Incidental Mutation 'R1482:Zfp618'
ID 164433
Institutional Source Beutler Lab
Gene Symbol Zfp618
Ensembl Gene ENSMUSG00000028358
Gene Name zinc finger protein 618
Synonyms Nedd10, 2810040O04Rik, D430033D05Rik, 2810031P15Rik
MMRRC Submission 039535-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.129) question?
Stock # R1482 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 62883810-63057945 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 63033685 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 307 (D307E)
Ref Sequence ENSEMBL: ENSMUSP00000030043 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030043] [ENSMUST00000064814] [ENSMUST00000107415]
AlphaFold Q80YY7
Predicted Effect possibly damaging
Transcript: ENSMUST00000030043
AA Change: D307E

PolyPhen 2 Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000030043
Gene: ENSMUSG00000028358
AA Change: D307E

DomainStartEndE-ValueType
ZnF_C2H2 90 112 5.06e-2 SMART
ZnF_C2H2 131 153 8.81e-2 SMART
ZnF_C2H2 199 221 2.91e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000064814
SMART Domains Protein: ENSMUSP00000069275
Gene: ENSMUSG00000028358

DomainStartEndE-ValueType
ZnF_C2H2 114 136 5.06e-2 SMART
ZnF_C2H2 155 177 8.81e-2 SMART
ZnF_C2H2 243 265 2.91e-2 SMART
low complexity region 288 295 N/A INTRINSIC
ZnF_C2H2 298 320 2.53e-2 SMART
PDB:2BW3|A 377 690 5e-8 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000107415
SMART Domains Protein: ENSMUSP00000103038
Gene: ENSMUSG00000028358

