Mutagenetix > Incidental Mutation

Incidental Mutation 'R1477:Zfp790'

164125

Institutional Source

Beutler Lab

Gene Symbol

Zfp790

Ensembl Gene

ENSMUSG00000011427

Gene Name

zinc finger protein 790

Synonyms

6330581L23Rik

MMRRC Submission

039530-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

R1477 (G1)

Quality Score

215

Status

Not validated

Chromosome

Chromosomal Location

29515539-29530430 bp(+) (GRCm39)

Type of Mutation

start gained

DNA Base Change (assembly)

C to T at 29522525 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000146955 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032796] [ENSMUST00000178162] [ENSMUST00000207328]

AlphaFold

Q80ZX2

Predicted Effect

probably benign
Transcript: ENSMUST00000032796

SMART Domains

Protein: ENSMUSP00000032796
Gene: ENSMUSG00000011427

Domain	Start	End	E-Value	Type
KRAB	5	65	3e-27	SMART
ZnF_C2H2	224	246	2.95e-3	SMART
ZnF_C2H2	252	274	2.53e-2	SMART
ZnF_C2H2	280	302	5.5e-3	SMART
ZnF_C2H2	308	330	2.75e-3	SMART
ZnF_C2H2	336	358	2.12e-4	SMART
ZnF_C2H2	364	386	1.03e-2	SMART
Pfam:zf-C2H2_6	391	403	2.4e-1	PFAM
ZnF_C2H2	448	470	9.56e1	SMART
ZnF_C2H2	476	498	7.26e-3	SMART
ZnF_C2H2	504	526	2.57e-3	SMART
ZnF_C2H2	532	554	6.42e-4	SMART
ZnF_C2H2	640	662	1.12e-3	SMART
ZnF_C2H2	668	690	2.12e-4	SMART
ZnF_C2H2	696	718	1.98e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000178162

SMART Domains

Protein: ENSMUSP00000136932
Gene: ENSMUSG00000011427

Domain	Start	End	E-Value	Type
KRAB	5	65	3e-27	SMART
ZnF_C2H2	224	246	2.95e-3	SMART
ZnF_C2H2	252	274	2.53e-2	SMART
ZnF_C2H2	280	302	5.5e-3	SMART
ZnF_C2H2	308	330	2.75e-3	SMART
ZnF_C2H2	336	358	2.12e-4	SMART
ZnF_C2H2	364	386	1.03e-2	SMART
ZnF_C2H2	448	470	9.56e1	SMART
ZnF_C2H2	476	498	7.26e-3	SMART
ZnF_C2H2	504	526	2.57e-3	SMART
ZnF_C2H2	532	554	6.42e-4	SMART
ZnF_C2H2	640	662	1.12e-3	SMART
ZnF_C2H2	668	690	2.12e-4	SMART
ZnF_C2H2	696	718	1.98e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000207328

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.4%
20x: 93.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl5	A	C	19: 55,279,904 (GRCm39)	D481A	probably benign	Het
Adam2	A	C	14: 66,315,149 (GRCm39)	L8R	possibly damaging	Het
Ajm1	G	C	2: 25,469,765 (GRCm39)	H49D	possibly damaging	Het
Arfgef1	A	T	1: 10,259,509 (GRCm39)	C619S	probably damaging	Het
Atm	A	G	9: 53,375,573 (GRCm39)	I2082T	probably benign	Het
Cgrrf1	A	G	14: 47,090,895 (GRCm39)	I210M	probably benign	Het
Clec2e	A	T	6: 129,072,163 (GRCm39)	V72E	probably benign	Het
Cmtr1	T	C	17: 29,916,131 (GRCm39)	V587A	possibly damaging	Het
Col1a2	T	C	6: 4,539,673 (GRCm39)	F1314L	unknown	Het
Ctbp2	T	C	7: 132,600,670 (GRCm39)	E618G	probably damaging	Het
Dnaaf6rt	G	A	1: 31,262,104 (GRCm39)	V29M	probably benign	Het
Dock8	A	T	19: 25,072,914 (GRCm39)	Y398F	possibly damaging	Het
Ezh1	A	T	11: 101,083,810 (GRCm39)	D733E	probably damaging	Het
Fbxl6	A	G	15: 76,421,934 (GRCm39)	S202P	probably benign	Het
Fcgbpl1	C	A	7: 27,856,518 (GRCm39)	Q2102K	probably benign	Het
Grid2ip	G	A	5: 143,361,340 (GRCm39)	A191T	probably damaging	Het
Helz2	T	C	2: 180,874,597 (GRCm39)	S1966G	probably benign	Het
Ipmk	A	G	10: 71,217,607 (GRCm39)	K385E	probably damaging	Het
Itga11	G	A	9: 62,662,493 (GRCm39)	V489I	probably benign	Het
Klhl6	T	C	16: 19,784,727 (GRCm39)	K137R	probably benign	Het
Meis1	G	A	11: 18,831,665 (GRCm39)	Q458*	probably null	Het
Mst1r	T	C	9: 107,785,523 (GRCm39)	S394P	probably benign	Het
Mus81	G	T	19: 5,536,362 (GRCm39)	H155Q	probably benign	Het
Neb	G	A	2: 52,154,134 (GRCm39)	L2326F	probably damaging	Het
Nf1	C	T	11: 79,286,685 (GRCm39)	Q162*	probably null	Het
Nin	T	C	12: 70,090,958 (GRCm39)	E819G	possibly damaging	Het
Nox4	T	C	7: 86,945,074 (GRCm39)	V79A	probably benign	Het
Or11g2	A	T	14: 50,856,170 (GRCm39)	I164F	probably damaging	Het
Or13a28	T	A	7: 140,218,355 (GRCm39)	I247N	possibly damaging	Het
Or5ae2	T	A	7: 84,506,225 (GRCm39)	I216N	probably damaging	Het
Or6d12	A	T	6: 116,493,626 (GRCm39)	Y296F	probably damaging	Het
Peg3	T	A	7: 6,719,141 (GRCm39)	D69V	probably damaging	Het
Pnp2	A	G	14: 51,196,992 (GRCm39)	E26G	probably benign	Het
Pnpt1	T	A	11: 29,087,102 (GRCm39)	C154S	probably benign	Het
Ppp1r26	C	T	2: 28,342,800 (GRCm39)	T810I	probably benign	Het
Ppp2r5b	A	G	19: 6,280,257 (GRCm39)	S349P	probably benign	Het
Prdm4	C	T	10: 85,740,129 (GRCm39)	V424I	probably benign	Het
Rraga	A	G	4: 86,494,996 (GRCm39)	I281V	probably benign	Het
Sall1	T	C	8: 89,759,510 (GRCm39)	E198G	probably damaging	Het
Serpina9	T	C	12: 103,963,362 (GRCm39)	D382G	possibly damaging	Het
Stt3b	A	G	9: 115,095,260 (GRCm39)	V257A	probably damaging	Het
Taf2	A	T	15: 54,925,568 (GRCm39)	Y225N	possibly damaging	Het
Tlr3	A	G	8: 45,851,202 (GRCm39)	L41P	probably damaging	Het
Trappc12	A	T	12: 28,787,751 (GRCm39)	V444E	probably benign	Het
Trim34a	T	A	7: 103,897,287 (GRCm39)	V117D	possibly damaging	Het
Ttbk1	A	C	17: 46,787,725 (GRCm39)	M259R	probably benign	Het
Ttll12	A	G	15: 83,464,303 (GRCm39)	V509A	probably damaging	Het
Ush2a	G	A	1: 188,581,273 (GRCm39)	V3718M	probably benign	Het
Vps35	T	A	8: 86,014,429 (GRCm39)	E73D	probably damaging	Het

