Incidental Mutation 'R1467:Fasn'
| ID |
164604 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fasn
|
| Ensembl Gene |
ENSMUSG00000025153 |
| Gene Name |
fatty acid synthase |
| Synonyms |
A630082H08Rik, FAS |
| MMRRC Submission |
039520-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1467 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
120696672-120715373 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 120701866 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 1871
(F1871S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000145585
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055655]
[ENSMUST00000206589]
|
| AlphaFold |
P19096 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055655
AA Change: F1873S
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000052872
Gene: ENSMUSG00000025153
AA Change: F1873S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ketoacyl-synt
|
1 |
239 |
6.8e-73 |
PFAM |
|
Pfam:Ketoacyl-synt_C
|
243 |
360 |
3.7e-38 |
PFAM |
|
Pfam:KAsynt_C_assoc
|
362 |
474 |
8.2e-46 |
PFAM |
|
Pfam:Acyl_transf_1
|
493 |
810 |
9.5e-115 |
PFAM |
|
Pfam:PS-DH
|
853 |
1169 |
9.9e-24 |
PFAM |
|
low complexity region
|
1175 |
1204 |
N/A |
INTRINSIC |
|
Pfam:Methyltransf_12
|
1238 |
1337 |
2e-9 |
PFAM |
|
PKS_ER
|
1532 |
1847 |
1.44e-147 |
SMART |
|
PKS_KR
|
1878 |
2059 |
2.33e-42 |
SMART |
|
Pfam:PP-binding
|
2119 |
2185 |
1.1e-10 |
PFAM |
|
Pfam:Thioesterase
|
2235 |
2494 |
1.6e-62 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146541
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155276
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206589
AA Change: F1871S
PolyPhen 2
Score 0.071 (Sensitivity: 0.94; Specificity: 0.84)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206637
|
| Meta Mutation Damage Score |
0.0613 |
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.1%
- 10x: 88.5%
- 20x: 62.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted mutation of this locus has implicated its product in embryogenesis as all homozygotes and most heterozygotes die prior to birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2010315B03Rik |
C |
A |
9: 124,058,093 (GRCm39) |
V9L |
possibly damaging |
Het |
| A630010A05Rik |
C |
A |
16: 14,436,447 (GRCm39) |
L167I |
possibly damaging |
Het |
| Abca14 |
A |
T |
7: 119,815,405 (GRCm39) |
M218L |
possibly damaging |
Het |
| Abca15 |
C |
A |
7: 119,939,761 (GRCm39) |
|
probably null |
Het |
| Acod1 |
T |
C |
14: 103,292,003 (GRCm39) |
F176L |
probably benign |
Het |
| Actr5 |
A |
G |
2: 158,480,617 (GRCm39) |
H545R |
probably benign |
Het |
| Adcy1 |
A |
G |
11: 7,088,396 (GRCm39) |
T472A |
probably damaging |
Het |
| Aldh1l1 |
A |
G |
6: 90,548,910 (GRCm39) |
K469R |
possibly damaging |
Het |
| Ambra1 |
A |
T |
2: 91,716,048 (GRCm39) |
Q853L |
probably damaging |
Het |
| Apol7e |
G |
T |
15: 77,601,966 (GRCm39) |
G188V |
probably damaging |
Het |
| AU018091 |
A |
T |
7: 3,214,089 (GRCm39) |
W43R |
probably benign |
Het |
| Baat |
A |
G |
4: 49,503,101 (GRCm39) |
V7A |
probably benign |
Het |
| Bcas1 |
C |
A |
2: 170,229,852 (GRCm39) |
Q249H |
possibly damaging |
Het |
| Bltp1 |
T |
A |
3: 37,090,094 (GRCm39) |
V676D |
probably damaging |
Het |
| Bptf |
G |
T |
11: 106,945,881 (GRCm39) |
Q2453K |
possibly damaging |
Het |
| Btg3 |
A |
G |
16: 78,161,688 (GRCm39) |
|
probably null |
Het |
| Cacna2d3 |
T |
C |
14: 29,055,736 (GRCm39) |
N298S |
possibly damaging |
Het |
| Carf |
G |
A |
1: 60,167,152 (GRCm39) |
V127I |
possibly damaging |
Het |
| Catsperg1 |
T |
C |
7: 28,884,433 (GRCm39) |
S916G |
probably damaging |
