Incidental Mutation 'R1185:Eif1ad19'
ID 165264
Institutional Source Beutler Lab
Gene Symbol Eif1ad19
Ensembl Gene ENSMUSG00000095724
Gene Name eukaryotic translation initiation factor 1A domain containing 19
Synonyms Gm21319
MMRRC Submission 039257-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R1185 (G1)
Quality Score 129
Status Not validated
Chromosome 12
Chromosomal Location 87739195-87742525 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87740478 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 27 (V27A)
Ref Sequence ENSEMBL: ENSMUSP00000126351 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164517]
AlphaFold F6YNI8
Predicted Effect probably benign
Transcript: ENSMUST00000164517
AA Change: V27A

PolyPhen 2 Score 0.145 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000126351
Gene: ENSMUSG00000095724
AA Change: V27A

DomainStartEndE-ValueType
low complexity region 3 19 N/A INTRINSIC
eIF1a 28 110 6.17e-44 SMART
low complexity region 125 144 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222683
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.3%
  • 10x: 93.0%
  • 20x: 79.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ac165356.1 C T 7: 105,682,686 (GRCm39) A190T probably benign Het
Aimp2 A G 5: 143,841,509 (GRCm39) S110P possibly damaging Het
Akap9 A G 5: 3,998,783 (GRCm39) T51A probably benign Het
Arhgef25 A G 10: 127,019,650 (GRCm39) F430L possibly damaging Het
Brap T C 5: 121,813,342 (GRCm39) V235A probably damaging Het
Cd69 C T 6: 129,247,148 (GRCm39) G23D probably damaging Het
Cecr2 C T 6: 120,735,166 (GRCm39) R24* probably null Het
Celsr2 T C 3: 108,307,025 (GRCm39) D1974G possibly damaging Het
Cps1 A G 1: 67,234,358 (GRCm39) K915R probably benign Het
Csmd1 T C 8: 16,408,362 (GRCm39) D401G probably damaging Het
Dusp13b A G 14: 21,785,086 (GRCm39) F141S probably damaging Het
Fam162b A G 10: 51,466,439 (GRCm39) W27R probably benign Het
Focad A G 4: 88,096,424 (GRCm39) T269A probably benign Het
Ghr T A 15: 3,357,544 (GRCm39) R241S possibly damaging Het
Hirip3 AAGAG AAG 7: 126,462,832 (GRCm39) probably null Het
Itgb2l A G 16: 96,230,240 (GRCm39) Y357H possibly damaging Het
Jrkl T C 9: 13,244,938 (GRCm39) D241G possibly damaging Het
Lmod1 A G 1: 135,291,967 (GRCm39) D274G probably benign Het
Lrrn2 A G 1: 132,866,959 (GRCm39) S675G probably benign Het
Ltbp4 G C 7: 27,009,960 (GRCm39) P1200R probably damaging Het
Mdn1 T C 4: 32,735,576 (GRCm39) L3414P possibly damaging Het
Muc19 A G 15: 91,762,743 (GRCm39) noncoding transcript Het
Neb A G 2: 52,186,310 (GRCm39) Y921H probably damaging Het
Or2n1c T A 17: 38,520,074 (GRCm39) *313R probably null Het
Pgap3 T C 11: 98,281,960 (GRCm39) D117G probably damaging Het
Ppp1r9b T C 11: 94,892,812 (GRCm39) F671L possibly damaging Het
Purg T G 8: 33,876,897 (GRCm39) Y178* probably null Het
Rsph10b G A 5: 143,903,280 (GRCm39) probably benign Het
Sorbs1 T A 19: 40,371,050 (GRCm39) D79V probably damaging Het
Tcaf3 T C 6: 42,568,368 (GRCm39) T663A probably damaging Het
Timd4 C A 11: 46,708,475 (GRCm39) T167K probably damaging Het
Tjp2 A G 19: 24,108,527 (GRCm39) L195P possibly damaging Het
Tnr G A 1: 159,679,856 (GRCm39) A277T probably benign Het
Trpm3 G A 19: 22,891,781 (GRCm39) probably benign Het
Unc13a C T 8: 72,114,477 (GRCm39) G181D probably benign Het
Vmn1r11 T A 6: 57,114,492 (GRCm39) L52Q possibly damaging Het
Vmn2r125 C A 4: 156,703,396 (GRCm39) A258D probably benign Het
Zfp27 T C 7: 29,595,254 (GRCm39) D237G possibly damaging Het
Zfp39 T C 11: 58,793,670 (GRCm39) T23A possibly damaging Het
Zfp459 T G 13: 67,556,600 (GRCm39) N161T probably benign Het
Other mutations in Eif1ad19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01118:Eif1ad19 APN 12 87,740,212 (GRCm39) missense probably damaging 1.00
R0089:Eif1ad19 UTSW 12 87,740,283 (GRCm39) missense probably damaging 1.00
R0559:Eif1ad19 UTSW 12 87,740,223 (GRCm39) missense probably benign
R1185:Eif1ad19 UTSW 12 87,740,478 (GRCm39) missense probably benign 0.14
R1185:Eif1ad19 UTSW 12 87,740,478 (GRCm39) missense probably benign 0.14
R3800:Eif1ad19 UTSW 12 87,740,491 (GRCm39) missense possibly damaging 0.95
R4531:Eif1ad19 UTSW 12 87,740,314 (GRCm39) nonsense probably null
R5013:Eif1ad19 UTSW 12 87,740,512 (GRCm39) nonsense probably null
R5817:Eif1ad19 UTSW 12 87,740,201 (GRCm39) missense probably benign 0.01
R7137:Eif1ad19 UTSW 12 87,740,316 (GRCm39) missense possibly damaging 0.90
R7187:Eif1ad19 UTSW 12 87,740,708 (GRCm39) start gained probably benign
R7403:Eif1ad19 UTSW 12 87,740,314 (GRCm39) missense probably benign 0.10
R7505:Eif1ad19 UTSW 12 87,740,270 (GRCm39) missense probably benign 0.20
R8711:Eif1ad19 UTSW 12 87,740,130 (GRCm39) missense unknown
R8966:Eif1ad19 UTSW 12 87,740,273 (GRCm39) nonsense probably null
R9751:Eif1ad19 UTSW 12 87,740,526 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- CATCATCCCCAGGACCAAATGTGTC -3'
(R):5'- AAAGGAGTCACAGCCACTGTCAGC -3'

Sequencing Primer
(F):5'- AGGACCAAATGTGTCCGTTTC -3'
(R):5'- AGCCACTGTCAGCCACTG -3'
Posted On 2014-03-28