Incidental Mutation 'R1378:Vmn2r7'
ID 162932
Institutional Source Beutler Lab
Gene Symbol Vmn2r7
Ensembl Gene ENSMUSG00000116028
Gene Name vomeronasal 2, receptor 7
Synonyms 4933425M15Rik
MMRRC Submission 039442-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R1378 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 64598081-64627023 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 64599025 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 511 (S511P)
Ref Sequence ENSEMBL: ENSMUSP00000131220 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161972] [ENSMUST00000168072]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000161972
AA Change: S602P

PolyPhen 2 Score 0.593 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000124192
Gene: ENSMUSG00000062200
AA Change: S602P

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 90 507 3.8e-77 PFAM
Pfam:NCD3G 549 602 3.4e-17 PFAM
Pfam:7tm_3 635 869 1.1e-47 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000168072
AA Change: S511P

PolyPhen 2 Score 0.593 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000131220
Gene: ENSMUSG00000116028
AA Change: S511P

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 5.1e-72 PFAM
Pfam:Peripla_BP_6 63 245 6.1e-10 PFAM
Pfam:NCD3G 458 511 1.8e-17 PFAM
Pfam:7tm_3 542 779 4.3e-76 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177146
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 89.3%
Validation Efficiency 100% (57/57)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1 A G 5: 36,126,030 (GRCm39) T342A probably damaging Het
Alg1 A G 16: 5,061,580 (GRCm39) N406D probably damaging Het
Atp13a4 A T 16: 29,239,246 (GRCm39) M825K probably damaging Het
Birc6 T A 17: 74,967,450 (GRCm39) I4117K probably damaging Het
Brinp2 A T 1: 158,074,624 (GRCm39) L499Q possibly damaging Het
Brwd1 A T 16: 95,842,570 (GRCm39) V789D probably benign Het
Ccdc153 C G 9: 44,154,958 (GRCm39) L94V probably null Het
Ccna1 A G 3: 54,957,150 (GRCm39) V237A probably damaging Het
Cct7 T A 6: 85,444,545 (GRCm39) probably null Het
Cenpb C T 2: 131,020,230 (GRCm39) probably benign Het
Chrne T A 11: 70,505,956 (GRCm39) probably null Het
Clstn3 T A 6: 124,415,378 (GRCm39) D662V probably damaging Het
Clu G T 14: 66,212,350 (GRCm39) C189F probably damaging Het
Cstdc5 A G 16: 36,179,929 (GRCm39) C63R probably benign Het
Cul7 C T 17: 46,973,052 (GRCm39) R1388C probably damaging Het
Dgka T C 10: 128,571,696 (GRCm39) probably null Het
Dop1b A G 16: 93,567,280 (GRCm39) T1236A probably benign Het
Edn2 A G 4: 120,019,095 (GRCm39) E28G probably benign Het
Elp3 T C 14: 65,830,380 (GRCm39) I24V probably benign Het
Faap24 T C 7: 35,092,326 (GRCm39) E197G probably benign Het
Fam13a T A 6: 58,933,736 (GRCm39) M285L probably benign Het
Gm9944 T A 4: 144,179,773 (GRCm39) probably benign Het
Gsdmc3 T C 15: 63,731,435 (GRCm39) probably benign Het
