Incidental Mutation 'R1519:Trip11'
| ID |
167314 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip11
|
| Ensembl Gene |
ENSMUSG00000021188 |
| Gene Name |
thyroid hormone receptor interactor 11 |
| Synonyms |
3110031G15Rik, TRIP230, 2610511G22Rik, GMAP-210, 6030460N08Rik |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1519 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
101800304-101879463 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 101852419 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 548
(D548E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000021605
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021605]
[ENSMUST00000176728]
[ENSMUST00000177183]
[ENSMUST00000177536]
|
| AlphaFold |
E9Q512 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000021605
AA Change: D548E
PolyPhen 2
Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000021605
Gene: ENSMUSG00000021188
AA Change: D548E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
54 |
130 |
N/A |
INTRINSIC |
|
coiled coil region
|
167 |
194 |
N/A |
INTRINSIC |
|
coiled coil region
|
218 |
702 |
N/A |
INTRINSIC |
|
coiled coil region
|
754 |
990 |
N/A |
INTRINSIC |
|
coiled coil region
|
1022 |
1051 |
N/A |
INTRINSIC |
|
coiled coil region
|
1196 |
1261 |
N/A |
INTRINSIC |
|
low complexity region
|
1310 |
1322 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1481 |
N/A |
INTRINSIC |
|
coiled coil region
|
1547 |
1657 |
N/A |
INTRINSIC |
|
coiled coil region
|
1681 |
1771 |
N/A |
INTRINSIC |
|
low complexity region
|
1934 |
1945 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176728
|
| SMART Domains |
Protein: ENSMUSP00000134992
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
Pfam:Orthopox_A5L
|
48 |
282 |
6.5e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177183
AA Change: D263E
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000134976
Gene: ENSMUSG00000021188
AA Change: D263E
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
33 |
158 |
N/A |
INTRINSIC |
|
coiled coil region
|
179 |
417 |
N/A |
INTRINSIC |
|
coiled coil region
|
469 |
705 |
N/A |
INTRINSIC |
|
coiled coil region
|
737 |
766 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
1025 |
1037 |
N/A |
INTRINSIC |
|
coiled coil region
|
1051 |
1196 |
N/A |
INTRINSIC |
|
coiled coil region
|
1262 |
1372 |
N/A |
INTRINSIC |
|
coiled coil region
|
1396 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1660 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177480
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177536
|
| SMART Domains |
Protein: ENSMUSP00000135669
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
53 |
129 |
N/A |
INTRINSIC |
|
coiled coil region
|
166 |
193 |
N/A |
INTRINSIC |
|
coiled coil region
|
217 |
517 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.4%
- 20x: 92.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(12) : Gene trapped(11) Chemically induced(1)
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017N19Rik |
C |
G |
10: 100,439,390 (GRCm39) |
P187R |
probably damaging |
Het |
| Abhd5 |
T |
C |
9: 122,208,079 (GRCm39) |
|
probably null |
Het |
| Acadvl |
A |
G |
11: 69,905,617 (GRCm39) |
|
probably null |
Het |
| Actn1 |
T |
C |
12: 80,251,852 (GRCm39) |
E75G |
probably damaging |
Het |
| Adam4 |
A |
T |
12: 81,467,651 (GRCm39) |
N323K |
possibly damaging |
Het |
| Anks6 |
G |
A |
4: 47,027,152 (GRCm39) |
R689W |
probably damaging |
Het |
| Anxa2 |
T |
C |
9: 69,392,523 (GRCm39) |
I124T |
probably damaging |
Het |
| Aph1c |
T |
C |
9: 66,740,547 (GRCm39) |
T10A |
probably benign |
Het |
| Arhgap40 |
T |
A |
2: 158,388,721 (GRCm39) |
W552R |
probably benign |
Het |
| Baz2b |
C |
T |
2: 59,778,598 (GRCm39) |
R754H |
possibly damaging |
Het |
| Blmh |
A |
G |
11: 76,857,607 (GRCm39) |
Y147C |
probably damaging |
Het |
| C1galt1 |
C |
T |
6: 7,866,402 (GRCm39) |
L83F |
probably damaging |
Het |
| Ccdc168 |
A |
G |
1: 44,096,130 (GRCm39) |
V1656A |
probably benign |
Het |
| Cdh23 |
A |
T |
10: 60,215,122 (GRCm39) |
Y1403N |
possibly damaging |
Het |
| Cic |
A |
T |
7: 24,993,235 (GRCm39) |
|
probably null |
Het |
| Coro1b |
T |
A |
19: 4,200,583 (GRCm39) |
V200D |
possibly damaging |
Het |
| Csl |
T |
A |
10: 99,593,817 (GRCm39) |
E416V |
probably damaging |
Het |
| Cyp3a25 |
A |
G |
5: 145,938,257 (GRCm39) |
|
probably null |
Het |
| Dennd2d |
T |
A |
3: 106,399,875 (GRCm39) |
F266Y |
probably damaging |
Het |
| Dnah10 |
A |
G |
5: 124,838,016 (GRCm39) |
E1072G |
probably damaging |
Het |
| Dnah6 |
T |
A |
6: 73,026,031 (GRCm39) |
K3435N |
probably damaging |
Het |
| Dnah9 |
G |
A |
11: 65,772,587 (GRCm39) |
A3715V |
probably damaging |
Het |
| Fam186a |
G |
A |
15: 99,845,536 (GRCm39) |
S236L |
unknown |
Het |
| Frs3 |
A |
G |
17: 48,013,903 (GRCm39) |
T199A |
probably benign |
Het |
| Fsd1 |
A |
G |
17: 56,300,870 (GRCm39) |
N243S |
probably benign |
Het |
| Gabra5 |
A |
C |
7: 57,058,641 (GRCm39) |
L369R |
probably benign |
Het |
| Gask1b |
A |
G |
3: 79,848,771 (GRCm39) |
N506D |
possibly damaging |
Het |
| Gins4 |
A |
G |
8: 23,724,792 (GRCm39) |
V54A |
probably benign |
Het |
| Gli1 |
T |
C |
10: 127,170,138 (GRCm39) |
E339G |
possibly damaging |
Het |
| Gm12185 |
A |
G |
11: 48,798,594 (GRCm39) |
V633A |
probably damaging |
Het |
| Gpr83 |
T |
A |
9: 14,779,493 (GRCm39) |
C182S |
probably null |
Het |
| Gspt1 |
A |
G |
16: 11,038,719 (GRCm39) |
V627A |
probably damaging |
Het |
| Heatr1 |
T |
C |
13: 12,427,040 (GRCm39) |
C722R |
probably benign |
Het |
| Jak1 |
C |
T |
4: 101,020,119 (GRCm39) |
R680Q |
probably damaging |
Het |
| Kif2c |
A |
G |
4: 117,027,137 (GRCm39) |
V287A |
probably damaging |
Het |
| Kmo |
C |
T |
1: 175,479,184 (GRCm39) |
P240L |
possibly damaging |
Het |
| Kmo |
A |
G |
1: 175,484,368 (GRCm39) |
E366G |
probably damaging |
Het |
| Lepr |
A |
T |
4: 101,646,541 (GRCm39) |
N824I |
probably damaging |
Het |
| Lyrm7 |
T |
A |
11: 54,739,425 (GRCm39) |
H75L |
possibly damaging |
Het |
| Map4k1 |
A |
T |
7: 28,690,461 (GRCm39) |
Q351L |
probably benign |
Het |
| Matcap2 |
T |
G |
9: 22,341,671 (GRCm39) |
L114R |
probably benign |
Het |
| Mgam |
T |
C |
6: 40,638,617 (GRCm39) |
I450T |
probably benign |
Het |
| Nbeal2 |
A |
G |
9: 110,465,373 (GRCm39) |
L955P |
probably damaging |
Het |
| Nlrp9c |
T |
C |
7: 26,077,526 (GRCm39) |
K752R |
possibly damaging |
Het |
| Nsmaf |
A |
T |
4: 6,438,062 (GRCm39) |
I70K |
probably benign |
Het |
| Or14a257 |
A |
G |
7: 86,138,333 (GRCm39) |
M142T |
probably damaging |
Het |
| Or5ac19 |
C |
T |
16: 59,089,307 (GRCm39) |
C241Y |
probably damaging |
Het |
| Otud7a |
A |
G |
7: 63,408,391 (GRCm39) |
Y898C |
probably damaging |
Het |
| Pcdhb18 |
A |
C |
18: 37,623,945 (GRCm39) |
D425A |
probably damaging |
Het |
| Prdm1 |
A |
T |
10: 44,315,982 (GRCm39) |
L733* |
probably null |
Het |
| Prdm2 |
A |
T |
4: 142,862,153 (GRCm39) |
I379N |
probably damaging |
Het |
| Ptprg |
A |
T |
14: 12,220,596 (GRCm38) |
Y436F |
probably damaging |
Het |
| Riok3 |
A |
G |
18: 12,270,363 (GRCm39) |
D167G |
probably damaging |
Het |
| Rnf215 |
G |
T |
11: 4,085,451 (GRCm39) |
R60L |
probably damaging |
Het |
| Scart1 |
G |
A |
7: 139,808,069 (GRCm39) |
V747I |
probably benign |
Het |
| Sdk1 |
A |
T |
5: 141,985,705 (GRCm39) |
H779L |
probably benign |
Het |
| Serpine2 |
A |
G |
1: 79,772,748 (GRCm39) |
F390L |
probably damaging |
Het |
| Sh3d21 |
T |
A |
4: 126,045,519 (GRCm39) |
K387* |
probably null |