Other mutations in Zfp790

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Zfp790	APN	7	29,527,988 (GRCm39)	missense	probably benign	0.32
IGL00979:Zfp790	APN	7	29,529,034 (GRCm39)	missense	probably benign	0.00
IGL02286:Zfp790	APN	7	29,529,160 (GRCm39)	missense	possibly damaging	0.53
IGL03136:Zfp790	APN	7	29,529,320 (GRCm39)	nonsense	probably null
R0021:Zfp790	UTSW	7	29,525,113 (GRCm39)	unclassified	probably benign
R0077:Zfp790	UTSW	7	29,524,300 (GRCm39)	missense	probably damaging	0.98
R1572:Zfp790	UTSW	7	29,527,564 (GRCm39)	missense	probably benign	0.33
R2015:Zfp790	UTSW	7	29,528,286 (GRCm39)	missense	probably benign	0.29
R4941:Zfp790	UTSW	7	29,528,916 (GRCm39)	missense	possibly damaging	0.83
R5019:Zfp790	UTSW	7	29,529,192 (GRCm39)	missense	probably benign	0.00
R5159:Zfp790	UTSW	7	29,529,192 (GRCm39)	missense	probably benign	0.00
R5160:Zfp790	UTSW	7	29,529,192 (GRCm39)	missense	probably benign	0.00
R5722:Zfp790	UTSW	7	29,529,514 (GRCm39)	nonsense	probably null
R5954:Zfp790	UTSW	7	29,528,929 (GRCm39)	missense	probably damaging	1.00
R6025:Zfp790	UTSW	7	29,528,970 (GRCm39)	missense	possibly damaging	0.71
R6312:Zfp790	UTSW	7	29,527,647 (GRCm39)	missense	probably damaging	1.00
R7392:Zfp790	UTSW	7	29,528,050 (GRCm39)	missense	possibly damaging	0.52
R7623:Zfp790	UTSW	7	29,525,130 (GRCm39)	nonsense	probably null
R8036:Zfp790	UTSW	7	29,528,346 (GRCm39)	missense	possibly damaging	0.92
R8175:Zfp790	UTSW	7	29,529,205 (GRCm39)	missense	possibly damaging	0.96
R8898:Zfp790	UTSW	7	29,522,525 (GRCm39)	start gained	probably benign
R8988:Zfp790	UTSW	7	29,527,593 (GRCm39)	missense	probably benign
R9176:Zfp790	UTSW	7	29,529,387 (GRCm39)	missense	probably benign	0.04
R9404:Zfp790	UTSW	7	29,525,185 (GRCm39)	missense	probably benign
R9519:Zfp790	UTSW	7	29,522,567 (GRCm39)	missense	unknown
Z1186:Zfp790	UTSW	7	29,529,109 (GRCm39)	missense	possibly damaging	0.53
Z1186:Zfp790	UTSW	7	29,529,258 (GRCm39)	missense	possibly damaging	0.92
Z1186:Zfp790	UTSW	7	29,529,208 (GRCm39)	missense	possibly damaging	0.72

Predicted Primers

PCR Primer
(F):5'- GGGAGAGTTCCATTCCCTGTGAAGA -3'
(R):5'- CGTGTGGGAGACATAAGGGTCTACT -3'

Sequencing Primer
(F):5'- gcctgcctctgctcctg -3'
(R):5'- TCTACTAACAGAAGAAAGAGCGCC -3'

Posted On

2014-03-28