Incidental Mutation 'R1147:Meis3'
ID 165161
Institutional Source Beutler Lab
Gene Symbol Meis3
Ensembl Gene ENSMUSG00000041420
Gene Name Meis homeobox 3
Synonyms Mrg2
MMRRC Submission 039220-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # R1147 (G1)
Quality Score 203
Status Not validated
Chromosome 7
Chromosomal Location 15909015-15920429 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to A at 15917701 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000135388 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002495] [ENSMUST00000176342] [ENSMUST00000176446] [ENSMUST00000176506] [ENSMUST00000177156] [ENSMUST00000177540]
AlphaFold P97368
Predicted Effect probably benign
Transcript: ENSMUST00000002495
SMART Domains Protein: ENSMUSP00000002495
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
low complexity region 230 244 N/A INTRINSIC
HOX 265 330 9.15e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175946
Predicted Effect probably benign
Transcript: ENSMUST00000176083
SMART Domains Protein: ENSMUSP00000135196
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
Pfam:Meis_PKNOX_N 99 183 6.5e-47 PFAM
low complexity region 230 244 N/A INTRINSIC
HOX 265 330 9.15e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176342
SMART Domains Protein: ENSMUSP00000135302
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176446
Predicted Effect probably benign
Transcript: ENSMUST00000176506
SMART Domains Protein: ENSMUSP00000134918
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
low complexity region 213 227 N/A INTRINSIC
HOX 248 313 9.15e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000177156
SMART Domains Protein: ENSMUSP00000135103
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
low complexity region 230 244 N/A INTRINSIC
Pfam:Homeobox_KN 283 313 2e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176714
Predicted Effect probably benign
Transcript: ENSMUST00000177540
SMART Domains Protein: ENSMUSP00000135388
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.3%
  • 10x: 96.0%
  • 20x: 91.6%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: The protein encoding this gene belongs to the three amino acid loop extension family of homeodomain transcription factors, which play essential roles in many embryonic processes. These proteins are characterized by an atypical homeodomain containing a three amino acid loop extension between helices 1 and 2. Expression of this gene begins during the compaction stage of embryogenesis and continues into the blastocyst stage. This gene is also expressed in pancreatic islet cells and beta-cells and regulates beta-cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam20 T C 8: 41,248,655 (GRCm39) I255T possibly damaging Het
Aknad1 T A 3: 108,659,857 (GRCm39) N290K possibly damaging Het
Ano8 C A 8: 71,934,661 (GRCm39) V447F probably damaging Het
Arhgef12 C T 9: 42,955,552 (GRCm39) probably benign Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Ash1l A T 3: 88,892,194 (GRCm39) M1358L possibly damaging Het
Ccdc110 A G 8: 46,397,121 (GRCm39) K837E possibly damaging Het
Cd19 T A 7: 126,010,217 (GRCm39) D384V possibly damaging Het
Ces1f C T 8: 93,984,909 (GRCm39) V473I possibly damaging Het
Chd6 C T 2: 160,832,191 (GRCm39) E994K probably damaging Het
Col5a2 G T 1: 45,415,931 (GRCm39) N1405K probably damaging Het
Dnah7b A G 1: 46,379,426 (GRCm39) D3720G probably damaging Het