DomainStartEndE-ValueType
ZnF_C2H2 146 168 5.06e-2 SMART
ZnF_C2H2 187 209 8.81e-2 SMART
ZnF_C2H2 255 277 2.91e-2 SMART
low complexity region 381 388 N/A INTRINSIC
ZnF_C2H2 391 413 2.53e-2 SMART
PDB:2BW3|A 479 783 9e-8 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151324
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 93.8%
  • 20x: 83.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810055G02Rik G A 19: 3,767,192 (GRCm39) D260N probably benign Het
Ankef1 A T 2: 136,392,078 (GRCm39) K422N possibly damaging Het
Anxa2 TCCC TCC 9: 69,397,036 (GRCm39) probably null Het
Aqp6 A T 15: 99,502,188 (GRCm39) *294C probably null Het
Baz2a T A 10: 127,944,877 (GRCm39) M38K possibly damaging Het
Bcl2l14 A G 6: 134,404,265 (GRCm39) D151G probably damaging Het
Cabp5 T A 7: 13,132,267 (GRCm39) L12* probably null Het
Cachd1 T C 4: 100,845,795 (GRCm39) V993A possibly damaging Het
Cd44 G A 2: 102,661,728 (GRCm39) T306I probably damaging Het
Cdc20 A T 4: 118,294,253 (GRCm39) N22K probably benign Het
Cdc6 T A 11: 98,807,807 (GRCm39) D433E possibly damaging Het
Clhc1 A G 11: 29,503,725 (GRCm39) D47G probably damaging Het
Csf2 T C 11: 54,139,389 (GRCm39) K65E probably benign Het
Cul9 T C 17: 46,819,473 (GRCm39) E2005G probably damaging Het
Dclk3 G T 9: 111,296,888 (GRCm39) R144L possibly damaging Het
Dcpp2 C T 17: 24,119,516 (GRCm39) T110I probably damaging Het
Disp1 A T 1: 182,868,038 (GRCm39) F1461I possibly damaging Het
Dnah1 C T 14: 31,016,831 (GRCm39) G1562D probably damaging Het
Ecpas T C 4: 58,820,163 (GRCm39) K1217E possibly damaging Het
Exoc3l2 C A 7: 19,229,284 (GRCm39) P234Q probably damaging Het
F2rl2 T C 13: 95,838,047 (GRCm39) V364A probably benign Het
Fam151a T C 4: 106,602,876 (GRCm39) L265P probably damaging Het
Fam151b T A 13: 92,586,674 (GRCm39) Q253L probably benign Het
Fat1 G A 8: 45,406,281 (GRCm39) V1011M probably benign Het
Fbxo6 G A 4: 148,230,441 (GRCm39) R274* probably null Het
Fgd4 G T 16: 16,302,337 (GRCm39) Q73K probably benign Het
Fth1 A G 19: 9,962,217 (GRCm39) T154A probably benign Het
Hgs C A 11: 120,370,866 (GRCm39) H572Q probably benign Het
Kcnk10 G A 12: 98,456,207 (GRCm39) T208I probably damaging Het
Kdm5b G A 1: 134,552,635 (GRCm39) V1204M probably damaging Het
Keg1 A C 19: 12,696,185 (GRCm39) H166P probably damaging Het
Kifap3 A T 1: 163,653,428 (GRCm39) N338I possibly damaging Het
Llcfc1 A T 6: 41,662,218 (GRCm39) D74V probably damaging Het
Lman2 A G 13: 55,499,218 (GRCm39) V219A possibly damaging Het
Mettl25 A G 10: 105,662,451 (GRCm39) I173T possibly damaging Het
Mov10 G T 3: 104,711,862 (GRCm39) P170Q probably damaging Het
Mtif2 G T 11: 29,486,847 (GRCm39) A286S probably damaging Het
Mtmr10 A G 7: 63,963,997 (GRCm39) Y244C probably damaging Het
Nbea A T 3: 55,987,414 (GRCm39) C359S probably damaging Het
Nbr1 C T 11: 101,463,667 (GRCm39) T633I probably benign Het
Nepn A T 10: 52,276,512 (GRCm39) T22S probably damaging Het
Nup214 C T 2: 31,924,478 (GRCm39) S1669F probably damaging Het
Oacyl T A 18: 65,871,043 (GRCm39) L342M probably damaging Het
Or2ag17 A G 7: 106,389,540 (GRCm39) F223L probably benign Het
Or52b2 T A 7: 104,986,463 (GRCm39) R153S probably damaging Het
Or6c205 T A 10: 129,087,012 (GRCm39) I203N possibly damaging Het
Or7e176 G A 9: 20,172,020 (GRCm39) V295I possibly damaging Het
Oxnad1 T C 14: 31,821,590 (GRCm39) probably null Het
Pard3b A T 1: 62,205,526 (GRCm39) D440V probably damaging Het
Pou3f2 T G 4: 22,486,960 (GRCm39) D391A possibly damaging Het
Ptprk T C 10: 28,139,512 (GRCm39) V79A probably benign Het
Rwdd2a A G 9: 86,456,331 (GRCm39) D169G probably damaging Het
Scn3b A C 9: 40,190,792 (GRCm39) D74A probably damaging Het
Setbp1 C T 18: 79,130,050 (GRCm39) D61N probably damaging Het
Setx T A 2: 29,053,004 (GRCm39) D2089E probably damaging Het
Vmn2r69 C G 7: 85,056,082 (GRCm39) W685C probably damaging Het
Vps8 A G 16: 21,400,348 (GRCm39) Q1272R probably benign Het
Wnk4 T C 11: 101,160,462 (GRCm39) F699L probably damaging Het
Zfp616 T A 11: 73,974,803 (GRCm39) N448K possibly damaging Het
Zfp687 A G 3: 94,914,844 (GRCm39) F1219S probably damaging Het
Zfpm2 T A 15: 40,962,687 (GRCm39) D248E probably damaging Het
Other mutations in Zfp618
