Incidental Mutation 'R1530:Rapgef6'
| ID |
166564 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rapgef6
|
| Ensembl Gene |
ENSMUSG00000037533 |
| Gene Name |
Rap guanine nucleotide exchange factor (GEF) 6 |
| Synonyms |
PDZ-GEF2, C030018K18Rik, Pdzgef2, RA-GEF-2 |
| MMRRC Submission |
039569-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1530 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
54413673-54590111 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 54552009 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Lysine
at position 959
(I959K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147135
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094536]
[ENSMUST00000101206]
[ENSMUST00000102743]
[ENSMUST00000108894]
[ENSMUST00000207429]
|
| AlphaFold |
Q5NCJ1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000094536
AA Change: I669K
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000092114
Gene: ENSMUSG00000037533
AA Change: I669K
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
|
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
|
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
|
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
|
RA
|
464 |
550 |
1.47e-20 |
SMART |
|
RasGEF
|
571 |
853 |
3.88e-84 |
SMART |
|
low complexity region
|
944 |
957 |
N/A |
INTRINSIC |
|
low complexity region
|
972 |
989 |
N/A |
INTRINSIC |
|
low complexity region
|
1016 |
1061 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000101206
AA Change: I954K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000098766
Gene: ENSMUSG00000037533
AA Change: I954K
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.45e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1095 |
5.35e-87 |
SMART |
|
low complexity region
|
1237 |
1250 |
N/A |
INTRINSIC |
|
low complexity region
|
1270 |
1293 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1364 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1452 |
N/A |
INTRINSIC |
|
low complexity region
|
1555 |
1568 |
N/A |
INTRINSIC |
|
low complexity region
|
1591 |
1604 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000102743
AA Change: I954K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000099804
Gene: ENSMUSG00000037533
AA Change: I954K
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.42e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1138 |
3.88e-84 |
SMART |
|
low complexity region
|
1229 |
1242 |
N/A |
INTRINSIC |
|
low complexity region
|
1262 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1337 |
1356 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1372 |
N/A |
INTRINSIC |
|
low complexity region
|
1436 |
1444 |
N/A |
INTRINSIC |
|
low complexity region
|
1547 |
1560 |
N/A |
INTRINSIC |
|
low complexity region
|
1583 |
1596 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000108894
AA Change: I669K
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000104522
Gene: ENSMUSG00000037533
AA Change: I669K
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
|
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
|
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
|
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
|
RA
|
464 |
550 |
1.47e-20 |
SMART |
|
RasGEF
|
571 |
810 |
5.35e-87 |
SMART |
|
low complexity region
|
952 |
965 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
997 |
N/A |
INTRINSIC |
|
low complexity region
|
1024 |
1069 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175600
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000207429
AA Change: I959K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(16) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(13) |
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actl6b |
T |
C |
5: 137,567,640 (GRCm39) |
C425R |
probably damaging |
Het |
| Adam15 |
A |
G |
3: 89,257,137 (GRCm39) |
S20P |
probably damaging |
Het |
| Adgra3 |
G |
A |
5: 50,118,479 (GRCm39) |
T1023I |
probably benign |
Het |
| Angel2 |
T |
A |
1: 190,671,285 (GRCm39) |
V46E |
probably damaging |
Het |
| Ankrd13c |
T |
A |
3: 157,697,358 (GRCm39) |
M321K |
probably damaging |
Het |
| Atad2b |
C |
T |
12: 4,992,018 (GRCm39) |
R206* |
probably null |
Het |
| Atp10b |
T |
A |
11: 43,088,351 (GRCm39) |
F319Y |
probably benign |
Het |
| AW554918 |
A |
G |
18: 25,533,161 (GRCm39) |
R272G |
probably damaging |
Het |
| Bpi |
T |
A |
2: 158,103,065 (GRCm39) |
I70N |
probably damaging |
Het |
| Brca1 |
T |
C |
11: 101,415,521 (GRCm39) |
D871G |
probably damaging |
Het |
| Capn3 |
G |
A |
2: 120,312,689 (GRCm39) |
A160T |
