Incidental Mutation 'R1185:Timd4'
ID 165260
Institutional Source Beutler Lab
Gene Symbol Timd4
Ensembl Gene ENSMUSG00000055546
Gene Name T cell immunoglobulin and mucin domain containing 4
Synonyms Tim4, B430010N18Rik, TIM-4
MMRRC Submission 039257-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R1185 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 46701627-46735159 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 46708475 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 167 (T167K)
Ref Sequence ENSEMBL: ENSMUSP00000069456 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068877]
AlphaFold Q6U7R4
PDB Structure Tim-4 [X-RAY DIFFRACTION]
Tim-4 in complex with sodium potassium tartrate [X-RAY DIFFRACTION]
Tim-4 in complex with phosphatidylserine [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000068877
AA Change: T167K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000069456
Gene: ENSMUSG00000055546
AA Change: T167K

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
IG 25 132 3.59e-5 SMART
low complexity region 135 182 N/A INTRINSIC
low complexity region 248 271 N/A INTRINSIC
transmembrane domain 279 301 N/A INTRINSIC
Meta Mutation Damage Score 0.1747 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.3%
  • 10x: 93.0%
  • 20x: 79.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired macrophage phagocytosis, altered macrophage physiology, and increased peritoneal lymphoid and meyloid cell numbers. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ac165356.1 C T 7: 105,682,686 (GRCm39) A190T probably benign Het
Aimp2 A G 5: 143,841,509 (GRCm39) S110P possibly damaging Het
Akap9 A G 5: 3,998,783 (GRCm39) T51A probably benign Het
Arhgef25 A G 10: 127,019,650 (GRCm39) F430L possibly damaging Het
Brap T C 5: 121,813,342 (GRCm39) V235A probably damaging Het
Cd69 C T 6: 129,247,148 (GRCm39) G23D probably damaging Het
Cecr2 C T 6: 120,735,166 (GRCm39) R24* probably null Het
Celsr2 T C 3: 108,307,025 (GRCm39) D1974G possibly damaging Het
Cps1 A G 1: 67,234,358 (GRCm39) K915R probably benign Het
Csmd1 T C 8: 16,408,362 (GRCm39) D401G probably damaging Het
Dusp13b A G 14: 21,785,086 (GRCm39) F141S probably damaging Het
Eif1ad19 A G 12: 87,740,478 (GRCm39) V27A probably benign Het
Fam162b A G 10: 51,466,439 (GRCm39) W27R probably benign Het
Focad A G 4: 88,096,424 (GRCm39) T269A probably benign Het
Ghr T A 15: 3,357,544 (GRCm39) R241S possibly damaging Het
Hirip3 AAGAG AAG 7: 126,462,832 (GRCm39) probably null Het
Itgb2l A G 16: 96,230,240 (GRCm39) Y357H possibly damaging Het
Jrkl T C 9: 13,244,938 (GRCm39) D241G possibly damaging Het
Lmod1 A G 1: 135,291,967 (GRCm39) D274G probably benign Het
Lrrn2 A G 1: 132,866,959 (GRCm39) S675G probably benign Het
Ltbp4 G C 7: 27,009,960 (GRCm39) P1200R probably damaging Het
Mdn1 T C 4: 32,735,576 (GRCm39) L3414P possibly damaging Het
Muc19 A G 15: 91,762,743 (GRCm39) noncoding transcript Het
Neb A G 2: 52,186,310 (GRCm39) Y921H probably damaging Het
Or2n1c T A 17: 38,520,074 (GRCm39) *313R probably null Het
Pgap3 T C 11: 98,281,960 (GRCm39) D117G probably damaging Het
Ppp1r9b T C 11: 94,892,812 (GRCm39) F671L possibly damaging Het
Purg T G 8: 33,876,897 (GRCm39) Y178* probably null Het
Rsph10b G A 5: 143,903,280 (GRCm39) probably benign Het
Sorbs1 T A 19: 40,371,050 (GRCm39) D79V probably damaging Het
Tcaf3 T C 6: 42,568,368 (GRCm39) T663A probably damaging Het
Tjp2 A G 19: 24,108,527 (GRCm39) L195P possibly damaging Het
Tnr G A 1: 159,679,856 (GRCm39) A277T probably benign Het
Trpm3 G A 19: 22,891,781 (GRCm39) probably benign Het
Unc13a C T 8: 72,114,477 (GRCm39) G181D probably benign Het
Vmn1r11 T A 6: 57,114,492 (GRCm39) L52Q possibly damaging Het
Vmn2r125 C A 4: 156,703,396 (GRCm39) A258D probably benign Het
Zfp27 T C 7: 29,595,254 (GRCm39) D237G possibly damaging Het
Zfp39 T C 11: 58,793,670 (GRCm39) T23A possibly damaging Het
Zfp459 T G 13: 67,556,600 (GRCm39) N161T probably benign Het
Other mutations in Timd4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02140:Timd4 APN 11 46,710,841 (GRCm39) missense possibly damaging 0.61
IGL02247:Timd4 APN 11 46,706,558 (GRCm39) missense probably damaging 1.00
IGL02803:Timd4 APN 11 46,706,521 (GRCm39) missense probably damaging 1.00
IGL02991:Timd4 APN 11 46,732,974 (GRCm39) splice site probably benign
R0318:Timd4 UTSW 11 46,727,898 (GRCm39) missense probably benign 0.00
R0427:Timd4 UTSW 11 46,710,084 (GRCm39) missense probably benign 0.00
R1175:Timd4 UTSW 11 46,708,498 (GRCm39) missense probably damaging 1.00
R1185:Timd4 UTSW 11 46,708,475 (GRCm39) missense probably damaging 0.99
R1185:Timd4 UTSW 11 46,708,475 (GRCm39) missense probably damaging 0.99
R1635:Timd4 UTSW 11 46,732,989 (GRCm39) missense possibly damaging 0.92
R2011:Timd4 UTSW 11 46,710,857 (GRCm39) missense possibly damaging 0.79
R2012:Timd4 UTSW 11 46,710,857 (GRCm39) missense possibly damaging 0.79
R4994:Timd4 UTSW 11 46,706,344 (GRCm39) missense probably damaging 0.99
R5511:Timd4 UTSW 11 46,710,807 (GRCm39) splice site probably null
R5739:Timd4 UTSW 11 46,708,573 (GRCm39) missense probably benign 0.10
R5991:Timd4 UTSW 11 46,734,030 (GRCm39) makesense probably null
R6207:Timd4 UTSW 11 46,706,353 (GRCm39) missense probably damaging 0.98
R6863:Timd4 UTSW 11 46,706,270 (GRCm39) nonsense probably null
R7230:Timd4 UTSW 11 46,701,691 (GRCm39) missense probably benign 0.01
R7254:Timd4 UTSW 11 46,734,016 (GRCm39) missense probably benign 0.04
R7466:Timd4 UTSW 11 46,708,585 (GRCm39) missense probably benign 0.01
R7750:Timd4 UTSW 11 46,706,354 (GRCm39) missense probably damaging 1.00
R8777:Timd4 UTSW 11 46,706,309 (GRCm39) missense possibly damaging 0.49
R8777-TAIL:Timd4 UTSW 11 46,706,309 (GRCm39) missense possibly damaging 0.49
Predicted Primers PCR Primer
(F):5'- GTGTGGTGAACAATTCAGGCCAATG -3'
(R):5'- ACTCCTCAGAGGTCAAGTGGAGAAC -3'

Sequencing Primer
(F):5'- TTCAGGCCAATGAACCAAGAG -3'
(R):5'- TTGCCCACTGTAGAAGAGTC -3'
Posted On 2014-03-28