Incidental Mutation 'R1364:Or10q1b'
ID 162868
Institutional Source Beutler Lab
Gene Symbol Or10q1b
Ensembl Gene ENSMUSG00000051156
Gene Name olfactory receptor family 10 subfamily Q member 1B
Synonyms MOR266-8, Olfr1491, GA_x6K02T2RE5P-4037809-4038768
MMRRC Submission 039429-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1364 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13682193-13683152 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13682809 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 206 (V206A)
Ref Sequence ENSEMBL: ENSMUSP00000149884 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052737] [ENSMUST00000214007] [ENSMUST00000215493] [ENSMUST00000216366] [ENSMUST00000216377] [ENSMUST00000216622]
AlphaFold Q8VEZ5
Predicted Effect probably benign
Transcript: ENSMUST00000052737
AA Change: V206A

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000057902
Gene: ENSMUSG00000051156
AA Change: V206A

DomainStartEndE-ValueType
Pfam:7tm_4 35 314 3.3e-52 PFAM
Pfam:7tm_1 45 295 5.9e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214007
AA Change: V206A

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000215493
AA Change: V206A

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000216366
AA Change: V206A

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000216377
AA Change: V206A

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000216622
AA Change: V206A

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.8%
Validation Efficiency 100% (38/38)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahi1 T A 10: 20,848,055 (GRCm39) L488I probably damaging Het
Bltp1 T C 3: 37,041,179 (GRCm39) F2519S probably damaging Het
Cobll1 A G 2: 64,956,654 (GRCm39) probably benign Het
Csn1s1 T C 5: 87,825,443 (GRCm39) probably benign Het
D430041D05Rik A T 2: 103,985,363 (GRCm39) S1920T possibly damaging Het
Dnah17 T A 11: 118,016,432 (GRCm39) probably benign Het
Fanca G A 8: 124,031,020 (GRCm39) probably benign Het
Fnbp1 T C 2: 30,949,043 (GRCm39) probably benign Het
Herc1 T A 9: 66,307,375 (GRCm39) L1023Q probably damaging Het
Hjurp T TN 1: 88,194,247 (GRCm39) probably null Het
Hycc1 T C 5: 24,170,351 (GRCm39) T333A probably benign Het
Kcnt1 A G 2: 25,798,106 (GRCm39) M906V probably damaging Het
Mfsd13a C T 19: 46,354,943 (GRCm39) T40I probably benign Het
Mid1 A C X: 168,769,090 (GRCm39) N215H probably damaging Het
Mug1 T A 6: 121,858,672 (GRCm39) L1130Q probably damaging Het
Nebl A T 2: 17,397,848 (GRCm39) probably benign Het
Otud7b A G 3: 96,058,768 (GRCm39) D320G probably damaging Het
Piezo1 T C 8: 123,225,310 (GRCm39) E563G possibly damaging Het
Prkd3 T C 17: 79,264,687 (GRCm39) T643A probably damaging Het
Prl3b1 G A 13: 27,427,848 (GRCm39) A53T probably benign Het
Rasl10b G A 11: 83,308,665 (GRCm39) probably null Het
Ripk3 A C 14: 56,022,717 (GRCm39) probably null Het
Sgsm3 T C 15: 80,892,143 (GRCm39) F237S probably damaging Het
Slit3 G A 11: 35,560,934 (GRCm39) V960I probably benign Het
Sptbn2 T C 19: 4,782,693 (GRCm39) L543P probably damaging Het
Tll2 G A 19: 41,108,667 (GRCm39) R328C probably damaging Het
Unkl A G 17: 25,408,597 (GRCm39) I54V probably benign Het
Wdr75 A G 1: 45,838,222 (GRCm39) T44A probably benign Het
Other mutations in Or10q1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Or10q1b APN 19 13,683,096 (GRCm39) missense probably benign 0.05
IGL02713:Or10q1b APN 19 13,682,553 (GRCm39) missense possibly damaging 0.78
IGL02822:Or10q1b APN 19 13,683,019 (GRCm39) missense probably benign 0.13
R0083:Or10q1b UTSW 19 13,683,042 (GRCm39) missense probably damaging 0.99
R0108:Or10q1b UTSW 19 13,683,042 (GRCm39) missense probably damaging 0.99
R0271:Or10q1b UTSW 19 13,682,499 (GRCm39) missense probably benign 0.03
R1538:Or10q1b UTSW 19 13,682,860 (GRCm39) missense probably damaging 1.00
R1575:Or10q1b UTSW 19 13,682,889 (GRCm39) missense probably benign 0.00
R1579:Or10q1b UTSW 19 13,682,566 (GRCm39) missense probably damaging 1.00
R2179:Or10q1b UTSW 19 13,682,758 (GRCm39) missense probably damaging 0.98
R4393:Or10q1b UTSW 19 13,682,554 (GRCm39) missense possibly damaging 0.50
R5837:Or10q1b UTSW 19 13,682,324 (GRCm39) nonsense probably null
R6001:Or10q1b UTSW 19 13,682,424 (GRCm39) missense probably damaging 0.98
R8064:Or10q1b UTSW 19 13,682,386 (GRCm39) missense probably damaging 1.00
R8132:Or10q1b UTSW 19 13,682,584 (GRCm39) missense probably damaging 1.00
R8294:Or10q1b UTSW 19 13,683,010 (GRCm39) missense probably benign 0.02
R8380:Or10q1b UTSW 19 13,682,608 (GRCm39) missense probably benign 0.11
R9608:Or10q1b UTSW 19 13,682,868 (GRCm39) missense probably damaging 1.00
Z1176:Or10q1b UTSW 19 13,682,567 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCAAGAAGCTGTGTGTTCAGATGG -3'
(R):5'- AGAGCACCTTTGACATCCTTGTTCC -3'

Sequencing Primer
(F):5'- AGATGGTGATGGGCTCTTTAAGC -3'
(R):5'- TAGACCAGGGCTATTTGCCG -3'
Posted On 2014-03-17