Incidental Mutation 'R0060:Tmem273'
ID 16398
Institutional Source Beutler Lab
Gene Symbol Tmem273
Ensembl Gene ENSMUSG00000041707
Gene Name transmembrane protein 273
Synonyms 1810011H11Rik
MMRRC Submission 038353-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R0060 (G1)
Quality Score
Status Validated
Chromosome 14
Chromosomal Location 32507920-32539941 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) C to A at 32528726 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000039191] [ENSMUST00000227060] [ENSMUST00000227871]
AlphaFold E9PVZ2
Predicted Effect probably benign
Transcript: ENSMUST00000039191
SMART Domains Protein: ENSMUSP00000132997
Gene: ENSMUSG00000041707

DomainStartEndE-ValueType
Pfam:DUF4514 16 75 3.6e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000227060
Predicted Effect probably benign
Transcript: ENSMUST00000227871
Predicted Effect probably benign
Transcript: ENSMUST00000228481
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228955
Coding Region Coverage
  • 1x: 90.4%
  • 3x: 88.3%
  • 10x: 83.8%
  • 20x: 78.1%
Validation Efficiency 94% (74/79)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810065E05Rik A C 11: 58,313,008 (GRCm39) probably benign Het
4930432E11Rik A G 7: 29,273,595 (GRCm39) noncoding transcript Het
A630091E08Rik A G 7: 98,192,875 (GRCm39) noncoding transcript Het
Abca8a T C 11: 109,961,306 (GRCm39) T539A probably damaging Het
Adam34 A T 8: 44,128,920 (GRCm39) probably benign Het
Ankrd60 A T 2: 173,414,406 (GRCm39) M1K probably null Het
Cald1 T C 6: 34,692,394 (GRCm39) probably benign Het
Capn7 T C 14: 31,087,561 (GRCm39) probably benign Het
Cd109 G A 9: 78,610,389 (GRCm39) E1145K probably damaging Het
Celsr1 A T 15: 85,806,399 (GRCm39) V2353D probably damaging Het
Cep135 A T 5: 76,769,197 (GRCm39) I616F probably benign Het
Cep162 T A 9: 87,119,878 (GRCm39) probably benign Het
Cep350 C T 1: 155,804,372 (GRCm39) D904N probably damaging Het
Cep85 T C 4: 133,894,611 (GRCm39) D65G probably damaging Het
Cfdp1 T C 8: 112,566,986 (GRCm39) probably benign Het
Chl1 T A 6: 103,688,019 (GRCm39) probably benign Het
Colec10 G A 15: 54,302,542 (GRCm39) probably benign Het
Crxos A G 7: 15,632,448 (GRCm39) T40A possibly damaging Het
Dnhd1 A G 7: 105,317,721 (GRCm39) D472G probably damaging Het
Dpp6 C A 5: 27,803,817 (GRCm39) N254K probably damaging Het
Eps8l3 T C 3: 107,786,857 (GRCm39) L11S probably damaging Het
Flad1 G A 3: 89,309,552 (GRCm39) R515* probably null Het
Fzd5 T C 1: 64,774,835 (GRCm39) T309A probably benign Het
Gm19685 T C 17: 61,075,418 (GRCm39) Het
Gsdme A G 6: 50,198,009 (GRCm39) I317T possibly damaging Het
H2bc1 A T 13: 24,117,928 (GRCm39) I71N possibly damaging Het
Incenp A G 19: 9,862,823 (GRCm39) probably benign Het
Itgad T C 7: 127,802,158 (GRCm39) S979P probably damaging Het
Kat2b T C 17: 53,961,571 (GRCm39) V557A probably damaging Het
Lamc1 A T 1: 153,117,614 (GRCm39) probably benign Het
Lgi4 G A 7: 30,762,996 (GRCm39) G157D probably damaging Het
Mga T C 2: 119,791,442 (GRCm39) probably null Het
Nubpl T C 12: 52,357,470 (GRCm39) probably benign Het
Or2b4 T C 17: 38,116,891 (GRCm39) L285P probably damaging Het
Or5be3 T C 2: 86,864,118 (GRCm39) Y149C probably damaging Het
Or8c20 C T 9: 38,260,808 (GRCm39) S143F probably benign Het
Peak1 A T 9: 56,135,107 (GRCm39) I78K probably damaging Het
Prune2 T A 19: 16,981,097 (GRCm39) F85I probably damaging Het
Rbm11 G T 16: 75,395,667 (GRCm39) D113Y probably damaging Het
Rif1 C T 2: 52,001,129 (GRCm39) R1528C probably damaging Het
Sema4d A G 13: 51,859,293 (GRCm39) probably benign Het
Slc30a4 T A 2: 122,527,104 (GRCm39) T381S probably benign Het
Slf2 G T 19: 44,936,443 (GRCm39) G696V probably damaging Het
Suv39h2 T C 2: 3,465,953 (GRCm39) Y134C probably damaging Het
Tmem89 T A 9: 108,744,485 (GRCm39) V126D probably damaging Het
Trf T C 9: 103,098,121 (GRCm39) T46A probably benign Het
Trmt6 C T 2: 132,648,689 (GRCm39) R415Q possibly damaging Het
Trp53bp1 T C 2: 121,035,006 (GRCm39) K1625E probably damaging Het
Usp6nl T A 2: 6,445,701 (GRCm39) D559E probably benign Het
Wdr75 A G 1: 45,855,777 (GRCm39) D476G probably benign Het
Wrap53 A C 11: 69,454,256 (GRCm39) L261V possibly damaging Het
Zcchc4 T A 5: 52,964,420 (GRCm39) I292N possibly damaging Het
Other mutations in Tmem273
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01930:Tmem273 APN 14 32,538,814 (GRCm39) missense probably benign 0.12
IGL03225:Tmem273 APN 14 32,527,133 (GRCm39) missense probably damaging 0.97
R0255:Tmem273 UTSW 14 32,530,320 (GRCm39) missense possibly damaging 0.91
R1520:Tmem273 UTSW 14 32,527,083 (GRCm39) intron probably benign
R4641:Tmem273 UTSW 14 32,528,839 (GRCm39) missense probably damaging 0.99
R5218:Tmem273 UTSW 14 32,538,793 (GRCm39) splice site probably null
R6111:Tmem273 UTSW 14 32,528,755 (GRCm39) missense possibly damaging 0.93
R6793:Tmem273 UTSW 14 32,528,778 (GRCm39) missense probably benign
R7714:Tmem273 UTSW 14 32,527,129 (GRCm39) missense possibly damaging 0.63
R8087:Tmem273 UTSW 14 32,507,926 (GRCm39) unclassified probably benign
Posted On 2013-01-20