Gvin3 T A 7: 106,201,373 (GRCm39) I624F probably damaging Het
Ift22 A C 5: 136,941,757 (GRCm39) K133T probably benign Het
Il23r T A 6: 67,429,394 (GRCm39) K316I possibly damaging Het
Klra17 T A 6: 129,842,647 (GRCm39) E217V probably damaging Het
Nell2 A T 15: 95,130,402 (GRCm39) V657E probably damaging Het
Nlrp4d C A 7: 10,098,111 (GRCm39) K850N probably benign Het
Nsmce4a C T 7: 130,139,900 (GRCm39) R276Q probably benign Het
Or10d4 T C 9: 39,580,962 (GRCm39) L203P probably damaging Het
Or4p8 T A 2: 88,727,370 (GRCm39) R190S probably benign Het
Or52s1b T C 7: 102,822,475 (GRCm39) D123G probably damaging Het
Or52z14 A T 7: 103,253,145 (GRCm39) R95* probably null Het
Pclo T C 5: 14,732,327 (GRCm39) S3610P probably benign Het
Pon3 T G 6: 5,230,813 (GRCm39) D238A probably benign Het
Ppp4r4 T C 12: 103,547,751 (GRCm39) probably benign Het
Rad18 T C 6: 112,658,297 (GRCm39) probably benign Het
Ralgapa1 T C 12: 55,723,711 (GRCm39) Y1652C probably damaging Het
Rem1 G A 2: 152,476,455 (GRCm39) V238M probably damaging Het
Sel1l T C 12: 91,799,871 (GRCm39) probably null Het
Soat1 A G 1: 156,294,352 (GRCm39) probably benign Het
Tex15 A T 8: 34,065,244 (GRCm39) N1558I probably damaging Het
Tmem132d A T 5: 128,346,011 (GRCm39) F170L probably benign Het
Tro G T X: 149,438,567 (GRCm39) P30Q probably damaging Het
Tubg2 G T 11: 101,047,699 (GRCm39) E95* probably null Het
Unc45b G A 11: 82,827,678 (GRCm39) S725N probably benign Het
Vps35l G T 7: 118,393,795 (GRCm39) E515* probably null Het
Vps35l A T 7: 118,393,796 (GRCm39) E515V probably damaging Het
Zfp174 G A 16: 3,667,353 (GRCm39) E181K probably benign Het
Other mutations in Vmn2r7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00961:Vmn2r7 APN 3 64,623,234 (GRCm39) missense possibly damaging 0.60
IGL01762:Vmn2r7 APN 3 64,598,856 (GRCm39) missense probably benign 0.39
IGL01903:Vmn2r7 APN 3 64,626,864 (GRCm39) missense probably benign 0.00
IGL02263:Vmn2r7 APN 3 64,598,868 (GRCm39) missense probably damaging 1.00
IGL02458:Vmn2r7 APN 3 64,600,446 (GRCm39) missense probably damaging 0.97
IGL02593:Vmn2r7 APN 3 64,600,443 (GRCm39) missense probably damaging 1.00
IGL02797:Vmn2r7 APN 3 64,598,666 (GRCm39) missense possibly damaging 0.80
IGL03047:Vmn2r7 UTSW 3 64,614,639 (GRCm39) missense possibly damaging 0.81
PIT4504001:Vmn2r7 UTSW 3 64,623,397 (GRCm39) missense probably benign 0.01
R0193:Vmn2r7 UTSW 3 64,598,460 (GRCm39) missense probably damaging 1.00
R0329:Vmn2r7 UTSW 3 64,598,439 (GRCm39) missense probably damaging 1.00
R0609:Vmn2r7 UTSW 3 64,623,900 (GRCm39) missense probably benign 0.44
R0735:Vmn2r7 UTSW 3 64,623,788 (GRCm39) missense probably benign 0.02
R0941:Vmn2r7 UTSW 3 64,624,000 (GRCm39) missense probably benign
R1065:Vmn2r7 UTSW 3 64,614,559 (GRCm39) missense possibly damaging 0.82
R1445:Vmn2r7 UTSW 3 64,632,223 (GRCm39) missense probably benign 0.01
R1506:Vmn2r7 UTSW 3 64,614,500 (GRCm39) missense probably benign