Dsel T C 1: 111,789,939 (GRCm39) T199A possibly damaging Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Flacc1 A T 1: 58,708,622 (GRCm39) Y215N probably damaging Het
Hrg G T 16: 22,779,754 (GRCm39) C344F probably damaging Het
Htt T C 5: 35,008,596 (GRCm39) Y1462H probably damaging Het
Kcnh2 T A 5: 24,529,385 (GRCm39) I784F probably damaging Het
Kifc3 T C 8: 95,864,546 (GRCm39) T55A probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lsamp G A 16: 41,994,499 (GRCm39) probably benign Het
Nlrp4d A T 7: 10,122,644 (GRCm39) N73K probably benign Het
Oog3 A G 4: 143,884,982 (GRCm39) F318S possibly damaging Het
Or2a20 A T 6: 43,194,146 (GRCm39) T100S probably damaging Het
Or52w1 G A 7: 105,018,484 (GRCm39) R308Q probably benign Het
Pde5a C T 3: 122,587,962 (GRCm39) T376M probably damaging Het
Pkhd1l1 A G 15: 44,400,837 (GRCm39) I2204V probably null Het
Ppp1r13l A G 7: 19,109,772 (GRCm39) D731G probably damaging Het
Prob1 G A 18: 35,787,859 (GRCm39) Q132* probably null Het
Ptk6 C T 2: 180,837,590 (GRCm39) G443D probably benign Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Ptprs T C 17: 56,730,504 (GRCm39) D749G probably damaging Het
Ralgapa1 A T 12: 55,749,265 (GRCm39) D1212E probably damaging Het
Rsad1 T C 11: 94,434,966 (GRCm39) Y290C probably damaging Het
Scamp1 A G 13: 94,361,394 (GRCm39) probably null Het
Slc6a11 T A 6: 114,221,831 (GRCm39) I507N possibly damaging Het
Stx18 T G 5: 38,284,267 (GRCm39) probably benign Het
Sybu A T 15: 44,609,651 (GRCm39) F78I probably damaging Het
Tecpr2 T G 12: 110,907,872 (GRCm39) probably benign Het
Tox A T 4: 6,823,055 (GRCm39) N87K possibly damaging Het
Trrap G A 5: 144,741,576 (GRCm39) G1308R probably damaging Het
Trub2 A G 2: 29,677,644 (GRCm39) probably benign Het
Vmn2r114 A T 17: 23,530,037 (GRCm39) H123Q probably benign Het
Vmn2r15 T A 5: 109,441,072 (GRCm39) Y262F probably damaging Het
Vmn2r33 C T 7: 7,557,144 (GRCm39) E519K probably benign Het
Zfat A T 15: 68,084,432 (GRCm39) probably benign Het
Zfp106 A T 2: 120,351,017 (GRCm39) C1545S probably damaging Het
Other mutations in Meis3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01014:Meis3 APN 7 15,912,872 (GRCm39) critical splice acceptor site probably benign 0.00
IGL02508:Meis3 APN 7 15,912,722 (GRCm39) splice site probably null
IGL03125:Meis3 APN 7 15,912,695 (GRCm39) missense probably damaging 1.00
IGL03383:Meis3 APN 7 15,917,744 (GRCm39) missense probably damaging 1.00
R0032:Meis3 UTSW 7 15,916,210 (GRCm39) unclassified probably benign
R1471:Meis3 UTSW 7 15,911,496 (GRCm39) nonsense probably null
R3054:Meis3 UTSW 7 15,916,378 (GRCm39) missense probably damaging 1.00
R3927:Meis3 UTSW 7 15,911,419 (GRCm39) missense probably benign 0.06
R5314:Meis3 UTSW 7 15,917,989 (GRCm39) missense probably damaging 0.99
R6713:Meis3 UTSW 7 15,916,255 (GRCm39) nonsense probably null
R6847:Meis3 UTSW 7 15,917,789 (GRCm39) missense probably damaging 1.00
R7218:Meis3 UTSW 7 15,918,626 (GRCm39) missense probably benign
R7517:Meis3 UTSW 7 15,911,743 (GRCm39) missense probably damaging 1.00
R7540:Meis3 UTSW 7 15,911,418 (GRCm39) nonsense probably null
R7699:Meis3 UTSW 7 15,911,481 (GRCm39) missense probably benign
R7700:Meis3 UTSW 7 15,911,481 (GRCm39) missense probably benign
R7790:Meis3 UTSW 7 15,916,322 (GRCm39) missense probably benign 0.37
R8902:Meis3 UTSW 7 15,911,887 (GRCm39) missense probably benign 0.17
R8909:Meis3 UTSW 7 15,919,385 (GRCm39) missense possibly damaging 0.83
R9095:Meis3 UTSW 7 15,917,764 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2014-03-28