Het |
| Cers1 |
T |
C |
8: 70,775,819 (GRCm39) |
S274P |
possibly damaging |
Het |
| Ces4a |
T |
A |
8: 105,864,667 (GRCm39) |
V48E |
possibly damaging |
Het |
| Cfap54 |
T |
A |
10: 92,805,625 (GRCm39) |
H1495L |
probably benign |
Het |
| Cntnap5a |
T |
A |
1: 115,612,898 (GRCm39) |
L11* |
probably null |
Het |
| Cr2 |
C |
T |
1: 194,839,817 (GRCm39) |
G913R |
probably damaging |
Het |
| Cul9 |
A |
G |
17: 46,836,299 (GRCm39) |
L1155P |
probably damaging |
Het |
| Dlec1 |
A |
T |
9: 118,971,646 (GRCm39) |
D1278V |
probably damaging |
Het |
| Dmrt2 |
A |
G |
19: 25,650,970 (GRCm39) |
E52G |
possibly damaging |
Het |
| Dsp |
A |
G |
13: 38,376,688 (GRCm39) |
K1491R |
probably benign |
Het |
| Ecpas |
A |
G |
4: 58,832,753 (GRCm39) |
V869A |
probably benign |
Het |
| Eef1d |
A |
T |
15: 75,767,770 (GRCm39) |
D206E |
probably damaging |
Het |
| Erbb2 |
C |
T |
11: 98,327,001 (GRCm39) |
Q1137* |
probably null |
Het |
| Ercc2 |
T |
A |
7: 19,119,811 (GRCm39) |
D157E |
probably benign |
Het |
| Eri1 |
A |
G |
8: 35,936,284 (GRCm39) |
*346Q |
probably null |
Het |
| Espl1 |
A |
G |
15: 102,228,293 (GRCm39) |
E1689G |
probably benign |
Het |
| Fap |
C |
T |
2: 62,347,964 (GRCm39) |
V539I |
probably benign |
Het |
| Gabpb1 |
T |
G |
2: 126,494,247 (GRCm39) |
Y126S |
probably damaging |
Het |
| Grm1 |
T |
C |
10: 10,595,702 (GRCm39) |
Y642C |
probably damaging |
Het |
| Heatr4 |
T |
C |
12: 84,024,841 (GRCm39) |
T327A |
possibly damaging |
Het |
| Hmbox1 |
T |
C |
14: 65,099,027 (GRCm39) |
D212G |
possibly damaging |
Het |
| Hmcn1 |
T |
A |
1: 150,565,341 (GRCm39) |
D2262V |
probably damaging |
Het |
| Hoxb9 |
A |
G |
11: 96,162,764 (GRCm39) |
T133A |
probably benign |
Het |
| Insr |
A |
T |
8: 3,219,720 (GRCm39) |
V934E |
probably damaging |
Het |
| Ipo9 |
T |
C |
1: 135,334,281 (GRCm39) |
E315G |
possibly damaging |
Het |
| Itga10 |
C |
T |
3: 96,559,545 (GRCm39) |
Q481* |
probably null |
Het |
| Kntc1 |
T |
A |
5: 123,925,047 (GRCm39) |
M1120K |
probably benign |
Het |
| Krt78 |
A |
G |
15: 101,854,728 (GRCm39) |
Y1028H |
possibly damaging |
Het |
| Lrrc38 |
A |
T |
4: 143,096,450 (GRCm39) |
I254F |
probably damaging |
Het |
| Lyrm7 |
A |
G |
11: 54,741,215 (GRCm39) |
F40L |
probably damaging |
Het |
| Mfsd4b1 |
C |
T |
10: 39,878,631 (GRCm39) |
S422N |
possibly damaging |
Het |
| Mlh3 |
A |
T |
12: 85,284,374 (GRCm39) |
L1380* |
probably null |
Het |
| Mrpl24 |
C |
A |
3: 87,829,744 (GRCm39) |
A110D |
probably benign |
Het |
| Mrps14 |
T |
C |
1: 160,024,520 (GRCm39) |
V17A |
probably benign |
Het |
| Mtcl1 |
T |
C |
17: 66,755,322 (GRCm39) |
D340G |
probably damaging |
Het |
| Neb |
T |
C |
2: 52,120,059 (GRCm39) |
Y3900C |
probably damaging |
Het |
| Neurod4 |
T |
C |
10: 130,106,473 (GRCm39) |
D267G |
probably benign |
Het |
| Nf1 |
A |
T |
11: 79,319,452 (GRCm39) |
I536F |
possibly damaging |
Het |
| Nkg7 |
C |
T |
7: 43,086,857 (GRCm39) |
P44S |
probably damaging |
Het |
| Or14c40 |
T |
C |
7: 86,313,185 (GRCm39) |
V105A |
possibly damaging |
Het |
| Or4a67 |
T |
C |
2: 88,597,832 (GRCm39) |
I276V |
probably benign |
Het |
| Pcif1 |
T |
C |
2: 164,731,058 (GRCm39) |
Y404H |
probably benign |
Het |
| Pcnx2 |
A |
T |
8: 126,480,289 (GRCm39) |
L2006Q |
possibly damaging |
Het |
| Pcnx3 |
A |
T |
19: 5,724,922 (GRCm39) |
S821T |
possibly damaging |
Het |
| Pde8b |
T |
A |
13: 95,170,680 (GRCm39) |
D662V |
probably damaging |
Het |
| Pkd1l3 |
C |
T |
8: 110,343,000 (GRCm39) |
P113S |
unknown |
Het |
| Pkd2l1 |
G |
T |
19: 44,142,648 (GRCm39) |
Q465K |
possibly damaging |
Het |
| Plch2 |
G |
T |
4: 155,068,189 (GRCm39) |
P1479Q |
probably benign |
Het |
| Plekhm3 |
A |
T |
1: 64,932,041 (GRCm39) |
I521N |
probably damaging |
Het |
| Pola2 |
A |
T |
19: 5,992,093 (GRCm39) |
Y526* |
probably null |
Het |
| Prss23 |
T |
C |
7: 89,159,217 (GRCm39) |
D284G |
probably damaging |
Het |
| Psme2b |
A |
G |
11: 48,836,467 (GRCm39) |
F160S |
probably damaging |
Het |
| Rap1gap2 |
A |
G |
11: 74,327,853 (GRCm39) |
V139A |
possibly damaging |
Het |
| Rbbp9 |
G |
T |
2: 144,385,777 (GRCm39) |
R163S |
possibly damaging |
Het |
| Rdh12 |
T |
C |
12: 79,260,522 (GRCm39) |
L206P |
probably damaging |
Het |
| Rhou |
T |
C |
8: 124,388,029 (GRCm39) |
W254R |
possibly damaging |
Het |
| Scfd1 |
A |
G |
12: 51,478,281 (GRCm39) |
K498E |
possibly damaging |
Het |
| Scn7a |
A |
G |
2: 66,519,902 (GRCm39) |
Y1001H |
probably benign |
Het |
| Setx |
T |
A |
2: 29,048,917 (GRCm39) |
V1981E |
probably damaging |
Het |
| Sfxn1 |
T |
C |
13: 54,247,890 (GRCm39) |
I205T |
possibly damaging |
Het |
| Shld2 |
G |
T |
14: 33,990,619 (GRCm39) |
H96N |
possibly damaging |
Het |
| Speer1g |
C |
T |
5: 11,180,337 (GRCm39) |
H82Y |
probably damaging |
Het |
| Spock1 |
G |
A |
13: 57,577,182 (GRCm39) |
R416C |
possibly damaging |
Het |
| Spred2 |
A |
G |
11: 19,968,109 (GRCm39) |
I222V |
probably benign |
Het |
| Stkld1 |
A |
T |
2: 26,839,407 (GRCm39) |
T358S |
probably benign |
Het |
| Strip1 |
T |
C |
3: 107,534,724 (GRCm39) |
E102G |
possibly damaging |
Het |
| Tars3 |
T |
C |
7: 65,305,444 (GRCm39) |
S223P |
probably damaging |
Het |
| Tdpoz1 |
T |
A |
3: 93,578,637 (GRCm39) |
E49V |
probably benign |
Het |
| Tert |
A |
G |
13: 73,776,328 (GRCm39) |
T360A |
probably benign |
Het |
| Tspear |
A |
G |
10: 77,717,026 (GRCm39) |
Y567C |
probably damaging |
Het |
| Ttc28 |
A |
G |
5: 111,433,254 (GRCm39) |
Q2096R |
probably benign |
Het |
| Ugt2b38 |
T |
G |
5: 87,560,232 (GRCm39) |
N361H |
probably damaging |
Het |
| Unc80 |
C |
T |
1: 66,560,740 (GRCm39) |
H823Y |
possibly damaging |
Het |
| Vmn2r111 |
T |
A |
17: 22,790,028 (GRCm39) |
H326L |
probably damaging |
Het |
| Vmn2r18 |
A |
G |
5: 151,510,301 (GRCm39) |
F24S |
possibly damaging |
Het |
| Vmn2r82 |
A |
T |
10: 79,232,133 (GRCm39) |
I711F |
probably benign |
Het |
| Vwa8 |
C |
T |
14: 79,341,134 (GRCm39) |
Q1537* |
probably null |
Het |
| Wdr64 |
G |
A |
1: 175,603,288 (GRCm39) |
V630I |
probably benign |
Het |
| Wnt6 |
G |
T |
1: 74,821,434 (GRCm39) |
W84L |
probably damaging |
Het |
| Zfp11 |
C |
A |
5: 129,735,254 (GRCm39) |
R69L |
probably benign |
Het |
|
| Other mutations in Fasn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00468:Fasn
|
APN |
11 |
120,711,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Fasn
|
APN |
11 |
120,708,055 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01131:Fasn
|
APN |
11 |
120,705,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01603:Fasn
|
APN |
11 |
120,706,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01606:Fasn
|
APN |
11 |
120,699,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01897:Fasn
|
APN |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Fasn
|
APN |
11 |
120,710,975 (GRCm39) |
splice site |
probably benign |
|
|
IGL01987:Fasn
|
APN |
11 |
120,708,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02103:Fasn
|
APN |
11 |
120,702,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Fasn
|
APN |
11 |
120,698,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02294:Fasn
|
APN |
11 |
120,701,102 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02336:Fasn
|
APN |
11 |
120,704,562 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02417:Fasn
|
APN |
11 |
120,711,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02452:Fasn
|
APN |
11 |
120,699,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Fasn
|
APN |
11 |
120,699,892 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02724:Fasn
|
APN |
11 |
120,700,659 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02862:Fasn
|
APN |
11 |
120,709,805 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02947:Fasn
|
APN |
11 |
120,706,502 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03025:Fasn
|
APN |
11 |
120,708,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03131:Fasn
|
APN |
11 |
120,701,550 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03157:Fasn
|
APN |
11 |
120,698,735 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03182:Fasn
|
APN |
11 |
120,703,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03370:Fasn
|
APN |
11 |
120,703,621 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
BB007:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
BB017:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0243:Fasn
|
UTSW |
11 |
120,706,141 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0304:Fasn
|
UTSW |
11 |
120,710,762 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0389:Fasn
|
UTSW |
11 |
120,707,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0449:Fasn
|
UTSW |
11 |
120,701,894 (GRCm39) |
missense |
probably benign |
|
|
R0626:Fasn
|
UTSW |
11 |
120,702,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1037:Fasn
|
UTSW |
11 |
120,700,277 (GRCm39) |
missense |
probably benign |
|
|
R1061:Fasn
|
UTSW |
11 |
120,713,008 (GRCm39) |
splice site |
probably null |
|
|
R1109:Fasn
|
UTSW |
11 |
120,703,150 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1498:Fasn
|
UTSW |
11 |
120,706,245 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1552:Fasn
|
UTSW |
11 |
120,709,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Fasn
|
UTSW |
11 |
120,704,075 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1624:Fasn
|
UTSW |
11 |
120,703,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Fasn
|
UTSW |
11 |
120,707,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1826:Fasn
|
UTSW |
11 |
120,699,325 (GRCm39) |
splice site |
probably benign |
|
|
R1846:Fasn
|
UTSW |
11 |
120,704,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2298:Fasn
|
UTSW |
11 |
120,704,642 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2513:Fasn
|
UTSW |
11 |
120,705,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3002:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3154:Fasn
|
UTSW |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3434:Fasn
|
UTSW |
11 |
120,713,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4794:Fasn
|
UTSW |
11 |
120,702,121 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4840:Fasn
|
UTSW |
11 |
120,703,885 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4863:Fasn
|
UTSW |
11 |
120,699,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4876:Fasn
|
UTSW |
11 |
120,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4915:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4916:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4918:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4936:Fasn
|
UTSW |
11 |
120,706,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Fasn
|
UTSW |
11 |
120,702,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5092:Fasn
|
UTSW |
11 |
120,705,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Fasn
|
UTSW |
11 |
120,702,217 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5175:Fasn
|
UTSW |
11 |
