Incidental Mutation 'R1526:Brd10'
ID 167479
Institutional Source Beutler Lab
Gene Symbol Brd10
Ensembl Gene ENSMUSG00000046138
Gene Name bromodomain containing 10
Synonyms 9930021J03Rik, Gm9832
MMRRC Submission 039566-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.138) question?
Stock # R1526 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 29691802-29783389 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 29712545 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 785 (K785E)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177155]
AlphaFold H3BKP8
Predicted Effect probably damaging
Transcript: ENSMUST00000059484
AA Change: K785E

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000054060
Gene: ENSMUSG00000046138
AA Change: K785E

DomainStartEndE-ValueType
low complexity region 4 66 N/A INTRINSIC
BROMO 75 198 1.22e-3 SMART
low complexity region 225 235 N/A INTRINSIC
coiled coil region 248 289 N/A INTRINSIC
low complexity region 347 365 N/A INTRINSIC
low complexity region 495 508 N/A INTRINSIC
coiled coil region 673 705 N/A INTRINSIC
low complexity region 722 756 N/A INTRINSIC
coiled coil region 764 796 N/A INTRINSIC
low complexity region 1146 1160 N/A INTRINSIC
internal_repeat_1 1164 1293 9.57e-8 PROSPERO
low complexity region 1295 1304 N/A INTRINSIC
low complexity region 1386 1415 N/A INTRINSIC
low complexity region 1468 1483 N/A INTRINSIC
low complexity region 1602 1624 N/A INTRINSIC
low complexity region 1647 1663 N/A INTRINSIC
low complexity region 1732 1745 N/A INTRINSIC
internal_repeat_1 1766 1910 9.57e-8 PROSPERO
low complexity region 1987 1993 N/A INTRINSIC
low complexity region 2013 2027 N/A INTRINSIC
low complexity region 2053 2071 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000175726
AA Change: K662E
Predicted Effect probably benign
Transcript: ENSMUST00000175764
SMART Domains Protein: ENSMUSP00000135031
Gene: ENSMUSG00000046138

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
low complexity region 379 393 N/A INTRINSIC
internal_repeat_1 397 526 2.65e-5 PROSPERO
low complexity region 528 537 N/A INTRINSIC
low complexity region 619 648 N/A INTRINSIC
low complexity region 701 716 N/A INTRINSIC
low complexity region 835 857 N/A INTRINSIC
low complexity region 880 896 N/A INTRINSIC
low complexity region 965 978 N/A INTRINSIC
internal_repeat_1 999 1143 2.65e-5 PROSPERO
low complexity region 1220 1226 N/A INTRINSIC
low complexity region 1246 1260 N/A INTRINSIC
low complexity region 1286 1304 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000176773
AA Change: K68E
Predicted Effect possibly damaging
Transcript: ENSMUST00000177155
AA Change: K718E

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000135473
Gene: ENSMUSG00000046138
AA Change: K718E

DomainStartEndE-ValueType
low complexity region 4 66 N/A INTRINSIC
BROMO 75 198 1.22e-3 SMART
low complexity region 205 219 N/A INTRINSIC
low complexity region 280 298 N/A INTRINSIC
low complexity region 428 441 N/A INTRINSIC
coiled coil region 606 638 N/A INTRINSIC
low complexity region 655 689 N/A INTRINSIC
coiled coil region 697 729 N/A INTRINSIC
low complexity region 1079 1093 N/A INTRINSIC
internal_repeat_1 1097 1226 1.32e-7 PROSPERO
low complexity region 1228 1237 N/A INTRINSIC
low complexity region 1319 1348 N/A INTRINSIC
low complexity region 1401 1416 N/A INTRINSIC
low complexity region 1535 1557 N/A INTRINSIC
