Incidental Mutation 'R1474:Celsr2'
| ID |
163874 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Celsr2
|
| Ensembl Gene |
ENSMUSG00000068740 |
| Gene Name |
cadherin, EGF LAG seven-pass G-type receptor 2 |
| Synonyms |
EGFL2, Adgrc2, flamingo, mfmi1 |
| MMRRC Submission |
039527-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1474 (G1)
|
| Quality Score |
199 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
108298167-108323383 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 108301055 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 2746
(E2746G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000088046
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000090558]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000090558
AA Change: E2746G
PolyPhen 2
Score 0.913 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000088046
Gene: ENSMUSG00000068740
AA Change: E2746G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
31 |
N/A |
INTRINSIC |
|
low complexity region
|
35 |
53 |
N/A |
INTRINSIC |
|
CA
|
203 |
287 |
1.36e-26 |
SMART |
|
CA
|
311 |
397 |
1.33e-29 |
SMART |
|
CA
|
421 |
503 |
2.59e-27 |
SMART |
|
CA
|
527 |
608 |
3.33e-30 |
SMART |
|
CA
|
632 |
710 |
5.18e-18 |
SMART |
|
CA
|
734 |
813 |
1.08e-29 |
SMART |
|
CA
|
837 |
919 |
8.08e-29 |
SMART |
|
low complexity region
|
920 |
932 |
N/A |
INTRINSIC |
|
CA
|
943 |
1021 |
4.3e-24 |
SMART |
|
CA
|
1049 |
1125 |
1.87e-1 |
SMART |
|
low complexity region
|
1188 |
1198 |
N/A |
INTRINSIC |
|
EGF
|
1231 |
1286 |
1.81e-3 |
SMART |
|
EGF_CA
|
1288 |
1324 |
2.24e-8 |
SMART |
|
EGF
|
1331 |
1366 |
6.65e-2 |
SMART |
|
LamG
|
1387 |
1554 |
8.4e-30 |
SMART |
|
EGF
|
1577 |
1610 |
8e-5 |
SMART |
|
LamG
|
1636 |
1770 |
1.56e-24 |
SMART |
|
EGF
|
1796 |
1829 |
2.35e-2 |
SMART |
|
EGF
|
1831 |
1867 |
3.88e-3 |
SMART |
|
TNFR
|
1908 |
1943 |
1.35e-1 |
SMART |
|
EGF_Lam
|
1924 |
1969 |
9.54e-12 |
SMART |
|
HormR
|
1972 |
2034 |
1.57e-20 |
SMART |
|
Pfam:GAIN
|
2046 |
2289 |
3e-62 |
PFAM |
|
GPS
|
2315 |
2368 |
1.86e-25 |
SMART |
|
Pfam:7tm_2
|
2373 |
2605 |
1.1e-48 |
PFAM |
|
low complexity region
|
2715 |
2733 |
N/A |
INTRINSIC |
|
low complexity region
|
2857 |
2873 |
N/A |
INTRINSIC |
|
low complexity region
|
2874 |
2881 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126349
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126935
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130941
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133216
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000147251
AA Change: E734G
PolyPhen 2
Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000122329
Gene: ENSMUSG00000068740
AA Change: E734G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:GAIN
|
35 |
278 |
5.1e-63 |
PFAM |
|
GPS
|
304 |
357 |
1.86e-25 |
SMART |
|
Pfam:7tm_2
|
362 |
594 |
2e-49 |
PFAM |
|
low complexity region
|
704 |
722 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
863 |
870 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0605 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.6%
|
| Validation Efficiency |
95% (104/110) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this allele have mild to moderately dilated lateral ventricles in the brain but are otherwise normal. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted, knock-out(1) Targeted, other(3)
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8a |
C |
A |
11: 109,960,635 (GRCm39) |