probably damaging |
Het |
| Cenpe |
T |
C |
3: 134,952,663 (GRCm39) |
L1451P |
possibly damaging |
Het |
| Chmp7 |
A |
G |
14: 69,969,937 (GRCm39) |
M1T |
probably null |
Het |
| Csrnp1 |
G |
C |
9: 119,802,612 (GRCm39) |
Q200E |
possibly damaging |
Het |
| Dscam |
G |
A |
16: 96,621,074 (GRCm39) |
P545S |
probably damaging |
Het |
| Erap1 |
A |
G |
13: 74,794,662 (GRCm39) |
E107G |
probably benign |
Het |
| Errfi1 |
A |
G |
4: 150,949,843 (GRCm39) |
I49V |
probably benign |
Het |
| Fam171b |
T |
C |
2: 83,710,533 (GRCm39) |
L735S |
probably damaging |
Het |
| Fancm |
T |
A |
12: 65,139,264 (GRCm39) |
|
probably null |
Het |
| Fbp2 |
G |
C |
13: 62,984,973 (GRCm39) |
P316R |
probably damaging |
Het |
| Fcer2a |
C |
A |
8: 3,732,976 (GRCm39) |
G255V |
probably damaging |
Het |
| Fhip2a |
T |
A |
19: 57,374,737 (GRCm39) |
I704N |
probably damaging |
Het |
| Fzd2 |
T |
C |
11: 102,496,134 (GRCm39) |
S193P |
probably benign |
Het |
| Gak |
A |
G |
5: 108,772,059 (GRCm39) |
V86A |
probably damaging |
Het |
| Gas2l3 |
A |
G |
10: 89,269,631 (GRCm39) |
I7T |
probably benign |
Het |
| Gbp11 |
T |
C |
5: 105,475,355 (GRCm39) |
H331R |
probably damaging |
Het |
| Gpr19 |
C |
T |
6: 134,846,961 (GRCm39) |
V241M |
probably damaging |
Het |
| Grk6 |
G |
A |
13: 55,606,612 (GRCm39) |
A437T |
probably damaging |
Het |
| Hip1 |
T |
C |
5: 135,473,634 (GRCm39) |
D253G |
probably damaging |
Het |
| Ifna9 |
G |
C |
4: 88,510,409 (GRCm39) |
Q72E |
possibly damaging |
Het |
| Il1r1 |
A |
G |
1: 40,351,521 (GRCm39) |
T384A |
probably benign |
Het |
| Ip6k1 |
C |
A |
9: 107,922,761 (GRCm39) |
C221* |
probably null |
Het |
| Kcna1 |
C |
A |
6: 126,619,494 (GRCm39) |
E275D |
probably benign |
Het |
| Kcnt2 |
C |
T |
1: 140,411,970 (GRCm39) |
Q468* |
probably null |
Het |
| Kin |
T |
C |
2: 10,097,150 (GRCm39) |
V333A |
probably damaging |
Het |
| Leprot |
G |
T |
4: 101,513,484 (GRCm39) |
V91L |
probably benign |
Het |
| Mettl21c |
A |
G |
1: 44,056,344 (GRCm39) |
|
probably null |
Het |
| Myom2 |
T |
C |
8: 15,172,384 (GRCm39) |
F1161S |
probably damaging |
Het |
| Ndor1 |
A |
G |
2: 25,138,921 (GRCm39) |
L321P |
probably benign |
Het |
| Nipal2 |
A |
T |
15: 34,625,168 (GRCm39) |
*72K |
probably null |
Het |
| Nol3 |
T |
C |
8: 106,005,858 (GRCm39) |
V84A |
probably benign |
Het |
| Or2y16 |
C |
T |
11: 49,334,732 (GRCm39) |
S18L |
probably benign |
Het |
| Or4c101 |
A |
T |
2: 88,389,827 (GRCm39) |
I5F |
probably benign |
Het |
| Or8b42 |
T |
C |
9: 38,341,620 (GRCm39) |
I14T |
probably damaging |
Het |
| Pcare |
A |
G |
17: 72,056,473 (GRCm39) |
V1068A |
probably benign |
Het |
| Pdgfra |
T |
A |
5: 75,349,671 (GRCm39) |
|
probably null |
Het |
| Pik3cb |
T |
C |
9: 98,936,026 (GRCm39) |
D802G |
probably damaging |
Het |
| Plac8l1 |
A |
T |
18: 42,311,996 (GRCm39) |
V141E |
probably damaging |
Het |
| Plxnb2 |
A |
G |
15: 89,051,395 (GRCm39) |
S275P |
probably benign |
Het |
| Prl3b1 |
G |
A |
13: 27,427,848 (GRCm39) |
A53T |
probably benign |
Het |
| Scn5a |
T |
C |
9: 119,324,628 (GRCm39) |
K1400R |
probably damaging |
Het |
| Sel1l |
A |
G |
12: 91,793,458 (GRCm39) |
S263P |
probably damaging |
Het |
| Setd5 |
G |
A |
6: 113,086,874 (GRCm39) |
V34I |
probably damaging |
Het |
| Slc34a1 |
A |
G |
13: 24,003,052 (GRCm39) |
D234G |
probably damaging |
Het |
| Spink5 |
T |
A |
18: 44,148,738 (GRCm39) |
S934T |
probably damaging |
Het |
| St18 |
A |
C |
1: 6,915,793 (GRCm39) |
|
probably null |
Het |
| St3gal4 |
T |
C |
9: 34,963,592 (GRCm39) |
I239V |
probably benign |
Het |
| Stag3 |
C |
T |
5: 138,295,674 (GRCm39) |
T399I |
probably damaging |
Het |
| Syt11 |
T |
C |
3: 88,669,674 (GRCm39) |
K6E |
probably damaging |
Het |
| Taf15 |
T |
C |
11: 83,378,122 (GRCm39) |
Y121H |
possibly damaging |
Het |
| Tdh |
T |
C |
14: 63,733,504 (GRCm39) |
Y113C |
probably damaging |
Het |
| Tgfbr1 |
T |
A |
4: 47,410,688 (GRCm39) |
W406R |
probably damaging |
Het |
| Tgm6 |
A |
G |
2: 129,993,202 (GRCm39) |
I563V |
possibly damaging |
Het |
| Tmem131 |
A |
G |
1: 36,866,090 (GRCm39) |
|
probably null |
Het |
| Tmub2 |
T |
C |
11: 102,178,312 (GRCm39) |
S72P |
probably benign |
Het |
| Trappc13 |
G |
A |
13: 104,286,651 (GRCm39) |
T202I |
probably damaging |
Het |
| Trim9 |
T |
C |
12: 70,319,202 (GRCm39) |
E449G |
probably damaging |
Het |
| Trip11 |
C |
A |
12: 101,879,026 (GRCm39) |
G21V |
unknown |
Het |
| Ttll12 |
G |
A |
15: 83,472,856 (GRCm39) |
R127C |
probably damaging |
Het |
| Vmn2r125 |
A |
T |
4: 156,703,447 (GRCm39) |
Y275F |
probably damaging |
Het |
| Xrcc5 |
A |
G |
1: 72,369,103 (GRCm39) |
D319G |
