Mutagenetix > Incidental Mutation

Incidental Mutation 'R1147:Oog3'

165150

Institutional Source

Beutler Lab

Gene Symbol

Oog3

Ensembl Gene

ENSMUSG00000050810

Gene Name

oogenesin 3

Synonyms

MMRRC Submission

039220-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

R1147 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

143884126-143889221 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 143884982 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 318 (F318S)

Ref Sequence

ENSEMBL: ENSMUSP00000059834 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050933]

AlphaFold

Q3UWY1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000050933
AA Change: F318S

PolyPhen 2 Score 0.807 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000059834
Gene: ENSMUSG00000050810
AA Change: F318S

Domain	Start	End	E-Value	Type
low complexity region	13	26	N/A	INTRINSIC
low complexity region	31	42	N/A	INTRINSIC
SCOP:d1a4ya_	226	428	7e-5	SMART

Meta Mutation Damage Score

0.5008

Coding Region Coverage

1x: 99.2%
3x: 98.3%
10x: 96.0%
20x: 91.6%

Validation Efficiency

98% (47/48)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam20	T	C	8: 41,248,655 (GRCm39)	I255T	possibly damaging	Het
Aknad1	T	A	3: 108,659,857 (GRCm39)	N290K	possibly damaging	Het
Ano8	C	A	8: 71,934,661 (GRCm39)	V447F	probably damaging	Het
Arhgef12	C	T	9: 42,955,552 (GRCm39)		probably benign	Het
Arsi	G	A	18: 61,049,723 (GRCm39)	G202E	probably benign	Het
Ash1l	A	T	3: 88,892,194 (GRCm39)	M1358L	possibly damaging	Het
Ccdc110	A	G	8: 46,397,121 (GRCm39)	K837E	possibly damaging	Het
Cd19	T	A	7: 126,010,217 (GRCm39)	D384V	possibly damaging	Het
Ces1f	C	T	8: 93,984,909 (GRCm39)	V473I	possibly damaging	Het
Chd6	C	T	2: 160,832,191 (GRCm39)	E994K	probably damaging	Het
Col5a2	G	T	1: 45,415,931 (GRCm39)	N1405K	probably damaging	Het
Dnah7b	A	G	1: 46,379,426 (GRCm39)	D3720G	probably damaging	Het
Dsel	T	C	1: 111,789,939 (GRCm39)	T199A	possibly damaging	Het
Fabp3	C	T	4: 130,206,180 (GRCm39)	T57I	probably benign	Het
Flacc1	A	T	1: 58,708,622 (GRCm39)	Y215N	probably damaging	Het
Hrg	G	T	16: 22,779,754 (GRCm39)	C344F	probably damaging	Het
Htt	T	C	5: 35,008,596 (GRCm39)	Y1462H	probably damaging	Het
Kcnh2	T	A	5: 24,529,385 (GRCm39)	I784F	probably damaging	Het
Kifc3	T	C	8: 95,864,546 (GRCm39)	T55A	probably damaging	Het
Kirrel1	C	T	3: 86,996,458 (GRCm39)	M380I	probably null	Het
Lsamp	G	A	16: 41,994,499 (GRCm39)		probably benign	Het
Meis3	G	A	7: 15,917,701 (GRCm39)		probably benign	Het
Nlrp4d	A	T	7: 10,122,644 (GRCm39)	N73K	probably benign	Het
Or2a20	A	T	6: 43,194,146 (GRCm39)	T100S	probably damaging	Het
Or52w1	G	A	7: 105,018,484 (GRCm39)	R308Q	probably benign	Het
Pde5a	C	T	3: 122,587,962 (GRCm39)	T376M	probably damaging	Het
Pkhd1l1	A	G	15: 44,400,837 (GRCm39)	I2204V	probably null	Het
Ppp1r13l	A	G	7: 19,109,772 (GRCm39)	D731G	probably damaging	Het
Prob1	G	A	18: 35,787,859 (GRCm39)	Q132*	probably null	Het
Ptk6	C	T	2: 180,837,590 (GRCm39)	G443D	probably benign	Het
Ptpro	T	A	6: 137,420,592 (GRCm39)	V1007D	probably damaging	Het
Ptprs	T	C	17: 56,730,504 (GRCm39)	D749G	probably damaging	Het
Ralgapa1	A	T	12: 55,749,265 (GRCm39)	D1212E	probably damaging	Het
Rsad1	T	C	11: 94,434,966 (GRCm39)	Y290C	probably damaging	Het
Scamp1	A	G	13: 94,361,394 (GRCm39)		probably null	Het
Slc6a11	T	A	6: 114,221,831 (GRCm39)	I507N	possibly damaging	Het
Stx18	T	G	5: 38,284,267 (GRCm39)		probably benign	Het
Sybu	A	T	15: 44,609,651 (GRCm39)	F78I	probably damaging	Het
Tecpr2	T	G	12: 110,907,872 (GRCm39)		probably benign	Het
Tox	A	T	4: 6,823,055 (GRCm39)	N87K	possibly damaging	Het
Trrap	G	A	5: 144,741,576 (GRCm39)	G1308R	probably damaging	Het
Trub2	A	G	2: 29,677,644 (GRCm39)		probably benign	Het
Vmn2r114	A	T	17: 23,530,037 (GRCm39)	H123Q	probably benign	Het
Vmn2r15	T	A	5: 109,441,072 (GRCm39)	Y262F	probably damaging	Het
Vmn2r33	C	T	7: 7,557,144 (GRCm39)	E519K	probably benign	Het
Zfat	A	T	15: 68,084,432 (GRCm39)		probably benign	Het
Zfp106	A	T	2: 120,351,017 (GRCm39)	C1545S	probably damaging	Het