A628S |
probably damaging |
Het |
| Abca9 |
T |
C |
11: 110,036,405 (GRCm39) |
N568S |
probably damaging |
Het |
| Ada |
C |
T |
2: 163,574,814 (GRCm39) |
A108T |
possibly damaging |
Het |
| Adam6a |
T |
A |
12: 113,508,069 (GRCm39) |
D147E |
possibly damaging |
Het |
| Ampd1 |
A |
T |
3: 103,006,154 (GRCm39) |
T655S |
probably damaging |
Het |
| Ankk1 |
A |
G |
9: 49,327,139 (GRCm39) |
F680S |
probably damaging |
Het |
| Asap1 |
G |
A |
15: 63,991,869 (GRCm39) |
T783I |
probably benign |
Het |
| Astn1 |
T |
A |
1: 158,329,923 (GRCm39) |
N259K |
probably damaging |
Het |
| Birc6 |
T |
C |
17: 74,886,673 (GRCm39) |
V667A |
probably damaging |
Het |
| Brat1 |
G |
A |
5: 140,698,382 (GRCm39) |
V185I |
probably benign |
Het |
| Btnl6 |
T |
C |
17: 34,732,620 (GRCm39) |
Y318C |
probably damaging |
Het |
| Caskin2 |
G |
A |
11: 115,694,522 (GRCm39) |
P360S |
probably benign |
Het |
| Ccdc121rt3 |
T |
C |
5: 112,503,642 (GRCm39) |
T21A |
probably benign |
Het |
| Cd68 |
T |
A |
11: 69,555,754 (GRCm39) |
|
probably benign |
Het |
| Cdca2 |
T |
C |
14: 67,952,355 (GRCm39) |
|
probably benign |
Het |
| Cdk6 |
G |
A |
5: 3,523,217 (GRCm39) |
M212I |
probably benign |
Het |
| Ceacam5 |
T |
A |
7: 17,481,159 (GRCm39) |
F302Y |
probably damaging |
Het |
| Clec4a4 |
G |
A |
6: 122,989,703 (GRCm39) |
V115I |
probably benign |
Het |
| Clip3 |
C |
A |
7: 29,998,307 (GRCm39) |
A251E |
possibly damaging |
Het |
| Cmah |
T |
C |
13: 24,623,180 (GRCm39) |
L350P |
probably damaging |
Het |
| Cntnap5a |
C |
T |
1: 116,370,103 (GRCm39) |
R907* |
probably null |
Het |
| Cntnap5b |
T |
C |
1: 99,999,814 (GRCm39) |
Y191H |
probably benign |
Het |
| Col4a4 |
A |
T |
1: 82,458,207 (GRCm39) |
C1122* |
probably null |
Het |
| Coq5 |
A |
G |
5: 115,433,842 (GRCm39) |
|
probably benign |
Het |
| Cpxcr1 |
A |
G |
X: 115,387,136 (GRCm39) |
K16E |
possibly damaging |
Het |
| Dclk3 |
T |
C |
9: 111,298,304 (GRCm39) |
I616T |
probably benign |
Het |
| Dhrs3 |
A |
T |
4: 144,646,057 (GRCm39) |
T122S |
probably damaging |
Het |
| Dnm1 |
T |
C |
2: 32,210,596 (GRCm39) |
I502V |
probably benign |
Het |
| Dscaml1 |
G |
T |
9: 45,596,519 (GRCm39) |
G788W |
probably damaging |
Het |
| Dusp10 |
C |
T |
1: 183,769,645 (GRCm39) |
|
probably null |
Het |
| Ehbp1l1 |
C |
A |
19: 5,769,112 (GRCm39) |
L730F |
possibly damaging |
Het |
| Eif2ak1 |
C |
T |
5: 143,808,785 (GRCm39) |
H75Y |
probably damaging |
Het |
| Evi2a |
T |
C |
11: 79,418,398 (GRCm39) |
T71A |
probably benign |
Het |
| Fam184a |
A |
T |
10: 53,511,461 (GRCm39) |
S1073T |
probably damaging |
Het |
| Fam227a |
T |
C |
15: 79,499,582 (GRCm39) |
Y591C |
probably damaging |
Het |
| Fam83a |
C |
T |
15: 57,873,272 (GRCm39) |
T367M |
probably benign |
Het |
| Fam83g |
A |
G |
11: 61,593,819 (GRCm39) |
D451G |
probably damaging |
Het |
| Fbn1 |
A |
G |
2: 125,203,185 (GRCm39) |
F1213L |
possibly damaging |
Het |
| Fcgbp |
G |
A |
7: 27,791,273 (GRCm39) |
V845I |
probably benign |
Het |
| Fermt1 |
C |
T |
2: 132,766,942 (GRCm39) |
E342K |
probably benign |
Het |
| Foxn1 |
T |
A |
11: 78,251,933 (GRCm39) |
M433L |
probably benign |
Het |
| Gm6632 |
T |
G |
5: 59,211,679 (GRCm39) |
|
noncoding transcript |
Het |
| Gnl3 |
A |
T |
14: 30,738,418 (GRCm39) |
|
probably benign |
Het |
| Hhipl1 |
C |
T |
12: 108,277,996 (GRCm39) |
T108I |
probably damaging |
Het |
| Hs2st1 |
A |
T |
3: 144,141,256 (GRCm39) |
F271I |
possibly damaging |
Het |
| Ido1 |
T |
C |
8: 25,074,462 (GRCm39) |
S303G |
probably damaging |
Het |
| Ints2 |
C |
T |
11: 86,117,607 (GRCm39) |
R705H |
probably damaging |
Het |
| Kcnc2 |
A |
G |
10: 112,292,305 (GRCm39) |
K49E |
probably damaging |
Het |
| Kif3b |
T |
A |
2: 153,162,235 (GRCm39) |
V482E |
probably damaging |
Het |
| Ldlrad2 |
G |
A |
4: 137,299,525 (GRCm39) |
P100S |
probably benign |
Het |
| Lrba |
G |
T |
3: 86,687,573 (GRCm39) |
|
probably benign |
Het |
| Lsm11 |
A |
T |
11: 45,824,730 (GRCm39) |
W266R |
probably benign |
Het |
| Mob3a |
A |
T |
10: 80,522,988 (GRCm39) |
M215K |
probably benign |
Het |
| Mterf1b |
T |
G |
5: 4,247,163 (GRCm39) |
L268R |
probably damaging |
Het |
| Mvk |
T |
C |
5: 114,598,157 (GRCm39) |
F365L |
probably damaging |
Het |
| Myo16 |
T |
A |
8: 10,552,796 (GRCm39) |
F945I |
probably damaging |
Het |
| Myo1f |
G |
T |
17: 33,813,001 (GRCm39) |
K602N |
possibly damaging |
Het |
| Nr2c2ap |
A |
T |
8: 70,585,765 (GRCm39) |
M108L |
probably benign |
Het |
| Ofcc1 |
C |
T |
13: 40,362,305 (GRCm39) |
G206R |
probably benign |
Het |
| Ogfrl1 |
A |
G |
1: 23,414,890 (GRCm39) |
F206L |
probably damaging |
Het |
| Ola1 |
A |
T |
2: 72,987,188 (GRCm39) |
I148N |
probably damaging |
Het |
| Or14c46 |
G |
T |
7: 85,918,270 (GRCm39) |
H242Q |
probably damaging |
Het |
| Or4d10b |
T |
A |
19: 12,036,844 (GRCm39) |
T91S |
probably benign |
Het |
| Or51f1d |
A |
G |
7: 102,701,288 (GRCm39) |
Y261C |
probably damaging |
Het |
| Or6c2 |
A |
T |
10: 129,362,824 (GRCm39) |
M243L |
probably benign |
Het |
| Or9m2 |
A |
G |
2: 87,821,334 (GRCm39) |
N293S |
probably damaging |
Het |
| Otof |
A |
G |
5: 30,536,876 (GRCm39) |
|
probably null |
Het |
| Pah |
G |
T |
10: 87,414,175 (GRCm39) |
K341N |
probably damaging |
Het |
| Pfdn5 |
T |
A |
15: 102,236,946 (GRCm39) |
|
probably null |
Het |
| Piezo2 |
A |
G |
18: 63,216,202 (GRCm39) |
C960R |
probably damaging |
Het |
| Pitx2 |
T |
C |
3: 129,012,488 (GRCm39) |
V306A |
probably damaging |
Het |
| Pkd1l2 |
C |
A |
8: 117,792,236 (GRCm39) |
|
probably benign |
Het |
| Plekho1 |
T |
C |
3: 95,896,878 (GRCm39) |
E197G |
probably damaging |
Het |
| Polr2i |
A |
G |
7: 29,932,227 (GRCm39) |
N34S |
probably damaging |
Het |
| Psph |
A |
T |
5: 129,848,614 (GRCm39) |
D22E |
probably damaging |
Het |
| Ptprs |
C |
A |
17: 56,731,128 (GRCm39) |
A687S |
probably damaging |
Het |
| Ralgapa1 |
T |
C |
12: 55,788,265 (GRCm39) |
K606R |
probably benign |
Het |
| Rigi |
A |
G |
4: 40,208,868 (GRCm39) |
V703A |
possibly damaging |
Het |
| Rims1 |
A |
G |
1: 22,577,362 (GRCm39) |
|
probably benign |
Het |
| Rnf213 |
C |
T |
11: 119,328,576 (GRCm39) |
P2002L |
probably damaging |
Het |
| Ryr3 |
A |
T |
2: 112,740,307 (GRCm39) |
C555S |
probably damaging |
Het |
| Sftpd |
C |
A |
14: 40,894,384 (GRCm39) |
G345V |
probably damaging |
Het |
| Slc41a1 |
T |
A |
1: 131,774,319 (GRCm39) |
M462K |
probably damaging |
Het |
| Slc44a2 |
A |
G |
9: 21,264,990 (GRCm39) |
E676G |
probably damaging |
Het |
| Sox6 |
T |
A |
7: 115,300,926 (GRCm39) |
|
probably benign |
Het |
| Spdye4b |
G |
A |
5: 143,181,472 (GRCm39) |
R109Q |
probably damaging |
Het |
| Spef1l |
C |
A |
7: 139,556,555 (GRCm39) |
R144L |
probably benign |
Het |
| Spink8 |
A |
T |
9: 109,649,706 (GRCm39) |
I63L |
probably damaging |
Het |
| St3gal3 |
A |
G |
4: 117,871,983 (GRCm39) |
L73P |
probably damaging |
Het |
| Stab1 |
A |
G |
14: 30,871,818 (GRCm39) |
L1247P |
probably benign |
Het |
| Tat |
A |
