Incidental Mutation 'R1484:Or1e26'
ID 163334
Institutional Source Beutler Lab
Gene Symbol Or1e26
Ensembl Gene ENSMUSG00000095095
Gene Name olfactory receptor family 1 subfamily E member 26
Synonyms Olfr385, GA_x6K02T2P1NL-3760313-3759375, MOR135-3
MMRRC Submission 039537-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.166) question?
Stock # R1484 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 73479624-73480562 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 73480187 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 126 (I126L)
Ref Sequence ENSEMBL: ENSMUSP00000149293 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071553] [ENSMUST00000215689]
AlphaFold Q8VGT1
Predicted Effect possibly damaging
Transcript: ENSMUST00000071553
AA Change: I126L

PolyPhen 2 Score 0.908 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000071484
Gene: ENSMUSG00000095095
AA Change: I126L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.1e-55 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.7e-6 PFAM
Pfam:7tm_1 41 290 2.2e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215689
AA Change: I126L

PolyPhen 2 Score 0.908 (Sensitivity: 0.81; Specificity: 0.94)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.4%
Validation Efficiency 97% (85/88)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930584F24Rik A T 5: 26,684,776 (GRCm39) noncoding transcript Het
Acvr1 A T 2: 58,369,901 (GRCm39) V36E probably damaging Het
Aldh4a1 A G 4: 139,370,758 (GRCm39) I414V probably benign Het
Alox5 C T 6: 116,431,128 (GRCm39) C100Y probably damaging Het
Ano5 T A 7: 51,216,068 (GRCm39) D348E probably damaging Het
Arhgap30 G A 1: 171,230,839 (GRCm39) V199M probably damaging Het
Arl13b T A 16: 62,626,999 (GRCm39) Q234L probably benign Het
Atxn1 C A 13: 45,711,052 (GRCm39) E627* probably null Het
Bend3 T C 10: 43,386,197 (GRCm39) F197L probably benign Het
Brca1 A T 11: 101,420,638 (GRCm39) V190E possibly damaging Het
Brpf1 T C 6: 113,292,096 (GRCm39) W381R probably damaging Het
Brwd1 A C 16: 95,829,491 (GRCm39) probably null Het
C1s2 T C 6: 124,602,604 (GRCm39) I530V possibly damaging Het
C2cd3 C T 7: 100,089,397 (GRCm39) R1638W probably damaging Het
Capns1 T A 7: 29,893,511 (GRCm39) probably benign Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cep126 G A 9: 8,100,554 (GRCm39) T660I possibly damaging Het
Cep295 A C 9: 15,246,080 (GRCm39) I744R probably damaging Het
Chd3 T C 11: 69,250,725 (GRCm39) E668G probably benign Het
Chek2 A G 5: 110,996,553 (GRCm39) T172A probably damaging Het
Col6a4 A G 9: 105,890,501 (GRCm39) probably null Het
Coq3 G A 4: 21,900,291 (GRCm39) V173I probably benign Het
Cyp4x1 A T 4: 114,970,098 (GRCm39) I343N probably damaging Het
Dnah7b T A 1: 46,176,703 (GRCm39) D774E probably benign Het
Dnai3 T C 3: 145,802,996 (GRCm39) D65G probably benign Het
Ecm1 G A 3: 95,643,275 (GRCm39) R342C probably damaging Het
Esrra T C 19: 6,890,197 (GRCm39) Y209C probably damaging Het
Gpr149 A T 3: 62,502,592 (GRCm39) D421E probably benign Het
Gpr15 T C 16: 58,538,937 (GRCm39) N51D probably damaging Het
Gpr156 T C 16: 37,812,558 (GRCm39) V298A probably damaging Het
