Mutagenetix > Incidental Mutation

Incidental Mutation 'R1533:Vmn2r103'

166781

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

MMRRC Submission

039572-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R1533 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

19993625-20032798 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 19993662 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 13 (I13T)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably benign
Transcript: ENSMUST00000172203
AA Change: I13T

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: I13T

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.4%
20x: 92.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	G	C	3: 121,928,807 (GRCm39)	G1340A	probably benign	Het
Ambra1	T	A	2: 91,717,210 (GRCm39)	Y836N	probably damaging	Het
Arhgap26	A	T	18: 39,504,130 (GRCm39)	H144L	probably benign	Het
B3gnt5	A	G	16: 19,588,364 (GRCm39)	I194M	probably damaging	Het
Bltp1	G	T	3: 37,095,524 (GRCm39)	G4509V	probably damaging	Het
Bod1l	A	T	5: 41,979,498 (GRCm39)	C605*	probably null	Het
C2cd3	G	T	7: 100,055,284 (GRCm39)	K482N	possibly damaging	Het
Cd300lg	T	A	11: 101,934,047 (GRCm39)	L98Q	probably damaging	Het
Cerkl	T	A	2: 79,171,701 (GRCm39)	I386F	possibly damaging	Het
Cfh	T	A	1: 140,028,716 (GRCm39)	D466V	possibly damaging	Het
Crtc1	A	T	8: 70,850,949 (GRCm39)	I221N	probably damaging	Het
Ctnnbl1	T	C	2: 157,678,563 (GRCm39)	S389P	probably benign	Het
Ctsb	A	T	14: 63,376,544 (GRCm39)	D258V	probably damaging	Het
Cuzd1	G	T	7: 130,913,432 (GRCm39)	T395N	probably damaging	Het
Dnah6	T	C	6: 73,128,536 (GRCm39)	T1240A	probably benign	Het
Dok7	T	A	5: 35,221,671 (GRCm39)		probably null	Het
Dscaml1	T	C	9: 45,361,882 (GRCm39)	V214A	probably damaging	Het
Enpp6	A	T	8: 47,518,469 (GRCm39)	Y199F	probably benign	Het
Entpd5	C	A	12: 84,441,434 (GRCm39)	K111N	probably damaging	Het
Fam98a	A	G	17: 75,848,276 (GRCm39)	L146S	probably damaging	Het
Fhod3	A	T	18: 25,248,921 (GRCm39)	I1367F	probably damaging	Het
Fmnl2	A	G	2: 52,995,549 (GRCm39)	E424G	probably damaging	Het
Fpr3	T	A	17: 18,190,922 (GRCm39)	Y64*	probably null	Het
Fzd6	A	T	15: 38,895,019 (GRCm39)	H395L	probably damaging	Het
Gcsh	T	A	8: 117,715,921 (GRCm39)	H54L	probably damaging	Het
Gsdma	T	A	11: 98,567,210 (GRCm39)	S437T	unknown	Het
Gzmc	A	G	14: 56,471,376 (GRCm39)	V55A	probably damaging	Het
Hecw2	T	A	1: 53,965,704 (GRCm39)		probably null	Het
Ifi207	A	G	1: 173,555,306 (GRCm39)	V792A	probably benign	Het
Itpr3	C	A	17: 27,314,534 (GRCm39)	N661K	possibly damaging	Het
Jmy	A	T	13: 93,577,819 (GRCm39)	I783N	probably benign	Het
Kcmf1	T	C	6: 72,820,003 (GRCm39)	E281G	possibly damaging	Het
Klra3	G	C	6: 130,310,107 (GRCm39)	R138G	probably benign	Het
Lgr6	T	A	1: 135,032,670 (GRCm39)	Y70F	possibly damaging	Het
Lnx1	T	G	5: 74,780,678 (GRCm39)	D330A	probably damaging	Het
Lrp5	T	C	19: 3,664,234 (GRCm39)	N106S	probably benign	Het
Mamdc4	C	A	2: 25,459,759 (GRCm39)	R135L	possibly damaging	Het
Mcm3ap	A	G	10: 76,340,121 (GRCm39)	E1464G	probably damaging	Het
Megf8	T	C	7: 25,034,280 (GRCm39)	V666A	possibly damaging	Het
Mettl3	T	A	14: 52,534,385 (GRCm39)	E331D	probably benign	Het
Mphosph9	T	C	5: 124,405,204 (GRCm39)	K789R	probably damaging	Het
Mtf2	T	C	5: 108,239,995 (GRCm39)	L234P	probably damaging	Het
Ncdn	C	A	4: 126,642,491 (GRCm39)	E389*	probably null	Het
Ndor1	A	G	2: 25,139,279 (GRCm39)	S231P	probably damaging	Het
Nelfa	T	G	5: 34,056,215 (GRCm39)	K483Q	probably damaging	Het
Odad1	T	A	7: 45,592,282 (GRCm39)	M354K	probably benign	Het
Opn1sw	C	T	6: 29,378,923 (GRCm39)	R243Q	probably benign	Het
Or13a24	T	A	7: 140,155,034 (GRCm39)		probably null	Het
Or9e1	A	G	11: 58,732,792 (GRCm39)	N284S	probably damaging	Het
Pik3cd	T	C	4: 149,739,653 (GRCm39)	E584G	probably damaging	Het
Plcb3	A	T	19: 6,935,041 (GRCm39)	M870K	possibly damaging	Het
Poc5	A	G	13: 96,528,152 (GRCm39)	D16G	probably damaging	Het
Prpf40a	A	G	2: 53,035,852 (GRCm39)	I633T	probably damaging	Het
Ptpn13	G	T	5: 103,704,044 (GRCm39)	E1359*	probably null	Het
Ptprr	C	A	10: 116,024,113 (GRCm39)	Y4*	probably null	Het
Rbm45	T	C	2: 76,202,503 (GRCm39)		probably null	Het
Rfng	C	T	11: 120,672,687 (GRCm39)	W320*	probably null	Het
Rgs6	G	T	12: 83,138,547 (GRCm39)	V294L	probably benign	Het
Rufy4	T	C	1: 74,169,002 (GRCm39)		probably null	Het
Ruvbl2	T	A	7: 45,073,566 (GRCm39)	N313I	probably damaging	Het
Sema4g	G	A	19: 44,981,256 (GRCm39)	V70M	probably damaging	Het
Siglec1	T	C	2: 130,918,078 (GRCm39)	T969A	probably benign	Het
Slc22a27	T	A	19: 7,844,348 (GRCm39)	T431S	possibly damaging	Het
Slc25a16	G	A	10: 62,756,643 (GRCm39)	R38H	probably damaging	Het
Slc38a6	T	C	12: 73,391,626 (GRCm39)	V296A	probably benign	Het
Slc39a11	C	T	11: 113,196,748 (GRCm39)	V212I	probably damaging	Het
Sltm	A	G	9: 70,493,948 (GRCm39)	K782E	probably damaging	Het
Styxl1	T	A	5: 135,799,175 (GRCm39)	Y23F	probably damaging	Het
Svs4	T	C	2: 164,120,148 (GRCm39)	I20V	unknown	Het
Syt14	G	T	1: 192,613,084 (GRCm39)	T572K	possibly damaging	Het
Tbc1d5	A	T	17: 51,227,603 (GRCm39)	I214N	possibly damaging	Het
Tm9sf3	A	G	19: 41,227,223 (GRCm39)	S283P	probably benign	Het
Tmtc1	C	T	6: 148,147,208 (GRCm39)		probably null	Het
Ttll7	T	A	3: 146,602,422 (GRCm39)	N73K	probably damaging	Het
Ttn	T	A	2: 76,602,802 (GRCm39)	K18473N	probably damaging	Het
Ubr2	A	C	17: 47,278,173 (GRCm39)	Y721*	probably null	Het
Vmn1r14	T	A	6: 57,211,286 (GRCm39)	I288N	probably damaging	Het
Vps13a	A	T	19: 16,678,494 (GRCm39)	Y1162*	probably null	Het
Vps51	C	A	19: 6,121,497 (GRCm39)	R175L	probably benign	Het
Zfp523	C	A	17: 28,423,473 (GRCm39)	S149R	probably benign	Het
Zik1	A	G	7: 10,224,053 (GRCm39)	I348T	possibly damaging	Het
Znfx1	T	A	2: 166,898,708 (GRCm39)	H72L	probably benign	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	20,013,364 (GRCm39)	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	20,015,227 (GRCm39)	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	20,013,259 (GRCm39)	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	20,013,229 (GRCm39)	missense	probably benign
IGL01404:Vmn2r103	APN	17	20,032,696 (GRCm39)	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	20,014,330 (GRCm39)	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	20,019,470 (GRCm39)	missense	probably benign
IGL02251:Vmn2r103	APN	17	20,014,231 (GRCm39)	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19,993,631 (GRCm39)	missense	probably benign
IGL02555:Vmn2r103	APN	17	20,031,873 (GRCm39)	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	20,014,389 (GRCm39)	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	20,014,218 (GRCm39)	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	20,032,510 (GRCm39)	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19,993,782 (GRCm39)	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	20,032,241 (GRCm39)	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	20,031,903 (GRCm39)	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	20,013,726 (GRCm39)	missense	probably benign	0.12
R0375:Vmn2r103	UTSW	17	20,013,121 (GRCm39)	missense	probably benign	0.06
R0755:Vmn2r103	UTSW	17	19,993,830 (GRCm39)	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	20,014,189 (GRCm39)	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	20,014,509 (GRCm39)	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	20,013,230 (GRCm39)	missense	probably benign
R1488:Vmn2r103	UTSW	17	20,013,922 (GRCm39)	missense	probably damaging	0.97
