Mutagenetix > Incidental Mutation

Incidental Mutation 'R1533:Fpr3'

166780

Institutional Source

Beutler Lab

Gene Symbol

Fpr3

Ensembl Gene

ENSMUSG00000079700

Gene Name

formyl peptide receptor 3

Synonyms

Fprl1, LXA4-R, Lxa4r, Fpr-rs1

MMRRC Submission

039572-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1533 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

18190720-18191939 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 18190922 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 64 (Y64*)

Ref Sequence

ENSEMBL: ENSMUSP00000111227 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054871] [ENSMUST00000115565]

AlphaFold

O08790

Predicted Effect

probably null
Transcript: ENSMUST00000054871
AA Change: Y64*

SMART Domains

Protein: ENSMUSP00000093316
Gene: ENSMUSG00000079700
AA Change: Y64*

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	302	2.2e-43	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000115565
AA Change: Y64*

SMART Domains

Protein: ENSMUSP00000111227
Gene: ENSMUSG00000079700
AA Change: Y64*

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	302	1.5e-36	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.4%
20x: 92.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	G	C	3: 121,928,807 (GRCm39)	G1340A	probably benign	Het
Ambra1	T	A	2: 91,717,210 (GRCm39)	Y836N	probably damaging	Het
Arhgap26	A	T	18: 39,504,130 (GRCm39)	H144L	probably benign	Het
B3gnt5	A	G	16: 19,588,364 (GRCm39)	I194M	probably damaging	Het
Bltp1	G	T	3: 37,095,524 (GRCm39)	G4509V	probably damaging	Het
Bod1l	A	T	5: 41,979,498 (GRCm39)	C605*	probably null	Het
C2cd3	G	T	7: 100,055,284 (GRCm39)	K482N	possibly damaging	Het
Cd300lg	T	A	11: 101,934,047 (GRCm39)	L98Q	probably damaging	Het
Cerkl	T	A	2: 79,171,701 (GRCm39)	I386F	possibly damaging	Het
Cfh	T	A	1: 140,028,716 (GRCm39)	D466V	possibly damaging	Het
Crtc1	A	T	8: 70,850,949 (GRCm39)	I221N	probably damaging	Het
Ctnnbl1	T	C	2: 157,678,563 (GRCm39)	S389P	probably benign	Het
Ctsb	A	T	14: 63,376,544 (GRCm39)	D258V	probably damaging	Het
Cuzd1	G	T	7: 130,913,432 (GRCm39)	T395N	probably damaging	Het
Dnah6	T	C	6: 73,128,536 (GRCm39)	T1240A	probably benign	Het
Dok7	T	A	5: 35,221,671 (GRCm39)		probably null	Het
Dscaml1	T	C	9: 45,361,882 (GRCm39)	V214A	probably damaging	Het
Enpp6	A	T	8: 47,518,469 (GRCm39)	Y199F	probably benign	Het
Entpd5	C	A	12: 84,441,434 (GRCm39)	K111N	probably damaging	Het
Fam98a	A	G	17: 75,848,276 (GRCm39)	L146S	probably damaging	Het
Fhod3	A	T	18: 25,248,921 (GRCm39)	I1367F	probably damaging	Het
Fmnl2	A	G	2: 52,995,549 (GRCm39)	E424G	probably damaging	Het
Fzd6	A	T	15: 38,895,019 (GRCm39)	H395L	probably damaging	Het
Gcsh	T	A	8: 117,715,921 (GRCm39)	H54L	probably damaging	Het
Gsdma	T	A	11: 98,567,210 (GRCm39)	S437T	unknown	Het
Gzmc	A	G	14: 56,471,376 (GRCm39)	V55A	probably damaging	Het
Hecw2	T	A	1: 53,965,704 (GRCm39)		probably null	Het
Ifi207	A	G	1: 173,555,306 (GRCm39)	V792A	probably benign	Het
Itpr3	C	A	17: 27,314,534 (GRCm39)	N661K	possibly damaging	Het
Jmy	A	T	13: 93,577,819 (GRCm39)	I783N	probably benign	Het
Kcmf1	T	C	6: 72,820,003 (GRCm39)	E281G	possibly damaging	Het