G |
8: 110,718,195 (GRCm39) |
R27G |
probably benign |
Het |
| Tcerg1l |
C |
T |
7: 137,881,804 (GRCm39) |
R295H |
probably damaging |
Het |
| Tfrc |
T |
C |
16: 32,445,467 (GRCm39) |
V596A |
probably damaging |
Het |
| Tgfb3 |
C |
T |
12: 86,116,120 (GRCm39) |
|
probably null |
Het |
| Tmed5 |
A |
T |
5: 108,280,248 (GRCm39) |
S15T |
probably benign |
Het |
| Tph1 |
A |
T |
7: 46,303,286 (GRCm39) |
S231T |
probably benign |
Het |
| Trim30d |
G |
A |
7: 104,121,701 (GRCm39) |
S198L |
probably damaging |
Het |
| Trpm6 |
T |
C |
19: 18,773,859 (GRCm39) |
M412T |
probably benign |
Het |
| Ttn |
G |
T |
2: 76,612,589 (GRCm39) |
D15417E |
probably benign |
Het |
| U2surp |
A |
G |
9: 95,375,251 (GRCm39) |
I157T |
possibly damaging |
Het |
| Ubr4 |
A |
G |
4: 139,156,890 (GRCm39) |
D2305G |
probably damaging |
Het |
| Uvssa |
A |
G |
5: 33,546,165 (GRCm39) |
K179E |
probably benign |
Het |
| Vps35l |
T |
C |
7: 118,359,436 (GRCm39) |
F230S |
probably damaging |
Het |
| Xirp2 |
A |
G |
2: 67,355,411 (GRCm39) |
K3391E |
probably benign |
Het |
| Xpo7 |
T |
A |
14: 70,936,473 (GRCm39) |
H170L |
probably benign |
Het |
| Zrsr2-ps1 |
T |
C |
11: 22,924,404 (GRCm39) |
W393R |
probably benign |
Het |
|
| Other mutations in Celsr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00898:Celsr2
|
APN |
3 |
108,321,195 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01020:Celsr2
|
APN |
3 |
108,310,586 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01420:Celsr2
|
APN |
3 |
108,301,079 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01448:Celsr2
|
APN |
3 |
108,300,555 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01559:Celsr2
|
APN |
3 |
108,314,183 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01674:Celsr2
|
APN |
3 |
108,322,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01863:Celsr2
|
APN |
3 |
108,301,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02309:Celsr2
|
APN |
3 |
108,303,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02325:Celsr2
|
APN |
3 |
108,320,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02409:Celsr2
|
APN |
3 |
108,321,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02514:Celsr2
|
APN |
3 |
108,304,826 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02812:Celsr2
|
APN |
3 |
108,321,429 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02894:Celsr2
|
APN |
3 |
108,302,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03281:Celsr2
|
APN |
3 |
108,320,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
barrow
|
UTSW |
3 |
108,302,281 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
goldeneye
|
UTSW |
3 |
108,302,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
1mM(1):Celsr2
|
UTSW |
3 |
108,308,154 (GRCm39) |
missense |
probably benign |
0.01 |
|
ANU74:Celsr2
|
UTSW |
3 |
108,319,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02799:Celsr2
|
UTSW |
3 |
108,321,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0011:Celsr2
|
UTSW |
3 |
108,320,718 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0031:Celsr2
|
UTSW |
3 |
108,320,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0049:Celsr2
|
UTSW |
3 |
108,304,570 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0049:Celsr2
|
UTSW |
3 |
108,304,570 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0090:Celsr2
|
UTSW |
3 |
108,300,643 (GRCm39) |
splice site |
probably benign |
|
|
R0140:Celsr2
|
UTSW |
3 |
108,305,249 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0524:Celsr2
|
UTSW |
3 |
108,308,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0607:Celsr2
|
UTSW |
3 |
108,311,211 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0662:Celsr2
|
UTSW |
3 |
108,305,836 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0690:Celsr2
|
UTSW |
3 |
108,322,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0691:Celsr2
|
UTSW |
3 |
108,319,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0710:Celsr2
|
UTSW |
3 |
108,320,028 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0730:Celsr2
|
UTSW |
3 |
108,305,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0815:Celsr2
|
UTSW |
3 |
108,308,617 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0848:Celsr2
|
UTSW |
3 |
108,321,654 (GRCm39) |
missense |
probably benign |
|
|
R0989:Celsr2
|
UTSW |
3 |
108,310,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1469:Celsr2
|
UTSW |
3 |
108,321,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Celsr2
|
UTSW |
3 |
108,321,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1608:Celsr2
|
UTSW |
3 |
108,309,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1653:Celsr2
|
UTSW |
3 |
108,320,836 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1659:Celsr2
|
UTSW |
3 |
108,321,411 (GRCm39) |
missense |
probably benign |
|
|
R1689:Celsr2
|
UTSW |
3 |
108,314,620 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1848:Celsr2
|
UTSW |
3 |
108,308,626 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1859:Celsr2
|
UTSW |
3 |
108,303,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1918:Celsr2
|
UTSW |
3 |
108,305,966 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1974:Celsr2
|
UTSW |
3 |
108,321,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2042:Celsr2
|
UTSW |
3 |
108,309,811 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2167:Celsr2
|
UTSW |
3 |
108,320,509 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2333:Celsr2
|
UTSW |
3 |
108,305,921 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2434:Celsr2
|
UTSW |
3 |
108,311,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2504:Celsr2
|
UTSW |
3 |
108,320,907 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3420:Celsr2
|
UTSW |
3 |
108,321,732 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3712:Celsr2
|
UTSW |
3 |
108,308,155 (GRCm39) |
missense |
probably benign |
|
|
R3723:Celsr2
|
UTSW |
3 |
108,304,731 (GRCm39) |
splice site |
probably benign |
|
|
R3809:Celsr2
|
UTSW |
3 |
108,310,555 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4018:Celsr2
|
UTSW |
3 |
108,302,281 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4126:Celsr2
|
UTSW |
3 |
108,309,413 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4177:Celsr2
|
UTSW |
3 |
108,321,294 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4232:Celsr2
|
UTSW |
3 |
108,321,088 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4293:Celsr2
|
UTSW |
3 |
108,300,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4458:Celsr2
|
UTSW |
3 |
108,302,313 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4621:Celsr2
|
UTSW |
3 |
108,302,532 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4645:Celsr2
|
UTSW |
3 |
108,303,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Celsr2
|
UTSW |
3 |
108,304,547 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4732:Celsr2
|
UTSW |
3 |