probably damaging |
Het |
| Zc3h14 |
T |
G |
12: 98,751,262 (GRCm39) |
C159W |
probably damaging |
Het |
| Zc3h7b |
C |
T |
15: 81,661,289 (GRCm39) |
P376L |
probably benign |
Het |
| Zfhx3 |
C |
T |
8: 109,675,121 (GRCm39) |
P2057L |
probably damaging |
Het |
|
| Other mutations in Rapgef6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00436:Rapgef6
|
APN |
11 |
54,570,091 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00507:Rapgef6
|
APN |
11 |
54,554,935 (GRCm39) |
nonsense |
probably null |
|
|
IGL00809:Rapgef6
|
APN |
11 |
54,540,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00843:Rapgef6
|
APN |
11 |
54,582,099 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00899:Rapgef6
|
APN |
11 |
54,510,844 (GRCm39) |
nonsense |
probably null |
|
|
IGL01372:Rapgef6
|
APN |
11 |
54,559,437 (GRCm39) |
splice site |
probably benign |
|
|
IGL01604:Rapgef6
|
APN |
11 |
54,585,389 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01935:Rapgef6
|
APN |
11 |
54,501,668 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL01991:Rapgef6
|
APN |
11 |
54,443,695 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL02243:Rapgef6
|
APN |
11 |
54,567,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02407:Rapgef6
|
APN |
11 |
54,567,181 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02676:Rapgef6
|
APN |
11 |
54,540,172 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02934:Rapgef6
|
APN |
11 |
54,516,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03076:Rapgef6
|
APN |
11 |
54,516,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03110:Rapgef6
|
APN |
11 |
54,586,915 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03256:Rapgef6
|
APN |
11 |
54,548,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
shocker
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
D4216:Rapgef6
|
UTSW |
11 |
54,559,572 (GRCm39) |
splice site |
probably benign |
|
|
PIT4305001:Rapgef6
|
UTSW |
11 |
54,570,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4366001:Rapgef6
|
UTSW |
11 |
54,582,446 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0125:Rapgef6
|
UTSW |
11 |
54,516,701 (GRCm39) |
nonsense |
probably null |
|
|
R0189:Rapgef6
|
UTSW |
11 |
54,582,075 (GRCm39) |
missense |
probably benign |
|
|
R0201:Rapgef6
|
UTSW |
11 |
54,510,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Rapgef6
|
UTSW |
11 |
54,516,789 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0524:Rapgef6
|
UTSW |
11 |
54,581,110 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0853:Rapgef6
|
UTSW |
11 |
54,559,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1203:Rapgef6
|
UTSW |
11 |
54,582,525 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1440:Rapgef6
|
UTSW |
11 |
54,517,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1453:Rapgef6
|
UTSW |
11 |
54,530,553 (GRCm39) |
splice site |
probably null |
|
|
R1593:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1620:Rapgef6
|
UTSW |
11 |
54,517,420 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1628:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1629:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1630:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1634:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1640:Rapgef6
|
UTSW |
11 |
54,548,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Rapgef6
|
UTSW |
11 |
54,582,458 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1722:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1743:Rapgef6
|
UTSW |
11 |
54,567,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1816:Rapgef6
|
UTSW |
11 |
54,585,314 (GRCm39) |
missense |
probably benign |
|
|
R1851:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1852:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1868:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1942:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1943:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2031:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2087:Rapgef6
|
UTSW |
11 |
54,522,075 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2106:Rapgef6
|
UTSW |
11 |
54,559,512 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2362:Rapgef6
|
UTSW |
11 |
54,585,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2484:Rapgef6
|
UTSW |
11 |
54,533,582 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2566:Rapgef6
|
UTSW |
11 |
54,578,537 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3744:Rapgef6
|
UTSW |
11 |
54,516,760 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3848:Rapgef6
|
UTSW |
11 |
54,582,134 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4823:Rapgef6
|
UTSW |
11 |
54,585,326 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4859:Rapgef6
|
UTSW |
11 |
54,526,989 (GRCm39) |
missense |
probably benign |
|
|
R4906:Rapgef6
|
UTSW |
11 |
54,443,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4911:Rapgef6
|
UTSW |
11 |
54,513,143 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4937:Rapgef6
|
UTSW |
11 |
54,548,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5033:Rapgef6
|
UTSW |
11 |
54,582,207 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5249:Rapgef6
|
UTSW |
11 |
54,413,943 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5304:Rapgef6
|
UTSW |
11 |
54,548,200 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5656:Rapgef6
|
UTSW |
11 |
54,526,962 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5701:Rapgef6
|
UTSW |
11 |
54,567,220 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5758:Rapgef6
|
UTSW |
11 |
54,559,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5973:Rapgef6
|
UTSW |
11 |
54,530,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6177:Rapgef6
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6268:Rapgef6
|
UTSW |
11 |
54,540,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6287:Rapgef6
|
UTSW |
11 |
54,517,164 (GRCm39) |
splice site |
probably null |
|
|
R6293:Rapgef6
|
UTSW |
11 |
54,525,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6471:Rapgef6
|
UTSW |
11 |
54,582,563 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6863:Rapgef6
|
UTSW |
11 |
54,437,206 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6950:Rapgef6
|
UTSW |
11 |
54,567,206 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7144:Rapgef6
|
UTSW |
11 |
54,548,191 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7171:Rapgef6
|
UTSW |
11 |
54,567,189 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7199:Rapgef6
|
UTSW |
11 |
54,437,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7291:Rapgef6
|
UTSW |
11 |
54,582,065 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7436:Rapgef6
|
UTSW |
11 |
54,501,747 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7498:Rapgef6
|
UTSW |
11 |
54,510,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7506:Rapgef6
|
UTSW |
11 |
54,526,997 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7527:Rapgef6
|
UTSW |
11 |
54,525,787 (GRCm39) |
missense |
unknown |
|
|
R7646:Rapgef6
|
UTSW |
11 |
54,516,780 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7655:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7656:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7687:Rapgef6
|
UTSW |
11 |
54,551,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7768:Rapgef6
|
UTSW |
11 |
54,517,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7788:Rapgef6
|
UTSW |
11 |
54,585,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7890:Rapgef6
|
UTSW |
11 |
54,517,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8113:Rapgef6
|
UTSW |
11 |
54,516,784 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8337:Rapgef6
|
UTSW |
11 |
54,522,127 (GRCm39) |
nonsense |
probably null |
|
|
R8393:Rapgef6
|
UTSW |
11 |
54,578,487 (GRCm39) |
missense |
probably benign |
|
|
R8465:Rapgef6
|
UTSW |
11 |
54,582,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8492:Rapgef6
|
UTSW |
11 |
54,581,063 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8791:Rapgef6
|
UTSW |
11 |
54,459,295 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8866:Rapgef6
|
UTSW |
11 |
54,443,700 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8917:Rapgef6
|
UTSW |
11 |
54,582,392 (GRCm39) |
nonsense |
probably null |
|
|
R8921:Rapgef6
|
UTSW |
11 |
54,570,065 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9031:Rapgef6
|
UTSW |
11 |
54,578,667 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9093:Rapgef6
|
UTSW |
11 |
54,487,912 (GRCm39) |
nonsense |
probably null |
|
|
R9354:Rapgef6
|
UTSW |
11 |
54,510,749 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9514:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9516:Rapgef6
|
UTSW |
11 |
54,582,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9739:Rapgef6
|
UTSW |
11 |
54,513,189 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9789:Rapgef6
|
UTSW |
11 |
54,540,097 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACCCAGCTCTCCATGAGAGACTT -3'
(R):5'- TATCAGGAATCTCCAGGGGCCACT -3'
Sequencing Primer
(F):5'- CGTAACATTGAGCCTACTGAATAC -3'
(R):5'- ggaagaggaggtggaaagatag -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation