Incidental Mutation 'R1531:Vps8'
| ID |
166251 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vps8
|
| Ensembl Gene |
ENSMUSG00000033653 |
| Gene Name |
VPS8 CORVET complex subunit |
| Synonyms |
|
| MMRRC Submission |
039570-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1531 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
21241868-21463430 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 21285226 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 402
(Y402*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112636
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096191]
[ENSMUST00000096192]
[ENSMUST00000115397]
[ENSMUST00000117598]
[ENSMUST00000118923]
|
| AlphaFold |
Q0P5W1 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000096191
AA Change: Y400*
|
| SMART Domains |
Protein: ENSMUSP00000093905
Gene: ENSMUSG00000033653
AA Change: Y400*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
7e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.7e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
Blast:RING
|
1257 |
1277 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000096192
AA Change: Y402*
|
| SMART Domains |
Protein: ENSMUSP00000093906
Gene: ENSMUSG00000033653
AA Change: Y402*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
1e-8 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.4e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000115397
AA Change: Y402*
|
| SMART Domains |
Protein: ENSMUSP00000111055
Gene: ENSMUSG00000033653
AA Change: Y402*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
8e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
613 |
796 |
1.3e-61 |
PFAM |
|
low complexity region
|
994 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1139 |
N/A |
INTRINSIC |
|
RING
|
1259 |
1310 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000117598
AA Change: Y400*
|
| SMART Domains |
Protein: ENSMUSP00000112937
Gene: ENSMUSG00000033653
AA Change: Y400*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
8e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.9e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
RING
|
1257 |
1308 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000118923
AA Change: Y402*
|
| SMART Domains |
Protein: ENSMUSP00000112636
Gene: ENSMUSG00000033653
AA Change: Y402*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
9e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.9e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125487
|
| SMART Domains |
Protein: ENSMUSP00000114719
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Vps8
|
182 |
365 |
8.5e-62 |
PFAM |
|
low complexity region
|
563 |
578 |
N/A |
INTRINSIC |
|
low complexity region
|
656 |
668 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
708 |
N/A |
INTRINSIC |
|
RING
|
828 |
879 |
1.23e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.6%
- 20x: 90.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Agtpbp1 |
T |
A |
13: 59,648,448 (GRCm39) |
|
probably null |
Het |
| Aldh3b2 |
T |
G |
19: 4,027,543 (GRCm39) |
F28C |
probably damaging |
Het |
| Apaf1 |
T |
C |
10: 90,890,383 (GRCm39) |
N540S |
probably damaging |
Het |
| Apob |
T |
C |
12: 8,047,880 (GRCm39) |
I953T |
possibly damaging |
Het |
| Arhgef1 |
A |
G |
7: 24,624,423 (GRCm39) |
T816A |
probably damaging |
Het |
| Arid4a |
T |
A |
12: 71,122,779 (GRCm39) |
F1053L |
probably benign |
Het |
| Atxn1l |
A |
C |
8: 110,458,691 (GRCm39) |
F524V |
probably damaging |
Het |
| Cad |
T |
A |
5: 31,233,563 (GRCm39) |
M1874K |
probably benign |
Het |
| Ccdc40 |
G |
A |
11: 119,154,015 (GRCm39) |
V1096I |
probably benign |
Het |
| Ccdc93 |
A |
G |
1: 121,408,551 (GRCm39) |
D358G |
probably benign |
Het |
| Cd96 |
T |
C |
16: 45,938,169 (GRCm39) |
T99A |
probably benign |
Het |
| Cdc42ep3 |
A |
T |
17: 79,642,473 (GRCm39) |
M149K |
probably benign |
Het |
| Cgas |
A |
G |
9: 78,349,763 (GRCm39) |
Y200H |
probably damaging |
Het |
| Cog4 |
A |
G |
8: 111,606,353 (GRCm39) |
E613G |
probably benign |
Het |
| Crebbp |
A |
T |
16: 3,902,381 (GRCm39) |
I2286N |
probably benign |
Het |
| Csf1 |
T |
C |
3: 107,655,654 (GRCm39) |
E459G |
possibly damaging |
Het |
| Csrp2 |
A |
T |
10: 110,771,066 (GRCm39) |
Y57F |
probably benign |
Het |
| Ctdspl |
C |
T |
9: 118,869,650 (GRCm39) |
P244L |
probably damaging |
