Incidental Mutation 'R1490:Gpd2'
ID 163636
Institutional Source Beutler Lab
Gene Symbol Gpd2
Ensembl Gene ENSMUSG00000026827
Gene Name glycerol phosphate dehydrogenase 2, mitochondrial
Synonyms Gdm1
MMRRC Submission 039542-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.593) question?
Stock # R1490 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 57127690-57260731 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 57245487 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 394 (V394A)
Ref Sequence ENSEMBL: ENSMUSP00000130992 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028167] [ENSMUST00000112618] [ENSMUST00000169687]
AlphaFold Q64521
Predicted Effect probably damaging
Transcript: ENSMUST00000028167
AA Change: V394A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000028167
Gene: ENSMUSG00000026827
AA Change: V394A

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
Pfam:FAD_binding_2 71 145 5.2e-7 PFAM
Pfam:FAD_oxidored 71 147 2.3e-9 PFAM
Pfam:DAO 71 441 8.9e-52 PFAM
EFh 627 655 1.38e1 SMART
EFh 663 691 1.27e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000112618
AA Change: V394A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000108237
Gene: ENSMUSG00000026827
AA Change: V394A

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
Pfam:FAD_binding_2 71 143 4.6e-7 PFAM
Pfam:DAO 71 441 2.9e-50 PFAM
Pfam:DAO_C 462 588 2.1e-42 PFAM
EFh 645 673 1.38e1 SMART
EFh 681 709 1.27e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141536
Predicted Effect probably damaging
Transcript: ENSMUST00000169687
AA Change: V394A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000130992
Gene: ENSMUSG00000026827
AA Change: V394A

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
Pfam:FAD_binding_2 71 145 5.2e-7 PFAM
Pfam:FAD_oxidored 71 147 2.3e-9 PFAM
Pfam:DAO 71 441 8.9e-52 PFAM
EFh 627 655 1.38e1 SMART
EFh 663 691 1.27e-3 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
PHENOTYPE: Homozygotes for targeted null mutations exhibit diminished hepatic ATP levels, decreased adiposity and fasting blood glucose, and, on an inbred background, reductions in preweaning viability and fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1l2 G A 10: 83,356,234 (GRCm39) T52I probably damaging Het
Arhgef28 G A 13: 98,114,952 (GRCm39) R633W probably damaging Het
Atg9a T C 1: 75,162,389 (GRCm39) N507S possibly damaging Het
Bsn A G 9: 107,991,193 (GRCm39) S1520P probably benign Het
Cacul1 G T 19: 60,568,837 (GRCm39) A107E probably damaging Het
Cd74 A G 18: 60,944,438 (GRCm39) D216G probably damaging Het
Cdh16 A T 8: 105,348,702 (GRCm39) W109R probably damaging Het
Cdip1 C T 16: 4,586,775 (GRCm39) V100I probably damaging Het
Ceacam3 A G 7: 16,897,071 (GRCm39) D679G probably damaging Het
Comp A G 8: 70,826,563 (GRCm39) D46G possibly damaging Het
Dlx3 T C 11: 95,011,430 (GRCm39) Y95H probably benign Het
Dmrta2 T C 4: 109,837,072 (GRCm39) S5P unknown Het
E130308A19Rik A G 4: 59,719,746 (GRCm39) Y426C probably damaging Het
Entpd3 A G 9: 120,383,225 (GRCm39) S87G probably benign Het