low complexity region 1580 1596 N/A INTRINSIC
low complexity region 1665 1678 N/A INTRINSIC
internal_repeat_1 1699 1843 1.32e-7 PROSPERO
low complexity region 1920 1926 N/A INTRINSIC
low complexity region 1946 1960 N/A INTRINSIC
low complexity region 1986 2004 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asap2 G T 12: 21,235,188 (GRCm39) A97S probably damaging Het
C1qtnf1 A T 11: 118,334,616 (GRCm39) E32V possibly damaging Het
Ccdc81 A G 7: 89,525,081 (GRCm39) L500P probably damaging Het
Cdo1 T C 18: 46,861,130 (GRCm39) E27G probably benign Het
Ceacam5 G A 7: 17,484,620 (GRCm39) G454D probably damaging Het
Cemip T C 7: 83,600,648 (GRCm39) D991G probably damaging Het
Cep170 A C 1: 176,616,071 (GRCm39) I79S probably damaging Het
Cep19 A G 16: 31,926,039 (GRCm39) Q149R possibly damaging Het
Cideb A T 14: 55,992,619 (GRCm39) L99* probably null Het
Cntnap5a A G 1: 116,356,207 (GRCm39) N746S probably benign Het
Col12a1 T C 9: 79,564,080 (GRCm39) N1715S probably benign Het
Col3a1 T C 1: 45,360,848 (GRCm39) S93P unknown Het
Csmd3 C A 15: 47,449,028 (GRCm39) probably null Het
Disp3 T C 4: 148,344,373 (GRCm39) I510V probably benign Het
Drosha T A 15: 12,914,070 (GRCm39) V1115E probably damaging Het
Dzip3 A C 16: 48,757,369 (GRCm39) L888R probably damaging Het
Emx2 C A 19: 59,452,442 (GRCm39) A242E probably benign Het
Fto G A 8: 92,168,314 (GRCm39) E256K possibly damaging Het
Gabrb2 A C 11: 42,482,715 (GRCm39) Y191S possibly damaging Het
Gm6526 A T 14: 43,987,394 (GRCm39) H110L probably damaging Het
Grin3b T A 10: 79,810,436 (GRCm39) N647K probably damaging Het
Ifit2 T G 19: 34,550,602 (GRCm39) S47R probably benign Het
Il5ra A T 6: 106,712,781 (GRCm39) V244E possibly damaging Het
Inppl1 A G 7: 101,482,153 (GRCm39) L141P probably benign Het
Iws1 A G 18: 32,213,178 (GRCm39) D202G probably benign Het
Kctd4 A C 14: 76,200,523 (GRCm39) I165L probably benign Het
Lrch3 G A 16: 32,770,746 (GRCm39) C116Y probably damaging Het
Mettl25 T C 10: 105,668,844 (GRCm39) T93A possibly damaging Het
Mgat4d A G 8: 84,095,666 (GRCm39) I314V probably benign Het
Mrgprb4 A T 7: 47,848,159 (GRCm39) Y256* probably null Het
Myo9b G T 8: 71,808,408 (GRCm39) V1672L probably damaging Het
Nek1 C T 8: 61,502,975 (GRCm39) P449L probably benign Het
Nucb2 G A 7: 116,123,642 (GRCm39) probably null Het
Obscn T C 11: 58,919,412 (GRCm39) Y6864C probably damaging Het
Omt2b A T 9: 78,235,420 (GRCm39) probably benign Het
Or2y3 T A 17: 38,393,486 (GRCm39) I128F probably damaging Het
Or4p18 C T 2: 88,232,777 (GRCm39) C167Y probably damaging Het
Or5ac15 G A 16: 58,940,293 (GRCm39) L47F probably damaging Het
Or6c208 A G 10: 129,224,176 (GRCm39) K225E probably benign Het
Otogl G T 10: 107,705,387 (GRCm39) P647T probably damaging Het
Oxnad1 A G 14: 31,824,244 (GRCm39) D271G probably benign Het
Pbx3 T C 2: 34,261,776 (GRCm39) I53V probably damaging Het
Pds5b T A 5: 150,639,865 (GRCm39) probably null Het
Ppp4r3a A T 12: 101,007,000 (GRCm39) D810E probably damaging Het
Ptpro A T 6: 137,438,724 (GRCm39) D1189V probably damaging Het
Ryr3 T C 2: 112,492,002 (GRCm39) N3758S probably damaging Het
Scarb2 G A 5: 92,594,200 (GRCm39) T454M possibly damaging Het
Sec23a A C 12: 59,032,972 (GRCm39) probably null Het
Spire2 C T 8: 124,095,502 (GRCm39) A535V probably benign Het
Svopl A T 6: 38,006,570 (GRCm39) F142L probably benign Het