R1590:Vmn2r103	UTSW	17	20,014,496 (GRCm39)	missense	probably benign
R1928:Vmn2r103	UTSW	17	20,032,029 (GRCm39)	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	20,032,562 (GRCm39)	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	20,014,056 (GRCm39)	missense	probably benign
R2219:Vmn2r103	UTSW	17	20,013,909 (GRCm39)	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19,993,793 (GRCm39)	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	20,013,862 (GRCm39)	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	20,032,411 (GRCm39)	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	20,013,866 (GRCm39)	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	20,014,495 (GRCm39)	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	20,013,958 (GRCm39)	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	20,013,958 (GRCm39)	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	20,013,958 (GRCm39)	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	20,032,077 (GRCm39)	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	20,015,338 (GRCm39)	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	20,015,338 (GRCm39)	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	20,032,031 (GRCm39)	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19,993,773 (GRCm39)	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	20,013,296 (GRCm39)	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	20,013,296 (GRCm39)	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	20,032,433 (GRCm39)	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	20,013,904 (GRCm39)	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	20,013,251 (GRCm39)	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	20,015,201 (GRCm39)	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	20,032,715 (GRCm39)	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	20,014,478 (GRCm39)	nonsense	probably null
R6114:Vmn2r103	UTSW	17	20,032,587 (GRCm39)	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	20,032,406 (GRCm39)	missense	probably benign
R6292:Vmn2r103	UTSW	17	20,013,866 (GRCm39)	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	20,014,344 (GRCm39)	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	20,032,166 (GRCm39)	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	20,032,239 (GRCm39)	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19,993,773 (GRCm39)	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	20,013,739 (GRCm39)	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	20,032,314 (GRCm39)	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	20,014,476 (GRCm39)	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	20,013,385 (GRCm39)	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	20,019,511 (GRCm39)	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	20,013,759 (GRCm39)	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	20,032,058 (GRCm39)	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	20,032,205 (GRCm39)	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	20,032,646 (GRCm39)	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	20,032,158 (GRCm39)	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	20,031,921 (GRCm39)	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	20,014,027 (GRCm39)	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	20,019,525 (GRCm39)	nonsense	probably null
R9743:Vmn2r103	UTSW	17	20,032,475 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	20,015,309 (GRCm39)	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- CGAAATTCCCAATGGCATTCTCAATCC -3'
(R):5'- CAGACATTGTGGCATAACAAGAATGGC -3'

Sequencing Primer
(F):5'- AATGGCATTCTCAATCCCTTGG -3'
(R):5'- CTGCCTGAGTGAGGAAAATGTTC -3'

Posted On

2014-04-13