Hmcn2 G A 2: 31,236,507 (GRCm39) G350D probably damaging Het
Ifih1 A T 2: 62,440,902 (GRCm39) N421K probably benign Het
Ilvbl C A 10: 78,412,564 (GRCm39) T95K probably damaging Het
Itgb4 T A 11: 115,890,625 (GRCm39) D1104E probably benign Het
Katnip C A 7: 125,415,743 (GRCm39) probably benign Het
Lipf A T 19: 33,942,180 (GRCm39) M37L probably benign Het
Lyst T A 13: 13,852,775 (GRCm39) N2258K probably benign Het
Moxd1 A G 10: 24,099,758 (GRCm39) Y86C probably damaging Het
Muc5ac T C 7: 141,367,629 (GRCm39) probably null Het
Myo16 G A 8: 10,610,145 (GRCm39) R1162H probably damaging Het
Myo5c A T 9: 75,208,092 (GRCm39) N1609Y probably damaging Het
Nbeal1 T C 1: 60,240,098 (GRCm39) F155L probably damaging Het
Nek4 A T 14: 30,704,290 (GRCm39) M602L possibly damaging Het
Nek9 A G 12: 85,348,622 (GRCm39) S971P probably damaging Het
Nfya A T 17: 48,700,570 (GRCm39) probably benign Het
Nrxn3 A T 12: 89,221,547 (GRCm39) N442I probably damaging Het
Nup42 A C 5: 24,383,075 (GRCm39) K200N probably benign Het
Or4c111 G A 2: 88,843,713 (GRCm39) R232* probably null Het
Or7g32 G A 9: 19,389,423 (GRCm39) T38I probably damaging Het
Pcdh15 T A 10: 74,126,833 (GRCm39) I304N probably damaging Het
Pigo G C 4: 43,024,779 (GRCm39) P107A probably damaging Het
Plce1 C T 19: 38,693,783 (GRCm39) Q769* probably null Het
Plin2 C T 4: 86,575,481 (GRCm39) R356H probably benign Het
Ppp1r9a G T 6: 5,113,712 (GRCm39) E739* probably null Het
Ppp3cc G T 14: 70,478,397 (GRCm39) N268K probably damaging Het
Prkag3 T A 1: 74,779,919 (GRCm39) D472V probably damaging Het
Ptch2 A T 4: 116,968,046 (GRCm39) D846V probably damaging Het
Rhob A T 12: 8,549,388 (GRCm39) M82K probably damaging Het
Rps6kc1 T A 1: 190,531,672 (GRCm39) R777W possibly damaging Het
Sap130 T A 18: 31,844,380 (GRCm39) V850E probably damaging Het
Sema3a T G 5: 13,523,407 (GRCm39) N125K probably damaging Het
Sema5a A G 15: 32,460,431 (GRCm39) D64G probably damaging Het
Sgo2b T A 8: 64,384,507 (GRCm39) D163V possibly damaging Het
Slc15a1 A T 14: 121,728,651 (GRCm39) Y31* probably null Het
Smchd1 A T 17: 71,685,252 (GRCm39) M1392K probably benign Het
Sobp T A 10: 43,036,827 (GRCm39) N37I probably damaging Het
Spock3 G T 8: 63,673,739 (GRCm39) C142F probably damaging Het
Stx6 A C 1: 155,053,650 (GRCm39) S86R probably benign Het
Sult2a4 C A 7: 13,643,726 (GRCm39) M280I probably benign Het
Synm A T 7: 67,386,080 (GRCm39) D527E probably damaging Het
Tax1bp1 C T 6: 52,710,305 (GRCm39) R195W probably damaging Het
Themis2 A T 4: 132,519,796 (GRCm39) N76K possibly damaging Het
Tmem8b A G 4: 43,690,234 (GRCm39) T890A probably benign Het
Traf7 T A 17: 24,730,785 (GRCm39) H366L possibly damaging Het
Trim30c A T 7: 104,032,459 (GRCm39) V289D probably benign Het
Tsr1 T A 11: 74,792,914 (GRCm39) D407E probably damaging Het
Ubap2 G T 4: 41,235,593 (GRCm39) A33E probably damaging Het
Unc13d C A 11: 115,964,701 (GRCm39) R255L possibly damaging Het
Ush2a G T 1: 188,542,534 (GRCm39) G3367* probably null Het
Vmn1r229 T C 17: 21,034,791 (GRCm39) L12P probably damaging Het
Vmn2r27 C A 6: 124,177,474 (GRCm39) G510V probably damaging Het
