441,092 (GRCm39) nonsense probably null
R6772:Vmn2r15 UTSW 5 109,434,238 (GRCm39) missense probably damaging 0.99
R6991:Vmn2r15 UTSW 5 109,441,180 (GRCm39) missense probably damaging 1.00
R7194:Vmn2r15 UTSW 5 109,440,649 (GRCm39) missense probably damaging 1.00
R7365:Vmn2r15 UTSW 5 109,445,388 (GRCm39) missense probably benign 0.15
R7365:Vmn2r15 UTSW 5 109,441,105 (GRCm39) missense probably benign 0.19
R7423:Vmn2r15 UTSW 5 109,445,394 (GRCm39) missense probably benign 0.00
R7552:Vmn2r15 UTSW 5 109,440,774 (GRCm39) nonsense probably null
R7619:Vmn2r15 UTSW 5 109,436,190 (GRCm39) critical splice donor site probably null
R7892:Vmn2r15 UTSW 5 109,434,217 (GRCm39) missense probably damaging 1.00
R7924:Vmn2r15 UTSW 5 109,434,254 (GRCm39) missense probably damaging 1.00
R8058:Vmn2r15 UTSW 5 109,440,956 (GRCm39) missense probably damaging 0.99
R8099:Vmn2r15 UTSW 5 109,441,185 (GRCm39) missense possibly damaging 0.58
R8189:Vmn2r15 UTSW 5 109,434,713 (GRCm39) missense probably benign 0.02
R8275:Vmn2r15 UTSW 5 109,434,150 (GRCm39) missense probably benign 0.08
R8277:Vmn2r15 UTSW 5 109,441,310 (GRCm39) missense probably damaging 1.00
R8277:Vmn2r15 UTSW 5 109,440,970 (GRCm39) missense probably benign 0.00
R8465:Vmn2r15 UTSW 5 109,445,302 (GRCm39) missense probably damaging 1.00
R8679:Vmn2r15 UTSW 5 109,434,779 (GRCm39) missense probably benign 0.31
R8682:Vmn2r15 UTSW 5 109,441,938 (GRCm39) missense probably damaging 0.98
R8809:Vmn2r15 UTSW 5 109,434,874 (GRCm39) missense probably benign 0.22
R9016:Vmn2r15 UTSW 5 109,442,109 (GRCm39) missense probably benign 0.01
R9372:Vmn2r15 UTSW 5 109,441,953 (GRCm39) missense possibly damaging 0.60
R9596:Vmn2r15 UTSW 5 109,440,791 (GRCm39) missense probably benign 0.01
R9619:Vmn2r15 UTSW 5 109,440,622 (GRCm39) missense possibly damaging 0.58
R9685:Vmn2r15 UTSW 5 109,440,598 (GRCm39) missense probably benign 0.05
R9716:Vmn2r15 UTSW 5 109,445,224 (GRCm39) missense possibly damaging 0.88
R9772:Vmn2r15 UTSW 5 109,434,923 (GRCm39) missense probably damaging 1.00
X0065:Vmn2r15 UTSW 5 109,441,174 (GRCm39) missense probably damaging 1.00
Z1187:Vmn2r15 UTSW 5 109,434,529 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCATACTCTCCAAGTTTTCATGTAGGCA -3'
(R):5'- GCAGCACACTGACTCTCTACGGTATAA -3'

Sequencing Primer
(F):5'- tggttaagagcactgcctg -3'
(R):5'- ATCTAGTTCAAGGTTGGCATTCAG -3'
Posted On 2014-03-17