Tas2r144 T C 6: 42,192,674 (GRCm39) I138T probably benign Het
Tbc1d15 A G 10: 115,039,135 (GRCm39) M535T probably benign Het
Tnfaip1 C T 11: 78,420,971 (GRCm39) V30M possibly damaging Het
Topaz1 T A 9: 122,625,108 (GRCm39) W1398R probably damaging Het
Tpo A G 12: 30,134,694 (GRCm39) S755P probably damaging Het
Ttn G T 2: 76,606,460 (GRCm39) S18116R probably damaging Het
Vmn2r78 A G 7: 86,571,465 (GRCm39) probably null Het
Wdr49 T A 3: 75,304,227 (GRCm39) K494M probably benign Het
Yeats2 A G 16: 20,024,836 (GRCm39) M697V probably damaging Het
Zfp407 G A 18: 84,579,158 (GRCm39) P652S possibly damaging Het
Zfp462 A G 4: 55,009,002 (GRCm39) M323V probably benign Het
Zfp629 G T 7: 127,209,931 (GRCm39) P626Q possibly damaging Het
Zfp804a A T 2: 82,088,532 (GRCm39) Y787F probably benign Het
Other mutations in Brd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01311:Brd10 APN 19 29,731,420 (GRCm39) missense probably benign 0.33
IGL01535:Brd10 APN 19 29,731,212 (GRCm39) missense possibly damaging 0.53
IGL02019:Brd10 APN 19 29,694,463 (GRCm39) missense probably benign 0.28
IGL02034:Brd10 APN 19 29,694,259 (GRCm39) missense possibly damaging 0.73
IGL03114:Brd10 APN 19 29,694,532 (GRCm39) missense probably benign 0.18
IGL03382:Brd10 APN 19 29,694,676 (GRCm39) missense probably damaging 1.00
R0020:Brd10 UTSW 19 29,693,597 (GRCm39) missense probably damaging 0.98
R0020:Brd10 UTSW 19 29,693,597 (GRCm39) missense probably damaging 0.98
R0142:Brd10 UTSW 19 29,695,654 (GRCm39) missense possibly damaging 0.93
R0178:Brd10 UTSW 19 29,732,188 (GRCm39) missense probably damaging 1.00
R0453:Brd10 UTSW 19 29,731,068 (GRCm39) missense probably damaging 1.00
R0730:Brd10 UTSW 19 29,695,381 (GRCm39) missense probably benign 0.00
R0735:Brd10 UTSW 19 29,695,038 (GRCm39) missense possibly damaging 0.92
R0891:Brd10 UTSW 19 29,695,053 (GRCm39) missense probably damaging 1.00
R0894:Brd10 UTSW 19 29,697,974 (GRCm39) splice site probably benign
R1289:Brd10 UTSW 19 29,700,852 (GRCm39) missense probably benign 0.07
R1368:Brd10 UTSW 19 29,693,796 (GRCm39) missense probably damaging 0.97
R1387:Brd10 UTSW 19 29,700,853 (GRCm39) missense probably benign 0.15
R1483:Brd10 UTSW 19 29,696,745 (GRCm39) missense possibly damaging 0.93
R1612:Brd10 UTSW 19 29,695,245 (GRCm39) missense possibly damaging 0.86
R1721:Brd10 UTSW 19 29,720,998 (GRCm39) missense probably damaging 0.99
R1764:Brd10 UTSW 19 29,696,560 (GRCm39) missense possibly damaging 0.53
R1822:Brd10 UTSW 19 29,693,814 (GRCm39) missense probably damaging 0.99
R1824:Brd10 UTSW 19 29,693,814 (GRCm39) missense probably damaging 0.99
R1859:Brd10 UTSW 19 29,732,323 (GRCm39) missense possibly damaging 0.53
R1868:Brd10 UTSW 19 29,720,998 (GRCm39) missense probably damaging 0.99
R1880:Brd10 UTSW 19 29,695,523 (GRCm39) missense probably benign 0.06
R1898:Brd10 UTSW 19 29,712,532 (GRCm39) missense possibly damaging 0.74
R1936:Brd10 UTSW 19 29,731,077 (GRCm39) missense possibly damaging 0.87
R1939:Brd10 UTSW 19 29,731,077 (GRCm39) missense possibly damaging 0.87
R1969:Brd10 UTSW 19 29,694,075 (GRCm39) missense possibly damaging 0.95
R2153:Brd10 UTSW 19 29,694,229 (GRCm39) missense probably benign 0.01
R2366:Brd10 UTSW 19 29,731,035 (GRCm39) missense probably damaging 0.99
R2379:Brd10 UTSW 19 29,696,275 (GRCm39) missense probably benign 0.01
R3107:Brd10 UTSW 19 29,700,847 (GRCm39) missense probably damaging 1.00