Eps8l1 A G 7: 4,473,888 (GRCm39) R232G probably damaging Het
Gart A T 16: 91,421,232 (GRCm39) V812D probably damaging Het
Gm10153 C T 7: 141,743,879 (GRCm39) C83Y unknown Het
Hpcal1 A T 12: 17,836,225 (GRCm39) E18D probably benign Het
Mdga2 T C 12: 66,844,530 (GRCm39) D156G probably benign Het
Mks1 A G 11: 87,753,595 (GRCm39) K510E probably benign Het
Ms4a19 A G 19: 11,118,902 (GRCm39) I69T probably benign Het
Mtmr4 G A 11: 87,503,051 (GRCm39) R1035Q probably damaging Het
Myh6 T A 14: 55,200,175 (GRCm39) K235* probably null Het
Nedd1 A G 10: 92,536,660 (GRCm39) F214S probably damaging Het
Or1e32 A G 11: 73,705,197 (GRCm39) V237A possibly damaging Het
Or1o3 A G 17: 37,573,733 (GRCm39) M274T probably benign Het
Or2l13 T C 16: 19,305,672 (GRCm39) M28T probably benign Het
Or52e15 A G 7: 104,645,700 (GRCm39) I137T possibly damaging Het
Pfkfb2 A C 1: 130,625,626 (GRCm39) probably null Het
Pfkfb4 T C 9: 108,856,688 (GRCm39) L398P probably damaging Het
Pfn3 T G 13: 55,562,732 (GRCm39) D83A probably damaging Het
Pi4ka C A 16: 17,204,132 (GRCm39) W54L probably damaging Het
Ppp3r1 A G 11: 17,148,275 (GRCm39) D161G probably benign Het
Prrc2a A G 17: 35,372,230 (GRCm39) S1757P probably benign Het
Samd7 A G 3: 30,812,502 (GRCm39) E314G probably benign Het
Slc17a4 A G 13: 24,088,736 (GRCm39) I217T probably benign Het
Slc22a1 A T 17: 12,881,780 (GRCm39) probably null Het
Slc7a7 C T 14: 54,646,103 (GRCm39) R120H probably damaging Het
Sos1 A T 17: 80,721,104 (GRCm39) H905Q probably benign Het
Thada G A 17: 84,754,029 (GRCm39) T314I possibly damaging Het
Tirap ACTGCTGCTGCTGCTGCTG ACTGCTGCTGCTGCTG 9: 35,100,362 (GRCm39) probably benign Het
Tlr11 A C 14: 50,600,633 (GRCm39) H873P probably benign Het
Tlr4 A T 4: 66,757,611 (GRCm39) T135S possibly damaging Het
Tmem116 T C 5: 121,633,174 (GRCm39) S183P probably damaging Het
Tubgcp3 A T 8: 12,689,550 (GRCm39) I572K probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Ush2a C T 1: 188,092,038 (GRCm39) T523I probably benign Het
Usp40 G A 1: 87,916,687 (GRCm39) Q364* probably null Het
Vmn1r61 T C 7: 5,614,242 (GRCm39) Q24R probably benign Het
Wdfy4 C A 14: 32,874,495 (GRCm39) probably null Het
Zfp458 G A 13: 67,405,573 (GRCm39) P286S probably damaging Het
Zfp68 A T 5: 138,605,091 (GRCm39) C373S probably benign Het
Zfp768 T A 7: 126,942,803 (GRCm39) I442F probably damaging Het
Zfp990 A G 4: 145,263,853 (GRCm39) R284G probably benign Het
Other mutations in Gpd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00946:Gpd2 APN 2 57,158,096 (GRCm39) critical splice donor site probably null
IGL01012:Gpd2 APN 2 57,254,542 (GRCm39) missense probably benign 0.00
IGL01096:Gpd2 APN 2 57,228,879 (GRCm39) missense probably damaging 0.98
IGL01642:Gpd2 APN 2 57,158,083 (GRCm39) nonsense probably null
IGL01816:Gpd2 APN 2 57,254,078 (GRCm39) nonsense probably null
IGL02257:Gpd2 APN 2 57,254,536 (GRCm39) missense probably benign 0.01
IGL02824:Gpd2 APN 2 57,254,339 (GRCm39) missense probably null 0.89
IGL02832:Gpd2 APN 2 57,228,991 (GRCm39) missense probably damaging 1.00
IGL03040:Gpd2 APN 2 57,245,805 (GRCm39) missense probably benign 0.06