108,306,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Celsr2
|
UTSW |
3 |
108,306,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4901:Celsr2
|
UTSW |
3 |
108,314,303 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4932:Celsr2
|
UTSW |
3 |
108,310,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4989:Celsr2
|
UTSW |
3 |
108,319,945 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5052:Celsr2
|
UTSW |
3 |
108,319,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5093:Celsr2
|
UTSW |
3 |
108,320,689 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5114:Celsr2
|
UTSW |
3 |
108,301,312 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5120:Celsr2
|
UTSW |
3 |
108,300,436 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5135:Celsr2
|
UTSW |
3 |
108,305,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5247:Celsr2
|
UTSW |
3 |
108,304,946 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5381:Celsr2
|
UTSW |
3 |
108,310,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5412:Celsr2
|
UTSW |
3 |
108,307,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5445:Celsr2
|
UTSW |
3 |
108,299,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5528:Celsr2
|
UTSW |
3 |
108,320,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5598:Celsr2
|
UTSW |
3 |
108,310,119 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5652:Celsr2
|
UTSW |
3 |
108,304,051 (GRCm39) |
missense |
probably null |
0.49 |
|
R5697:Celsr2
|
UTSW |
3 |
108,311,237 (GRCm39) |
nonsense |
probably null |
|
|
R5718:Celsr2
|
UTSW |
3 |
108,300,674 (GRCm39) |
missense |
probably benign |
|
|
R5869:Celsr2
|
UTSW |
3 |
108,321,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Celsr2
|
UTSW |
3 |
108,321,259 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6021:Celsr2
|
UTSW |
3 |
108,308,561 (GRCm39) |
missense |
probably benign |
|
|
R6054:Celsr2
|
UTSW |
3 |
108,314,279 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6244:Celsr2
|
UTSW |
3 |
108,300,444 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6313:Celsr2
|
UTSW |
3 |
108,308,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6322:Celsr2
|
UTSW |
3 |
108,319,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6555:Celsr2
|
UTSW |
3 |
108,302,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6682:Celsr2
|
UTSW |
3 |
108,307,817 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7062:Celsr2
|
UTSW |
3 |
108,309,826 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7110:Celsr2
|
UTSW |
3 |
108,305,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Celsr2
|
UTSW |
3 |
108,322,675 (GRCm39) |
missense |
unknown |
|
|
R7326:Celsr2
|
UTSW |
3 |
108,302,311 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7425:Celsr2
|
UTSW |
3 |
108,309,773 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Celsr2
|
UTSW |
3 |
108,320,406 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7461:Celsr2
|
UTSW |
3 |
108,302,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7502:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7613:Celsr2
|
UTSW |
3 |
108,302,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7644:Celsr2
|
UTSW |
3 |
108,320,806 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7666:Celsr2
|
UTSW |
3 |
108,305,904 (GRCm39) |
missense |
probably benign |
|
|
R7687:Celsr2
|
UTSW |
3 |
108,305,085 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7695:Celsr2
|
UTSW |
3 |
