Incidental Mutation 'R1518:Or52n3'
ID 167189
Institutional Source Beutler Lab
Gene Symbol Or52n3
Ensembl Gene ENSMUSG00000073917
Gene Name olfactory receptor family 52 subfamily N member 3
Synonyms MOR34-7, Olfr665, GA_x6K02T2PBJ9-7509539-7510489
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R1518 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 104529916-104530866 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 104530515 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 200 (Y200*)
Ref Sequence ENSEMBL: ENSMUSP00000150229 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098165] [ENSMUST00000215761] [ENSMUST00000216257] [ENSMUST00000216971]
AlphaFold Q8VG79
Predicted Effect probably null
Transcript: ENSMUST00000098165
AA Change: Y200*
SMART Domains Protein: ENSMUSP00000095768
Gene: ENSMUSG00000073917
AA Change: Y200*

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 6.4e-105 PFAM
Pfam:7TM_GPCR_Srsx 37 310 1e-5 PFAM
Pfam:7tm_1 43 295 1.4e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215761
AA Change: Y200*
Predicted Effect probably null
Transcript: ENSMUST00000216257
AA Change: Y200*
Predicted Effect probably null
Transcript: ENSMUST00000216971
AA Change: Y200*
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg4 T A 9: 44,186,666 (GRCm39) M493L probably benign Het
Abtb2 G A 2: 103,539,629 (GRCm39) V665I probably benign Het
Adamtsl1 C G 4: 86,260,840 (GRCm39) S1017W probably damaging Het
Aebp1 A G 11: 5,821,469 (GRCm39) T623A possibly damaging Het
Alox5 A G 6: 116,390,741 (GRCm39) F470S probably damaging Het
Angpt2 T C 8: 18,755,855 (GRCm39) E204G probably benign Het
Apip A G 2: 102,919,838 (GRCm39) E138G probably damaging Het
Apob C T 12: 8,039,207 (GRCm39) T466M probably benign Het
Atp2b3 GACAACA GACA X: 72,588,729 (GRCm39) probably benign Het
Atxn7l3 A T 11: 102,185,340 (GRCm39) D56E probably benign Het
Cacna1s C T 1: 136,026,289 (GRCm39) A1092V probably damaging Het
Calr3 A G 8: 73,181,044 (GRCm39) F183L probably damaging Het
Cd300lb T A 11: 114,816,877 (GRCm39) D55V probably benign Het
Chid1 A C 7: 141,108,384 (GRCm39) V145G probably damaging Het
Chst15 T C 7: 131,871,855 (GRCm39) N142S probably damaging Het
Cnot4 C T 6: 35,028,389 (GRCm39) R409Q probably damaging Het
Cope T G 8: 70,765,411 (GRCm39) I287S possibly damaging Het
Cpd A T 11: 76,731,212 (GRCm39) probably null Het
Cux1 G T 5: 136,337,133 (GRCm39) T785K probably benign Het
Dennd2b A G 7: 109,156,562 (GRCm39) S63P probably damaging Het
Dthd1 T C 5: 62,979,383 (GRCm39) S348P probably damaging Het
Eno3 G T 11: 70,551,903 (GRCm39) E64* probably null Het
Entpd1 T A 19: 40,713,507 (GRCm39) Y184* probably null Het
Erv3 A T 2: 131,698,083 (GRCm39) M92K probably benign Het
Flg2 T A 3: 93,110,445 (GRCm39) H824Q unknown Het
Fndc9 G A 11: 46,128,930 (GRCm39) G150S probably benign Het
Gdap1 G A 1: 17,217,169 (GRCm39) V43I possibly damaging Het
Ifi213 C A 1: 173,417,229 (GRCm39) L394F probably damaging Het
Ift88 A G 14: 57,668,085 (GRCm39) T29A possibly damaging Het
Kdm4c A T 4: 74,252,063 (GRCm39) I437L probably benign Het
Kras T A 6: 145,177,977 (GRCm39) E98D probably benign Het
Lcorl C A 5: 45,891,543 (GRCm39) R353I possibly damaging Het
Lrrc4c A G 2: 97,460,921 (GRCm39) I516V probably benign Het
Lrrc51 T C 7: 101,564,803 (GRCm39) D85G probably damaging Het
Lypd6b G A 2: 49,837,504 (GRCm39) A159T probably damaging Het
Magel2 G A 7: 62,030,188 (GRCm39) V1031I unknown Het
Man1c1 A T 4: 134,308,100 (GRCm39) N338K probably benign Het
Mdn1 C A 4: 32,739,977 (GRCm39) Q3744K probably damaging Het
Micu3 G T 8: 40,788,893 (GRCm39) A135S possibly damaging Het
Muc4 T C 16: 32,569,167 (GRCm39) S76P possibly damaging Het
Nin T G 12: 70,061,547 (GRCm39) T2106P probably benign Het
Nlrp4e T C 7: 23,021,268 (GRCm39) I585T probably benign Het
Npy1r C T 8: 67,156,847 (GRCm39) A89V probably benign Het
Or11g27 T C 14: 50,771,622 (GRCm39) V251A probably damaging Het
