Mutagenetix > Incidental Mutation

Incidental Mutation 'R1506:Or10j2'

167910

Institutional Source

Beutler Lab

Gene Symbol

Or10j2

Ensembl Gene

ENSMUSG00000049605

Gene Name

olfactory receptor family 10 subfamily J member 2

Synonyms

MOR267-8, Olfr418, Olfr1403, GA_x6K02T2P20D-20826777-20827719, Olfr418-ps1, MOR267-12P, GA_x6K02T2R7CC-581296-580364

MMRRC Submission

039554-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R1506 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

173097714-173098704 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 173098336 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 198 (N198S)

Ref Sequence

ENSEMBL: ENSMUSP00000150427 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059754] [ENSMUST00000111224] [ENSMUST00000213420]

AlphaFold

A0A140T8J6

Predicted Effect

probably benign
Transcript: ENSMUST00000059754
AA Change: N198S

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000052418
Gene: ENSMUSG00000049605
AA Change: N198S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	1.6e-55	PFAM
Pfam:7tm_1	41	289	5.7e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000111224

SMART Domains

Protein: ENSMUSP00000106855
Gene: ENSMUSG00000079180

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
PTX	20	219	1.93e-94	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000213420
AA Change: N198S

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.5%
20x: 93.7%

Validation Efficiency

98% (61/62)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc3	G	T	11: 94,248,144 (GRCm39)	T1152K	possibly damaging	Het
Acp3	T	A	9: 104,201,373 (GRCm39)	T82S	probably damaging	Het
Adam23	C	T	1: 63,586,973 (GRCm39)	P445S	probably benign	Het
Ap3b1	T	A	13: 94,582,651 (GRCm39)		probably benign	Het
Artn	A	G	4: 117,784,058 (GRCm39)	V136A	probably damaging	Het
Ash1l	A	G	3: 88,965,806 (GRCm39)	T2403A	probably damaging	Het
Bbof1	G	T	12: 84,470,273 (GRCm39)	V120L	probably damaging	Het
Boc	A	G	16: 44,323,928 (GRCm39)	Y158H	probably damaging	Het
Casp8	A	G	1: 58,863,355 (GRCm39)	E105G	probably damaging	Het
Cers4	T	C	8: 4,570,557 (GRCm39)	F206L	probably benign	Het
Chrna9	A	G	5: 66,126,479 (GRCm39)	T78A	probably benign	Het
Creb3	A	T	4: 43,566,193 (GRCm39)	T263S	possibly damaging	Het
Cyp2c40	A	G	19: 39,766,443 (GRCm39)	V384A	probably damaging	Het
Dip2b	G	A	15: 100,080,994 (GRCm39)	V879M	probably damaging	Het
Dnah17	C	A	11: 118,016,213 (GRCm39)	V14F	possibly damaging	Het
Epb41l4b	T	A	4: 57,088,824 (GRCm39)	K144N	probably damaging	Het
Ercc6	A	T	14: 32,291,821 (GRCm39)	I1062F	probably benign	Het
Fabp3	C	T	4: 130,206,180 (GRCm39)	T57I	probably benign	Het
Fat2	C	A	11: 55,175,090 (GRCm39)	E1874D	probably benign	Het
Fbxw21	T	A	9: 108,977,257 (GRCm39)	I151F	probably damaging	Het
Fhip2a	A	G	19: 57,357,007 (GRCm39)	I33V	probably benign	Het
Foxn1	A	G	11: 78,256,761 (GRCm39)		probably benign	Het
Gpr63	G	A	4: 25,008,227 (GRCm39)	R317H	probably damaging	Het
Grip1	C	A	10: 119,814,356 (GRCm39)	H296N	probably damaging	Het
Gtdc1	A	T	2: 44,465,506 (GRCm39)	M288K	possibly damaging	Het
Guf1	T	A	5: 69,724,509 (GRCm39)	D488E	possibly damaging	Het
Gvin3	C	T	7: 106,200,788 (GRCm39)	D819N	probably benign	Het
Heatr5b	C	A	17: 79,060,576 (GRCm39)	R2033L	probably damaging	Het
Hsd17b2	T	A	8: 118,429,004 (GRCm39)		probably null	Het
Ino80	A	T	2: 119,255,746 (GRCm39)	L913*	probably null	Het
Inppl1	A	C	7: 101,473,174 (GRCm39)	S1159A	probably benign	Het
Kcnk7	G	A	19: 5,756,140 (GRCm39)	C122Y	probably damaging	Het
Mtor	A	G	4: 148,620,962 (GRCm39)		probably benign	Het
Muc4	A	T	16: 32,574,033 (GRCm39)	S704C	possibly damaging	Het
Nckap5	A	T	1: 125,953,650 (GRCm39)	C967*	probably null	Het
Nek10	T	C	14: 14,999,078 (GRCm38)		probably benign	Het
Oas1h	A	T	5: 121,009,951 (GRCm39)	D342V	possibly damaging	Het
Or2ak7	T	A	11: 58,575,014 (GRCm39)	L105Q	probably benign	Het
Or2n1	A	T	17: 38,486,091 (GRCm39)	M39L	probably benign	Het
Or4m1	A	G	14: 50,557,941 (GRCm39)	V117A	probably benign	Het
Or8b1b	T	C	9: 38,375,439 (GRCm39)	M34T	probably benign	Het
Prex1	A	T	2: 166,429,001 (GRCm39)	V694E	probably damaging	Het
Rad50	G	A	11: 53,570,312 (GRCm39)	A810V	probably damaging	Het
Rcor1	T	C	12: 111,076,271 (GRCm39)	S410P	probably damaging	Het
Rps14	A	T	18: 60,909,551 (GRCm39)	N26I	probably benign	Het
Slc38a1	T	C	15: 96,483,431 (GRCm39)	D299G	probably benign	Het
Slc5a1	T	A	5: 33,312,052 (GRCm39)	N481K	possibly damaging	Het
Slco3a1	A	T	7: 74,009,683 (GRCm39)		probably null	Het
Spart	T	C	3: 55,024,992 (GRCm39)	S196P	probably damaging	Het
Speg	A	G	1: 75,394,307 (GRCm39)	T1701A	probably benign	Het
Sugt1	A	G	14: 79,862,365 (GRCm39)	N271S	probably benign	Het
Tbx15	A	T	3: 99,259,228 (GRCm39)	L366F	possibly damaging	Het
Tnc	G	A	4: 63,925,921 (GRCm39)	T953I	possibly damaging	Het
Uqcc1	A	G	2: 155,753,738 (GRCm39)	S46P	probably damaging	Het
Vmn2r18	T	C	5: 151,499,099 (GRCm39)		probably null	Het
Vmn2r7	T	A	3: 64,614,500 (GRCm39)	Y438F	probably benign	Het
Vmn2r72	T	A	7: 85,398,419 (GRCm39)	K520N	probably benign	Het
Vps52	T	C	17: 34,176,868 (GRCm39)	L74P	probably damaging	Het
Xpo5	G	T	17: 46,538,814 (GRCm39)	M673I	probably benign	Het
Zscan18	A	G	7: 12,508,129 (GRCm39)	V457A	probably damaging	Het

Other mutations in Or10j2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01413:Or10j2	APN	1	173,098,275 (GRCm39)	missense	probably damaging	1.00
IGL01418:Or10j2	APN	1	173,098,275 (GRCm39)	missense	probably damaging	1.00
IGL01930:Or10j2	APN	1	173,098,177 (GRCm39)	missense	probably benign
IGL01963:Or10j2	APN	1	173,097,919 (GRCm39)	missense	probably damaging	0.99
IGL02104:Or10j2	APN	1	173,098,603 (GRCm39)	missense	probably damaging	0.96
IGL02192:Or10j2	APN	1	173,098,417 (GRCm39)	missense	probably damaging	1.00
IGL02256:Or10j2	APN	1	173,098,194 (GRCm39)	missense	probably benign	0.04
IGL02340:Or10j2	APN	1	173,097,972 (GRCm39)	missense	probably benign	0.10
IGL02454:Or10j2	APN	1	173,098,507 (GRCm39)	missense	probably damaging	0.99
IGL02638:Or10j2	APN	1	173,097,898 (GRCm39)	missense	probably benign	0.07
FR4737:Or10j2	UTSW	1	173,098,197 (GRCm39)	frame shift	probably null
FR4976:Or10j2	UTSW	1	173,098,197 (GRCm39)	frame shift	probably null
R0552:Or10j2	UTSW	1	173,098,372 (GRCm39)	missense	probably benign	0.05
R0621:Or10j2	UTSW	1	173,098,242 (GRCm39)	missense	possibly damaging	0.48
R0735:Or10j2	UTSW	1	173,098,569 (GRCm39)	missense	probably benign	0.05
R1670:Or10j2	UTSW	1	173,098,467 (GRCm39)	missense	probably damaging	1.00
R2111:Or10j2	UTSW	1	173,097,879 (GRCm39)	missense	probably benign
R2204:Or10j2	UTSW	1	173,097,703 (GRCm39)	splice site	probably null
R4475:Or10j2	UTSW	1	173,098,480 (GRCm39)	missense	probably damaging	0.99
R4909:Or10j2	UTSW	1	173,098,546 (GRCm39)	missense	probably damaging	0.97
R5457:Or10j2	UTSW	1	173,098,141 (GRCm39)	missense	probably benign	0.00
R6124:Or10j2	UTSW	1	173,097,846 (GRCm39)	missense	probably damaging	1.00
R6456:Or10j2	UTSW	1	173,098,105 (GRCm39)	missense	probably damaging	1.00
R7220:Or10j2	UTSW	1	173,097,811 (GRCm39)	missense	possibly damaging	0.56
R7240:Or10j2	UTSW	1	173,098,561 (GRCm39)	missense	probably benign	0.27
R7672:Or10j2	UTSW	1	173,098,440 (GRCm39)	missense	probably benign	0.18
R8073:Or10j2	UTSW	1	173,098,552 (GRCm39)	missense	probably benign	0.42
R8116:Or10j2	UTSW	1	173,098,047 (GRCm39)	missense	possibly damaging	0.88
R8982:Or10j2	UTSW	1	173,098,306 (GRCm39)	missense	probably damaging	1.00
R9038:Or10j2	UTSW	1	173,098,147 (GRCm39)	missense	possibly damaging	0.63
R9668:Or10j2	UTSW	1	173,098,183 (GRCm39)	missense	possibly damaging	0.94
RF032:Or10j2	UTSW	1	173,098,276 (GRCm39)	frame shift	probably null
RF036:Or10j2	UTSW	1	173,098,276 (GRCm39)	frame shift	probably null
RF040:Or10j2	UTSW	1	173,098,276 (GRCm39)	frame shift	probably null
X0019:Or10j2	UTSW	1	173,098,124 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- CAACTGCTTTCTGCTTACAGCGATG -3'
(R):5'- GGCACAACCATAGTGGATGATGACC -3'

Sequencing Primer
(F):5'- CTTGAGGTACTCGGTTATCATGAAC -3'
(R):5'- TAGTGGATGATGACCACCGTG -3'

Posted On

2014-04-13