120,707,195 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5183:Fasn
|
UTSW |
11 |
120,699,708 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5506:Fasn
|
UTSW |
11 |
120,700,336 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5557:Fasn
|
UTSW |
11 |
120,703,252 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5614:Fasn
|
UTSW |
11 |
120,704,154 (GRCm39) |
missense |
probably benign |
|
|
R5728:Fasn
|
UTSW |
11 |
120,704,339 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5838:Fasn
|
UTSW |
11 |
120,706,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5959:Fasn
|
UTSW |
11 |
120,699,390 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6029:Fasn
|
UTSW |
11 |
120,711,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6134:Fasn
|
UTSW |
11 |
120,713,012 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6335:Fasn
|
UTSW |
11 |
120,706,185 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6452:Fasn
|
UTSW |
11 |
120,706,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6627:Fasn
|
UTSW |
11 |
120,709,753 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6742:Fasn
|
UTSW |
11 |
120,701,279 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6767:Fasn
|
UTSW |
11 |
120,708,313 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6927:Fasn
|
UTSW |
11 |
120,699,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6976:Fasn
|
UTSW |
11 |
120,710,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Fasn
|
UTSW |
11 |
120,710,946 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7157:Fasn
|
UTSW |
11 |
120,701,291 (GRCm39) |
nonsense |
probably null |
|
|
R7373:Fasn
|
UTSW |
11 |
120,704,802 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7575:Fasn
|
UTSW |
11 |
120,703,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7652:Fasn
|
UTSW |
11 |
120,707,154 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7670:Fasn
|
UTSW |
11 |
120,704,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Fasn
|
UTSW |
11 |
120,700,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7930:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R8007:Fasn
|
UTSW |
11 |
120,700,353 (GRCm39) |
missense |
probably benign |
|
|
R8012:Fasn
|
UTSW |
11 |
120,702,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8185:Fasn
|
UTSW |
11 |
120,702,969 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8557:Fasn
|
UTSW |
11 |
120,706,610 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8711:Fasn
|
UTSW |
11 |
120,709,944 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8772:Fasn
|
UTSW |
11 |
120,711,362 (GRCm39) |
missense |
probably benign |
|
|
R8856:Fasn
|
UTSW |
11 |
120,708,979 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8875:Fasn
|
UTSW |
11 |
120,703,224 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9071:Fasn
|
UTSW |
11 |
120,708,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9153:Fasn
|
UTSW |
11 |
120,706,496 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9238:Fasn
|
UTSW |
11 |
120,705,871 (GRCm39) |
missense |
probably benign |
|
|
R9249:Fasn
|
UTSW |
11 |
120,703,915 (GRCm39) |
missense |
probably benign |
|
|
R9345:Fasn
|
UTSW |
11 |
120,706,735 (GRCm39) |
missense |
probably benign |
0.22 |
|
X0067:Fasn
|
UTSW |
11 |
120,707,129 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Fasn
|
UTSW |
11 |
120,706,297 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACTCCCGAATGTGCTTGGCTTG -3'
(R):5'- AAGATGCCTTCCGCTACATGGCTC -3'
Sequencing Primer
(F):5'- CTATGGAGCTGCACCAGAG -3'
(R):5'- TGGCAAAGTCCTTGTCCAG -3'
|
| Posted On |
2014-03-28 |
Incidental Mutation