Het |
| Cyp2c29 |
A |
G |
19: 39,313,412 (GRCm39) |
R303G |
probably damaging |
Het |
| Cyp4a10 |
C |
A |
4: 115,375,632 (GRCm39) |
Y38* |
probably null |
Het |
| Dmgdh |
T |
A |
13: 93,880,919 (GRCm39) |
I783N |
probably damaging |
Het |
| Efcc1 |
G |
A |
6: 87,708,148 (GRCm39) |
E92K |
probably benign |
Het |
| Eif2ak4 |
T |
A |
2: 118,273,691 (GRCm39) |
L872H |
probably damaging |
Het |
| Elp2 |
T |
A |
18: 24,764,461 (GRCm39) |
S603T |
probably benign |
Het |
| Eml2 |
T |
A |
7: 18,930,179 (GRCm39) |
L300H |
probably damaging |
Het |
| Esp3 |
A |
G |
17: 40,946,827 (GRCm39) |
K50R |
possibly damaging |
Het |
| Esrp1 |
A |
G |
4: 11,379,375 (GRCm39) |
F136L |
probably damaging |
Het |
| Exoc1 |
T |
A |
5: 76,707,011 (GRCm39) |
D497E |
probably damaging |
Het |
| Fat3 |
A |
G |
9: 15,908,761 (GRCm39) |
S2414P |
probably damaging |
Het |
| Foxj3 |
C |
T |
4: 119,477,398 (GRCm39) |
P369S |
unknown |
Het |
| Gkn2 |
G |
T |
6: 87,352,921 (GRCm39) |
|
probably null |
Het |
| Gm17333 |
AAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAA |
AAGAAGAGAAGAGAAGAGAAGAGAAGAGAA |
16: 77,649,766 (GRCm39) |
|
noncoding transcript |
Het |
| Gm21905 |
A |
T |
5: 68,103,724 (GRCm39) |
|
probably benign |
Het |
| Grhl1 |
T |
A |
12: 24,632,962 (GRCm39) |
|
probably null |
Het |
| Grk6 |
A |
G |
13: 55,599,967 (GRCm39) |
Y221C |
probably damaging |
Het |
| Hcrtr1 |
T |
A |
4: 130,024,720 (GRCm39) |
K389* |
probably null |
Het |
| Hk1 |
G |
A |
10: 62,120,563 (GRCm39) |
R545C |
probably damaging |
Het |
| Hsp90b1 |
A |
T |
10: 86,532,659 (GRCm39) |
I339N |
probably benign |
Het |
| Ikzf3 |
T |
C |
11: 98,381,272 (GRCm39) |
R103G |
probably damaging |
Het |
| Itgad |
A |
C |
7: 127,777,542 (GRCm39) |
I141L |
probably benign |
Het |
| Jmjd6 |
T |
A |
11: 116,733,266 (GRCm39) |
Y137F |
probably benign |
Het |
| Kcna1 |
A |
G |
6: 126,619,030 (GRCm39) |
V430A |
probably benign |
Het |
| Kel |
A |
G |
6: 41,665,560 (GRCm39) |
V520A |
probably damaging |
Het |
| Klhl41 |
G |
A |
2: 69,501,084 (GRCm39) |
V182I |
probably benign |
Het |
| Ldhb |
C |
A |
6: 142,447,121 (GRCm39) |
M64I |
probably benign |
Het |
| Lrrc23 |
A |
G |
6: 124,753,077 (GRCm39) |
S190P |
possibly damaging |
Het |
| Mboat2 |
T |
C |
12: 25,009,029 (GRCm39) |
V445A |
probably benign |
Het |
| Mlycd |
G |
A |
8: 120,128,258 (GRCm39) |
W188* |
probably null |
Het |
| Mpp3 |
C |
T |
11: 101,899,475 (GRCm39) |
E349K |
probably benign |
Het |
| Mtres1 |
A |
G |
10: 43,401,316 (GRCm39) |
V211A |
probably benign |
Het |
| Myh4 |
A |
G |
11: 67,141,366 (GRCm39) |
M780V |
probably benign |
Het |
| Myh6 |
G |
A |
14: 55,193,963 (GRCm39) |
R809C |
probably damaging |
Het |
| Mylip |
G |
A |
13: 45,560,046 (GRCm39) |
V161M |
possibly damaging |
Het |
| Nrp1 |
G |
A |
8: 129,152,450 (GRCm39) |
V220I |
probably null |
Het |
| Nup210 |
A |
T |
6: 91,011,823 (GRCm39) |
N455K |
probably benign |
Het |
| Or14j10 |
A |
T |
17: 37,935,243 (GRCm39) |
Y94* |
probably null |
Het |
| Or51f1d |
C |
A |
7: 102,700,795 (GRCm39) |
Q97K |
probably benign |
Het |
| Pbld2 |
G |
T |
10: 62,889,732 (GRCm39) |
|
probably null |
Het |
| Pclo |
C |
G |
5: 14,571,917 (GRCm39) |
P434R |
probably damaging |
Het |
| Pdlim3 |
A |
G |
8: 46,349,800 (GRCm39) |
K37E |
probably damaging |
Het |
| Prkdc |
T |
A |
16: 15,589,970 (GRCm39) |
I2611N |
probably benign |
Het |
| Prr12 |
T |
C |
7: 44,677,954 (GRCm39) |
D2019G |
unknown |
Het |
| Rab27a |
A |
G |
9: 73,002,685 (GRCm39) |
T205A |
probably benign |
Het |
| Rcan3 |
A |
G |
4: 135,152,595 (GRCm39) |
L42P |
probably damaging |
Het |
| Rchy1 |
T |
C |
5: 92,103,474 (GRCm39) |
|
probably null |
Het |
| Sema6a |
T |
C |
18: 47,382,066 (GRCm39) |
H827R |
probably damaging |
Het |
| Sertad4 |
A |
G |
1: 192,533,258 (GRCm39) |
|
probably null |
Het |
| Smarcd1 |
T |
A |
15: 99,605,264 (GRCm39) |
C282S |
probably damaging |
Het |
| Speg |
A |
G |
1: 75,377,866 (GRCm39) |
T769A |
possibly damaging |
Het |
| Syne1 |
T |
A |
10: 5,297,875 (GRCm39) |
K1141* |
probably null |
Het |
| Synpo2 |
T |
C |
3: 122,911,315 (GRCm39) |
E110G |
probably benign |
Het |
| Tg |
T |
A |
15: 66,722,351 (GRCm39) |
D333E |
probably benign |
Het |
| Tmem132c |
A |
G |
5: 127,436,955 (GRCm39) |
Y148C |
probably damaging |
Het |
| Tmem215 |
T |
A |
4: 40,473,965 (GRCm39) |
V14E |
probably damaging |
Het |
| Tmem229b |
