Incidental Mutation 'R1530:Prl3b1'
ID 166578
Institutional Source Beutler Lab
Gene Symbol Prl3b1
Ensembl Gene ENSMUSG00000038891
Gene Name prolactin family 3, subfamily b, member 1
Synonyms mplII, PL, Pl-2, mPL-II, Pl2, prolactin-like, Csh2
MMRRC Submission 039569-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R1530 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 27426413-27433666 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 27427848 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 53 (A53T)
Ref Sequence ENSEMBL: ENSMUSP00000047680 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035273] [ENSMUST00000225089]
AlphaFold P09586
Predicted Effect probably benign
Transcript: ENSMUST00000035273
AA Change: A53T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000047680
Gene: ENSMUSG00000038891
AA Change: A53T

DomainStartEndE-ValueType
Pfam:Hormone_1 18 222 1e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000225089
AA Change: A53T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl6b T C 5: 137,567,640 (GRCm39) C425R probably damaging Het
Adam15 A G 3: 89,257,137 (GRCm39) S20P probably damaging Het
Adgra3 G A 5: 50,118,479 (GRCm39) T1023I probably benign Het
Angel2 T A 1: 190,671,285 (GRCm39) V46E probably damaging Het
Ankrd13c T A 3: 157,697,358 (GRCm39) M321K probably damaging Het
Atad2b C T 12: 4,992,018 (GRCm39) R206* probably null Het
Atp10b T A 11: 43,088,351 (GRCm39) F319Y probably benign Het
AW554918 A G 18: 25,533,161 (GRCm39) R272G probably damaging Het
Bpi T A 2: 158,103,065 (GRCm39) I70N probably damaging Het
Brca1 T C 11: 101,415,521 (GRCm39) D871G probably damaging Het
Capn3 G A 2: 120,312,689 (GRCm39) A160T probably damaging Het
Cenpe T C 3: 134,952,663 (GRCm39) L1451P possibly damaging Het
Chmp7 A G 14: 69,969,937 (GRCm39) M1T probably null Het
Csrnp1 G C 9: 119,802,612 (GRCm39) Q200E possibly damaging Het
Dscam G A 16: 96,621,074 (GRCm39) P545S probably damaging Het
Erap1 A G 13: 74,794,662 (GRCm39) E107G probably benign Het
Errfi1 A G 4: 150,949,843 (GRCm39) I49V probably benign Het
Fam171b T C 2: 83,710,533 (GRCm39) L735S probably damaging Het
Fancm T A 12: 65,139,264 (GRCm39) probably null Het
Fbp2 G C 13: 62,984,973 (GRCm39) P316R probably damaging Het
Fcer2a C A 8: 3,732,976 (GRCm39) G255V probably damaging Het
Fhip2a T A 19: 57,374,737 (GRCm39) I704N probably damaging Het
Fzd2 T C 11: 102,496,134 (GRCm39) S193P probably benign Het
Gak A G 5: 108,772,059 (GRCm39) V86A probably damaging Het
Gas2l3 A G 10: 89,269,631 (GRCm39) I7T probably benign Het
Gbp11 T C 5: 105,475,355 (GRCm39) H331R probably damaging Het
Gpr19 C T 6: 134,846,961 (GRCm39) V241M probably damaging Het
Grk6 G A 13: 55,606,612 (GRCm39) A437T probably damaging Het
Hip1 T C 5: 135,473,634 (GRCm39) D253G probably damaging Het
Ifna9 G C 4: 88,510,409 (GRCm39) Q72E possibly damaging Het
Il1r1 A G 1: 40,351,521 (GRCm39) T384A probably benign Het
Ip6k1 C A 9: 107,922,761 (GRCm39) C221* probably null Het
Kcna1 C A 6: 126,619,494 (GRCm39) E275D probably benign Het
Kcnt2 C T 1: 140,411,970 (GRCm39) Q468* probably null Het
Kin T C 2: 10,097,150 (GRCm39) V333A probably damaging Het
Leprot G T 4: 101,513,484 (GRCm39) V91L probably benign Het
Mettl21c A G 1: 44,056,344 (GRCm39) probably null Het
Myom2 T C 8: 15,172,384 (GRCm39) F1161S probably damaging Het
Ndor1 A G 2: 25,138,921 (GRCm39) L321P probably benign Het
Nipal2 A T 15: 34,625,168 (GRCm39) *72K probably null Het
Nol3 T C 8: 106,005,858 (GRCm39) V84A probably benign Het
Or2y16 C T 11: 49,334,732 (GRCm39) S18L probably benign Het
Or4c101 A T 2: 88,389,827 (GRCm39) I5F probably benign Het
Or8b42 T C 9: 38,341,620 (GRCm39) I14T probably damaging Het
Pcare A G 17: 72,056,473 (GRCm39) V1068A probably benign Het
Pdgfra T A 5: 75,349,671 (GRCm39) probably null Het
Pik3cb T C 9: 98,936,026 (GRCm39) D802G probably damaging Het
Plac8l1 A T 18: 42,311,996 (GRCm39) V141E probably damaging Het
Plxnb2 A G 15: 89,051,395 (GRCm39) S275P probably benign Het
Rapgef6 T A 11: 54,552,009 (GRCm39) I959K probably damaging Het