Or4c115 G A 2: 88,927,944 (GRCm39) A109V probably benign Het
Or52ae7 T A 7: 103,119,249 (GRCm39) M1K probably null Het
Or5w13 A T 2: 87,523,872 (GRCm39) M118K probably damaging Het
Parp14 T G 16: 35,677,008 (GRCm39) T987P possibly damaging Het
Pde7b A T 10: 20,423,867 (GRCm39) V3E probably damaging Het
Pdlim7 G T 13: 55,656,107 (GRCm39) Y104* probably null Het
Pgm2l1 A G 7: 99,910,932 (GRCm39) K292R probably benign Het
Plec T C 15: 76,072,401 (GRCm39) E728G probably damaging Het
Plppr4 T C 3: 117,129,152 (GRCm39) Y105C probably damaging Het
Polr1c A T 17: 46,558,821 (GRCm39) N23K possibly damaging Het
Ppp5c A T 7: 16,743,861 (GRCm39) M191K probably damaging Het
Prkca T C 11: 107,869,142 (GRCm39) D57G probably damaging Het
Prkcb A G 7: 122,143,854 (GRCm39) probably null Het
Prl6a1 C A 13: 27,502,910 (GRCm39) Q169K possibly damaging Het
Prl6a1 A T 13: 27,502,911 (GRCm39) Q169L probably null Het
Psmd14 G A 2: 61,591,335 (GRCm39) R46H probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Ramp2 A G 11: 101,138,408 (GRCm39) T22A probably benign Het
Rbm19 AGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGA 5: 120,278,345 (GRCm39) probably benign Het
Rbm25 A T 12: 83,715,219 (GRCm39) E463D possibly damaging Het
Retnlb A G 16: 48,637,678 (GRCm39) I35V probably benign Het
Sestd1 A G 2: 77,071,976 (GRCm39) Y49H probably damaging Het
Setd2 T A 9: 110,431,306 (GRCm39) I2378N probably damaging Het
Slc26a1 A T 5: 108,819,740 (GRCm39) C486* probably null Het
Spef2 T A 15: 9,667,316 (GRCm39) I791F probably damaging Het
Sptb T C 12: 76,650,798 (GRCm39) T1726A possibly damaging Het
Stk38l T A 6: 146,673,129 (GRCm39) M296K probably benign Het
Taf5 T C 19: 47,070,285 (GRCm39) F624L probably damaging Het
Tmem30c G T 16: 57,086,855 (GRCm39) T316K probably damaging Het
Trpm2 A G 10: 77,778,839 (GRCm39) S376P possibly damaging Het
Vmn2r82 A T 10: 79,214,702 (GRCm39) L228F probably damaging Het
Zfp607b G A 7: 27,398,087 (GRCm39) C57Y possibly damaging Het
Zfp983 A G 17: 21,881,269 (GRCm39) H399R probably damaging Het
Zfp984 A T 4: 147,840,002 (GRCm39) M283K probably benign Het
Other mutations in Or52n3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Or52n3 APN 7 104,530,724 (GRCm39) missense probably benign 0.01
IGL01408:Or52n3 APN 7 104,530,037 (GRCm39) missense probably benign 0.02
IGL02022:Or52n3 APN 7 104,530,141 (GRCm39) missense probably damaging 1.00
R0349:Or52n3 UTSW 7 104,530,199 (GRCm39) missense possibly damaging 0.48
R0585:Or52n3 UTSW 7 104,530,706 (GRCm39) missense probably damaging 1.00
R1659:Or52n3 UTSW 7 104,530,387 (GRCm39) missense probably benign 0.00
R1727:Or52n3 UTSW 7 104,530,721 (GRCm39) missense probably benign 0.11
R1762:Or52n3 UTSW 7 104,530,447 (GRCm39) missense probably damaging 0.99
R4052:Or52n3 UTSW 7 104,530,810 (GRCm39) missense probably damaging 0.99
R4208:Or52n3 UTSW 7 104,530,810 (GRCm39) missense probably damaging 0.99
R5486:Or52n3 UTSW 7 104,530,168 (GRCm39) missense probably benign 0.02
R5513:Or52n3 UTSW 7 104,530,706 (GRCm39) missense probably damaging 1.00
R6148:Or52n3 UTSW 7 104,530,289 (GRCm39) missense possibly damaging 0.84
R6593:Or52n3 UTSW 7 104,530,640 (GRCm39) missense probably damaging 1.00
R7143:Or52n3 UTSW 7 104,530,393 (GRCm39) missense probably damaging 1.00
R7189:Or52n3 UTSW 7 104,530,348 (GRCm39) nonsense probably null
R7413:Or52n3 UTSW 7 104,530,057 (GRCm39) missense probably benign 0.07
R8690:Or52n3 UTSW 7 104,530,762 (GRCm39) missense probably damaging 1.00
R8819:Or52n3 UTSW 7 104,530,862 (GRCm39) missense possibly damaging 0.90
R8820:Or52n3 UTSW 7 104,530,862 (GRCm39) missense possibly damaging 0.90
R9430:Or52n3 UTSW 7 104,530,204 (GRCm39) missense possibly damaging 0.92
R9464:Or52n3 UTSW 7 104,530,050 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACCGGCCCATGTACTACTTTCTAGC -3'
(R):5'- GGGTATAGTGGTTCTCCCAAAGCG -3'

Sequencing Primer
(F):5'- AGCCATGTTGTCTGCTACAG -3'
(R):5'- TGGTTCTCCCAAAGCGATGAG -3'
Posted On 2014-04-13