A |
G |
12: 79,011,685 (GRCm39) |
L82P |
probably damaging |
Het |
| Togaram1 |
A |
G |
12: 65,013,039 (GRCm39) |
T97A |
probably benign |
Het |
| Trappc9 |
G |
A |
15: 72,565,397 (GRCm39) |
R965* |
probably null |
Het |
| Trio |
T |
C |
15: 27,833,071 (GRCm39) |
I104V |
probably benign |
Het |
| Trp73 |
A |
G |
4: 154,148,352 (GRCm39) |
F354S |
probably benign |
Het |
| Ttyh2 |
T |
C |
11: 114,577,278 (GRCm39) |
L63P |
probably damaging |
Het |
| Ulk4 |
G |
C |
9: 120,873,841 (GRCm39) |
P1197A |
probably damaging |
Het |
| Vmn1r176 |
T |
C |
7: 23,534,536 (GRCm39) |
M206V |
possibly damaging |
Het |
| Zbtb41 |
A |
G |
1: 139,350,931 (GRCm39) |
I15V |
probably benign |
Het |
| Zc3hav1 |
T |
C |
6: 38,284,170 (GRCm39) |
I982V |
possibly damaging |
Het |
| Zmynd19 |
T |
A |
2: 24,848,123 (GRCm39) |
N106K |
probably benign |
Het |
|
| Other mutations in Vps8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Vps8
|
APN |
16 |
21,261,084 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00596:Vps8
|
APN |
16 |
21,267,162 (GRCm39) |
splice site |
probably benign |
|
|
IGL00985:Vps8
|
APN |
16 |
21,296,334 (GRCm39) |
splice site |
probably benign |
|
|
IGL01356:Vps8
|
APN |
16 |
21,336,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01375:Vps8
|
APN |
16 |
21,378,122 (GRCm39) |
nonsense |
probably null |
|
|
IGL01643:Vps8
|
APN |
16 |
21,336,972 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02159:Vps8
|
APN |
16 |
21,285,234 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02214:Vps8
|
APN |
16 |
21,336,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vps8
|
APN |
16 |
21,340,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02651:Vps8
|
APN |
16 |
21,336,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03174:Vps8
|
APN |
16 |
21,285,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03337:Vps8
|
APN |
16 |
21,381,918 (GRCm39) |
missense |
probably benign |
|
|
IGL03383:Vps8
|
APN |
16 |
21,254,573 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03402:Vps8
|
APN |
16 |
21,267,148 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
empires
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
porky
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
realm
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
realms
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
Reich
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
reichen
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
IGL03052:Vps8
|
UTSW |
16 |
21,267,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4677001:Vps8
|
UTSW |
16 |
21,319,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0125:Vps8
|
UTSW |
16 |
21,288,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0137:Vps8
|
UTSW |
16 |
21,323,136 (GRCm39) |
splice site |
probably benign |
|
|
R0362:Vps8
|
UTSW |
16 |
21,426,977 (GRCm39) |
intron |
probably benign |
|
|
R0384:Vps8
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
R0492:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0525:Vps8
|
UTSW |
16 |
21,358,859 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0531:Vps8
|
UTSW |
16 |
21,278,561 (GRCm39) |
intron |
probably benign |
|
|
R0605:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0636:Vps8
|
UTSW |
16 |
21,253,683 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0707:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Vps8
|
UTSW |
16 |
21,275,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Vps8
|
UTSW |
16 |
21,278,570 (GRCm39) |
intron |
probably benign |
|
|
R1203:Vps8
|
UTSW |
16 |
21,330,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1482:Vps8
|
UTSW |
16 |
21,400,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1642:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R1956:Vps8
|
UTSW |
16 |
21,279,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Vps8
|
UTSW |
16 |
21,395,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2287:Vps8
|
UTSW |
16 |
21,387,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Vps8
|
UTSW |
16 |
21,261,123 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3943:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4043:Vps8
|
UTSW |
16 |
21,345,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Vps8
|
UTSW |
16 |
21,314,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4398:Vps8
