Mutagenetix > Incidental Mutation

Incidental Mutation 'R1509:Macf1'

168121

Institutional Source

Beutler Lab

Gene Symbol

Macf1

Ensembl Gene

ENSMUSG00000028649

Gene Name

microtubule-actin crosslinking factor 1

Synonyms

trabeculin alpha, Aclp7, Acf7

MMRRC Submission

039556-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1509 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

123243426-123581331 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 123577802 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 61 (V61L)

Ref Sequence

ENSEMBL: ENSMUSP00000080755 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000082108] [ENSMUST00000084301] [ENSMUST00000097897] [ENSMUST00000106224]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000082108
AA Change: V61L

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000080755
Gene: ENSMUSG00000028649
AA Change: V61L

Domain	Start	End	E-Value	Type
low complexity region	6	35	N/A	INTRINSIC
low complexity region	65	79	N/A	INTRINSIC
CH	80	179	5.63e-28	SMART
CH	196	293	7.49e-24	SMART
SPEC	317	420	4.11e0	SMART
SPEC	583	680	4.32e-9	SMART
SPEC	683	783	5.75e-5	SMART
Blast:SPEC	790	955	4e-82	BLAST
coiled coil region	1046	1067	N/A	INTRINSIC
SPEC	1278	1407	2.35e0	SMART
SPEC	1425	1533	1.12e-7	SMART
SPEC	1550	1658	3.94e-3	SMART
SPEC	1818	1928	4.03e-9	SMART
SPEC	1935	2041	1.75e-9	SMART
SPEC	2048	2150	5.57e-3	SMART
SPEC	2157	2256	4.56e0	SMART
SPEC	2263	2394	3.46e-1	SMART
SPEC	2401	2506	1.29e-7	SMART
SPEC	2513	2617	1.19e-2	SMART
SPEC	2624	2727	2.7e-1	SMART
SPEC	2734	2837	4.99e-14	SMART
SPEC	2844	2944	1.9e-5	SMART
SPEC	2951	3057	2.83e0	SMART
SPEC	3060	3162	2.14e-4	SMART
SPEC	3169	3273	3.01e-8	SMART
SPEC	3280	3382	4.48e-16	SMART
SPEC	3389	3491	1.26e-10	SMART
SPEC	3498	3600	2.26e-3	SMART
SPEC	3607	3709	4.29e-4	SMART
SPEC	3716	3817	9.99e-14	SMART
SPEC	3824	3930	5.79e-2	SMART
SPEC	3937	4039	6.59e-14	SMART
SPEC	4046	4149	3.7e-17	SMART
SPEC	4156	4258	1.16e-23	SMART
SPEC	4265	4368	3.58e-15	SMART
SPEC	4375	4477	2.61e-17	SMART
SPEC	4484	4587	9.38e-19	SMART
SPEC	4594	4695	2.29e-22	SMART
SPEC	4702	4804	4.99e-14	SMART
SPEC	4811	4941	1.45e-10	SMART
EFh	4979	5007	5.08e-3	SMART
EFh	5015	5043	1.17e-2	SMART
GAS2	5054	5132	8.5e-54	SMART
low complexity region	5154	5199	N/A	INTRINSIC
low complexity region	5248	5273	N/A	INTRINSIC
low complexity region	5290	5302	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000084301
AA Change: V61L

PolyPhen 2 Score 0.875 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000081324
Gene: ENSMUSG00000028649
AA Change: V61L

Domain	Start	End	E-Value	Type
low complexity region	6	35	N/A	INTRINSIC
low complexity region	65	79	N/A	INTRINSIC
CH	80	179	2.8e-30	SMART
CH	196	293	3.6e-26	SMART
SPEC	317	420	2.6e-2	SMART
SPEC	583	680	2.7e-11	SMART
SPEC	683	783	3.6e-7	SMART
Blast:SPEC	790	955	5e-82	BLAST
coiled coil region	1046	1067	N/A	INTRINSIC
SPEC	1278	1407	1.5e-2	SMART
SPEC	1425	1533	6.9e-10	SMART
PLEC	1530	1576	5.3e-6	SMART
PLEC	1577	1614	1.2e-2	SMART
PLEC	1616	1653	8.7e-2	SMART
PLEC	1654	1691	8.3e-2	SMART
PLEC	1695	1729	1.3e-1	SMART
PLEC	1731	1767	1.4e-4	SMART
PLEC	1768	1805	2e-12	SMART
PLEC	1808	1843	5.2e-4	SMART
PLEC	1844	1881	4e-2	SMART
PLEC	1884	1919	1.9e0	SMART
low complexity region	1986	1997	N/A	INTRINSIC
low complexity region	2219	2228	N/A	INTRINSIC
PLEC	2275	2312	4.5e-6	SMART
PLEC	2347	2388	1.7e-7	SMART
PLEC	2389	2426	1.2e-5	SMART
PLEC	2447	2484	6.3e-3	SMART
PLEC	2485	2522	2.1e-4	SMART
PLEC	2523	2561	1.5e-1	SMART
PLEC	2586	2633	3.1e-1	SMART
PLEC	2671	2708	6.5e-10	SMART
PLEC	2709	2746	2.3e-3	SMART
low complexity region	2940	2950	N/A	INTRINSIC
coiled coil region	3355	3388	N/A	INTRINSIC
low complexity region	3419	3429	N/A	INTRINSIC
low complexity region	3555	3576	N/A	INTRINSIC
SPEC	3577	3683	7.1e-3	SMART
SPEC	3841	3951	2.6e-11	SMART
SPEC	3958	4064	1.1e-11	SMART
SPEC	4071	4173	3.6e-5	SMART
SPEC	4180	4279	2.9e-2	SMART
SPEC	4286	4417	2.2e-3	SMART
SPEC	4424	4529	8.2e-10	SMART
SPEC	4536	4640	7.4e-5	SMART
SPEC	4647	4750	1.7e-3	SMART
SPEC	4757	4860	3.2e-16	SMART
SPEC	4867	4967	1.2e-7	SMART
SPEC	4974	5080	1.8e-2	SMART
SPEC	5083	5185	1.3e-6	SMART
SPEC	5192	5296	2e-10	SMART
SPEC	5303	5405	2.8e-18	SMART
SPEC	5412	5514	7.7e-13	SMART
SPEC	5521	5623	1.5e-5	SMART
SPEC	5630	5732	2.7e-6	SMART
SPEC	5739	5840	6.1e-16	SMART
SPEC	5847	5953	3.6e-4	SMART
SPEC	5960	6062	4.1e-16	SMART
SPEC	6069	6172	2.4e-19	SMART
SPEC	6179	6281	7.6e-26	SMART
SPEC	6288	6391	2.2e-17	SMART
SPEC	6398	6500	1.6e-19	SMART
SPEC	6507	6610	5.7e-21	SMART
SPEC	6617	6718	1.5e-24	SMART
SPEC	6725	6827	3.2e-16	SMART
SPEC	6834	6964	9.4e-13	SMART
EFh	7002	7030	2.4e-5	SMART
EFh	7038	7066	5.8e-5	SMART
GAS2	7077	7155	5.5e-56	SMART
low complexity region	7177	7222	N/A	INTRINSIC
low complexity region	7271	7296	N/A	INTRINSIC
low complexity region	7313	7325	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000097897
AA Change: V61L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000095507
Gene: ENSMUSG00000028649
AA Change: V61L

Domain	Start	End	E-Value	Type
low complexity region	6	35	N/A	INTRINSIC
low complexity region	65	79	N/A	INTRINSIC
CH	80	179	5.63e-28	SMART
CH	196	293	7.49e-24	SMART
SPEC	317	420	4.11e0	SMART
SPEC	583	680	4.32e-9	SMART
SPEC	683	783	5.75e-5	SMART
Blast:SPEC	790	955	4e-82	BLAST
coiled coil region	1046	1067	N/A	INTRINSIC
SPEC	1278	1407	2.35e0	SMART
SPEC	1425	1533	1.12e-7	SMART
PLEC	1530	1576	8.58e-4	SMART
PLEC	1577	1614	1.9e0	SMART
PLEC	1616	1653	1.38e1	SMART
PLEC	1654	1691	1.3e1	SMART
PLEC	1695	1729	2.1e1	SMART
PLEC	1731	1767	2.23e-2	SMART
PLEC	1768	1805	3.32e-10	SMART
PLEC	1808	1843	8.32e-2	SMART
PLEC	1844	1881	6.42e0	SMART
PLEC	1884	1919	3e2	SMART
low complexity region	1986	1997	N/A	INTRINSIC
low complexity region	2219	2228	N/A	INTRINSIC
PLEC	2275	2312	6.97e-4	SMART
PLEC	2347	2388	2.68e-5	SMART
PLEC	2389	2426	1.84e-3	SMART
PLEC	2447	2484	1.01e0	SMART
PLEC	2485	2522	3.38e-2	SMART
PLEC	2523	2561	2.39e1	SMART
PLEC	2586	2633	4.99e1	SMART
PLEC	2671	2708	1.05e-7	SMART
PLEC	2709	2746	3.57e-1	SMART
low complexity region	2940	2950	N/A	INTRINSIC
coiled coil region	3355	3388	N/A	INTRINSIC
low complexity region	3419	3429	N/A	INTRINSIC
low complexity region	3555	3576	N/A	INTRINSIC
SPEC	3577	3685	3.94e-3	SMART
SPEC	3845	3955	4.03e-9	SMART
SPEC	3962	4068	1.75e-9	SMART
SPEC	4075	4177	5.57e-3	SMART
SPEC	4184	4283	4.56e0	SMART
SPEC	4290	4421	3.46e-1	SMART
SPEC	4428	4533	1.29e-7	SMART
SPEC	4540	4644	1.19e-2	SMART
SPEC	4651	4754	2.7e-1	SMART
SPEC	4761	4864	4.99e-14	SMART
SPEC	4871	4971	1.9e-5	SMART
SPEC	4978	5084	2.83e0	SMART
SPEC	5087	5189	2.14e-4	SMART
SPEC	5196	5300	3.01e-8	SMART
SPEC	5307	5409	4.48e-16	SMART
SPEC	5416	5518	1.26e-10	SMART
SPEC	5525	5627	2.26e-3	SMART
SPEC	5634	5736	4.29e-4	SMART
SPEC	5743	5844	9.99e-14	SMART
SPEC	5851	5957	5.79e-2	SMART
SPEC	5964	6066	6.59e-14	SMART
SPEC	6073	6176	3.7e-17	SMART
SPEC	6183	6285	1.16e-23	SMART
SPEC	6292	6395	3.58e-15	SMART
SPEC	6402	6504	2.61e-17	SMART
SPEC	6511	6614	9.38e-19	SMART
SPEC	6621	6722	2.29e-22	SMART
SPEC	6729	6831	4.99e-14	SMART
SPEC	6838	6968	1.45e-10	SMART
EFh	7006	7034	5.08e-3	SMART
EFh	7042	7070	1.17e-2	SMART
GAS2	7081	7159	8.5e-54	SMART
low complexity region	7181	7226	N/A	INTRINSIC
low complexity region	7275	7300	N/A	INTRINSIC
low complexity region	7317	7329	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000106224
AA Change: V61L

PolyPhen 2 Score 0.875 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000101831
Gene: ENSMUSG00000028649
AA Change: V61L

Domain	Start	End	E-Value	Type
low complexity region	6	35	N/A	INTRINSIC
low complexity region	65	79	N/A	INTRINSIC
CH	80	179	5.63e-28	SMART
CH	196	293	7.49e-24	SMART
SPEC	317	420	4.11e0	SMART
SPEC	583	680	4.32e-9	SMART
SPEC	683	783	5.75e-5	SMART
Blast:SPEC	790	955	5e-82	BLAST
coiled coil region	1046	1067	N/A	INTRINSIC
SPEC	1278	1407	2.35e0	SMART
SPEC	1425	1533	1.12e-7	SMART
PLEC	1530	1576	8.58e-4	SMART
PLEC	1577	1614	1.9e0	SMART
PLEC	1616	1653	1.38e1	SMART
PLEC	1654	1691	1.3e1	SMART
PLEC	1695	1729	2.1e1	SMART
PLEC	1731	1767	2.23e-2	SMART
PLEC	1768	1805	3.32e-10	SMART
PLEC	1808	1843	8.32e-2	SMART
PLEC	1844	1881	6.42e0	SMART
PLEC	1884	1919	3e2	SMART
low complexity region	1986	1997	N/A	INTRINSIC
low complexity region	2219	2228	N/A	INTRINSIC
PLEC	2275	2312	6.97e-4	SMART
PLEC	2347	2388	2.68e-5	SMART
PLEC	2389	2426	1.84e-3	SMART
PLEC	2447	2484	1.01e0	SMART
PLEC	2485	2522	3.38e-2	SMART
PLEC	2523	2561	2.39e1	SMART
PLEC	2586	2633	4.99e1	SMART
PLEC	2671	2708	1.05e-7	SMART
PLEC	2709	2746	3.57e-1	SMART
low complexity region	2940	2950	N/A	INTRINSIC
coiled coil region	3355	3388	N/A	INTRINSIC
low complexity region	3419	3429	N/A	INTRINSIC
low complexity region	3555	3576	N/A	INTRINSIC
SPEC	3577	3685	3.94e-3	SMART
SPEC	3845	3955	4.03e-9	SMART
SPEC	3962	4068	1.75e-9	SMART
SPEC	4075	4177	5.57e-3	SMART
SPEC	4184	4283	4.56e0	SMART
SPEC	4290	4421	3.46e-1	SMART
SPEC	4428	4533	1.29e-7	SMART
SPEC	4540	4642	9.34e-2	SMART
SPEC	4649	4752	2.7e-1	SMART
SPEC	4759	4862	4.99e-14	SMART
SPEC	4869	4969	1.9e-5	SMART
SPEC	4976	5082	2.83e0	SMART
SPEC	5085	5187	2.14e-4	SMART
SPEC	5194	5298	3.01e-8	SMART
SPEC	5305	5407	4.48e-16	SMART
SPEC	5414	5516	1.26e-10	SMART
SPEC	5523	5625	2.26e-3	SMART
SPEC	5632	5734	4.29e-4	SMART
SPEC	5741	5842	9.99e-14	SMART
SPEC	5849	5955	5.79e-2	SMART
SPEC	5962	6064	6.59e-14	SMART
SPEC	6071	6174	3.7e-17	SMART
SPEC	6181	6283	1.16e-23	SMART
SPEC	6290	6393	3.58e-15	SMART
SPEC	6400	6502	2.61e-17	SMART
SPEC	6509	6612	9.38e-19	SMART
SPEC	6619	6720	2.29e-22	SMART
SPEC	6727	6829	4.99e-14	SMART
SPEC	6836	6966	1.45e-10	SMART
EFh	7004	7032	5.08e-3	SMART
EFh	7040	7068	1.17e-2	SMART
GAS2	7079	7157	8.5e-54	SMART
low complexity region	7179	7224	N/A	INTRINSIC
low complexity region	7273	7298	N/A	INTRINSIC
low complexity region	7315	7327	N/A	INTRINSIC

Meta Mutation Damage Score

0.1032

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.4%
20x: 93.1%

Validation Efficiency

99% (89/90)

MGI Phenotype

PHENOTYPE: Mice homozygous for a null allele exhibit lethality before somitogenesis with failure of the primitive streak to form. Mice heterozygous for a knock-out and floxed allele activated in neurons exhibit impaired cortical neuron migration, respiratory distress, and early postnatal lethality. [provided by MGI curators]

Allele List at MGI

All alleles(784) : Targeted(4) Gene trapped(780)

Other mutations in this stock

Total: 86 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	T	C	13: 77,340,766 (GRCm39)	S132P	probably benign	Het
AC153895.1	T	C	6: 50,020,451 (GRCm39)	R54G	unknown	Het
Acot12	G	A	13: 91,919,994 (GRCm39)		probably null	Het
Adhfe1	T	A	1: 9,623,671 (GRCm39)	D98E	probably benign	Het
Ago2	A	G	15: 72,988,213 (GRCm39)	F594S	probably damaging	Het
Aldh18a1	A	G	19: 40,545,927 (GRCm39)	I620T	probably damaging	Het
Aspscr1	C	A	11: 120,592,342 (GRCm39)	A294D	probably damaging	Het
Bod1l	C	G	5: 41,976,883 (GRCm39)	R1477T	probably damaging	Het
Ccdc18	C	A	5: 108,336,844 (GRCm39)	A741D	possibly damaging	Het
Ces4a	G	A	8: 105,864,729 (GRCm39)	G69S	probably damaging	Het
Cfap52	C	T	11: 67,829,819 (GRCm39)	V317I	probably benign	Het
Cgn	A	T	3: 94,681,568 (GRCm39)	L509Q	probably benign	Het
Crb2	A	G	2: 37,676,631 (GRCm39)	H204R	probably benign	Het
Cspg4b	A	G	13: 113,504,790 (GRCm39)	N431S	probably damaging	Het
Ddx39a	G	A	8: 84,446,527 (GRCm39)	V99M	probably damaging	Het
Dis3l2	T	A	1: 86,948,808 (GRCm39)	C582S	possibly damaging	Het
Dmbt1	G	A	7: 130,676,061 (GRCm39)		probably benign	Het
Dnah6	T	C	6: 73,004,425 (GRCm39)	E3846G	probably damaging	Het
Dstyk	A	G	1: 132,384,084 (GRCm39)	E655G	probably damaging	Het
Epha4	T	C	1: 77,357,523 (GRCm39)	Y825C	probably damaging	Het
Esp36	T	A	17: 38,728,173 (GRCm39)	N36I	probably damaging	Het
Fabp3	C	T	4: 130,206,180 (GRCm39)	T57I	probably benign	Het
Fem1c	A	G	18: 46,657,280 (GRCm39)	S145P	probably benign	Het
Galnt13	T	C	2: 54,623,094 (GRCm39)	I80T	probably damaging	Het
Gm5698	T	C	1: 31,016,728 (GRCm39)	T108A	probably benign	Het
Hipk3	A	G	2: 104,271,607 (GRCm39)	S442P	probably benign	Het
Hmcn2	T	A	2: 31,204,491 (GRCm39)	V22D	possibly damaging	Het
Hspg2	C	T	4: 137,238,552 (GRCm39)		probably benign	Het
Ide	A	G	19: 37,262,603 (GRCm39)		probably null	Het
Ifnar1	C	A	16: 91,300,384 (GRCm39)	P462Q	probably damaging	Het
Itgb2l	T	A	16: 96,228,049 (GRCm39)	I485F	probably benign	Het
Jakmip3	C	T	7: 138,629,505 (GRCm39)	R549W	possibly damaging	Het
Lrrc36	A	G	8: 106,187,761 (GRCm39)	Q680R	probably damaging	Het
Lysmd3	T	G	13: 81,817,390 (GRCm39)	H122Q	probably benign	Het
Map1b	T	C	13: 99,568,036 (GRCm39)	T1562A	unknown	Het
Map3k20	A	T	2: 72,194,968 (GRCm39)		probably benign	Het
Mroh8	A	G	2: 157,075,125 (GRCm39)	V457A	probably benign	Het
Mrpl40	T	A	16: 18,694,159 (GRCm39)		probably null	Het
Ms4a10	C	T	19: 10,941,472 (GRCm39)	V166I	probably benign	Het
Mycl	A	G	4: 122,894,100 (GRCm39)	D300G	probably damaging	Het
Naca	T	A	10: 127,879,266 (GRCm39)		probably benign	Het
Ncoa4	T	C	14: 31,895,391 (GRCm39)	S172P	probably damaging	Het
Nfatc3	T	C	8: 106,810,486 (GRCm39)	F421L	possibly damaging	Het
Nucb1	C	A	7: 45,144,649 (GRCm39)	K301N	probably benign	Het
Or1af1	A	G	2: 37,109,966 (GRCm39)	H155R	probably damaging	Het
Or52ae9	A	T	7: 103,390,243 (GRCm39)	M68K	probably benign	Het
Or5b99	T	A	19: 12,976,815 (GRCm39)	I155N	possibly damaging	Het
Panx1	A	T	9: 14,921,341 (GRCm39)	V178E	possibly damaging	Het
Pkd1l3	G	A	8: 110,367,402 (GRCm39)	V1210I	probably damaging	Het
Polr2a	A	T	11: 69,638,039 (GRCm39)	H143Q	possibly damaging	Het
Potefam1	A	T	2: 111,048,972 (GRCm39)	M269K	probably benign	Het
Prdm12	G	A	2: 31,544,186 (GRCm39)	R263H	probably damaging	Het
Prkdc	A	C	16: 15,549,430 (GRCm39)	K1998T	probably damaging	Het
Rab11fip1	A	T	8: 27,643,051 (GRCm39)	S583T	probably damaging	Het
Rnf157	T	A	11: 116,237,921 (GRCm39)	T567S	probably benign	Het
Rp1	T	C	1: 4,417,917 (GRCm39)	K1065R	probably damaging	Het
Rp1	A	G	1: 4,418,760 (GRCm39)	I784T	probably benign	Het
Rps10	A	C	17: 27,850,182 (GRCm39)	F150V	probably benign	Het
Rrp12	A	T	19: 41,870,639 (GRCm39)	F499I	probably damaging	Het
Sez6l2	G	A	7: 126,562,535 (GRCm39)	R604H	probably damaging	Het
Slc25a21	G	T	12: 56,904,864 (GRCm39)	Q57K	probably benign	Het
Slc27a2	A	G	2: 126,395,234 (GRCm39)	T54A	possibly damaging	Het
Slc9a9	T	A	9: 95,111,011 (GRCm39)	S610T	probably benign	Het
Smc1b	A	T	15: 84,970,335 (GRCm39)	S973T	probably benign	Het
Smc6	G	A	12: 11,329,734 (GRCm39)	S164N	possibly damaging	Het
Sp1	A	G	15: 102,316,314 (GRCm39)	T32A	possibly damaging	Het
Spen	T	C	4: 141,202,946 (GRCm39)	I1894V	probably benign	Het
Spen	T	C	4: 141,203,011 (GRCm39)	K1872R	possibly damaging	Het
Stab1	C	A	14: 30,873,541 (GRCm39)		probably benign	Het
Taar7d	T	G	10: 23,904,102 (GRCm39)	F328C	probably damaging	Het
Ticam1	A	T	17: 56,578,113 (GRCm39)	S327R	probably benign	Het
Tmem248	C	T	5: 130,258,295 (GRCm39)		probably benign	Het
Tom1	T	C	8: 75,781,259 (GRCm39)	S83P	probably damaging	Het
Txk	T	A	5: 72,856,453 (GRCm39)	Y446F	probably damaging	Het
Ubap1l	T	A	9: 65,279,237 (GRCm39)	C179S	probably benign	Het
Utrn	T	C	10: 12,331,185 (GRCm39)	E474G	possibly damaging	Het
Vmn2r14	T	C	5: 109,363,862 (GRCm39)	M685V	probably benign	Het
Vmn2r7	A	T	3: 64,623,881 (GRCm39)	Y146*	probably null	Het
Wdr1	G	A	5: 38,697,905 (GRCm39)	T220M	probably damaging	Het
Xpo7	T	C	14: 70,915,582 (GRCm39)	D726G	probably damaging	Het
Zbtb14	C	G	17: 69,694,759 (GRCm39)	I152M	probably benign	Het
Zbtb3	A	G	19: 8,780,771 (GRCm39)	D128G	probably damaging	Het
Zeb1os1	A	G	18: 5,583,794 (GRCm39)		noncoding transcript	Het
Zfp462	T	A	4: 55,007,667 (GRCm39)	D35E	probably damaging	Het
Zfp467	A	G	6: 48,415,621 (GRCm39)	S344P	possibly damaging	Het
Zfpm1	A	T	8: 123,034,285 (GRCm39)	D73V	possibly damaging	Het

Other mutations in Macf1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00983:Macf1	APN	4	123,275,915 (GRCm39)	missense	probably damaging	0.99
IGL01293:Macf1	APN	4	123,365,104 (GRCm39)	missense	probably benign	0.00
IGL01307:Macf1	APN	4	123,276,922 (GRCm39)	missense	probably damaging	1.00
IGL01314:Macf1	APN	4	123,380,513 (GRCm39)	missense	probably damaging	1.00
IGL01321:Macf1	APN	4	123,334,567 (GRCm39)	missense	probably damaging	1.00
IGL01327:Macf1	APN	4	123,403,705 (GRCm39)	missense	probably benign	0.20
IGL01365:Macf1	APN	4	123,284,962 (GRCm39)	missense	probably damaging	1.00
IGL01465:Macf1	APN	4	123,384,514 (GRCm39)	missense	probably benign	0.00
IGL01527:Macf1	APN	4	123,386,953 (GRCm39)	missense	possibly damaging	0.93
IGL01533:Macf1	APN	4	123,367,666 (GRCm39)	missense	probably damaging	1.00
IGL01539:Macf1	APN	4	123,289,701 (GRCm39)	splice site	probably benign
IGL01543:Macf1	APN	4	123,295,250 (GRCm39)	missense	probably damaging	1.00
IGL01553:Macf1	APN	4	123,386,956 (GRCm39)	nonsense	probably null
IGL01558:Macf1	APN	4	123,346,798 (GRCm39)	missense	probably benign	0.00
IGL01633:Macf1	APN	4	123,395,964 (GRCm39)	missense	probably damaging	0.99
IGL01684:Macf1	APN	4	123,359,723 (GRCm39)	missense	probably damaging	1.00
IGL01715:Macf1	APN	4	123,284,879 (GRCm39)	missense	probably damaging	1.00
IGL01844:Macf1	APN	4	123,334,485 (GRCm39)	missense	probably benign	0.34
IGL01870:Macf1	APN	4	123,367,906 (GRCm39)	missense	probably damaging	0.99
IGL01916:Macf1	APN	4	123,335,423 (GRCm39)	missense	probably damaging	1.00
IGL01916:Macf1	APN	4	123,369,830 (GRCm39)	missense	probably damaging	1.00
IGL01923:Macf1	APN	4	123,274,237 (GRCm39)	missense	possibly damaging	0.46
IGL02017:Macf1	APN	4	123,393,724 (GRCm39)	missense	probably damaging	1.00
IGL02022:Macf1	APN	4	123,284,842 (GRCm39)	critical splice donor site	probably null
IGL02084:Macf1	APN	4	123,326,396 (GRCm39)	missense	probably benign	0.02
IGL02084:Macf1	APN	4	123,353,167 (GRCm39)	missense	probably damaging	1.00
IGL02142:Macf1	APN	4	123,365,842 (GRCm39)	missense	probably benign	0.11
IGL02151:Macf1	APN	4	123,265,559 (GRCm39)	splice site	probably benign
IGL02164:Macf1	APN	4	123,374,065 (GRCm39)	missense	probably benign	0.03
IGL02174:Macf1	APN	4	123,385,587 (GRCm39)	missense	probably damaging	1.00
IGL02229:Macf1	APN	4	123,403,619 (GRCm39)	missense	probably damaging	1.00
IGL02277:Macf1	APN	4	123,380,497 (GRCm39)	missense	probably damaging	1.00
IGL02283:Macf1	APN	4	123,365,168 (GRCm39)	missense	probably benign	0.01
IGL02314:Macf1	APN	4	123,338,630 (GRCm39)	missense	probably damaging	0.99
IGL02327:Macf1	APN	4	123,365,523 (GRCm39)	missense	probably benign	0.06
IGL02348:Macf1	APN	4	123,406,659 (GRCm39)	missense	probably damaging	1.00
IGL02441:Macf1	APN	4	123,281,029 (GRCm39)	missense	probably damaging	1.00
IGL02585:Macf1	APN	4	123,366,077 (GRCm39)	missense	probably benign	0.00
IGL02602:Macf1	APN	4	123,248,956 (GRCm39)	missense	probably damaging	1.00
IGL03204:Macf1	APN	4	123,249,070 (GRCm39)	splice site	probably benign
anakex	UTSW	4	123,302,064 (GRCm39)	missense	probably damaging	0.97
esfuerzo	UTSW	4	123,369,922 (GRCm39)	missense	probably benign	0.22
Royal_flush	UTSW	4	123,259,148 (GRCm39)	splice site	probably null
standard	UTSW	4	123,380,199 (GRCm39)	missense	probably damaging	1.00
suspension	UTSW	4	123,391,548 (GRCm39)	missense	probably damaging	1.00
voragine	UTSW	4	123,248,895 (GRCm39)	missense	probably damaging	1.00
BB010:Macf1	UTSW	4	123,303,444 (GRCm39)	missense	probably benign	0.00
BB020:Macf1	UTSW	4	123,303,444 (GRCm39)	missense	probably benign	0.00
H8562:Macf1	UTSW	4	123,359,833 (GRCm39)	missense	probably benign	0.13
IGL03052:Macf1	UTSW	4	123,281,188 (GRCm39)	missense	probably damaging	1.00
N/A - 535:Macf1	UTSW	4	123,367,601 (GRCm39)	missense	possibly damaging	0.82
PIT4576001:Macf1	UTSW	4	123,367,114 (GRCm39)	missense	probably benign	0.43
R0021:Macf1	UTSW	4	123,369,370 (GRCm39)	missense	probably damaging	1.00
R0023:Macf1	UTSW	4	123,382,107 (GRCm39)	splice site	probably benign
R0023:Macf1	UTSW	4	123,382,107 (GRCm39)	splice site	probably benign
R0028:Macf1	UTSW	4	123,275,895 (GRCm39)	missense	probably damaging	1.00
R0066:Macf1	UTSW	4	123,325,943 (GRCm39)	nonsense	probably null
R0066:Macf1	UTSW	4	123,325,943 (GRCm39)	nonsense	probably null
R0067:Macf1	UTSW	4	123,369,041 (GRCm39)	missense	possibly damaging	0.90
R0067:Macf1	UTSW	4	123,369,041 (GRCm39)	missense	possibly damaging	0.90
R0078:Macf1	UTSW	4	123,367,661 (GRCm39)	missense	probably damaging	1.00
R0106:Macf1	UTSW	4	123,302,357 (GRCm39)	missense	probably benign	0.00
R0123:Macf1	UTSW	4	123,326,636 (GRCm39)	missense	possibly damaging	0.78
R0129:Macf1	UTSW	4	123,327,068 (GRCm39)	missense	probably damaging	1.00
R0134:Macf1	UTSW	4	123,326,636 (GRCm39)	missense	possibly damaging	0.78
R0138:Macf1	UTSW	4	123,334,540 (GRCm39)	missense	probably damaging	1.00
R0145:Macf1	UTSW	4	123,281,190 (GRCm39)	missense	probably damaging	1.00
R0195:Macf1	UTSW	4	123,328,709 (GRCm39)	missense	probably damaging	0.99
R0227:Macf1	UTSW	4	123,293,184 (GRCm39)	missense	probably benign	0.14
R0233:Macf1	UTSW	4	123,343,920 (GRCm39)	splice site	probably benign
R0254:Macf1	UTSW	4	123,326,572 (GRCm39)	missense	probably damaging	1.00
R0357:Macf1	UTSW	4	123,351,776 (GRCm39)	missense	probably damaging	1.00
R0398:Macf1	UTSW	4	123,244,810 (GRCm39)	missense	probably damaging	1.00
R0413:Macf1	UTSW	4	123,366,062 (GRCm39)	missense	probably benign
R0426:Macf1	UTSW	4	123,377,453 (GRCm39)	nonsense	probably null
R0441:Macf1	UTSW	4	123,259,148 (GRCm39)	splice site	probably null
R0453:Macf1	UTSW	4	123,338,737 (GRCm39)	missense	probably benign	0.35
R0481:Macf1	UTSW	4	123,377,815 (GRCm39)	splice site	probably null
R0502:Macf1	UTSW	4	123,363,608 (GRCm39)	missense	probably damaging	1.00
R0503:Macf1	UTSW	4	123,363,608 (GRCm39)	missense	probably damaging	1.00
R0519:Macf1	UTSW	4	123,365,113 (GRCm39)	missense	probably benign	0.03
R0543:Macf1	UTSW	4	123,270,171 (GRCm39)	missense	probably damaging	1.00
R0621:Macf1	UTSW	4	123,274,327 (GRCm39)	missense	probably damaging	1.00
R0631:Macf1	UTSW	4	123,349,317 (GRCm39)	nonsense	probably null
R0720:Macf1	UTSW	4	123,326,718 (GRCm39)	missense	probably damaging	1.00
R0730:Macf1	UTSW	4	123,276,323 (GRCm39)	splice site	probably benign
R0755:Macf1	UTSW	4	123,263,719 (GRCm39)	missense	probably damaging	0.99
R0836:Macf1	UTSW	4	123,388,675 (GRCm39)	critical splice donor site	probably null
R0847:Macf1	UTSW	4	123,293,159 (GRCm39)	missense	probably benign	0.03
R0850:Macf1	UTSW	4	123,368,195 (GRCm39)	missense	probably benign
R0924:Macf1	UTSW	4	123,279,271 (GRCm39)	missense	probably damaging	1.00
R0973:Macf1	UTSW	4	123,369,793 (GRCm39)	missense	possibly damaging	0.76
R1025:Macf1	UTSW	4	123,367,609 (GRCm39)	missense	probably damaging	1.00
R1076:Macf1	UTSW	4	123,279,391 (GRCm39)	missense	probably damaging	1.00
R1253:Macf1	UTSW	4	123,351,760 (GRCm39)	missense	probably damaging	1.00
R1301:Macf1	UTSW	4	123,380,451 (GRCm39)	splice site	probably benign
R1337:Macf1	UTSW	4	123,370,068 (GRCm39)	missense	probably benign	0.34
R1344:Macf1	UTSW	4	123,327,246 (GRCm39)	missense	probably damaging	0.99
R1404:Macf1	UTSW	4	123,270,309 (GRCm39)	missense	probably damaging	1.00
R1404:Macf1	UTSW	4	123,270,309 (GRCm39)	missense	probably damaging	1.00
R1443:Macf1	UTSW	4	123,404,800 (GRCm39)	missense	probably damaging	1.00
R1452:Macf1	UTSW	4	123,387,791 (GRCm39)	missense	probably benign
R1465:Macf1	UTSW	4	123,386,947 (GRCm39)	missense	probably damaging	0.98
R1465:Macf1	UTSW	4	123,386,947 (GRCm39)	missense	probably damaging	0.98
R1483:Macf1	UTSW	4	123,404,770 (GRCm39)	missense	probably damaging	1.00
R1510:Macf1	UTSW	4	123,328,555 (GRCm39)	missense	probably null	1.00
R1515:Macf1	UTSW	4	123,272,273 (GRCm39)	missense	probably damaging	1.00
R1524:Macf1	UTSW	4	123,326,323 (GRCm39)	missense	possibly damaging	0.75
R1528:Macf1	UTSW	4	123,369,807 (GRCm39)	missense	probably benign	0.30
R1535:Macf1	UTSW	4	123,334,486 (GRCm39)	missense	probably benign	0.05
R1556:Macf1	UTSW	4	123,348,813 (GRCm39)	missense	probably damaging	1.00
R1564:Macf1	UTSW	4	123,353,150 (GRCm39)	missense	probably benign	0.00
R1586:Macf1	UTSW	4	123,403,639 (GRCm39)	missense	probably benign	0.20
R1626:Macf1	UTSW	4	123,365,327 (GRCm39)	missense	probably benign
R1629:Macf1	UTSW	4	123,402,208 (GRCm39)	nonsense	probably null
R1649:Macf1	UTSW	4	123,377,846 (GRCm39)	missense	probably damaging	0.96
R1650:Macf1	UTSW	4	123,350,393 (GRCm39)	nonsense	probably null
R1706:Macf1	UTSW	4	123,264,377 (GRCm39)	critical splice donor site	probably null
R1713:Macf1	UTSW	4	123,272,487 (GRCm39)	missense	probably damaging	1.00
R1716:Macf1	UTSW	4	123,295,196 (GRCm39)	missense	probably damaging	1.00
R1744:Macf1	UTSW	4	123,369,646 (GRCm39)	missense	probably damaging	1.00
R1752:Macf1	UTSW	4	123,377,465 (GRCm39)	missense	possibly damaging	0.92
R1771:Macf1	UTSW	4	123,405,901 (GRCm39)	missense	probably damaging	1.00
R1812:Macf1	UTSW	4	123,325,817 (GRCm39)	missense	probably damaging	1.00
R1818:Macf1	UTSW	4	123,270,210 (GRCm39)	missense	probably damaging	1.00
R1853:Macf1	UTSW	4	123,406,513 (GRCm39)	splice site	probably null
R1856:Macf1	UTSW	4	123,263,641 (GRCm39)	missense	probably damaging	1.00
R1869:Macf1	UTSW	4	123,244,921 (GRCm39)	missense	probably damaging	1.00
R1880:Macf1	UTSW	4	123,332,384 (GRCm39)	missense	probably damaging	1.00
R1888:Macf1	UTSW	4	123,368,505 (GRCm39)	missense	probably benign
R1888:Macf1	UTSW	4	123,368,505 (GRCm39)	missense	probably benign
R1888:Macf1	UTSW	4	123,348,835 (GRCm39)	missense	possibly damaging	0.91
R1888:Macf1	UTSW	4	123,348,835 (GRCm39)	missense	possibly damaging	0.91
R1902:Macf1	UTSW	4	123,364,958 (GRCm39)	missense	probably benign	0.01
R1907:Macf1	UTSW	4	123,266,192 (GRCm39)	missense	probably damaging	1.00
R1908:Macf1	UTSW	4	123,351,634 (GRCm39)	missense	possibly damaging	0.67
R1932:Macf1	UTSW	4	123,345,830 (GRCm39)	missense	probably damaging	1.00
R1944:Macf1	UTSW	4	123,264,459 (GRCm39)	missense	probably damaging	1.00
R1945:Macf1	UTSW	4	123,384,453 (GRCm39)	nonsense	probably null
R1975:Macf1	UTSW	4	123,383,005 (GRCm39)	missense	probably damaging	1.00
R1989:Macf1	UTSW	4	123,391,519 (GRCm39)	critical splice donor site	probably null
R1991:Macf1	UTSW	4	123,350,488 (GRCm39)	missense	probably damaging	1.00
R1992:Macf1	UTSW	4	123,350,488 (GRCm39)	missense	probably damaging	1.00
R2013:Macf1	UTSW	4	123,577,807 (GRCm39)	missense	probably damaging	1.00
R2021:Macf1	UTSW	4	123,366,523 (GRCm39)	missense	probably damaging	1.00
R2022:Macf1	UTSW	4	123,366,523 (GRCm39)	missense	probably damaging	1.00
R2023:Macf1	UTSW	4	123,366,523 (GRCm39)	missense	probably damaging	1.00
R2024:Macf1	UTSW	4	123,265,711 (GRCm39)	missense	probably damaging	1.00
R2025:Macf1	UTSW	4	123,265,711 (GRCm39)	missense	probably damaging	1.00
R2027:Macf1	UTSW	4	123,265,711 (GRCm39)	missense	probably damaging	1.00
R2049:Macf1	UTSW	4	123,248,895 (GRCm39)	missense	probably damaging	1.00
R2060:Macf1	UTSW	4	123,393,712 (GRCm39)	splice site	probably null
R2092:Macf1	UTSW	4	123,276,971 (GRCm39)	missense	probably damaging	1.00
R2100:Macf1	UTSW	4	123,291,699 (GRCm39)	nonsense	probably null
R2128:Macf1	UTSW	4	123,386,567 (GRCm39)	missense	probably benign	0.11
R2129:Macf1	UTSW	4	123,262,608 (GRCm39)	splice site	probably benign
R2140:Macf1	UTSW	4	123,248,895 (GRCm39)	missense	probably damaging	1.00
R2142:Macf1	UTSW	4	123,248,895 (GRCm39)	missense	probably damaging	1.00
R2182:Macf1	UTSW	4	123,386,464 (GRCm39)	missense	probably damaging	0.98
R2185:Macf1	UTSW	4	123,369,349 (GRCm39)	missense	probably damaging	0.99
R2190:Macf1	UTSW	4	123,353,005 (GRCm39)	missense	probably benign	0.11
R2320:Macf1	UTSW	4	123,333,288 (GRCm39)	missense	probably benign	0.02
R2382:Macf1	UTSW	4	123,268,625 (GRCm39)	missense	probably damaging	1.00
R2429:Macf1	UTSW	4	123,326,377 (GRCm39)	missense	probably damaging	0.99
R2432:Macf1	UTSW	4	123,577,789 (GRCm39)	missense	probably damaging	1.00
R2484:Macf1	UTSW	4	123,367,465 (GRCm39)	missense	probably damaging	1.00
R2842:Macf1	UTSW	4	123,270,210 (GRCm39)	missense	probably damaging	1.00