Klra3	G	C	6: 130,310,107 (GRCm39)	R138G	probably benign	Het
Lgr6	T	A	1: 135,032,670 (GRCm39)	Y70F	possibly damaging	Het
Lnx1	T	G	5: 74,780,678 (GRCm39)	D330A	probably damaging	Het
Lrp5	T	C	19: 3,664,234 (GRCm39)	N106S	probably benign	Het
Mamdc4	C	A	2: 25,459,759 (GRCm39)	R135L	possibly damaging	Het
Mcm3ap	A	G	10: 76,340,121 (GRCm39)	E1464G	probably damaging	Het
Megf8	T	C	7: 25,034,280 (GRCm39)	V666A	possibly damaging	Het
Mettl3	T	A	14: 52,534,385 (GRCm39)	E331D	probably benign	Het
Mphosph9	T	C	5: 124,405,204 (GRCm39)	K789R	probably damaging	Het
Mtf2	T	C	5: 108,239,995 (GRCm39)	L234P	probably damaging	Het
Ncdn	C	A	4: 126,642,491 (GRCm39)	E389*	probably null	Het
Ndor1	A	G	2: 25,139,279 (GRCm39)	S231P	probably damaging	Het
Nelfa	T	G	5: 34,056,215 (GRCm39)	K483Q	probably damaging	Het
Odad1	T	A	7: 45,592,282 (GRCm39)	M354K	probably benign	Het
Opn1sw	C	T	6: 29,378,923 (GRCm39)	R243Q	probably benign	Het
Or13a24	T	A	7: 140,155,034 (GRCm39)		probably null	Het
Or9e1	A	G	11: 58,732,792 (GRCm39)	N284S	probably damaging	Het
Pik3cd	T	C	4: 149,739,653 (GRCm39)	E584G	probably damaging	Het
Plcb3	A	T	19: 6,935,041 (GRCm39)	M870K	possibly damaging	Het
Poc5	A	G	13: 96,528,152 (GRCm39)	D16G	probably damaging	Het
Prpf40a	A	G	2: 53,035,852 (GRCm39)	I633T	probably damaging	Het
Ptpn13	G	T	5: 103,704,044 (GRCm39)	E1359*	probably null	Het
Ptprr	C	A	10: 116,024,113 (GRCm39)	Y4*	probably null	Het
Rbm45	T	C	2: 76,202,503 (GRCm39)		probably null	Het
Rfng	C	T	11: 120,672,687 (GRCm39)	W320*	probably null	Het
Rgs6	G	T	12: 83,138,547 (GRCm39)	V294L	probably benign	Het
Rufy4	T	C	1: 74,169,002 (GRCm39)		probably null	Het
Ruvbl2	T	A	7: 45,073,566 (GRCm39)	N313I	probably damaging	Het
Sema4g	G	A	19: 44,981,256 (GRCm39)	V70M	probably damaging	Het
Siglec1	T	C	2: 130,918,078 (GRCm39)	T969A	probably benign	Het
Slc22a27	T	A	19: 7,844,348 (GRCm39)	T431S	possibly damaging	Het
Slc25a16	G	A	10: 62,756,643 (GRCm39)	R38H	probably damaging	Het
Slc38a6	T	C	12: 73,391,626 (GRCm39)	V296A	probably benign	Het
Slc39a11	C	T	11: 113,196,748 (GRCm39)	V212I	probably damaging	Het
Sltm	A	G	9: 70,493,948 (GRCm39)	K782E	probably damaging	Het
Styxl1	T	A	5: 135,799,175 (GRCm39)	Y23F	probably damaging	Het
Svs4	T	C	2: 164,120,148 (GRCm39)	I20V	unknown	Het
Syt14	G	T	1: 192,613,084 (GRCm39)	T572K	possibly damaging	Het
Tbc1d5	A	T	17: 51,227,603 (GRCm39)	I214N	possibly damaging	Het
Tm9sf3	A	G	19: 41,227,223 (GRCm39)	S283P	probably benign	Het
Tmtc1	C	T	6: 148,147,208 (GRCm39)		probably null	Het
Ttll7	T	A	3: 146,602,422 (GRCm39)	N73K	probably damaging	Het
Ttn	T	A	2: 76,602,802 (GRCm39)	K18473N	probably damaging	Het
Ubr2	A	C	17: 47,278,173 (GRCm39)	Y721*	probably null	Het
Vmn1r14	T	A	6: 57,211,286 (GRCm39)	I288N	probably damaging	Het
Vmn2r103	T	C	17: 19,993,662 (GRCm39)	I13T	probably benign	Het
Vps13a	A	T	19: 16,678,494 (GRCm39)	Y1162*	probably null	Het
Vps51	C	A	19: 6,121,497 (GRCm39)	R175L	probably benign	Het
Zfp523	C	A	17: 28,423,473 (GRCm39)	S149R	probably benign	Het
Zik1	A	G	7: 10,224,053 (GRCm39)	I348T	possibly damaging	Het
Znfx1	T	A	2: 166,898,708 (GRCm39)	H72L	probably benign	Het

