Incidental Mutation 'R1520:Cyp4a32'
ID 167352
Institutional Source Beutler Lab
Gene Symbol Cyp4a32
Ensembl Gene ENSMUSG00000063929
Gene Name cytochrome P450, family 4, subfamily a, polypeptide 32
Synonyms OTTMUSG00000008689
MMRRC Submission 039564-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R1520 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 115458166-115478799 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 115471849 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 420 (N420S)
Ref Sequence ENSEMBL: ENSMUSP00000081369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084342]
AlphaFold A2A8T1
Predicted Effect probably damaging
Transcript: ENSMUST00000084342
AA Change: N420S

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000081369
Gene: ENSMUSG00000063929
AA Change: N420S

DomainStartEndE-ValueType
transmembrane domain 15 32 N/A INTRINSIC
Pfam:p450 51 504 1.3e-133 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129918
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 A G 10: 79,844,664 (GRCm39) N1491S possibly damaging Het
Abcb1b G A 5: 8,864,768 (GRCm39) A249T probably damaging Het
Acacb A G 5: 114,340,001 (GRCm39) D804G possibly damaging Het
Agpat3 A T 10: 78,123,857 (GRCm39) M1K probably null Het
Akr1c12 A C 13: 4,326,298 (GRCm39) I61R probably damaging Het
Antxr2 G A 5: 98,108,551 (GRCm39) A320V probably benign Het
Aoc1l2 T A 6: 48,908,231 (GRCm39) Y410* probably null Het
Arhgef1 A G 7: 24,619,129 (GRCm39) R454G probably damaging Het
C1ql4 T C 15: 98,985,548 (GRCm39) H21R probably benign Het
Celsr3 T C 9: 108,725,857 (GRCm39) S3029P probably damaging Het
Chaf1a T C 17: 56,354,302 (GRCm39) C191R unknown Het
Corin A C 5: 72,488,238 (GRCm39) C627G probably damaging Het
Cyp3a11 T C 5: 145,799,263 (GRCm39) Y308C probably damaging Het
Eftud2 A G 11: 102,730,266 (GRCm39) S889P probably damaging Het
Eng A G 2: 32,562,953 (GRCm39) H267R probably benign Het
Ep400 A G 5: 110,839,644 (GRCm39) probably benign Het
Fmo9 G T 1: 166,495,024 (GRCm39) H292Q probably benign Het
Frmpd4 T C X: 166,275,949 (GRCm39) S373G probably damaging Het
Fsip2 T A 2: 82,811,058 (GRCm39) I2459K possibly damaging Het
Gbp5 A T 3: 142,213,775 (GRCm39) H523L probably damaging Het
Gpr65 T C 12: 98,241,434 (GRCm39) V29A probably benign Het
Igkv7-33 T A 6: 70,036,132 (GRCm39) probably benign Het
Iqcc G A 4: 129,510,762 (GRCm39) T251I possibly damaging Het
Jund A G 8: 71,151,923 (GRCm39) T73A probably benign Het
Kif14 A G 1: 136,431,062 (GRCm39) D1153G probably benign Het
Mcm8 T C 2: 132,681,375 (GRCm39) V617A probably benign Het
Mdga1 A G 17: 30,065,493 (GRCm39) F646L probably benign Het
Morc3 A G 16: 93,641,129 (GRCm39) K54E probably damaging Het
Mutyh T C 4: 116,674,749 (GRCm39) L357P probably damaging Het
Mylk4 T C 13: 32,896,821 (GRCm39) probably null Het
Or4k41 G A 2: 111,279,619 (GRCm39) V45I probably benign Het
Osbpl3 T A 6: 50,323,411 (GRCm39) D224V possibly damaging Het
Parp4 T C 14: 56,835,863 (GRCm39) I469T probably damaging Het
Pkd1l2 A G 8: 117,772,898 (GRCm39) V1043A probably benign Het
Plod3 A G 5: 137,020,165 (GRCm39) N460S probably damaging Het
Preb A G 5: 31,115,868 (GRCm39) F192L probably benign Het
Prkra T C 2: 76,469,622 (GRCm39) T146A possibly damaging Het
Pwwp4a G T X: 72,171,261 (GRCm39) G218C probably damaging Het
Rag2 T C 2: 101,460,476 (GRCm39) I262T probably damaging Het
Rgr A G 14: 36,766,672 (GRCm39) W125R probably damaging Het
Rit1 T A 3: 88,636,620 (GRCm39) F211I probably benign Het