R2912:Macf1	UTSW	4	123,369,704 (GRCm39)	missense	probably damaging	1.00
R2913:Macf1	UTSW	4	123,369,704 (GRCm39)	missense	probably damaging	1.00
R2914:Macf1	UTSW	4	123,369,704 (GRCm39)	missense	probably damaging	1.00
R2938:Macf1	UTSW	4	123,326,695 (GRCm39)	missense	probably damaging	0.99
R3082:Macf1	UTSW	4	123,255,236 (GRCm39)	splice site	probably null
R3086:Macf1	UTSW	4	123,328,901 (GRCm39)	missense	probably benign	0.00
R3408:Macf1	UTSW	4	123,275,574 (GRCm39)	missense	probably damaging	1.00
R3499:Macf1	UTSW	4	123,421,098 (GRCm39)	nonsense	probably null
R3696:Macf1	UTSW	4	123,350,155 (GRCm39)	missense	probably damaging	1.00
R3716:Macf1	UTSW	4	123,367,295 (GRCm39)	missense	probably benign	0.01
R3727:Macf1	UTSW	4	123,353,104 (GRCm39)	missense	probably damaging	1.00
R3770:Macf1	UTSW	4	123,268,560 (GRCm39)	missense	probably damaging	1.00
R3813:Macf1	UTSW	4	123,268,560 (GRCm39)	missense	probably damaging	1.00
R3825:Macf1	UTSW	4	123,338,744 (GRCm39)	missense	probably benign	0.11
R3893:Macf1	UTSW	4	123,380,199 (GRCm39)	missense	probably damaging	1.00
R3896:Macf1	UTSW	4	123,364,987 (GRCm39)	missense	possibly damaging	0.55
R3947:Macf1	UTSW	4	123,274,213 (GRCm39)	missense	probably damaging	1.00
R4031:Macf1	UTSW	4	123,275,105 (GRCm39)	missense	probably damaging	1.00
R4052:Macf1	UTSW	4	123,365,810 (GRCm39)	missense	probably benign	0.00
R4077:Macf1	UTSW	4	123,365,884 (GRCm39)	missense	probably benign	0.07
R4078:Macf1	UTSW	4	123,365,884 (GRCm39)	missense	probably benign	0.07
R4084:Macf1	UTSW	4	123,343,865 (GRCm39)	missense	probably damaging	0.98
R4094:Macf1	UTSW	4	123,353,062 (GRCm39)	missense	probably benign	0.00
R4154:Macf1	UTSW	4	123,365,606 (GRCm39)	missense	probably damaging	1.00
R4190:Macf1	UTSW	4	123,366,835 (GRCm39)	missense	possibly damaging	0.95
R4191:Macf1	UTSW	4	123,366,835 (GRCm39)	missense	possibly damaging	0.95
R4192:Macf1	UTSW	4	123,366,835 (GRCm39)	missense	possibly damaging	0.95
R4232:Macf1	UTSW	4	123,326,185 (GRCm39)	missense	probably damaging	1.00
R4299:Macf1	UTSW	4	123,293,199 (GRCm39)	missense	probably damaging	1.00
R4326:Macf1	UTSW	4	123,276,005 (GRCm39)	missense	probably damaging	1.00
R4327:Macf1	UTSW	4	123,276,005 (GRCm39)	missense	probably damaging	1.00
R4355:Macf1	UTSW	4	123,368,884 (GRCm39)	missense	possibly damaging	0.79
R4380:Macf1	UTSW	4	123,248,285 (GRCm39)	intron	probably benign
R4422:Macf1	UTSW	4	123,359,839 (GRCm39)	missense	probably damaging	0.96
R4436:Macf1	UTSW	4	123,421,135 (GRCm39)	missense	probably benign	0.03
R4472:Macf1	UTSW	4	123,289,782 (GRCm39)	missense	probably damaging	1.00
R4515:Macf1	UTSW	4	123,387,781 (GRCm39)	missense	probably damaging	1.00
R4549:Macf1	UTSW	4	123,367,486 (GRCm39)	missense	possibly damaging	0.75
R4621:Macf1	UTSW	4	123,266,141 (GRCm39)	critical splice donor site	probably null
R4622:Macf1	UTSW	4	123,266,141 (GRCm39)	critical splice donor site	probably null
R4623:Macf1	UTSW	4	123,266,141 (GRCm39)	critical splice donor site	probably null
R4630:Macf1	UTSW	4	123,367,432 (GRCm39)	missense	possibly damaging	0.84
R4647:Macf1	UTSW	4	123,367,420 (GRCm39)	missense	probably benign	0.01
R4650:Macf1	UTSW	4	123,367,412 (GRCm39)	missense	probably benign	0.00
R4674:Macf1	UTSW	4	123,366,190 (GRCm39)	missense	probably benign	0.22
R4751:Macf1	UTSW	4	123,365,443 (GRCm39)	missense	probably benign	0.01
R4762:Macf1	UTSW	4	123,349,237 (GRCm39)	missense	probably benign	0.00
R4776:Macf1	UTSW	4	123,369,808 (GRCm39)	missense	probably benign	0.00
R4777:Macf1	UTSW	4	123,270,295 (GRCm39)	missense	probably damaging	1.00
R4860:Macf1	UTSW	4	123,380,543 (GRCm39)	missense	probably damaging	1.00
R4860:Macf1	UTSW	4	123,380,543 (GRCm39)	missense	probably damaging	1.00
R4865:Macf1	UTSW	4	123,327,096 (GRCm39)	missense	probably damaging	1.00
R4867:Macf1	UTSW	4	123,365,993 (GRCm39)	missense	probably damaging	0.97
R4884:Macf1	UTSW	4	123,348,802 (GRCm39)	missense	probably benign	0.02
R4890:Macf1	UTSW	4	123,342,031 (GRCm39)	missense	probably damaging	1.00
R4913:Macf1	UTSW	4	123,393,682 (GRCm39)	missense	probably damaging	1.00
R4925:Macf1	UTSW	4	123,420,445 (GRCm39)	missense	probably benign
R4948:Macf1	UTSW	4	123,391,548 (GRCm39)	missense	probably damaging	1.00
R4958:Macf1	UTSW	4	123,369,157 (GRCm39)	missense	probably damaging	0.99
R4986:Macf1	UTSW	4	123,284,914 (GRCm39)	missense	probably damaging	1.00
R4999:Macf1	UTSW	4	123,388,702 (GRCm39)	missense	probably benign	0.14
R5004:Macf1	UTSW	4	123,279,268 (GRCm39)	missense	probably damaging	1.00
R5017:Macf1	UTSW	4	123,345,906 (GRCm39)	missense	probably damaging	1.00
R5018:Macf1	UTSW	4	123,279,392 (GRCm39)	missense	probably damaging	1.00
R5026:Macf1	UTSW	4	123,333,287 (GRCm39)	missense	possibly damaging	0.95
R5037:Macf1	UTSW	4	123,349,312 (GRCm39)	missense	probably damaging	0.97
R5039:Macf1	UTSW	4	123,405,013 (GRCm39)	missense	probably damaging	1.00
R5041:Macf1	UTSW	4	123,290,839 (GRCm39)	splice site	probably null
R5100:Macf1	UTSW	4	123,368,261 (GRCm39)	missense	probably benign	0.11
R5110:Macf1	UTSW	4	123,261,801 (GRCm39)	missense	probably damaging	0.99
R5122:Macf1	UTSW	4	123,346,085 (GRCm39)	missense	probably damaging	1.00
R5187:Macf1	UTSW	4	123,365,882 (GRCm39)	missense	probably benign	0.00
R5191:Macf1	UTSW	4	123,366,755 (GRCm39)	missense	probably benign	0.00
R5201:Macf1	UTSW	4	123,369,738 (GRCm39)	nonsense	probably null
R5236:Macf1	UTSW	4	123,291,614 (GRCm39)	missense	probably damaging	1.00
R5248:Macf1	UTSW	4	123,295,567 (GRCm39)	nonsense	probably null
R5251:Macf1	UTSW	4	123,343,760 (GRCm39)	missense	probably benign	0.20
R5319:Macf1	UTSW	4	123,367,229 (GRCm39)	missense	probably damaging	1.00
R5326:Macf1	UTSW	4	123,244,784 (GRCm39)	frame shift	probably null
R5327:Macf1	UTSW	4	123,244,784 (GRCm39)	frame shift	probably null
R5328:Macf1	UTSW	4	123,244,784 (GRCm39)	frame shift	probably null
R5350:Macf1	UTSW	4	123,421,251 (GRCm39)	start codon destroyed	probably null	0.02
R5390:Macf1	UTSW	4	123,365,546 (GRCm39)	missense	probably damaging	0.98
R5419:Macf1	UTSW	4	123,290,917 (GRCm39)	missense	possibly damaging	0.70
