Mutagenetix > Incidental Mutation

Incidental Mutation 'R0097:Vmn1r228'

16311

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r228

Ensembl Gene

ENSMUSG00000060245

Gene Name

vomeronasal 1 receptor 228

Synonyms

V1re3

MMRRC Submission

038383-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

R0097 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

20996321-20997763 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20996625 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 298 (M298V)

Ref Sequence

ENSEMBL: ENSMUSP00000072243 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072410]

AlphaFold

Q8R2A7

Predicted Effect

probably benign
Transcript: ENSMUST00000072410
AA Change: M298V

PolyPhen 2 Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000072243
Gene: ENSMUSG00000060245
AA Change: M298V

Domain	Start	End	E-Value	Type
Pfam:TAS2R	32	317	2.6e-11	PFAM
Pfam:7tm_1	53	316	2.6e-9	PFAM
Pfam:V1R	63	321	1.3e-26	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 89.4%
3x: 86.4%
10x: 78.0%
20x: 64.9%

Validation Efficiency

86% (56/65)

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	A	T	3: 124,206,129 (GRCm39)	I353K	probably benign	Het
Albfm1	T	A	5: 90,732,795 (GRCm39)	S535R	probably benign	Het
Arfgap2	T	A	2: 91,105,160 (GRCm39)	V422E	probably benign	Het
Baz1b	T	C	5: 135,227,113 (GRCm39)	S105P	probably benign	Het
Cacna1s	T	A	1: 136,028,360 (GRCm39)	M899K	possibly damaging	Het
Ccnd2	G	A	6: 127,123,015 (GRCm39)	A180V	probably benign	Het
Ciao3	T	C	17: 25,995,976 (GRCm39)	S67P	possibly damaging	Het
Dmrta1	A	T	4: 89,577,109 (GRCm39)	R188S	probably benign	Het
Eml3	T	A	19: 8,914,015 (GRCm39)	F465L	probably benign	Het
Gm9938	T	A	19: 23,701,828 (GRCm39)		probably benign	Het
Gpr87	G	A	3: 59,086,506 (GRCm39)	T333I	probably damaging	Het
Lzic	A	G	4: 149,572,533 (GRCm39)	E41G	probably damaging	Het
Mprip	T	A	11: 59,649,317 (GRCm39)	L1007Q	possibly damaging	Het
Mtfr2	T	A	10: 20,224,122 (GRCm39)	S19T	probably damaging	Het
Mycbp2	A	T	14: 103,393,198 (GRCm39)	M3121K	probably damaging	Het
Myocd	T	A	11: 65,069,840 (GRCm39)	M667L	possibly damaging	Het
Neb	T	C	2: 52,094,906 (GRCm39)	N4882S	probably damaging	Het
Neo1	T	C	9: 58,882,021 (GRCm38)		probably benign	Het
Neu2	A	G	1: 87,525,188 (GRCm39)	D391G	probably benign	Het
Nol4	C	A	18: 22,852,198 (GRCm39)	A456S	probably benign	Het
Or5m13	T	C	2: 85,749,184 (GRCm39)	V305A	probably benign	Het
Padi6	C	T	4: 140,458,268 (GRCm39)	V513M	probably benign	Het
Prss38	A	G	11: 59,266,434 (GRCm39)	L8S	possibly damaging	Het
Rab5b	A	T	10: 128,518,809 (GRCm39)	F108I	probably damaging	Het
Ryr3	T	C	2: 112,630,400 (GRCm39)	D2157G	probably damaging	Het
Secisbp2l	T	C	2: 125,613,376 (GRCm39)	D206G	probably damaging	Het
Sh3pxd2b	T	A	11: 32,353,978 (GRCm39)	I182N	probably damaging	Het
Slc3a1	A	T	17: 85,340,288 (GRCm39)	I237F	probably damaging	Het
St6galnac6	T	C	2: 32,489,814 (GRCm39)	L8P	probably damaging	Het
T	A	T	17: 8,658,733 (GRCm39)		probably benign	Het
Tenm4	A	T	7: 96,542,133 (GRCm39)	D1882V	probably damaging	Het
Tgfbr1	T	A	4: 47,403,451 (GRCm39)	L283*	probably null	Het
Ubp1	T	C	9: 113,802,575 (GRCm39)		probably benign	Het
Ushbp1	C	T	8: 71,843,357 (GRCm39)	C314Y	probably damaging	Het
Vav2	A	T	2: 27,189,374 (GRCm39)		probably benign	Het
Zmpste24	A	T	4: 120,952,740 (GRCm39)		probably benign	Het

Other mutations in Vmn1r228

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01368:Vmn1r228	APN	17	20,996,774 (GRCm39)	missense	probably benign	0.07
IGL03275:Vmn1r228	APN	17	20,997,104 (GRCm39)	missense	probably damaging	1.00
PIT4498001:Vmn1r228	UTSW	17	20,996,772 (GRCm39)	missense	probably benign	0.00
R0097:Vmn1r228	UTSW	17	20,996,625 (GRCm39)	missense	probably benign	0.05
R0270:Vmn1r228	UTSW	17	20,996,858 (GRCm39)	missense	possibly damaging	0.60
R0279:Vmn1r228	UTSW	17	20,996,637 (GRCm39)	missense	probably benign	0.02
R1544:Vmn1r228	UTSW	17	20,997,285 (GRCm39)	missense	probably benign	0.00
R1695:Vmn1r228	UTSW	17	20,996,560 (GRCm39)	missense	possibly damaging	0.49
R2086:Vmn1r228	UTSW	17	20,997,455 (GRCm39)	missense	possibly damaging	0.71
R2275:Vmn1r228	UTSW	17	20,996,807 (GRCm39)	missense	probably damaging	1.00
R2965:Vmn1r228	UTSW	17	20,996,609 (GRCm39)	missense	probably damaging	0.99
R4425:Vmn1r228	UTSW	17	20,996,861 (GRCm39)	missense	probably damaging	1.00
R4447:Vmn1r228	UTSW	17	20,997,369 (GRCm39)	missense	probably damaging	0.96
R5031:Vmn1r228	UTSW	17	20,996,943 (GRCm39)	nonsense	probably null
R6345:Vmn1r228	UTSW	17	20,997,144 (GRCm39)	missense	probably damaging	1.00
R7064:Vmn1r228	UTSW	17	20,997,285 (GRCm39)	missense	probably benign	0.00
R7880:Vmn1r228	UTSW	17	20,996,672 (GRCm39)	missense	probably damaging	1.00
R8000:Vmn1r228	UTSW	17	20,997,227 (GRCm39)	missense	possibly damaging	0.88
R8290:Vmn1r228	UTSW	17	20,996,724 (GRCm39)	missense	probably benign	0.09
R9022:Vmn1r228	UTSW	17	20,996,778 (GRCm39)	missense	probably damaging	1.00
R9027:Vmn1r228	UTSW	17	20,997,422 (GRCm39)	missense	probably benign	0.01
R9291:Vmn1r228	UTSW	17	20,997,023 (GRCm39)	missense	probably benign
R9492:Vmn1r228	UTSW	17	20,996,862 (GRCm39)	missense	probably damaging	1.00
R9618:Vmn1r228	UTSW	17	20,997,045 (GRCm39)	missense	probably benign	0.00
X0018:Vmn1r228	UTSW	17	20,996,963 (GRCm39)	missense	probably benign	0.08

Posted On

2013-01-20