Het |
| Slc13a2 |
T |
C |
11: 78,288,572 (GRCm39) |
Y568C |
possibly damaging |
Het |
| Slc27a5 |
T |
C |
7: 12,722,386 (GRCm39) |
|
probably null |
Het |
| Slc32a1 |
T |
C |
2: 158,456,497 (GRCm39) |
L384P |
probably damaging |
Het |
| Sorcs1 |
T |
C |
19: 50,241,025 (GRCm39) |
N454D |
probably benign |
Het |
| Spag8 |
T |
C |
4: 43,652,777 (GRCm39) |
Y228C |
possibly damaging |
Het |
| Spata31e4 |
G |
A |
13: 50,854,443 (GRCm39) |
|
probably null |
Het |
| Spc25 |
T |
C |
2: 69,030,431 (GRCm39) |
I71V |
probably damaging |
Het |
| Tcte1 |
T |
A |
17: 45,846,178 (GRCm39) |
F261I |
probably damaging |
Het |
| Thsd7a |
T |
A |
6: 12,471,174 (GRCm39) |
K481N |
probably benign |
Het |
| Tll2 |
G |
T |
19: 41,074,839 (GRCm39) |
N908K |
probably benign |
Het |
| Tmem236 |
T |
C |
2: 14,197,091 (GRCm39) |
V93A |
probably benign |
Het |
| Top2b |
G |
A |
14: 16,408,953 (GRCm38) |
|
probably null |
Het |
| Topaz1 |
G |
A |
9: 122,596,076 (GRCm39) |
S949N |
probably benign |
Het |
| Triobp |
A |
G |
15: 78,857,938 (GRCm39) |
T1180A |
probably benign |
Het |
| Trpv2 |
T |
A |
11: 62,480,652 (GRCm39) |
|
probably null |
Het |
| Ulbp3 |
A |
G |
10: 3,075,230 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn1r12 |
T |
A |
6: 57,136,540 (GRCm39) |
H212Q |
probably damaging |
Het |
| Vmn2r112 |
A |
G |
17: 22,837,884 (GRCm39) |
T782A |
possibly damaging |
Het |
| Vmn2r7 |
A |
G |
3: 64,623,876 (GRCm39) |
V239A |
possibly damaging |
Het |
| Vmn2r80 |
T |
A |
10: 79,030,053 (GRCm39) |
N626K |
probably damaging |
Het |
| Vmn2r99 |
A |
G |
17: 19,600,322 (GRCm39) |
S449G |
probably benign |
Het |
| Wfikkn2 |
T |
C |
11: 94,128,933 (GRCm39) |
T403A |
probably benign |
Het |
| Xirp2 |
A |
G |
2: 67,346,023 (GRCm39) |
I2755V |
probably benign |
Het |
| Yjefn3 |
A |
G |
8: 70,341,729 (GRCm39) |
V153A |
probably benign |
Het |
| Zfp677 |
C |
A |
17: 21,617,499 (GRCm39) |
H185Q |
possibly damaging |
Het |
| Zfp947 |
C |
T |
17: 22,365,273 (GRCm39) |
V134I |
probably benign |
Het |
|
| Other mutations in Trip11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00430:Trip11
|
APN |
12 |
101,852,406 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00484:Trip11
|
APN |
12 |
101,851,570 (GRCm39) |
nonsense |
probably null |
|
|
IGL00972:Trip11
|
APN |
12 |
101,860,596 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01476:Trip11
|
APN |
12 |
101,865,170 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01591:Trip11
|
APN |
12 |
101,849,604 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01667:Trip11
|
APN |
12 |
101,845,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Trip11
|
APN |
12 |
101,850,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01789:Trip11
|
APN |
12 |
101,838,090 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01814:Trip11
|
APN |
12 |
101,850,747 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01898:Trip11
|
APN |
12 |
101,851,935 (GRCm39) |
missense |
probably benign |
|
|
IGL01924:Trip11
|
APN |
12 |
101,853,143 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02020:Trip11
|
APN |
12 |
101,850,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02475:Trip11
|
APN |
12 |
101,861,942 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02544:Trip11
|
APN |
12 |
101,859,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02678:Trip11
|
APN |
12 |
101,849,649 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02714:Trip11
|
APN |
12 |
101,850,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02718:Trip11
|
APN |
12 |
101,852,284 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02904:Trip11
|
APN |
12 |
101,853,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03012:Trip11
|
APN |
12 |