IGL03107:Gpd2 APN 2 57,245,581 (GRCm39) missense probably damaging 1.00
IGL03131:Gpd2 APN 2 57,228,855 (GRCm39) splice site probably benign
IGL03218:Gpd2 APN 2 57,197,066 (GRCm39) missense probably damaging 1.00
IGL03226:Gpd2 APN 2 57,194,498 (GRCm39) critical splice donor site probably null
IGL03372:Gpd2 APN 2 57,245,519 (GRCm39) missense probably damaging 1.00
R0012:Gpd2 UTSW 2 57,228,880 (GRCm39) missense probably damaging 1.00
R0285:Gpd2 UTSW 2 57,228,967 (GRCm39) missense probably benign 0.16
R0379:Gpd2 UTSW 2 57,235,275 (GRCm39) missense probably damaging 1.00
R0401:Gpd2 UTSW 2 57,230,105 (GRCm39) missense possibly damaging 0.94
R1347:Gpd2 UTSW 2 57,247,683 (GRCm39) missense probably damaging 0.99
R1347:Gpd2 UTSW 2 57,247,683 (GRCm39) missense probably damaging 0.99
R1468:Gpd2 UTSW 2 57,245,786 (GRCm39) missense probably damaging 1.00
R1468:Gpd2 UTSW 2 57,245,786 (GRCm39) missense probably damaging 1.00
R1672:Gpd2 UTSW 2 57,247,712 (GRCm39) missense probably damaging 0.97
R1709:Gpd2 UTSW 2 57,247,667 (GRCm39) missense probably damaging 1.00
R1735:Gpd2 UTSW 2 57,245,563 (GRCm39) missense probably damaging 1.00
R2056:Gpd2 UTSW 2 57,229,025 (GRCm39) critical splice donor site probably null
R2959:Gpd2 UTSW 2 57,228,987 (GRCm39) nonsense probably null
R2960:Gpd2 UTSW 2 57,228,987 (GRCm39) nonsense probably null
R2961:Gpd2 UTSW 2 57,228,987 (GRCm39) nonsense probably null
R2962:Gpd2 UTSW 2 57,228,987 (GRCm39) nonsense probably null
R3008:Gpd2 UTSW 2 57,228,987 (GRCm39) nonsense probably null
R3009:Gpd2 UTSW 2 57,228,987 (GRCm39) nonsense probably null
R3881:Gpd2 UTSW 2 57,228,987 (GRCm39) nonsense probably null
R4073:Gpd2 UTSW 2 57,180,025 (GRCm39) missense probably damaging 1.00
R4153:Gpd2 UTSW 2 57,245,783 (GRCm39) missense probably damaging 1.00
R4564:Gpd2 UTSW 2 57,197,095 (GRCm39) missense possibly damaging 0.77
R4952:Gpd2 UTSW 2 57,197,025 (GRCm39) nonsense probably null
R5030:Gpd2 UTSW 2 57,194,417 (GRCm39) missense probably damaging 0.98
R5101:Gpd2 UTSW 2 57,245,913 (GRCm39) missense probably damaging 1.00
R5185:Gpd2 UTSW 2 57,230,216 (GRCm39) missense probably damaging 1.00
R6020:Gpd2 UTSW 2 57,254,525 (GRCm39) missense probably benign 0.18
R6325:Gpd2 UTSW 2 57,194,408 (GRCm39) missense probably damaging 0.96
R6536:Gpd2 UTSW 2 57,235,367 (GRCm39) missense probably benign 0.40
R6923:Gpd2 UTSW 2 57,245,800 (GRCm39) missense probably damaging 0.98
R7058:Gpd2 UTSW 2 57,197,112 (GRCm39) splice site probably null
R7380:Gpd2 UTSW 2 57,230,171 (GRCm39) missense probably damaging 1.00
R8052:Gpd2 UTSW 2 57,196,962 (GRCm39) nonsense probably null
R8098:Gpd2 UTSW 2 57,180,020 (GRCm39) missense possibly damaging 0.94
R8467:Gpd2 UTSW 2 57,254,596 (GRCm39) missense possibly damaging 0.95
R8851:Gpd2 UTSW 2 57,197,062 (GRCm39) missense possibly damaging 0.62
R9515:Gpd2 UTSW 2 57,195,866 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- GACACGTTTCCCCATGACCTTCAG -3'
(R):5'- ATGTCCACGAACCTCGCTCTCAAG -3'

Sequencing Primer
(F):5'- GAAAATTCTCTTTGTGTCACAGGTCC -3'
(R):5'- TTGCCTCCTTGAAGGAACAG -3'
Posted On 2014-03-28