Incidental Mutation 'R1482:Or6c205'
ID 164459
Institutional Source Beutler Lab
Gene Symbol Or6c205
Ensembl Gene ENSMUSG00000096220
Gene Name olfactory receptor family 6 subfamily C member 205
Synonyms Olfr1518, MOR111-6, MOR111-7, MOR111-7, GA_x6K02T2PULF-10936819-10937757, Olfr775
MMRRC Submission 039535-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R1482 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 129086405-129087343 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 129087012 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 203 (I203N)
Ref Sequence ENSEMBL: ENSMUSP00000150345 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097163] [ENSMUST00000214109]
AlphaFold Q7TRI4
Predicted Effect possibly damaging
Transcript: ENSMUST00000097163
AA Change: I203N

PolyPhen 2 Score 0.801 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000132845
Gene: ENSMUSG00000096220
AA Change: I203N

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 9.9e-52 PFAM
Pfam:7tm_1 39 288 9.1e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214109
AA Change: I203N

PolyPhen 2 Score 0.801 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 93.8%
  • 20x: 83.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810055G02Rik G A 19: 3,767,192 (GRCm39) D260N probably benign Het
Ankef1 A T 2: 136,392,078 (GRCm39) K422N possibly damaging Het
Anxa2 TCCC TCC 9: 69,397,036 (GRCm39) probably null Het
Aqp6 A T 15: 99,502,188 (GRCm39) *294C probably null Het
Baz2a T A 10: 127,944,877 (GRCm39) M38K possibly damaging Het
Bcl2l14 A G 6: 134,404,265 (GRCm39) D151G probably damaging Het
Cabp5 T A 7: 13,132,267 (GRCm39) L12* probably null Het
Cachd1 T C 4: 100,845,795 (GRCm39) V993A possibly damaging Het
Cd44 G A 2: 102,661,728 (GRCm39) T306I probably damaging Het
Cdc20 A T 4: 118,294,253 (GRCm39) N22K probably benign Het
Cdc6 T A 11: 98,807,807 (GRCm39) D433E possibly damaging Het
Clhc1 A G 11: 29,503,725 (GRCm39) D47G probably damaging Het
Csf2 T C 11: 54,139,389 (GRCm39) K65E probably benign Het
Cul9 T C 17: 46,819,473 (GRCm39) E2005G probably damaging Het
Dclk3 G T 9: 111,296,888 (GRCm39) R144L possibly damaging Het
Dcpp2 C T 17: 24,119,516 (GRCm39) T110I probably damaging Het
Disp1 A T 1: 182,868,038 (GRCm39) F1461I possibly damaging Het
Dnah1 C T 14: 31,016,831 (GRCm39) G1562D probably damaging Het
Ecpas T C 4: 58,820,163 (GRCm39) K1217E possibly damaging Het
Exoc3l2 C A 7: 19,229,284 (GRCm39) P234Q probably damaging Het
F2rl2 T C 13: 95,838,047 (GRCm39) V364A probably benign Het
Fam151a T C 4: 106,602,876 (GRCm39) L265P probably damaging Het
Fam151b T A 13: 92,586,674 (GRCm39) Q253L probably benign Het
Fat1 G A 8: 45,406,281 (GRCm39) V1011M probably benign Het
Fbxo6 G A 4: 148,230,441 (GRCm39) R274* probably null Het
Fgd4 G T 16: 16,302,337 (GRCm39) Q73K probably benign Het
Fth1 A G 19: 9,962,217 (GRCm39) T154A probably benign Het
Hgs C A 11: 120,370,866 (GRCm39) H572Q probably benign Het
Kcnk10 G A 12: 98,456,207 (GRCm39) T208I probably damaging Het
Kdm5b G A 1: 134,552,635 (GRCm39) V1204M probably damaging Het
Keg1 A C 19: 12,696,185 (GRCm39) H166P probably damaging Het
Kifap3 A T 1: 163,653,428 (GRCm39) N338I possibly damaging Het
Llcfc1 A T 6: 41,662,218 (GRCm39) D74V probably damaging Het
