Mutagenetix > Incidental Mutation

Incidental Mutation 'R0069:Trgv7'

16436

Institutional Source

Beutler Lab

Gene Symbol

Trgv7

Ensembl Gene

ENSMUSG00000076744

Gene Name

T cell receptor gamma, variable 7

Synonyms

Tcrg-V7

MMRRC Submission

038360-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

R0069 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

19362212-19362662 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19362592 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 94 (R94G)

Ref Sequence

ENSEMBL: ENSMUSP00000100334 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103553]

AlphaFold

A0A0A6YYE8

Predicted Effect

probably benign
Transcript: ENSMUST00000103553
AA Change: R94G

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000100334
Gene: ENSMUSG00000076744
AA Change: R94G

Domain	Start	End	E-Value	Type
low complexity region	2	14	N/A	INTRINSIC
IG	26	117	2.19e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000197661

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 86.4%
3x: 80.4%
10x: 57.4%
20x: 26.1%

Validation Efficiency

94% (60/64)

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	A	T	6: 128,538,525 (GRCm39)	C632S	probably damaging	Het
Ccnb1ip1	G	A	14: 81,519,382 (GRCm38)	Q322*	probably null	Het
Cd101	A	G	3: 100,915,533 (GRCm39)	V678A	probably benign	Het
Creb1	A	G	1: 64,615,367 (GRCm39)	I240V	possibly damaging	Het
Dctn2	A	T	10: 127,113,354 (GRCm39)		probably null	Het
Diablo	A	T	5: 123,656,087 (GRCm39)	S117R	probably damaging	Het
Ebf2	A	T	14: 67,647,499 (GRCm39)	R349S	probably damaging	Het
Gne	A	C	4: 44,060,099 (GRCm39)	V98G	probably damaging	Het
Ints3	A	G	3: 90,307,954 (GRCm39)		probably benign	Het
Itgal	A	G	7: 126,909,503 (GRCm39)	T56A	probably benign	Het
Lzts3	T	A	2: 130,478,460 (GRCm39)	T213S	probably benign	Het
Myo1d	A	G	11: 80,528,779 (GRCm39)	I681T	probably damaging	Het
Pde8a	T	C	7: 80,968,871 (GRCm39)		probably benign	Het
Pole2	A	T	12: 69,256,661 (GRCm39)	V288E	probably damaging	Het
Poteg	T	C	8: 27,937,849 (GRCm39)	S2P	probably benign	Het
Ppp2r5c	A	T	12: 110,534,204 (GRCm39)	M356L	probably benign	Het
Rad54l2	C	A	9: 106,587,564 (GRCm39)	V734L	possibly damaging	Het
Ryr1	A	C	7: 28,809,930 (GRCm39)		probably benign	Het
Slfn10-ps	A	G	11: 82,926,368 (GRCm39)		noncoding transcript	Het
Sult1e1	A	T	5: 87,727,756 (GRCm39)	H175Q	probably damaging	Het
Ube2e3	C	A	2: 78,750,293 (GRCm39)		probably benign	Het
Vps13d	A	G	4: 144,789,133 (GRCm39)	I746T	probably benign	Het
Xpnpep3	T	C	15: 81,314,999 (GRCm39)	V233A	probably benign	Het
Zfp329	A	T	7: 12,544,859 (GRCm39)	S222T	probably damaging	Het
Zswim6	T	C	13: 107,875,098 (GRCm39)		noncoding transcript	Het

Other mutations in Trgv7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01640:Trgv7	APN	13	19,362,260 (GRCm39)	splice site	probably benign
IGL02320:Trgv7	APN	13	19,362,249 (GRCm39)	missense	unknown
IGL03178:Trgv7	APN	13	19,362,211 (GRCm39)	utr 5 prime	probably benign
IGL03310:Trgv7	APN	13	19,362,664 (GRCm39)	unclassified	probably benign
R3925:Trgv7	UTSW	13	19,362,644 (GRCm39)	missense	probably damaging	1.00
R5030:Trgv7	UTSW	13	19,362,558 (GRCm39)	missense	probably damaging	0.97
R5085:Trgv7	UTSW	13	19,362,598 (GRCm39)	nonsense	probably null
R9456:Trgv7	UTSW	13	19,362,385 (GRCm39)	nonsense	probably null

Posted On

2013-01-20