|Institutional Source||Beutler Lab|
|Gene Name||G protein-coupled receptor 37|
|Synonyms||parkin-associated endothelin B-like receptor, Pael-R|
|Is this an essential gene?||Possibly non essential (E-score: 0.259)|
|Stock #||R1481 (G1)|
|Chromosomal Location||25665878-25690729 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 25669138 bp|
|Amino Acid Change||Aspartic acid to Glycine at position 569 (D569G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000052185 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000054867] [ENSMUST00000200812]|
|Predicted Effect||probably damaging
AA Change: D569G
PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
AA Change: D569G
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.086|
|Coding Region Coverage||
|Validation Efficiency||100% (71/71)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
PHENOTYPE: Mice homozygous for disruptions in this gene exhibit reduced striatal dopamine content, enhanced amphetamine sensitivity, reduced motor activity and coordination and increased percentage of body fat in females. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gpr37||
(F):5'- TGATCTGAGACTGTTGGCCTCCTTC -3'
(R):5'- TGCTCAACATCATCAGCCAGTTCC -3'
(F):5'- TGCATTGTTCCCCTGTAAGG -3'
(R):5'- AACATCATCAGCCAGTTCCTTTTG -3'