Lman2 A G 13: 55,499,218 (GRCm39) V219A possibly damaging Het
Mettl25 A G 10: 105,662,451 (GRCm39) I173T possibly damaging Het
Mov10 G T 3: 104,711,862 (GRCm39) P170Q probably damaging Het
Mtif2 G T 11: 29,486,847 (GRCm39) A286S probably damaging Het
Mtmr10 A G 7: 63,963,997 (GRCm39) Y244C probably damaging Het
Nbea A T 3: 55,987,414 (GRCm39) C359S probably damaging Het
Nbr1 C T 11: 101,463,667 (GRCm39) T633I probably benign Het
Nepn A T 10: 52,276,512 (GRCm39) T22S probably damaging Het
Nup214 C T 2: 31,924,478 (GRCm39) S1669F probably damaging Het
Oacyl T A 18: 65,871,043 (GRCm39) L342M probably damaging Het
Or2ag17 A G 7: 106,389,540 (GRCm39) F223L probably benign Het
Or52b2 T A 7: 104,986,463 (GRCm39) R153S probably damaging Het
Or7e176 G A 9: 20,172,020 (GRCm39) V295I possibly damaging Het
Oxnad1 T C 14: 31,821,590 (GRCm39) probably null Het
Pard3b A T 1: 62,205,526 (GRCm39) D440V probably damaging Het
Pou3f2 T G 4: 22,486,960 (GRCm39) D391A possibly damaging Het
Ptprk T C 10: 28,139,512 (GRCm39) V79A probably benign Het
Rwdd2a A G 9: 86,456,331 (GRCm39) D169G probably damaging Het
Scn3b A C 9: 40,190,792 (GRCm39) D74A probably damaging Het
Setbp1 C T 18: 79,130,050 (GRCm39) D61N probably damaging Het
Setx T A 2: 29,053,004 (GRCm39) D2089E probably damaging Het
Vmn2r69 C G 7: 85,056,082 (GRCm39) W685C probably damaging Het
Vps8 A G 16: 21,400,348 (GRCm39) Q1272R probably benign Het
Wnk4 T C 11: 101,160,462 (GRCm39) F699L probably damaging Het
Zfp616 T A 11: 73,974,803 (GRCm39) N448K possibly damaging Het
Zfp618 C A 4: 63,033,685 (GRCm39) D307E possibly damaging Het
Zfp687 A G 3: 94,914,844 (GRCm39) F1219S probably damaging Het
Zfpm2 T A 15: 40,962,687 (GRCm39) D248E probably damaging Het
Other mutations in Or6c205
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01025:Or6c205 APN 10 129,086,609 (GRCm39) missense possibly damaging 0.79
IGL01310:Or6c205 APN 10 129,086,865 (GRCm39) missense possibly damaging 0.85
IGL02185:Or6c205 APN 10 129,086,904 (GRCm39) missense possibly damaging 0.60
IGL02887:Or6c205 APN 10 129,086,794 (GRCm39) nonsense probably null
R0584:Or6c205 UTSW 10 129,086,817 (GRCm39) missense probably benign 0.01
R1845:Or6c205 UTSW 10 129,086,463 (GRCm39) missense probably benign 0.00
R2062:Or6c205 UTSW 10 129,087,001 (GRCm39) nonsense probably null
R2131:Or6c205 UTSW 10 129,086,943 (GRCm39) missense probably benign 0.05
R4975:Or6c205 UTSW 10 129,087,141 (GRCm39) missense probably damaging 1.00
R6714:Or6c205 UTSW 10 129,086,809 (GRCm39) missense possibly damaging 0.91
R7803:Or6c205 UTSW 10 129,086,864 (GRCm39) missense probably benign 0.04
R8060:Or6c205 UTSW 10 129,086,915 (GRCm39) missense possibly damaging 0.62
R8177:Or6c205 UTSW 10 129,086,790 (GRCm39) missense probably benign 0.05
R8878:Or6c205 UTSW 10 129,086,883 (GRCm39) missense probably benign 0.39
R9007:Or6c205 UTSW 10 129,086,669 (GRCm39) missense possibly damaging 0.94
R9332:Or6c205 UTSW 10 129,086,972 (GRCm39) missense probably damaging 0.99
R9571:Or6c205 UTSW 10 129,087,182 (GRCm39) missense possibly damaging 0.50
Predicted Primers PCR Primer
(F):5'- CAGAAAGTCTGCACCCTTCTTGTCC -3'
(R):5'- ATTGAGAACAGCCACCCCTTTGG -3'

Sequencing Primer
(F):5'- CTCACCTCATGGCTGATAGG -3'
(R):5'- ACCCCTTTGGTCAGTGATG -3'
Posted On 2014-03-28