Scn5a T C 9: 119,324,628 (GRCm39) K1400R probably damaging Het
Sel1l A G 12: 91,793,458 (GRCm39) S263P probably damaging Het
Setd5 G A 6: 113,086,874 (GRCm39) V34I probably damaging Het
Slc34a1 A G 13: 24,003,052 (GRCm39) D234G probably damaging Het
Spink5 T A 18: 44,148,738 (GRCm39) S934T probably damaging Het
St18 A C 1: 6,915,793 (GRCm39) probably null Het
St3gal4 T C 9: 34,963,592 (GRCm39) I239V probably benign Het
Stag3 C T 5: 138,295,674 (GRCm39) T399I probably damaging Het
Syt11 T C 3: 88,669,674 (GRCm39) K6E probably damaging Het
Taf15 T C 11: 83,378,122 (GRCm39) Y121H possibly damaging Het
Tdh T C 14: 63,733,504 (GRCm39) Y113C probably damaging Het
Tgfbr1 T A 4: 47,410,688 (GRCm39) W406R probably damaging Het
Tgm6 A G 2: 129,993,202 (GRCm39) I563V possibly damaging Het
Tmem131 A G 1: 36,866,090 (GRCm39) probably null Het
Tmub2 T C 11: 102,178,312 (GRCm39) S72P probably benign Het
Trappc13 G A 13: 104,286,651 (GRCm39) T202I probably damaging Het
Trim9 T C 12: 70,319,202 (GRCm39) E449G probably damaging Het
Trip11 C A 12: 101,879,026 (GRCm39) G21V unknown Het
Ttll12 G A 15: 83,472,856 (GRCm39) R127C probably damaging Het
Vmn2r125 A T 4: 156,703,447 (GRCm39) Y275F probably damaging Het
Xrcc5 A G 1: 72,369,103 (GRCm39) D319G probably damaging Het
Zc3h14 T G 12: 98,751,262 (GRCm39) C159W probably damaging Het
Zc3h7b C T 15: 81,661,289 (GRCm39) P376L probably benign Het
Zfhx3 C T 8: 109,675,121 (GRCm39) P2057L probably damaging Het
Other mutations in Prl3b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02385:Prl3b1 APN 13 27,433,366 (GRCm39) missense possibly damaging 0.51
IGL02669:Prl3b1 APN 13 27,429,795 (GRCm39) missense probably benign 0.24
IGL03035:Prl3b1 APN 13 27,433,516 (GRCm39) unclassified probably benign
IGL03077:Prl3b1 APN 13 27,429,759 (GRCm39) missense probably benign 0.00
Gabby UTSW 13 27,431,928 (GRCm39) missense probably damaging 1.00
peaches UTSW 13 27,426,473 (GRCm39) start codon destroyed probably null 1.00
Pits UTSW 13 27,431,957 (GRCm39) critical splice donor site probably null
R2014_Prl3b1_632 UTSW 13 27,431,948 (GRCm39) missense probably benign 0.00
R0716:Prl3b1 UTSW 13 27,427,779 (GRCm39) missense probably benign 0.02
R0758:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0773:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0774:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0775:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1364:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1366:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1367:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1368:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1884:Prl3b1 UTSW 13 27,431,886 (GRCm39) missense possibly damaging 0.95
R1990:Prl3b1 UTSW 13 27,429,775 (GRCm39) missense possibly damaging 0.94
R1991:Prl3b1 UTSW 13 27,431,895 (GRCm39) missense possibly damaging 0.60
R2014:Prl3b1 UTSW 13 27,431,948 (GRCm39) missense probably benign 0.00
R2885:Prl3b1 UTSW 13 27,433,505 (GRCm39) missense probably damaging 1.00
R4259:Prl3b1 UTSW 13 27,427,889 (GRCm39) splice site probably null
R4580:Prl3b1 UTSW 13 27,433,450 (GRCm39) missense possibly damaging 0.93
R4913:Prl3b1 UTSW 13 27,433,460 (GRCm39) missense probably damaging 0.99
R5897:Prl3b1 UTSW 13 27,429,858 (GRCm39) missense probably benign 0.08
R6235:Prl3b1 UTSW 13 27,431,928 (GRCm39) missense probably damaging 1.00
R6366:Prl3b1 UTSW 13 27,427,875 (GRCm39) missense probably benign 0.00
R6597:Prl3b1 UTSW 13 27,431,957 (GRCm39) critical splice donor site probably null
R7179:Prl3b1 UTSW 13 27,427,827 (GRCm39) missense probably benign 0.05
R7312:Prl3b1 UTSW 13 27,426,473 (GRCm39) start codon destroyed probably null 1.00
X0026:Prl3b1 UTSW 13 27,431,906 (GRCm39) missense probably benign 0.21
Z1177:Prl3b1 UTSW 13 27,427,742 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- GGACAGACAGTATAGCCTCTACAGTGT -3'
(R):5'- AGGGTTTGATGATTGCTCCATTGGAA -3'

Sequencing Primer
(F):5'- CAGTATAGCCTCTACAGTGTCATTTG -3'
(R):5'- ggaggaggtgagaggtgg -3'
Posted On 2014-04-13