Incidental Mutation 'R1526:Or2y3'
ID 167474
Institutional Source Beutler Lab
Gene Symbol Or2y3
Ensembl Gene ENSMUSG00000043312
Gene Name olfactory receptor family 2 subfamily Y member 3
Synonyms GA_x6K02T2PSCP-2531299-2530355, MOR256-4, Olfr131
MMRRC Submission 039566-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R1526 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 38392923-38393867 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38393486 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 128 (I128F)
Ref Sequence ENSEMBL: ENSMUSP00000150562 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059560] [ENSMUST00000172933] [ENSMUST00000215940] [ENSMUST00000216523]
AlphaFold Q8VGC8
Predicted Effect probably damaging
Transcript: ENSMUST00000059560
AA Change: I128F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000061861
Gene: ENSMUSG00000043312
AA Change: I128F

DomainStartEndE-ValueType
Pfam:7tm_1 43 294 4e-35 PFAM
Pfam:7tm_4 141 287 2.7e-40 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000172933
AA Change: I128F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000134532
Gene: ENSMUSG00000043312
AA Change: I128F

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 9.5e-57 PFAM
Pfam:7tm_1 43 294 1.2e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173218
Predicted Effect probably damaging
Transcript: ENSMUST00000215940
AA Change: I128F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000216523
AA Change: I128F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asap2 G T 12: 21,235,188 (GRCm39) A97S probably damaging Het
Brd10 T C 19: 29,712,545 (GRCm39) K785E probably damaging Het
C1qtnf1 A T 11: 118,334,616 (GRCm39) E32V possibly damaging Het
Ccdc81 A G 7: 89,525,081 (GRCm39) L500P probably damaging Het
Cdo1 T C 18: 46,861,130 (GRCm39) E27G probably benign Het
Ceacam5 G A 7: 17,484,620 (GRCm39) G454D probably damaging Het
Cemip T C 7: 83,600,648 (GRCm39) D991G probably damaging Het
Cep170 A C 1: 176,616,071 (GRCm39) I79S probably damaging Het
Cep19 A G 16: 31,926,039 (GRCm39) Q149R possibly damaging Het
Cideb A T 14: 55,992,619 (GRCm39) L99* probably null Het
Cntnap5a A G 1: 116,356,207 (GRCm39) N746S probably benign Het
Col12a1 T C 9: 79,564,080 (GRCm39) N1715S probably benign Het
Col3a1 T C 1: 45,360,848 (GRCm39) S93P unknown Het
Csmd3 C A 15: 47,449,028 (GRCm39) probably null Het
Disp3 T C 4: 148,344,373 (GRCm39) I510V probably benign Het
Drosha T A 15: 12,914,070 (GRCm39) V1115E probably damaging Het
Dzip3 A C 16: 48,757,369 (GRCm39) L888R probably damaging Het
Emx2 C A 19: 59,452,442 (GRCm39) A242E probably benign Het
Fto G A 8: 92,168,314 (GRCm39) E256K possibly damaging Het
Gabrb2 A C 11: 42,482,715 (GRCm39) Y191S possibly damaging Het
Gm6526 A T 14: 43,987,394 (GRCm39) H110L probably damaging Het
Grin3b T A 10: 79,810,436 (GRCm39) N647K probably damaging Het
Ifit2 T G 19: 34,550,602 (GRCm39) S47R probably benign Het
Il5ra A T 6: 106,712,781 (GRCm39) V244E possibly damaging Het
Inppl1 A G 7: 101,482,153 (GRCm39) L141P probably benign Het
Iws1 A G 18: 32,213,178 (GRCm39) D202G probably benign Het
Kctd4 A C 14: 76,200,523 (GRCm39) I165L probably benign Het
Lrch3 G A 16: 32,770,746 (GRCm39) C116Y probably damaging Het
Mettl25 T C 10: 105,668,844 (GRCm39) T93A possibly damaging Het
Mgat4d A G 8: 84,095,666 (GRCm39) I314V probably benign Het
Mrgprb4 A T 7: 47,848,159 (GRCm39) Y256* probably null Het
Myo9b G T 8: 71,808,408 (GRCm39) V1672L probably damaging Het
Nek1 C T 8: 61,502,975 (GRCm39) P449L probably benign Het
Nucb2 G A 7: 116,123,642 (GRCm39) probably null Het
Obscn T C 11: 58,919,412 (GRCm39) Y6864C probably damaging Het
Omt2b A T 9: 78,235,420 (GRCm39) probably benign Het
Or4p18 C T 2: 88,232,777 (GRCm39) C167Y probably damaging Het
Or5ac15 G A 16: 58,940,293 (GRCm39) L47F probably damaging Het
Or6c208 A G 10: 129,224,176 (GRCm39) K225E probably benign Het
Otogl G T 10: 107,705,387 (GRCm39) P647T probably damaging Het
Oxnad1 A G 14: 31,824,244 (GRCm39) D271G probably benign Het
Pbx3 T C 2: 34,261,776 (GRCm39) I53V probably damaging Het
Pds5b T A 5: 150,639,865 (GRCm39) probably null Het
Ppp4r3a A T 12: 101,007,000 (GRCm39) D810E probably damaging Het
Ptpro A T 6: 137,438,724 (GRCm39) D1189V probably damaging Het
Ryr3 T C 2: 112,492,002 (GRCm39) N3758S probably damaging Het
Scarb2 G A 5: 92,594,200 (GRCm39) T454M possibly damaging Het
Sec23a A C 12: 59,032,972 (GRCm39) probably null Het
Spire2 C T 8: 124,095,502 (GRCm39) A535V probably benign Het
Svopl A T 6: 38,006,570 (GRCm39) F142L probably benign Het
Tas2r144 T C 6: 42,192,674 (GRCm39) I138T probably benign Het
Tbc1d15 A G 10: 115,039,135 (GRCm39) M535T probably benign Het
Tnfaip1 C T 11: 78,420,971 (GRCm39) V30M possibly damaging Het
Topaz1 T A 9: 122,625,108 (GRCm39) W1398R probably damaging Het
Tpo A G 12: 30,134,694 (GRCm39) S755P probably damaging Het
Ttn G T 2: 76,606,460 (GRCm39) S18116R probably damaging Het
Vmn2r78 A G 7: 86,571,465 (GRCm39) probably null Het
Wdr49 T A 3: 75,304,227 (GRCm39) K494M probably benign Het
Yeats2 A G 16: 20,024,836 (GRCm39) M697V probably damaging Het
Zfp407 G A 18: 84,579,158 (GRCm39) P652S possibly damaging Het
Zfp462 A G 4: 55,009,002 (GRCm39) M323V probably benign Het
Zfp629 G T 7: 127,209,931 (GRCm39) P626Q possibly damaging Het
Zfp804a A T 2: 82,088,532 (GRCm39) Y787F probably benign Het
Other mutations in Or2y3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01063:Or2y3 APN 17 38,393,544 (GRCm39) missense possibly damaging 0.48
IGL01287:Or2y3 APN 17 38,392,998 (GRCm39) missense probably damaging 1.00
IGL01637:Or2y3 APN 17 38,392,994 (GRCm39) missense possibly damaging 0.90
IGL02833:Or2y3 APN 17 38,393,243 (GRCm39) missense possibly damaging 0.84
IGL02927:Or2y3 APN 17 38,393,114 (GRCm39) missense probably benign 0.00
R0662:Or2y3 UTSW 17 38,393,824 (GRCm39) missense probably benign 0.09
R0755:Or2y3 UTSW 17 38,393,085 (GRCm39) nonsense probably null
R2155:Or2y3 UTSW 17 38,393,071 (GRCm39) missense probably damaging 1.00
R3123:Or2y3 UTSW 17 38,392,903 (GRCm39) splice site probably null
R3125:Or2y3 UTSW 17 38,392,903 (GRCm39) splice site probably null
R4135:Or2y3 UTSW 17 38,393,248 (GRCm39) missense possibly damaging 0.52
R4244:Or2y3 UTSW 17 38,393,321 (GRCm39) missense probably benign 0.12
R5104:Or2y3 UTSW 17 38,393,174 (GRCm39) missense possibly damaging 0.47
R5182:Or2y3 UTSW 17 38,393,005 (GRCm39) missense probably benign 0.03
R5293:Or2y3 UTSW 17 38,393,131 (GRCm39) missense probably damaging 1.00
R5738:Or2y3 UTSW 17 38,393,347 (GRCm39) missense probably damaging 1.00
R5924:Or2y3 UTSW 17 38,393,254 (GRCm39) missense probably benign 0.01
R6218:Or2y3 UTSW 17 38,393,620 (GRCm39) missense probably damaging 0.98
R6362:Or2y3 UTSW 17 38,393,620 (GRCm39) missense probably damaging 0.99
R6961:Or2y3 UTSW 17 38,393,096 (GRCm39) missense probably damaging 0.99
R7838:Or2y3 UTSW 17 38,393,293 (GRCm39) missense probably benign 0.00
R8088:Or2y3 UTSW 17 38,393,452 (GRCm39) missense possibly damaging 0.78
R8730:Or2y3 UTSW 17 38,392,925 (GRCm39) makesense probably null
R9303:Or2y3 UTSW 17 38,393,629 (GRCm39) missense probably damaging 1.00
R9305:Or2y3 UTSW 17 38,393,629 (GRCm39) missense probably damaging 1.00
R9378:Or2y3 UTSW 17 38,393,056 (GRCm39) missense possibly damaging 0.92
R9776:Or2y3 UTSW 17 38,393,470 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GAACAGTGCCAAAAGCTTGCCC -3'
(R):5'- CCACGACTGGAAATGGCTCTTCTTG -3'

Sequencing Primer
(F):5'- TGCATATCCACTGATGGCAG -3'
(R):5'- AACCCTTTTGGGGAATTCAGC -3'
Posted On 2014-04-13