101,850,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03191:Trip11
|
APN |
12 |
101,865,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Trip11
|
APN |
12 |
101,849,677 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03337:Trip11
|
APN |
12 |
101,851,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
NA:Trip11
|
UTSW |
12 |
101,860,580 (GRCm39) |
splice site |
probably null |
|
|
R0027:Trip11
|
UTSW |
12 |
101,851,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0028:Trip11
|
UTSW |
12 |
101,851,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trip11
|
UTSW |
12 |
101,851,931 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0556:Trip11
|
UTSW |
12 |
101,850,777 (GRCm39) |
nonsense |
probably null |
|
|
R0573:Trip11
|
UTSW |
12 |
101,853,119 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0626:Trip11
|
UTSW |
12 |
101,852,235 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1530:Trip11
|
UTSW |
12 |
101,879,026 (GRCm39) |
missense |
unknown |
|
|
R1647:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1648:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1856:Trip11
|
UTSW |
12 |
101,849,592 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Trip11
|
UTSW |
12 |
101,803,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Trip11
|
UTSW |
12 |
101,851,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2206:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2207:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2304:Trip11
|
UTSW |
12 |
101,865,236 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R2328:Trip11
|
UTSW |
12 |
101,845,086 (GRCm39) |
makesense |
probably null |
|
|
R2513:Trip11
|
UTSW |
12 |
101,803,986 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3499:Trip11
|
UTSW |
12 |
101,859,953 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4105:Trip11
|
UTSW |
12 |
101,860,581 (GRCm39) |
nonsense |
probably null |
|
|
R4124:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4126:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4128:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4175:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4176:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4181:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4296:Trip11
|
UTSW |
12 |
101,852,127 (GRCm39) |
nonsense |
probably null |
|
|
R4302:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Trip11
|
UTSW |
12 |
101,853,198 (GRCm39) |
missense |
probably benign |
|
|
R4342:Trip11
|
UTSW |
12 |
101,850,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Trip11
|
UTSW |
12 |
101,852,499 (GRCm39) |
nonsense |
probably null |
|
|
R4586:Trip11
|
UTSW |
12 |
101,849,600 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4634:Trip11
|
UTSW |
12 |
101,803,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4696:Trip11
|
UTSW |
12 |
101,851,549 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4792:Trip11
|
UTSW |
12 |
101,851,705 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4903:Trip11
|
UTSW |
12 |
101,853,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5001:Trip11
|
UTSW |
12 |
101,851,169 (GRCm39) |
nonsense |
probably null |
|
|
R5017:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5227:Trip11
|
UTSW |
12 |
101,851,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5231:Trip11
|
UTSW |
12 |
101,851,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5539:Trip11
|
UTSW |
12 |
101,851,386 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5754:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5755:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5890:Trip11
|
UTSW |
12 |
101,852,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5910:Trip11
|
UTSW |