Sc5d C T 9: 42,169,946 (GRCm39) V92I probably benign Het
Serinc2 C T 4: 130,154,543 (GRCm39) V234I probably benign Het
Srp54b T C 12: 55,304,354 (GRCm39) M434T possibly damaging Het
Srrt C A 5: 137,297,028 (GRCm39) R69L probably damaging Het
Sv2b A G 7: 74,807,077 (GRCm39) L191P probably damaging Het
Tcf12 C A 9: 71,790,388 (GRCm39) probably null Het
Tmem273 A T 14: 32,527,083 (GRCm39) probably benign Het
Tmem87b T C 2: 128,681,176 (GRCm39) probably null Het
Ttn T C 2: 76,647,392 (GRCm39) E11031G possibly damaging Het
Uaca A T 9: 60,778,663 (GRCm39) T1017S probably benign Het
Urb1 C A 16: 90,571,633 (GRCm39) V1059L probably benign Het
V1rd19 G A 7: 23,702,623 (GRCm39) A30T probably damaging Het
Vldlr C T 19: 27,217,943 (GRCm39) L91F probably damaging Het
Vldlr G T 19: 27,224,466 (GRCm39) A770S possibly damaging Het
Vmn2r80 A G 10: 79,030,594 (GRCm39) T807A probably damaging Het
Wwox C T 8: 115,438,873 (GRCm39) P313L probably benign Het
Zap70 T C 1: 36,810,036 (GRCm39) S49P probably damaging Het
Zfp317 A G 9: 19,559,144 (GRCm39) I453V possibly damaging Het
Other mutations in Cyp4a32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02225:Cyp4a32 APN 4 115,467,700 (GRCm39) missense probably benign
IGL02546:Cyp4a32 APN 4 115,468,520 (GRCm39) missense probably damaging 0.98
IGL02578:Cyp4a32 APN 4 115,466,939 (GRCm39) missense possibly damaging 0.79
IGL02663:Cyp4a32 APN 4 115,467,787 (GRCm39) missense probably damaging 1.00
IGL02832:Cyp4a32 APN 4 115,471,818 (GRCm39) missense probably damaging 0.99
IGL03283:Cyp4a32 APN 4 115,468,280 (GRCm39) missense possibly damaging 0.79
IGL03357:Cyp4a32 APN 4 115,468,798 (GRCm39) missense probably benign 0.00
IGL03406:Cyp4a32 APN 4 115,459,500 (GRCm39) missense probably benign 0.00
R0379:Cyp4a32 UTSW 4 115,478,671 (GRCm39) missense probably damaging 1.00
R1339:Cyp4a32 UTSW 4 115,468,760 (GRCm39) missense probably damaging 0.98
R1435:Cyp4a32 UTSW 4 115,463,863 (GRCm39) missense probably damaging 0.97
R1445:Cyp4a32 UTSW 4 115,460,147 (GRCm39) nonsense probably null
R1587:Cyp4a32 UTSW 4 115,467,731 (GRCm39) missense probably benign 0.06
R1719:Cyp4a32 UTSW 4 115,468,505 (GRCm39) missense possibly damaging 0.61
R1932:Cyp4a32 UTSW 4 115,468,474 (GRCm39) missense possibly damaging 0.78
R4184:Cyp4a32 UTSW 4 115,478,720 (GRCm39) missense possibly damaging 0.94
R4580:Cyp4a32 UTSW 4 115,460,126 (GRCm39) splice site silent
R5004:Cyp4a32 UTSW 4 115,458,238 (GRCm39) missense probably damaging 0.98
R6345:Cyp4a32 UTSW 4 115,459,560 (GRCm39) missense possibly damaging 0.81
R7231:Cyp4a32 UTSW 4 115,466,894 (GRCm39) missense probably damaging 1.00
R7241:Cyp4a32 UTSW 4 115,459,499 (GRCm39) missense probably benign
R7419:Cyp4a32 UTSW 4 115,468,234 (GRCm39) missense probably benign
R7716:Cyp4a32 UTSW 4 115,458,283 (GRCm39) missense probably damaging 1.00
R8921:Cyp4a32 UTSW 4 115,468,460 (GRCm39) missense probably damaging 0.99
R9009:Cyp4a32 UTSW 4 115,467,802 (GRCm39) missense probably null 1.00
R9266:Cyp4a32 UTSW 4 115,468,307 (GRCm39) missense probably damaging 1.00
R9330:Cyp4a32 UTSW 4 115,478,635 (GRCm39) missense probably damaging 1.00
R9345:Cyp4a32 UTSW 4 115,467,699 (GRCm39) missense probably benign
R9442:Cyp4a32 UTSW 4 115,468,422 (GRCm39) missense probably benign 0.21
Z1177:Cyp4a32 UTSW 4 115,468,542 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TGCAGAAAGTGATGTTCTATAGCACCC -3'
(R):5'- TCATACACAGGATCTCACCTGGCTC -3'

Sequencing Primer
(F):5'- GTTCTATAGCACCCAAGTATCTTGTG -3'
(R):5'- AGTCTGGTGCAAACCTGG -3'
Posted On 2014-04-13