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01301:Zfp618 APN 4 63,051,063 (GRCm39) missense probably damaging 1.00
IGL01563:Zfp618 APN 4 62,998,133 (GRCm39) missense probably benign 0.38
IGL01726:Zfp618 APN 4 63,050,872 (GRCm39) missense probably damaging 1.00
IGL02139:Zfp618 APN 4 63,051,773 (GRCm39) missense probably damaging 1.00
IGL02182:Zfp618 APN 4 63,013,798 (GRCm39) splice site probably benign
IGL02533:Zfp618 APN 4 63,007,642 (GRCm39) missense probably damaging 1.00
IGL03231:Zfp618 APN 4 63,012,716 (GRCm39) missense probably damaging 1.00
IGL03257:Zfp618 APN 4 63,050,908 (GRCm39) missense probably damaging 1.00
ANU18:Zfp618 UTSW 4 63,051,063 (GRCm39) missense probably damaging 1.00
IGL03014:Zfp618 UTSW 4 62,998,325 (GRCm39) missense probably damaging 1.00
R0288:Zfp618 UTSW 4 63,051,171 (GRCm39) missense possibly damaging 0.57
R0408:Zfp618 UTSW 4 63,004,809 (GRCm39) missense probably damaging 0.97
R0685:Zfp618 UTSW 4 63,052,011 (GRCm39) missense probably benign 0.21
R1585:Zfp618 UTSW 4 63,051,175 (GRCm39) missense probably damaging 1.00
R1649:Zfp618 UTSW 4 63,013,774 (GRCm39) missense probably damaging 1.00
R1744:Zfp618 UTSW 4 63,004,871 (GRCm39) splice site probably benign
R1793:Zfp618 UTSW 4 63,051,474 (GRCm39) missense probably damaging 0.97
R1952:Zfp618 UTSW 4 63,050,555 (GRCm39) splice site probably null
R1996:Zfp618 UTSW 4 63,049,452 (GRCm39) splice site probably null
R3792:Zfp618 UTSW 4 63,033,728 (GRCm39) intron probably benign
R3803:Zfp618 UTSW 4 63,051,256 (GRCm39) missense probably damaging 1.00
R3821:Zfp618 UTSW 4 63,051,801 (GRCm39) missense probably benign 0.00
R3838:Zfp618 UTSW 4 63,051,801 (GRCm39) missense probably benign 0.00
R4009:Zfp618 UTSW 4 63,051,801 (GRCm39) missense probably benign 0.00
R4010:Zfp618 UTSW 4 63,051,801 (GRCm39) missense probably benign 0.00
R4565:Zfp618 UTSW 4 63,039,588 (GRCm39) missense probably damaging 1.00
R4611:Zfp618 UTSW 4 63,051,216 (GRCm39) missense probably damaging 1.00
R5019:Zfp618 UTSW 4 63,021,789 (GRCm39) missense probably damaging 1.00
R5154:Zfp618 UTSW 4 63,051,446 (GRCm39) missense probably damaging 1.00
R5183:Zfp618 UTSW 4 63,017,519 (GRCm39) missense probably benign
R5354:Zfp618 UTSW 4 62,998,265 (GRCm39) missense probably damaging 1.00
R5383:Zfp618 UTSW 4 63,013,729 (GRCm39) missense probably benign 0.33
R5774:Zfp618 UTSW 4 63,050,799 (GRCm39) missense probably damaging 1.00
R5932:Zfp618 UTSW 4 63,036,803 (GRCm39) nonsense probably null
R6101:Zfp618 UTSW 4 63,051,478 (GRCm39) missense probably benign 0.09
R6105:Zfp618 UTSW 4 63,051,478 (GRCm39) missense probably benign 0.09
R6478:Zfp618 UTSW 4 63,050,943 (GRCm39) missense probably damaging 1.00
R6598:Zfp618 UTSW 4 63,007,636 (GRCm39) missense probably damaging 1.00
R7386:Zfp618 UTSW 4 63,013,622 (GRCm39) critical splice donor site probably null
R7666:Zfp618 UTSW 4 63,050,954 (GRCm39) nonsense probably null
R7678:Zfp618 UTSW 4 63,004,858 (GRCm39) missense probably benign 0.07
R7975:Zfp618 UTSW 4 63,049,352 (GRCm39) missense possibly damaging 0.93
R8276:Zfp618 UTSW 4 63,051,193 (GRCm39) missense probably damaging 1.00
R8421:Zfp618 UTSW 4 63,051,483 (GRCm39) missense probably damaging 1.00
R8988:Zfp618 UTSW 4 63,012,708 (GRCm39) missense probably benign 0.09
R9022:Zfp618 UTSW 4 63,012,687 (GRCm39) missense probably damaging 1.00
R9150:Zfp618 UTSW 4 63,039,603 (GRCm39) nonsense probably null
R9163:Zfp618 UTSW 4 63,051,511 (GRCm39) missense probably damaging 1.00
R9364:Zfp618 UTSW 4 63,036,824 (GRCm39) missense probably damaging 0.99
R9382:Zfp618 UTSW 4 63,051,258 (GRCm39) missense probably damaging 0.97
R9424:Zfp618 UTSW 4 63,051,282 (GRCm39) missense probably benign 0.00
R9462:Zfp618 UTSW 4 63,051,510 (GRCm39) missense possibly damaging 0.94
R9576:Zfp618 UTSW 4 63,051,282 (GRCm39) missense probably benign 0.00
R9587:Zfp618 UTSW 4 63,051,916 (GRCm39) missense
X0011:Zfp618 UTSW 4 62,998,243 (GRCm39) missense probably damaging 0.99
Z1176:Zfp618 UTSW 4 63,051,000 (GRCm39) missense probably benign 0.12
Z1176:Zfp618 UTSW 4 63,013,734 (GRCm39) missense probably benign 0.29
Predicted Primers PCR Primer
(F):5'- GACTTTCAAAGGTTCTCGGGCTCC -3'
(R):5'- ACTTGGTCTGCCAGGGTTACAGAG -3'

Sequencing Primer
(F):5'- ATCCAGACACGGGTTCTGAG -3'
(R):5'- CTTGTTCTTGCAGGGGAACA -3'
Posted On 2014-03-28