|
UTSW |
16 |
21,323,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4477:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4478:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4479:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4480:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4571:Vps8
|
UTSW |
16 |
21,254,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Vps8
|
UTSW |
16 |
21,318,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Vps8
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
R4713:Vps8
|
UTSW |
16 |
21,261,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Vps8
|
UTSW |
16 |
21,267,154 (GRCm39) |
splice site |
probably null |
|
|
R4959:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4973:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Vps8
|
UTSW |
16 |
21,285,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vps8
|
UTSW |
16 |
21,280,158 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5144:Vps8
|
UTSW |
16 |
21,378,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5168:Vps8
|
UTSW |
16 |
21,351,849 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5168:Vps8
|
UTSW |
16 |
21,276,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5222:Vps8
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
R5231:Vps8
|
UTSW |
16 |
21,395,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Vps8
|
UTSW |
16 |
21,280,189 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5963:Vps8
|
UTSW |
16 |
21,288,871 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6010:Vps8
|
UTSW |
16 |
21,363,955 (GRCm39) |
intron |
probably benign |
|
|
R6023:Vps8
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6173:Vps8
|
UTSW |
16 |
21,314,682 (GRCm39) |
splice site |
probably null |
|
|
R6185:Vps8
|
UTSW |
16 |
21,288,891 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6264:Vps8
|
UTSW |
16 |
21,378,099 (GRCm39) |
nonsense |
probably null |
|
|
R6409:Vps8
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6522:Vps8
|
UTSW |
16 |
21,261,129 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6528:Vps8
|
UTSW |
16 |
21,372,875 (GRCm39) |
nonsense |
probably null |
|
|
R6784:Vps8
|
UTSW |
16 |
21,381,957 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Vps8
|
UTSW |
16 |
21,393,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R7103:Vps8
|
UTSW |
16 |
21,345,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7149:Vps8
|
UTSW |
16 |
21,278,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Vps8
|
UTSW |
16 |
21,275,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7206:Vps8
|
UTSW |
16 |
21,276,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Vps8
|
UTSW |
16 |
21,253,722 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7782:Vps8
|
UTSW |
16 |
21,330,308 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7806:Vps8
|
UTSW |
16 |
21,278,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Vps8
|
UTSW |
16 |
21,351,070 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7943:Vps8
|
UTSW |
16 |
21,296,622 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8075:Vps8
|
UTSW |
16 |
21,340,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8190:Vps8
|
UTSW |
16 |
21,393,780 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8307:Vps8
|
UTSW |
16 |
21,314,652 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8483:Vps8
|
UTSW |
16 |
21,393,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8814:Vps8
|
UTSW |
16 |
21,395,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9064:Vps8
|
UTSW |
16 |
21,288,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Vps8
|
UTSW |
16 |
21,340,668 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9404:Vps8
|
UTSW |
16 |
21,426,927 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9544:Vps8
|
UTSW |
16 |
21,336,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9570:Vps8
|
UTSW |
16 |
21,462,953 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9634:Vps8
|
UTSW |
16 |
21,372,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9702:Vps8
|
UTSW |
16 |
21,462,883 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTGTAGTAAGCTCGGGAAAACGC -3'
(R):5'- AGGACCTGGCATTGAAACCTCAAAG -3'
Sequencing Primer
(F):5'- CTGAAGTGAATATTAGCACCTCAGG -3'
(R):5'- GCTTCAAAGCCAAGTCAGG -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation