Incidental Mutation 'V5622:Zfp268'
| ID |
166125 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp268
|
| Ensembl Gene |
ENSMUSG00000078502 |
| Gene Name |
zinc finger protein 268 |
| Synonyms |
Gm13212 |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.374)
|
| Stock # |
V5622 ()
of strain
521
|
| Quality Score |
115 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
145311770-145351915 bp(+) (GRCm39) |
| Type of Mutation |
start gained |
| DNA Base Change (assembly) |
C to T
at 145311891 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112918
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105739]
[ENSMUST00000119718]
|
| AlphaFold |
B1ASQ7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105739
|
| SMART Domains |
Protein: ENSMUSP00000101365
Gene: ENSMUSG00000078502
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
72 |
3.23e-18 |
SMART |
|
ZnF_C2H2
|
238 |
260 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
266 |
288 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
294 |
316 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
322 |
344 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
350 |
372 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
1.06e-4 |
SMART |
|
ZnF_C2H2
|
406 |
428 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
434 |
456 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
462 |
484 |
1.06e-4 |
SMART |
|
ZnF_C2H2
|
490 |
512 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
518 |
540 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
546 |
568 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
574 |
596 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
602 |
624 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
630 |
652 |
1.06e-4 |
SMART |
|
ZnF_C2H2
|
658 |
680 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
686 |
708 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
714 |
736 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
742 |
764 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
770 |
792 |
4.79e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119718
|
| SMART Domains |
Protein: ENSMUSP00000112918
Gene: ENSMUSG00000078502
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
72 |
3.23e-18 |
SMART |
|
internal_repeat_1
|
141 |
211 |
2.19e-13 |
PROSPERO |
|
ZnF_C2H2
|
238 |
260 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
266 |
288 |
1.18e-2 |
SMART |
|
low complexity region
|
320 |
335 |
N/A |
INTRINSIC |
|
low complexity region
|
350 |
357 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 94.1%
- 3x: 94.1%
- 10x: 94.0%
- 20x: 93.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2510039O18Rik |
C |
T |
4: 148,026,233 (GRCm39) |
S251F |
probably benign |
Het |
| Ccar2 |
G |
T |
14: 70,388,738 (GRCm39) |
L158I |
probably damaging |
Het |
| Col1a2 |
G |
A |
6: 4,518,822 (GRCm39) |
|
probably benign |
Het |
| Gm10719 |
A |
G |
9: 3,021,253 (GRCm39) |
|
probably null |
Het |
| Gm10720 |
A |
C |
9: 3,015,669 (GRCm39) |
N6H |
probably benign |
Het |
| Gm21738 |
C |
T |
14: 19,417,180 (GRCm38) |
C116Y |
probably damaging |
Het |
| Gm8688 |
T |
G |
8: 100,391,152 (GRCm39) |
|
noncoding transcript |
Het |
| Hjurp |
A |
G |
1: 88,205,247 (GRCm39) |
|
probably benign |
Het |
| Hspg2 |
C |
A |
4: 137,261,049 (GRCm39) |
Q1648K |
probably damaging |
Het |
| Hvcn1 |
TGAGGAGGAGGAGGAGGAG |
TGAGGAGGAGGAGGAG |
5: 122,371,602 (GRCm39) |
|
probably benign |
Het |
| Megf11 |
C |
A |
9: 64,597,351 (GRCm39) |
C674* |
probably null |
Het |
| Mroh2a |
C |
T |
1: 88,154,813 (GRCm39) |
|
probably benign |
Het |
| Muc4 |
T |
C |
16: 32,570,643 (GRCm39) |
S568P |
probably benign |
Het |
| Naip2 |
A |
T |
13: 100,291,529 (GRCm39) |
D1136E |
probably benign |
Het |
| Npm1 |
C |
T |
11: 33,111,186 (GRCm39) |
V60I |
probably benign |
Het |
| Ppp2r5a |
G |
A |
1: 191,091,189 (GRCm39) |
R213W |
probably damaging |
Het |
| Ppp2r5a |
C |
T |
1: 191,091,198 (GRCm39) |
V210I |
probably benign |
Het |
| Trim43b |
T |
C |
9: 88,974,598 (GRCm39) |
|
probably benign |
Het |
| Vmn2r115 |
T |
C |
17: 23,565,201 (GRCm39) |
S363P |
probably damaging |
Het |
| Vmn2r115 |
T |
C |
17: 23,578,333 (GRCm39) |
I602T |
probably benign |
Het |
| Vmn2r117 |
C |
T |
17: 23,696,814 (GRCm39) |
A198T |
probably damaging |
Het |
| Vmn2r117 |
C |
G |
17: 23,698,479 (GRCm39) |
Q31H |
possibly damaging |
Het |
| Vmn2r88 |
C |
G |
14: 51,650,584 (GRCm39) |
T99S |
probably benign |
Het |
| Wdr17 |
C |
T |
8: 55,146,131 (GRCm39) |
A90T |
possibly damaging |
Het |
| Zbtb12 |
C |
A |
17: 35,115,277 (GRCm39) |
A354E |
possibly damaging |
Het |
| Zfp180 |
A |
G |
7: 23,781,456 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Zfp268 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01797:Zfp268
|
APN |
4 |
145,347,241 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02678:Zfp268
|
APN |
4 |
145,349,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03035:Zfp268
|
APN |
4 |
145,348,802 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
BB008:Zfp268
|
UTSW |
4 |
145,349,126 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
BB018:Zfp268
|
UTSW |
4 |
145,349,126 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0090:Zfp268
|
UTSW |
4 |
145,349,195 (GRCm39) |
nonsense |
probably null |
|
|
R0904:Zfp268
|
UTSW |
4 |
145,348,745 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1617:Zfp268
|
UTSW |
4 |
145,350,877 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R1851:Zfp268
|
UTSW |
4 |
145,350,820 (GRCm39) |
unclassified |
probably benign |
|
|
R1864:Zfp268
|
UTSW |
4 |
145,348,998 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2093:Zfp268
|
UTSW |
4 |
145,349,139 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2132:Zfp268
|
UTSW |
4 |
145,350,803 (GRCm39) |
unclassified |
probably benign |
|
|
R2240:Zfp268
|
UTSW |
4 |
145,311,891 (GRCm39) |
start gained |
probably benign |
|
|
R4177:Zfp268
|
UTSW |
4 |
145,347,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4584:Zfp268
|
UTSW |
4 |
145,343,747 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4991:Zfp268
|
UTSW |
4 |
145,348,904 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5164:Zfp268
|
UTSW |
4 |
145,348,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6175:Zfp268
|
UTSW |
4 |
145,350,811 (GRCm39) |
unclassified |
probably benign |
|
|
R6176:Zfp268
|
UTSW |
4 |
145,350,628 (GRCm39) |
nonsense |
probably null |
|
|
R6498:Zfp268
|
UTSW |
4 |
145,349,459 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6984:Zfp268
|
UTSW |
4 |
145,347,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7134:Zfp268
|
UTSW |
4 |
145,349,375 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7931:Zfp268
|
UTSW |
4 |
145,349,126 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R8017:Zfp268
|
UTSW |
4 |
145,349,138 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8282:Zfp268
|
UTSW |
4 |
145,349,547 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9320:Zfp268
|
UTSW |
4 |
145,349,156 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9358:Zfp268
|
UTSW |
4 |
145,349,613 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9435:Zfp268
|
UTSW |
4 |
145,349,045 (GRCm39) |
missense |
|
|
|
Z1176:Zfp268
|
UTSW |
4 |
145,349,538 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
|
| Posted On |
2014-04-07 |
Incidental Mutation