R4012:Brd10 UTSW 19 29,720,990 (GRCm39) missense probably damaging 1.00
R4222:Brd10 UTSW 19 29,696,149 (GRCm39) missense probably benign 0.18
R4328:Brd10 UTSW 19 29,720,961 (GRCm39) missense probably benign 0.00
R4329:Brd10 UTSW 19 29,720,961 (GRCm39) missense probably benign 0.00
R4387:Brd10 UTSW 19 29,782,715 (GRCm39) unclassified probably benign
R4688:Brd10 UTSW 19 29,694,501 (GRCm39) missense probably benign 0.33
R4796:Brd10 UTSW 19 29,731,018 (GRCm39) missense probably benign 0.33
R4820:Brd10 UTSW 19 29,695,809 (GRCm39) missense possibly damaging 0.53
R4832:Brd10 UTSW 19 29,694,616 (GRCm39) missense possibly damaging 0.53
R5056:Brd10 UTSW 19 29,694,759 (GRCm39) missense probably benign
R5150:Brd10 UTSW 19 29,782,950 (GRCm39) missense probably damaging 0.96
R5224:Brd10 UTSW 19 29,696,450 (GRCm39) missense possibly damaging 0.73
R5306:Brd10 UTSW 19 29,707,230 (GRCm39) intron probably benign
R5460:Brd10 UTSW 19 29,732,250 (GRCm39) missense probably damaging 0.98
R5477:Brd10 UTSW 19 29,731,518 (GRCm39) missense probably benign 0.33
R5531:Brd10 UTSW 19 29,731,072 (GRCm39) missense possibly damaging 0.73
R5559:Brd10 UTSW 19 29,694,363 (GRCm39) missense possibly damaging 0.91
R5647:Brd10 UTSW 19 29,731,210 (GRCm39) missense possibly damaging 0.73
R5886:Brd10 UTSW 19 29,696,677 (GRCm39) missense probably benign 0.03
R6029:Brd10 UTSW 19 29,732,367 (GRCm39) unclassified probably benign
R6240:Brd10 UTSW 19 29,694,640 (GRCm39) missense probably benign 0.18
R6331:Brd10 UTSW 19 29,695,147 (GRCm39) missense probably benign 0.33
R6456:Brd10 UTSW 19 29,693,914 (GRCm39) missense possibly damaging 0.93
R6584:Brd10 UTSW 19 29,696,128 (GRCm39) missense possibly damaging 0.53
R6661:Brd10 UTSW 19 29,700,864 (GRCm39) missense possibly damaging 0.53
R6991:Brd10 UTSW 19 29,696,508 (GRCm39) missense possibly damaging 0.86
R7059:Brd10 UTSW 19 29,696,945 (GRCm39) missense probably benign 0.33
R7128:Brd10 UTSW 19 29,693,881 (GRCm39) missense possibly damaging 0.53
R7211:Brd10 UTSW 19 29,763,712 (GRCm39) missense
R7471:Brd10 UTSW 19 29,707,139 (GRCm39) splice site probably null
R7686:Brd10 UTSW 19 29,694,870 (GRCm39) missense probably benign 0.34
R8012:Brd10 UTSW 19 29,695,534 (GRCm39) missense possibly damaging 0.73
R8203:Brd10 UTSW 19 29,693,443 (GRCm39) missense probably benign 0.18
R8353:Brd10 UTSW 19 29,731,242 (GRCm39) missense possibly damaging 0.53
R8672:Brd10 UTSW 19 29,731,564 (GRCm39) missense probably benign
R8755:Brd10 UTSW 19 29,693,890 (GRCm39) missense probably benign 0.03
R8918:Brd10 UTSW 19 29,696,841 (GRCm39) missense possibly damaging 0.53
R8954:Brd10 UTSW 19 29,696,126 (GRCm39) missense possibly damaging 0.72
R9038:Brd10 UTSW 19 29,731,900 (GRCm39) missense possibly damaging 0.86
R9195:Brd10 UTSW 19 29,763,703 (GRCm39) missense
R9204:Brd10 UTSW 19 29,696,938 (GRCm39) missense possibly damaging 0.73
R9518:Brd10 UTSW 19 29,731,541 (GRCm39) missense possibly damaging 0.53
R9743:Brd10 UTSW 19 29,694,261 (GRCm39) missense probably benign
R9747:Brd10 UTSW 19 29,731,911 (GRCm39) missense possibly damaging 0.73
RF011:Brd10 UTSW 19 29,721,009 (GRCm39) missense possibly damaging 0.53
X0027:Brd10 UTSW 19 29,712,599 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCTTGGTAGAAATAAACAAAGGGGCCTG -3'
(R):5'- CCATAACACAAATGTAGCGGTGGGG -3'

Sequencing Primer
(F):5'- AGACTATACCTGTTATAAACCAGGC -3'
(R):5'- GACTGCCAGTGTGAAACTTTAGC -3'
Posted On 2014-04-13