Other mutations in Fpr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01067:Fpr3	APN	17	18,190,828 (GRCm39)	missense	probably benign	0.17
IGL01520:Fpr3	APN	17	18,191,325 (GRCm39)	missense	possibly damaging	0.69
IGL02166:Fpr3	APN	17	18,190,726 (GRCm39)	utr 5 prime	probably benign
IGL02380:Fpr3	APN	17	18,191,254 (GRCm39)	missense	probably benign	0.00
IGL02587:Fpr3	APN	17	18,190,953 (GRCm39)	missense	probably benign	0.12
R1521:Fpr3	UTSW	17	18,191,277 (GRCm39)	missense	probably damaging	1.00
R1913:Fpr3	UTSW	17	18,191,670 (GRCm39)	missense	probably damaging	0.96
R2099:Fpr3	UTSW	17	18,191,443 (GRCm39)	missense	probably damaging	1.00
R2140:Fpr3	UTSW	17	18,190,879 (GRCm39)	missense	probably damaging	1.00
R2206:Fpr3	UTSW	17	18,190,908 (GRCm39)	missense	probably damaging	1.00
R2219:Fpr3	UTSW	17	18,191,644 (GRCm39)	missense	possibly damaging	0.93
R2224:Fpr3	UTSW	17	18,191,455 (GRCm39)	missense	probably damaging	1.00
R2244:Fpr3	UTSW	17	18,191,449 (GRCm39)	missense	probably benign	0.03
R2994:Fpr3	UTSW	17	18,191,130 (GRCm39)	nonsense	probably null
R5364:Fpr3	UTSW	17	18,190,806 (GRCm39)	missense	probably benign	0.00
R6179:Fpr3	UTSW	17	18,190,919 (GRCm39)	nonsense	probably null
R6781:Fpr3	UTSW	17	18,190,978 (GRCm39)	missense	probably benign	0.09
R6909:Fpr3	UTSW	17	18,191,429 (GRCm39)	missense	probably benign	0.00
R7565:Fpr3	UTSW	17	18,191,227 (GRCm39)	missense	probably damaging	1.00
R8008:Fpr3	UTSW	17	18,191,715 (GRCm39)	missense	probably benign	0.03
R8097:Fpr3	UTSW	17	18,191,054 (GRCm39)	missense	probably damaging	1.00
R8351:Fpr3	UTSW	17	18,191,436 (GRCm39)	missense	probably benign	0.27
R8732:Fpr3	UTSW	17	18,191,223 (GRCm39)	missense	possibly damaging	0.94
R8994:Fpr3	UTSW	17	18,191,341 (GRCm39)	missense	possibly damaging	0.92
R9076:Fpr3	UTSW	17	18,191,725 (GRCm39)	missense	probably benign
R9206:Fpr3	UTSW	17	18,191,131 (GRCm39)	missense	probably damaging	1.00
R9208:Fpr3	UTSW	17	18,191,131 (GRCm39)	missense	probably damaging	1.00
R9327:Fpr3	UTSW	17	18,191,713 (GRCm39)	missense	probably damaging	1.00
R9553:Fpr3	UTSW	17	18,191,612 (GRCm39)	missense	probably damaging	1.00
X0021:Fpr3	UTSW	17	18,191,500 (GRCm39)	missense	probably benign	0.06
Z1176:Fpr3	UTSW	17	18,191,255 (GRCm39)	missense	possibly damaging	0.55

Predicted Primers

PCR Primer
(F):5'- TTTTCCTCTGGCAGTGAACAGTCC -3'
(R):5'- GTCCAAGGCAATGACAGCAATCAAG -3'

Sequencing Primer
(F):5'- TTTCAGGTGCAGTCAAAATGG -3'
(R):5'- AGAAGACACTTCCAAATAGGTTTAC -3'

Posted On

2014-04-13