108,310,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8002:Celsr2
|
UTSW |
3 |
108,311,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8052:Celsr2
|
UTSW |
3 |
108,319,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Celsr2
|
UTSW |
3 |
108,303,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Celsr2
|
UTSW |
3 |
108,320,847 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8381:Celsr2
|
UTSW |
3 |
108,302,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8427:Celsr2
|
UTSW |
3 |
108,299,949 (GRCm39) |
makesense |
probably null |
|
|
R8435:Celsr2
|
UTSW |
3 |
108,321,715 (GRCm39) |
missense |
probably benign |
|
|
R8438:Celsr2
|
UTSW |
3 |
108,301,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8458:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8460:Celsr2
|
UTSW |
3 |
108,304,093 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8462:Celsr2
|
UTSW |
3 |
108,320,167 (GRCm39) |
nonsense |
probably null |
|
|
R8479:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8480:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8512:Celsr2
|
UTSW |
3 |
108,321,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8694:Celsr2
|
UTSW |
3 |
108,314,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8772:Celsr2
|
UTSW |
3 |
108,304,389 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8843:Celsr2
|
UTSW |
3 |
108,303,443 (GRCm39) |
splice site |
probably benign |
|
|
R8888:Celsr2
|
UTSW |
3 |
108,320,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8895:Celsr2
|
UTSW |
3 |
108,320,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8917:Celsr2
|
UTSW |
3 |
108,303,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9119:Celsr2
|
UTSW |
3 |
108,309,288 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9169:Celsr2
|
UTSW |
3 |
108,309,862 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9209:Celsr2
|
UTSW |
3 |
108,321,349 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9342:Celsr2
|
UTSW |
3 |
108,320,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Celsr2
|
UTSW |
3 |
108,322,084 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9493:Celsr2
|
UTSW |
3 |
108,301,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9564:Celsr2
|
UTSW |
3 |
108,321,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9598:Celsr2
|
UTSW |
3 |
108,322,578 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9629:Celsr2
|
UTSW |
3 |
108,308,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9691:Celsr2
|
UTSW |
3 |
108,301,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0020:Celsr2
|
UTSW |
3 |
108,303,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0050:Celsr2
|
UTSW |
3 |
108,308,588 (GRCm39) |
missense |
probably benign |
0.09 |
|
Z1088:Celsr2
|
UTSW |
3 |
108,321,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Celsr2
|
UTSW |
3 |
108,319,657 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1176:Celsr2
|
UTSW |
3 |
108,300,447 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1177:Celsr2
|
UTSW |
3 |
108,320,887 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1177:Celsr2
|
UTSW |
3 |
108,319,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1191:Celsr2
|
UTSW |
3 |
108,321,865 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGACAGTTAGGATAGCCACCAC -3'
(R):5'- TTTAGGGAGGAGTCCACGCTGAAC -3'
Sequencing Primer
(F):5'- CCCCAGCTCTATTTTCCAAAAAG -3'
(R):5'- CTGTTCTTGGAAGGCCAAGC -3'
|
| Posted On |
2014-03-28 |
Incidental Mutation