R5428:Macf1	UTSW	4	123,278,661 (GRCm39)	missense	probably damaging	1.00
R5432:Macf1	UTSW	4	123,353,129 (GRCm39)	nonsense	probably null
R5466:Macf1	UTSW	4	123,346,658 (GRCm39)	missense	possibly damaging	0.75
R5472:Macf1	UTSW	4	123,343,854 (GRCm39)	missense	probably benign
R5564:Macf1	UTSW	4	123,420,538 (GRCm39)	missense	possibly damaging	0.92
R5566:Macf1	UTSW	4	123,328,957 (GRCm39)	missense	probably damaging	0.98
R5597:Macf1	UTSW	4	123,433,570 (GRCm39)	intron	probably benign
R5669:Macf1	UTSW	4	123,370,018 (GRCm39)	missense	probably damaging	1.00
R5682:Macf1	UTSW	4	123,328,552 (GRCm39)	missense	probably damaging	1.00
R5701:Macf1	UTSW	4	123,397,018 (GRCm39)	missense	probably damaging	1.00
R5715:Macf1	UTSW	4	123,577,807 (GRCm39)	missense	probably damaging	1.00
R5760:Macf1	UTSW	4	123,407,677 (GRCm39)	missense	probably damaging	1.00
R5806:Macf1	UTSW	4	123,265,680 (GRCm39)	missense	probably damaging	1.00
R5838:Macf1	UTSW	4	123,345,947 (GRCm39)	missense	possibly damaging	0.95
R5839:Macf1	UTSW	4	123,275,117 (GRCm39)	missense	probably damaging	1.00
R5850:Macf1	UTSW	4	123,401,099 (GRCm39)	missense	probably damaging	1.00
R5875:Macf1	UTSW	4	123,326,107 (GRCm39)	missense	possibly damaging	0.78
R5912:Macf1	UTSW	4	123,290,951 (GRCm39)	missense	probably damaging	1.00
R5913:Macf1	UTSW	4	123,369,832 (GRCm39)	missense	probably damaging	1.00
R5921:Macf1	UTSW	4	123,420,504 (GRCm39)	missense	probably benign
R5940:Macf1	UTSW	4	123,326,674 (GRCm39)	missense	probably damaging	1.00
R5950:Macf1	UTSW	4	123,333,229 (GRCm39)	splice site	probably null
R6005:Macf1	UTSW	4	123,368,068 (GRCm39)	missense	possibly damaging	0.82
R6029:Macf1	UTSW	4	123,401,126 (GRCm39)	missense	probably damaging	1.00
R6041:Macf1	UTSW	4	123,407,641 (GRCm39)	missense	probably damaging	1.00
R6057:Macf1	UTSW	4	123,404,536 (GRCm39)	missense	probably damaging	0.98
R6156:Macf1	UTSW	4	123,366,073 (GRCm39)	missense	probably benign	0.00
R6186:Macf1	UTSW	4	123,377,968 (GRCm39)	missense	probably damaging	1.00
R6197:Macf1	UTSW	4	123,346,085 (GRCm39)	missense	probably damaging	1.00
R6262:Macf1	UTSW	4	123,366,983 (GRCm39)	missense	possibly damaging	0.79
R6296:Macf1	UTSW	4	123,326,668 (GRCm39)	missense	probably damaging	1.00
R6340:Macf1	UTSW	4	123,342,042 (GRCm39)	missense	probably benign	0.13
R6369:Macf1	UTSW	4	123,304,355 (GRCm39)	missense	possibly damaging	0.90
R6414:Macf1	UTSW	4	123,386,988 (GRCm39)	missense	possibly damaging	0.93
R6429:Macf1	UTSW	4	123,295,387 (GRCm39)	splice site	probably null
R6501:Macf1	UTSW	4	123,363,425 (GRCm39)	splice site	probably null
R6508:Macf1	UTSW	4	123,363,535 (GRCm39)	missense	probably damaging	0.96
R6519:Macf1	UTSW	4	123,366,118 (GRCm39)	missense	probably benign	0.13
R6535:Macf1	UTSW	4	123,365,728 (GRCm39)	missense	possibly damaging	0.82
R6537:Macf1	UTSW	4	123,386,518 (GRCm39)	missense	probably damaging	1.00
R6546:Macf1	UTSW	4	123,326,074 (GRCm39)	missense	probably benign	0.14
R6583:Macf1	UTSW	4	123,364,739 (GRCm39)	splice site	probably null
R6597:Macf1	UTSW	4	123,276,485 (GRCm39)	missense	probably damaging	1.00
R6693:Macf1	UTSW	4	123,367,601 (GRCm39)	missense	possibly damaging	0.82
R6696:Macf1	UTSW	4	123,403,596 (GRCm39)	missense	probably damaging	1.00
R6704:Macf1	UTSW	4	123,304,555 (GRCm39)	intron	probably benign
R6716:Macf1	UTSW	4	123,402,231 (GRCm39)	missense	probably damaging	1.00
R6789:Macf1	UTSW	4	123,266,231 (GRCm39)	missense	probably damaging	1.00
R6807:Macf1	UTSW	4	123,268,208 (GRCm39)	missense	probably damaging	1.00
R6825:Macf1	UTSW	4	123,277,015 (GRCm39)	splice site	probably null
R6881:Macf1	UTSW	4	123,326,246 (GRCm39)	missense	probably damaging	1.00
R6894:Macf1	UTSW	4	123,377,480 (GRCm39)	missense	possibly damaging	0.89
R6924:Macf1	UTSW	4	123,421,145 (GRCm39)	missense	possibly damaging	0.53
R6962:Macf1	UTSW	4	123,334,515 (GRCm39)	missense	probably benign	0.01
R6965:Macf1	UTSW	4	123,302,538 (GRCm39)	missense	probably benign	0.38
R6969:Macf1	UTSW	4	123,351,593 (GRCm39)	missense	probably benign	0.01
R7032:Macf1	UTSW	4	123,366,101 (GRCm39)	missense	probably benign	0.00
R7055:Macf1	UTSW	4	123,302,989 (GRCm39)	missense	probably benign	0.01
R7078:Macf1	UTSW	4	123,325,936 (GRCm39)	missense	probably damaging	0.99
R7215:Macf1	UTSW	4	123,401,097 (GRCm39)	missense	probably damaging	1.00
R7263:Macf1	UTSW	4	123,271,943 (GRCm39)	missense	probably damaging	1.00
R7265:Macf1	UTSW	4	123,301,670 (GRCm39)	missense	probably benign	0.00
R7278:Macf1	UTSW	4	123,334,536 (GRCm39)	missense	possibly damaging	0.87
R7312:Macf1	UTSW	4	123,400,130 (GRCm39)	missense	probably damaging	1.00
R7324:Macf1	UTSW	4	123,268,218 (GRCm39)	missense	probably benign	0.09
R7334:Macf1	UTSW	4	123,293,235 (GRCm39)	missense	probably damaging	1.00
R7342:Macf1	UTSW	4	123,275,917 (GRCm39)	missense	probably damaging	1.00
R7409:Macf1	UTSW	4	123,398,263 (GRCm39)	missense	probably damaging	1.00
R7436:Macf1	UTSW	4	123,350,436 (GRCm39)	missense	probably benign
R7440:Macf1	UTSW	4	123,349,239 (GRCm39)	nonsense	probably null
R7462:Macf1	UTSW	4	123,386,556 (GRCm39)	missense	probably damaging	1.00
R7471:Macf1	UTSW	4	123,366,082 (GRCm39)	missense	probably benign	0.00
R7472:Macf1	UTSW	4	123,326,860 (GRCm39)	missense	probably benign	0.16
R7486:Macf1	UTSW	4	123,303,374 (GRCm39)	missense	probably benign	0.00
R7492:Macf1	UTSW	4	123,369,524 (GRCm39)	missense	possibly damaging	0.83
R7511:Macf1	UTSW	4	123,367,093 (GRCm39)	missense	possibly damaging	0.72
R7528:Macf1	UTSW	4	123,325,852 (GRCm39)	missense	possibly damaging	0.90
R7547:Macf1	UTSW	4	123,335,410 (GRCm39)	missense	probably damaging	1.00
R7592:Macf1	UTSW	4	123,304,686 (GRCm39)	intron	probably benign
R7723:Macf1	UTSW	4	123,326,717 (GRCm39)	missense	probably benign	0.00
R7731:Macf1	UTSW	4	123,338,672 (GRCm39)	missense	probably benign	0.19
R7739:Macf1	UTSW	4	123,279,391 (GRCm39)	missense	probably damaging	1.00
R7740:Macf1	UTSW	4	123,578,096 (GRCm39)	start gained	probably benign
R7798:Macf1	UTSW	4	123,271,893 (GRCm39)	missense	probably damaging	1.00
R7799:Macf1	UTSW	4	123,420,906 (GRCm39)	missense	probably benign	0.00