R1509:Vmn2r7 UTSW 3 64,623,881 (GRCm39) nonsense probably null
R1519:Vmn2r7 UTSW 3 64,623,876 (GRCm39) missense possibly damaging 0.95
R1706:Vmn2r7 UTSW 3 64,598,880 (GRCm39) missense possibly damaging 0.79
R2113:Vmn2r7 UTSW 3 64,599,025 (GRCm39) missense possibly damaging 0.59
R3725:Vmn2r7 UTSW 3 64,632,412 (GRCm39) missense possibly damaging 0.65
R3874:Vmn2r7 UTSW 3 64,627,032 (GRCm39) missense possibly damaging 0.69
R3902:Vmn2r7 UTSW 3 64,626,937 (GRCm39) missense possibly damaging 0.46
R4084:Vmn2r7 UTSW 3 64,600,414 (GRCm39) missense probably benign 0.08
R4117:Vmn2r7 UTSW 3 64,623,138 (GRCm39) intron probably benign
R4333:Vmn2r7 UTSW 3 64,598,199 (GRCm39) missense probably damaging 1.00
R4551:Vmn2r7 UTSW 3 64,598,110 (GRCm39) missense possibly damaging 0.86
R4643:Vmn2r7 UTSW 3 64,623,825 (GRCm39) missense probably damaging 1.00
R4654:Vmn2r7 UTSW 3 64,626,864 (GRCm39) missense probably benign 0.00
R5091:Vmn2r7 UTSW 3 64,598,205 (GRCm39) missense possibly damaging 0.63
R5109:Vmn2r7 UTSW 3 64,598,088 (GRCm39) missense probably null 0.84
R5372:Vmn2r7 UTSW 3 64,623,745 (GRCm39) missense probably damaging 1.00
R5415:Vmn2r7 UTSW 3 64,623,658 (GRCm39) missense probably benign 0.07
R5740:Vmn2r7 UTSW 3 64,614,654 (GRCm39) missense probably benign
R5977:Vmn2r7 UTSW 3 64,623,464 (GRCm39) nonsense probably null
R6019:Vmn2r7 UTSW 3 64,623,643 (GRCm39) missense probably damaging 1.00
R6058:Vmn2r7 UTSW 3 64,632,436 (GRCm39) missense probably benign 0.00
R6139:Vmn2r7 UTSW 3 64,623,339 (GRCm39) missense probably damaging 1.00
R6696:Vmn2r7 UTSW 3 64,614,495 (GRCm39) missense probably benign 0.01
R6887:Vmn2r7 UTSW 3 64,598,248 (GRCm39) missense probably damaging 1.00
R6918:Vmn2r7 UTSW 3 64,598,760 (GRCm39) missense probably benign 0.03
R6949:Vmn2r7 UTSW 3 64,598,542 (GRCm39) missense probably damaging 0.99
R6980:Vmn2r7 UTSW 3 64,623,987 (GRCm39) missense possibly damaging 0.67
R7196:Vmn2r7 UTSW 3 64,623,198 (GRCm39) missense probably benign 0.00
R7286:Vmn2r7 UTSW 3 64,598,301 (GRCm39) missense probably benign 0.00
R7455:Vmn2r7 UTSW 3 64,624,014 (GRCm39) missense probably benign
R7557:Vmn2r7 UTSW 3 64,632,394 (GRCm39) missense probably benign
R7864:Vmn2r7 UTSW 3 64,598,947 (GRCm39) missense probably benign 0.10
R8046:Vmn2r7 UTSW 3 64,614,479 (GRCm39) missense probably damaging 1.00
R8068:Vmn2r7 UTSW 3 64,623,507 (GRCm39) missense probably benign 0.01
R8252:Vmn2r7 UTSW 3 64,600,527 (GRCm39) missense probably benign 0.00
R8814:Vmn2r7 UTSW 3 64,623,984 (GRCm39) missense probably benign 0.14
R9497:Vmn2r7 UTSW 3 64,614,474 (GRCm39) missense probably benign 0.04
R9722:Vmn2r7 UTSW 3 64,598,407 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCCAGAGACACCTGAATGAGGAAG -3'
(R):5'- TGTCACATCATCTGCACCAAGGC -3'

Sequencing Primer
(F):5'- CCTGAATGAGGAAGCTCAGCTC -3'
(R):5'- GCACCAAGGCCCCTTTTATAA -3'
Posted On 2014-03-17