Other mutations in Oog3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02413:Oog3	APN	4	143,884,721 (GRCm39)	missense	probably benign	0.00
IGL02517:Oog3	APN	4	143,885,920 (GRCm39)	missense	probably damaging	1.00
IGL02635:Oog3	APN	4	143,884,715 (GRCm39)	missense	probably damaging	1.00
R0016:Oog3	UTSW	4	143,884,641 (GRCm39)	missense	probably damaging	1.00
R0016:Oog3	UTSW	4	143,884,641 (GRCm39)	missense	probably damaging	1.00
R0269:Oog3	UTSW	4	143,886,784 (GRCm39)	missense	probably benign	0.10
R0617:Oog3	UTSW	4	143,886,784 (GRCm39)	missense	probably benign	0.10
R1147:Oog3	UTSW	4	143,884,982 (GRCm39)	missense	possibly damaging	0.81
R1562:Oog3	UTSW	4	143,889,169 (GRCm39)	missense	probably damaging	0.98
R1669:Oog3	UTSW	4	143,885,008 (GRCm39)	missense	probably benign	0.06
R1766:Oog3	UTSW	4	143,885,692 (GRCm39)	missense	possibly damaging	0.49
R2002:Oog3	UTSW	4	143,884,675 (GRCm39)	missense	possibly damaging	0.96
R2109:Oog3	UTSW	4	143,886,082 (GRCm39)	missense	probably damaging	1.00
R2394:Oog3	UTSW	4	143,885,884 (GRCm39)	missense	probably benign	0.00
R4615:Oog3	UTSW	4	143,884,899 (GRCm39)	missense	probably benign	0.00
R4632:Oog3	UTSW	4	143,884,698 (GRCm39)	missense	probably benign	0.00
R4816:Oog3	UTSW	4	143,885,731 (GRCm39)	missense	probably damaging	1.00
R5459:Oog3	UTSW	4	143,885,815 (GRCm39)	missense	probably benign
R5547:Oog3	UTSW	4	143,884,598 (GRCm39)	missense	probably benign	0.27
R6811:Oog3	UTSW	4	143,886,152 (GRCm39)	missense	probably benign	0.00
R6931:Oog3	UTSW	4	143,885,923 (GRCm39)	missense	probably benign	0.00
R7052:Oog3	UTSW	4	143,887,027 (GRCm39)	missense	probably damaging	1.00
R7194:Oog3	UTSW	4	143,889,169 (GRCm39)	missense	probably damaging	0.98
R7312:Oog3	UTSW	4	143,886,801 (GRCm39)	missense	probably benign	0.08
R7486:Oog3	UTSW	4	143,884,742 (GRCm39)	missense	probably benign	0.16
R7622:Oog3	UTSW	4	143,884,889 (GRCm39)	missense	probably benign	0.00
R8782:Oog3	UTSW	4	143,885,962 (GRCm39)	missense	probably benign	0.01
R8790:Oog3	UTSW	4	143,885,710 (GRCm39)	missense	possibly damaging	0.59
R8794:Oog3	UTSW	4	143,884,556 (GRCm39)	missense	probably benign	0.01
R9586:Oog3	UTSW	4	143,884,966 (GRCm39)	nonsense	probably null
R9652:Oog3	UTSW	4	143,884,489 (GRCm39)	missense	probably benign	0.01
R9653:Oog3	UTSW	4	143,884,489 (GRCm39)	missense	probably benign	0.01
Z1088:Oog3	UTSW	4	143,886,206 (GRCm39)	missense	probably benign	0.04
Z1088:Oog3	UTSW	4	143,884,877 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- AGCAGGGCATTGAATTGAGGTTCC -3'
(R):5'- TGCTGTAGTTTCCAGCAAGGCAC -3'

Sequencing Primer
(F):5'- GAATTGAGGTTCCCCCATATCAC -3'
(R):5'- GTTTCCAGCAAGGCACTGAATC -3'

Posted On

2014-03-28