R7801:Macf1	UTSW	4	123,302,064 (GRCm39)	missense	probably damaging	0.97
R7842:Macf1	UTSW	4	123,420,702 (GRCm39)	missense	probably benign	0.12
R7849:Macf1	UTSW	4	123,301,392 (GRCm39)	missense	probably benign	0.00
R7873:Macf1	UTSW	4	123,398,344 (GRCm39)	critical splice acceptor site	probably null
R7933:Macf1	UTSW	4	123,303,444 (GRCm39)	missense	probably benign	0.00
R7934:Macf1	UTSW	4	123,367,727 (GRCm39)	missense	possibly damaging	0.89
R7947:Macf1	UTSW	4	123,295,200 (GRCm39)	missense	probably damaging	0.98
R7988:Macf1	UTSW	4	123,400,273 (GRCm39)	missense	probably damaging	1.00
R7992:Macf1	UTSW	4	123,289,753 (GRCm39)	missense	probably damaging	1.00
R8013:Macf1	UTSW	4	123,420,619 (GRCm39)	missense	probably benign	0.00
R8014:Macf1	UTSW	4	123,420,619 (GRCm39)	missense	probably benign	0.00
R8029:Macf1	UTSW	4	123,338,685 (GRCm39)	missense	possibly damaging	0.50
R8064:Macf1	UTSW	4	123,353,167 (GRCm39)	missense	possibly damaging	0.91
R8085:Macf1	UTSW	4	123,303,875 (GRCm39)	missense	possibly damaging	0.46
R8094:Macf1	UTSW	4	123,263,660 (GRCm39)	missense	probably damaging	0.99
R8099:Macf1	UTSW	4	123,369,922 (GRCm39)	missense	probably benign	0.22
R8147:Macf1	UTSW	4	123,385,491 (GRCm39)	missense	probably damaging	1.00
R8151:Macf1	UTSW	4	123,291,206 (GRCm39)	missense	possibly damaging	0.91
R8186:Macf1	UTSW	4	123,275,923 (GRCm39)	missense	possibly damaging	0.89
R8186:Macf1	UTSW	4	123,266,219 (GRCm39)	missense	probably damaging	1.00
R8192:Macf1	UTSW	4	123,334,390 (GRCm39)	missense	probably damaging	1.00
R8196:Macf1	UTSW	4	123,276,497 (GRCm39)	missense	probably damaging	1.00
R8260:Macf1	UTSW	4	123,365,863 (GRCm39)	missense	probably benign
R8305:Macf1	UTSW	4	123,289,414 (GRCm39)	intron	probably benign
R8333:Macf1	UTSW	4	123,279,245 (GRCm39)	splice site	probably null
R8334:Macf1	UTSW	4	123,325,901 (GRCm39)	missense	possibly damaging	0.82
R8344:Macf1	UTSW	4	123,420,649 (GRCm39)	missense	probably benign
R8344:Macf1	UTSW	4	123,278,476 (GRCm39)	missense	probably damaging	1.00
R8422:Macf1	UTSW	4	123,303,279 (GRCm39)	missense	possibly damaging	0.46
R8459:Macf1	UTSW	4	123,374,107 (GRCm39)	missense	possibly damaging	0.68
R8466:Macf1	UTSW	4	123,349,237 (GRCm39)	missense	probably benign	0.00
R8472:Macf1	UTSW	4	123,346,795 (GRCm39)	missense	probably damaging	1.00
R8556:Macf1	UTSW	4	123,382,136 (GRCm39)	missense	probably damaging	1.00
R8679:Macf1	UTSW	4	123,405,869 (GRCm39)	missense	probably benign	0.00
R8723:Macf1	UTSW	4	123,348,910 (GRCm39)	nonsense	probably null
R8732:Macf1	UTSW	4	123,403,563 (GRCm39)	critical splice donor site	probably null
R8747:Macf1	UTSW	4	123,248,944 (GRCm39)	missense	probably damaging	1.00
R8748:Macf1	UTSW	4	123,368,068 (GRCm39)	missense	probably benign	0.00
R8785:Macf1	UTSW	4	123,342,053 (GRCm39)	critical splice acceptor site	probably null
R8826:Macf1	UTSW	4	123,276,022 (GRCm39)	missense	probably damaging	1.00
R8828:Macf1	UTSW	4	123,302,204 (GRCm39)	missense	probably benign	0.01
R8833:Macf1	UTSW	4	123,365,134 (GRCm39)	missense	probably benign
R8889:Macf1	UTSW	4	123,249,036 (GRCm39)	missense	probably damaging	1.00
R8892:Macf1	UTSW	4	123,249,036 (GRCm39)	missense	probably damaging	1.00
R8893:Macf1	UTSW	4	123,304,323 (GRCm39)	missense	probably benign	0.27
R8899:Macf1	UTSW	4	123,368,852 (GRCm39)	missense	probably benign	0.00
R8956:Macf1	UTSW	4	123,368,641 (GRCm39)	missense	probably benign
R9037:Macf1	UTSW	4	123,365,518 (GRCm39)	missense	probably benign	0.03
R9086:Macf1	UTSW	4	123,377,944 (GRCm39)	missense	probably damaging	1.00
R9111:Macf1	UTSW	4	123,406,819 (GRCm39)	missense	probably damaging	1.00
R9126:Macf1	UTSW	4	123,276,193 (GRCm39)	missense	possibly damaging	0.88
R9139:Macf1	UTSW	4	123,328,564 (GRCm39)	missense	probably damaging	1.00
R9140:Macf1	UTSW	4	123,367,855 (GRCm39)	missense	possibly damaging	0.92
R9149:Macf1	UTSW	4	123,365,326 (GRCm39)	missense	probably benign	0.40
R9163:Macf1	UTSW	4	123,403,686 (GRCm39)	missense	probably damaging	1.00
R9177:Macf1	UTSW	4	123,367,582 (GRCm39)	missense	probably damaging	1.00
R9206:Macf1	UTSW	4	123,577,925 (GRCm39)	missense	unknown
R9208:Macf1	UTSW	4	123,577,925 (GRCm39)	missense	unknown
R9209:Macf1	UTSW	4	123,326,227 (GRCm39)	missense	probably damaging	1.00
R9219:Macf1	UTSW	4	123,301,554 (GRCm39)	missense	possibly damaging	0.81
R9224:Macf1	UTSW	4	123,326,690 (GRCm39)	missense	probably damaging	1.00
R9241:Macf1	UTSW	4	123,271,952 (GRCm39)	missense	probably damaging	1.00
R9268:Macf1	UTSW	4	123,367,582 (GRCm39)	missense	probably damaging	1.00
R9276:Macf1	UTSW	4	123,328,501 (GRCm39)	missense	probably damaging	1.00
R9296:Macf1	UTSW	4	123,400,246 (GRCm39)	missense	probably damaging	0.99
R9369:Macf1	UTSW	4	123,349,150 (GRCm39)	critical splice donor site	probably null
R9438:Macf1	UTSW	4	123,279,366 (GRCm39)	missense	probably benign	0.01
R9443:Macf1	UTSW	4	123,365,668 (GRCm39)	missense	probably benign
R9529:Macf1	UTSW	4	123,407,680 (GRCm39)	missense	probably damaging	1.00
R9600:Macf1	UTSW	4	123,365,002 (GRCm39)	missense	possibly damaging	0.76
R9613:Macf1	UTSW	4	123,420,288 (GRCm39)	missense	probably benign	0.41
R9686:Macf1	UTSW	4	123,377,491 (GRCm39)	missense	possibly damaging	0.64
R9689:Macf1	UTSW	4	123,365,654 (GRCm39)	missense	probably benign
R9740:Macf1	UTSW	4	123,366,853 (GRCm39)	missense	probably damaging	1.00
R9740:Macf1	UTSW	4	123,266,177 (GRCm39)	missense	probably damaging	1.00
R9764:Macf1	UTSW	4	123,366,136 (GRCm39)	missense	probably benign	0.02
R9779:Macf1	UTSW	4	123,348,789 (GRCm39)	missense	probably benign	0.02
RF011:Macf1	UTSW	4	123,367,648 (GRCm39)	missense	probably damaging	1.00
X0022:Macf1	UTSW	4	123,343,835 (GRCm39)	missense	probably damaging	0.99
X0027:Macf1	UTSW	4	123,397,062 (GRCm39)	missense	probably damaging	1.00
X0064:Macf1	UTSW	4	123,405,667 (GRCm39)	missense	probably damaging	1.00
Z1177:Macf1	UTSW	4	123,365,268 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- CTCATTCAGCATGGGGTAACAGGG -3'
(R):5'- GTCAAGTCAAGTCAGTAGCAGGCAG -3'

Sequencing Primer
(F):5'- GGCTTCctttttctttttttttttcc -3'
(R):5'- gtagcaggcagagccag -3'

Posted On

2014-04-13