Incidental Mutation 'R0064:Ccdc25'
ID16389
Institutional Source Beutler Lab
Gene Symbol Ccdc25
Ensembl Gene ENSMUSG00000022035
Gene Namecoiled-coil domain containing 25
Synonyms2610528H13Rik
MMRRC Submission 038356-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.124) question?
Stock #R0064 (G1)
Quality Score
Status Validated
Chromosome14
Chromosomal Location65837302-65866607 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 65854112 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Lysine at position 60 (I60K)
Ref Sequence ENSEMBL: ENSMUSP00000022614 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022614]
Predicted Effect possibly damaging
Transcript: ENSMUST00000022614
AA Change: I60K

PolyPhen 2 Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000022614
Gene: ENSMUSG00000022035
AA Change: I60K

DomainStartEndE-ValueType
Pfam:DUF814 8 100 2.2e-31 PFAM
coiled coil region 151 186 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225823
Meta Mutation Damage Score 0.49 question?
Coding Region Coverage
  • 1x: 87.7%
  • 3x: 83.1%
  • 10x: 65.7%
  • 20x: 35.9%
Validation Efficiency 92% (56/61)
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd18 A G 3: 40,933,853 I377M probably benign Het
Cdk1 T C 10: 69,345,077 D101G probably benign Het
Cep126 A T 9: 8,130,182 probably benign Het
Col1a2 G A 6: 4,518,822 probably benign Het
Crlf3 A G 11: 80,057,902 I239T possibly damaging Het
Cul1 A G 6: 47,502,415 probably benign Het
Fbp2 A T 13: 62,854,048 F118I probably damaging Het
Fgd3 T G 13: 49,296,425 D116A possibly damaging Het
Gm270 C A 13: 49,765,891 noncoding transcript Het
Knl1 T A 2: 119,076,243 N1604K probably benign Het
Lpl A G 8: 68,892,704 H120R probably damaging Het
Myo18a G T 11: 77,847,344 R1704L probably damaging Het
Nlrc3 G T 16: 3,964,087 T486K possibly damaging Het
Obscn A C 11: 59,027,466 V6260G probably damaging Het
Olfr714 T C 7: 107,074,280 F151L probably benign Het
Pmpca C A 2: 26,395,507 D498E probably benign Het
Pnpla7 G T 2: 24,997,227 E28* probably null Het
Polg C A 7: 79,461,884 W206C probably damaging Het
Spata31 T C 13: 64,922,098 Y687H probably damaging Het
Sybu T A 15: 44,672,993 T646S probably benign Het
Tns3 G A 11: 8,435,856 Q1381* probably null Het
Trank1 A G 9: 111,343,195 D84G probably damaging Het
Urb1 A G 16: 90,779,140 F843L probably benign Het
Zfp287 A T 11: 62,714,938 L370H possibly damaging Het
Other mutations in Ccdc25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01150:Ccdc25 APN 14 65860202 missense possibly damaging 0.82
R0064:Ccdc25 UTSW 14 65854112 missense possibly damaging 0.79
R1782:Ccdc25 UTSW 14 65854148 missense probably benign 0.25
R6813:Ccdc25 UTSW 14 65856433 missense probably benign 0.33
R7110:Ccdc25 UTSW 14 65856716 missense not run
Posted On2013-01-20