12 |
101,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6083:Trip11
|
UTSW |
12 |
101,856,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6208:Trip11
|
UTSW |
12 |
101,865,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6216:Trip11
|
UTSW |
12 |
101,856,859 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6315:Trip11
|
UTSW |
12 |
101,851,837 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6413:Trip11
|
UTSW |
12 |
101,851,790 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6590:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6690:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6914:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6938:Trip11
|
UTSW |
12 |
101,803,886 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Trip11
|
UTSW |
12 |
101,859,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Trip11
|
UTSW |
12 |
101,852,126 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7133:Trip11
|
UTSW |
12 |
101,850,329 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7271:Trip11
|
UTSW |
12 |
101,850,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7424:Trip11
|
UTSW |
12 |
101,851,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Trip11
|
UTSW |
12 |
101,850,278 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7472:Trip11
|
UTSW |
12 |
101,851,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7491:Trip11
|
UTSW |
12 |
101,851,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7752:Trip11
|
UTSW |
12 |
101,853,233 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7763:Trip11
|
UTSW |
12 |
101,811,114 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7779:Trip11
|
UTSW |
12 |
101,849,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7844:Trip11
|
UTSW |
12 |
101,844,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8055:Trip11
|
UTSW |
12 |
101,803,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8076:Trip11
|
UTSW |
12 |
101,849,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Trip11
|
UTSW |
12 |
101,860,643 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8294:Trip11
|
UTSW |
12 |
101,811,160 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8318:Trip11
|
UTSW |
12 |
101,879,063 (GRCm39) |
missense |
unknown |
|
|
R8690:Trip11
|
UTSW |
12 |
101,839,656 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8879:Trip11
|
UTSW |
12 |
101,828,857 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8964:Trip11
|
UTSW |
12 |
101,811,315 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9005:Trip11
|
UTSW |
12 |
101,845,131 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9013:Trip11
|
UTSW |
12 |
101,851,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9020:Trip11
|
UTSW |
12 |
101,850,770 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9041:Trip11
|
UTSW |
12 |
101,845,127 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9234:Trip11
|
UTSW |
12 |
101,811,990 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9447:Trip11
|
UTSW |
12 |
101,850,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9631:Trip11
|
UTSW |
12 |
101,859,807 (GRCm39) |
missense |
probably benign |
|
|
R9641:Trip11
|
UTSW |
12 |
101,859,957 (GRCm39) |
nonsense |
probably null |
|
|
R9691:Trip11
|
UTSW |
12 |
101,850,123 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Trip11
|
UTSW |
12 |
101,850,765 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
X0020:Trip11
|
UTSW |
12 |
101,852,172 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TAACTCACTCCTGACTGTGGACAGCTC -3'
(R):5'- GTTTGTTGAAGCCTGCTCTCACATTTG -3'
Sequencing Primer
(F):5'- GACTGTGGACAGCTCCTCTTC -3'
(R):5'- CAAAGTGAAGGAGATAGTGTCATC -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation