Incidental Mutation 'IGL00155:Cxcl9'
ID1645
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cxcl9
Ensembl Gene ENSMUSG00000029417
Gene Namechemokine (C-X-C motif) ligand 9
SynonymsMig, CMK, crg-10, Scyb9
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00155
Quality Score
Status
Chromosome5
Chromosomal Location92321347-92328079 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 92323869 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Leucine at position 104 (H104L)
Ref Sequence ENSEMBL: ENSMUSP00000108716 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113093]
Predicted Effect possibly damaging
Transcript: ENSMUST00000113093
AA Change: H104L

PolyPhen 2 Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000108716
Gene: ENSMUSG00000029417
AA Change: H104L

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
SCY 27 88 2.08e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202404
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele show a significant reduction in CD4+ T cell infiltration into the cornea in response to ocular HSV-1 infection, and produce lower titers of antibodies in response to primary infection with the intracellular bacterium Francisella tularensis live vaccine strain. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N22Rik A G 5: 11,921,410 S110G possibly damaging Het
Aacs T C 5: 125,513,171 F498S probably damaging Het
Arhgap11a A G 2: 113,834,256 S561P probably benign Het
Best3 T C 10: 116,988,727 Y33H probably damaging Het
Cd209b T A 8: 3,919,945 probably benign Het
Cep152 A G 2: 125,563,888 S1575P probably benign Het
Crabp2 A G 3: 87,952,199 Y52C probably damaging Het
Crybg1 T C 10: 43,992,509 D1017G probably damaging Het
Ctnna2 A T 6: 76,980,761 W137R probably damaging Het
Ddr2 A G 1: 169,984,427 I742T possibly damaging Het
Frem1 A G 4: 82,959,389 V223A possibly damaging Het
Fzd10 T A 5: 128,601,528 I104N probably damaging Het
Greb1 A G 12: 16,711,961 S473P probably damaging Het
Gtf2i T C 5: 134,242,748 Y873C probably damaging Het
Igsf6 T A 7: 121,070,653 K89* probably null Het
Ints3 A G 3: 90,406,329 F331L probably damaging Het
Kcnh3 A T 15: 99,242,473 H1080L possibly damaging Het
Mettl15 A T 2: 109,093,176 Y300* probably null Het
Mms19 A G 19: 41,948,233 F654L probably benign Het
Myc A G 15: 61,989,820 H425R probably benign Het
Ntn1 G T 11: 68,226,619 probably benign Het
Ormdl2 C A 10: 128,820,075 G69W probably damaging Het
Pdpr T C 8: 111,102,072 V69A possibly damaging Het
Rbbp6 T C 7: 122,988,685 I254T probably damaging Het
Sema6d A G 2: 124,659,865 R543G possibly damaging Het
Slc18a1 C T 8: 69,051,346 A314T probably damaging Het
Slc22a26 A G 19: 7,782,836 L514P probably damaging Het
Slc22a28 A C 19: 8,130,203 S167A possibly damaging Het
Tchh A G 3: 93,445,299 E682G unknown Het
Thbs2 A T 17: 14,668,835 M1134K probably damaging Het
Tmem26 A G 10: 68,775,354 S218G probably damaging Het
Tmprss11c A T 5: 86,239,395 S208R probably benign Het
Tnfrsf8 T C 4: 145,292,591 probably null Het
Ush2a T C 1: 188,864,678 S3872P probably benign Het
Vmn1r69 T C 7: 10,579,952 N205S probably benign Het
Vmn2r54 T A 7: 12,631,913 probably benign Het
Wwtr1 A T 3: 57,463,521 M328K possibly damaging Het
Zfp64 G A 2: 168,926,681 S337L probably benign Het
Other mutations in Cxcl9
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1327:Cxcl9 UTSW 5 92326850 missense probably damaging 1.00
R1476:Cxcl9 UTSW 5 92325113 missense probably damaging 1.00
R5752:Cxcl9 UTSW 5 92323856 missense probably benign
R7215:Cxcl9 UTSW 5 92323888 nonsense probably null
Posted On2011-07-12