Vps4b T C 1: 106,707,712 (GRCm39) E257G probably damaging Het
Vps72 T C 3: 95,026,462 (GRCm39) S136P probably damaging Het
Wdr36 T C 18: 32,976,938 (GRCm39) I181T possibly damaging Het
Wfikkn1 C T 17: 26,096,765 (GRCm39) A520T probably benign Het
Other mutations in Or1e26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01570:Or1e26 APN 11 73,480,209 (GRCm39) missense probably benign 0.34
IGL02045:Or1e26 APN 11 73,480,058 (GRCm39) missense probably damaging 1.00
IGL02324:Or1e26 APN 11 73,480,081 (GRCm39) missense probably benign 0.02
IGL02328:Or1e26 APN 11 73,480,081 (GRCm39) missense probably benign 0.02
IGL02562:Or1e26 APN 11 73,480,237 (GRCm39) missense probably benign
IGL02715:Or1e26 APN 11 73,479,947 (GRCm39) missense probably benign 0.00
IGL03182:Or1e26 APN 11 73,480,268 (GRCm39) missense probably benign 0.04
IGL03048:Or1e26 UTSW 11 73,479,831 (GRCm39) missense possibly damaging 0.56
R0346:Or1e26 UTSW 11 73,480,283 (GRCm39) missense probably damaging 1.00
R0675:Or1e26 UTSW 11 73,480,078 (GRCm39) missense probably damaging 1.00
R0751:Or1e26 UTSW 11 73,479,970 (GRCm39) missense probably benign 0.02
R1220:Or1e26 UTSW 11 73,480,203 (GRCm39) nonsense probably null
R1389:Or1e26 UTSW 11 73,480,369 (GRCm39) missense possibly damaging 0.88
R1619:Or1e26 UTSW 11 73,480,118 (GRCm39) missense probably damaging 1.00
R2290:Or1e26 UTSW 11 73,479,745 (GRCm39) missense probably benign 0.37
R3713:Or1e26 UTSW 11 73,479,731 (GRCm39) missense probably damaging 1.00
R3781:Or1e26 UTSW 11 73,480,194 (GRCm39) nonsense probably null
R3781:Or1e26 UTSW 11 73,479,839 (GRCm39) missense probably damaging 1.00
R3782:Or1e26 UTSW 11 73,480,194 (GRCm39) nonsense probably null
R3782:Or1e26 UTSW 11 73,479,839 (GRCm39) missense probably damaging 1.00
R4402:Or1e26 UTSW 11 73,480,081 (GRCm39) missense probably benign 0.02
R4721:Or1e26 UTSW 11 73,480,273 (GRCm39) missense probably damaging 1.00
R5157:Or1e26 UTSW 11 73,480,549 (GRCm39) missense probably damaging 1.00
R5995:Or1e26 UTSW 11 73,480,076 (GRCm39) missense probably benign
R6373:Or1e26 UTSW 11 73,479,724 (GRCm39) missense probably benign 0.42
R6658:Or1e26 UTSW 11 73,479,874 (GRCm39) missense probably damaging 0.99
R7046:Or1e26 UTSW 11 73,480,558 (GRCm39) missense probably benign
R7096:Or1e26 UTSW 11 73,480,463 (GRCm39) missense probably benign 0.03
R7238:Or1e26 UTSW 11 73,480,561 (GRCm39) start codon destroyed probably null 0.99
R7537:Or1e26 UTSW 11 73,480,094 (GRCm39) missense probably benign 0.04
R7548:Or1e26 UTSW 11 73,479,802 (GRCm39) missense possibly damaging 0.56
R7888:Or1e26 UTSW 11 73,480,354 (GRCm39) missense probably damaging 0.99
R7968:Or1e26 UTSW 11 73,480,154 (GRCm39) missense probably benign 0.05
R8923:Or1e26 UTSW 11 73,480,076 (GRCm39) missense probably benign
R9006:Or1e26 UTSW 11 73,480,036 (GRCm39) missense probably benign 0.40
R9281:Or1e26 UTSW 11 73,480,133 (GRCm39) missense probably benign
R9689:Or1e26 UTSW 11 73,479,686 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGGGATTCAGCATGGGAGTCACC -3'
(R):5'- GTCACAATGCCCAAGTTGCTGC -3'

Sequencing Primer
(F):5'- GCAGTGTCCTTCACAGTAGAG -3'
(R):5'- TGCAGAACATGCAAAGCCAG -3'
Posted On 2014-03-28