Incidental Mutation 'R0076:Stk10'
ID 16839
Institutional Source Beutler Lab
Gene Symbol Stk10
Ensembl Gene ENSMUSG00000020272
Gene Name serine/threonine kinase 10
Synonyms Lok, Gek1
MMRRC Submission 038363-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R0076 (G1)
Quality Score
Status Validated
Chromosome 11
Chromosomal Location 32483305-32574587 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 32553722 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 580 (T580A)
Ref Sequence ENSEMBL: ENSMUSP00000099885 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102821]
AlphaFold O55098
Predicted Effect probably benign
Transcript: ENSMUST00000102821
AA Change: T580A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000099885
Gene: ENSMUSG00000020272
AA Change: T580A

DomainStartEndE-ValueType
S_TKc 36 294 8.66e-92 SMART
low complexity region 316 334 N/A INTRINSIC
low complexity region 544 577 N/A INTRINSIC
Pfam:PKK 586 724 1.9e-41 PFAM
Pfam:PKK 754 894 2.2e-37 PFAM
Meta Mutation Damage Score 0.0576 question?
Coding Region Coverage
  • 1x: 89.9%
  • 3x: 87.5%
  • 10x: 81.6%
  • 20x: 72.8%
Validation Efficiency 92% (83/90)
MGI Phenotype FUNCTION: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted disruption of this gene results in enhanced cell adhesion in mitogen-stimulated T cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 T G 7: 119,972,908 (GRCm39) probably benign Het
Acp3 A G 9: 104,201,417 (GRCm39) probably benign Het
Ada T A 2: 163,569,523 (GRCm39) probably benign Het
Ankrd17 T A 5: 90,392,265 (GRCm39) K1693* probably null Het
Arhgef38 T A 3: 132,866,507 (GRCm39) H210L possibly damaging Het
Car10 G A 11: 93,381,423 (GRCm39) E129K possibly damaging Het
Cask A G X: 13,544,513 (GRCm39) probably benign Het
Cd19 T C 7: 126,010,034 (GRCm39) D406G probably damaging Het
Cd93 T C 2: 148,284,056 (GRCm39) D430G probably benign Het
Cds1 T C 5: 101,965,706 (GRCm39) probably benign Het
Cerkl A T 2: 79,173,633 (GRCm39) S259T possibly damaging Het
Cfap91 G A 16: 38,123,046 (GRCm39) Q661* probably null Het
Cog8 T C 8: 107,780,765 (GRCm39) I164M possibly damaging Het
Col4a1 G A 8: 11,268,713 (GRCm39) P1009L probably damaging Het
Col9a1 G A 1: 24,276,578 (GRCm39) probably null Het
Dcc G A 18: 71,454,117 (GRCm39) Q1241* probably null Het
Dock3 A C 9: 106,788,685 (GRCm39) probably benign Het
Dus1l A T 11: 120,683,634 (GRCm39) probably benign Het
Dvl2 G A 11: 69,898,926 (GRCm39) E438K probably damaging Het
Eif3g A G 9: 20,809,049 (GRCm39) F85S probably damaging Het
Fam234b A G 6: 135,204,224 (GRCm39) M456V probably benign Het
Fbxo47 G A 11: 97,748,481 (GRCm39) probably benign Het
Fyb2 A G 4: 104,802,661 (GRCm39) T188A possibly damaging Het
Gm11437 T C 11: 84,039,462 (GRCm39) T288A possibly damaging Het
Gm5546 T A 3: 104,260,448 (GRCm39) noncoding transcript Het
Gmfb C A 14: 47,054,912 (GRCm39) A11S probably benign Het
Gpat4 G A 8: 23,680,721 (GRCm39) probably benign Het
Ifitm6 T A 7: 140,595,920 (GRCm39) R124S possibly damaging Het
Il17rd T A 14: 26,816,811 (GRCm39) L172Q probably damaging Het
Il4 A T 11: 53,504,741 (GRCm39) L13Q probably damaging Het
Kif2b A G 11: 91,466,735 (GRCm39) M516T probably damaging Het
Kmt2a A G 9: 44,741,356 (GRCm39) probably benign Het
Mark1-ps1 T A 17: 54,254,905 (GRCm39) noncoding transcript Het
Mndal G T 1: 173,702,013 (GRCm39) C96* probably null Het
Mroh1 T C 15: 76,335,340 (GRCm39) S1365P probably benign Het
Mrpl12 A G 11: 120,376,268 (GRCm39) probably benign Het
Mthfsd C A 8: 121,825,478 (GRCm39) V270F probably benign Het
Nbas T A 12: 13,374,337 (GRCm39) V555D probably damaging Het
Pcdhb16 T C 18: 37,611,412 (GRCm39) V124A probably damaging Het
Pla2g10 T A 16: 13,533,382 (GRCm39) Y131F possibly damaging Het
Plec T C 15: 76,075,614 (GRCm39) probably benign Het
Polr2b T A 5: 77,474,408 (GRCm39) V415E possibly damaging Het
Pou6f1 G A 15: 100,485,717 (GRCm39) Q106* probably null Het
Ptprd T C 4: 75,865,276 (GRCm39) probably benign Het
Rad54b G A 4: 11,609,480 (GRCm39) probably benign Het
Rspo1 G A 4: 124,885,190 (GRCm39) R22Q probably benign Het
Scn7a A G 2: 66,544,381 (GRCm39) V370A probably benign Het
Sec1 A G 7: 45,328,315 (GRCm39) V244A probably damaging Het
Serac1 A G 17: 6,115,212 (GRCm39) probably benign Het
Slco2b1 A T 7: 99,334,708 (GRCm39) Y254* probably null Het
Steap3 G A 1: 120,155,460 (GRCm39) R500C probably damaging Het
Tpo C T 12: 30,154,022 (GRCm39) G228R probably damaging Het
Tpx2 T C 2: 152,735,603 (GRCm39) F744L probably damaging Het
Ube3b G T 5: 114,546,278 (GRCm39) probably null Het
Vmn2r84 A G 10: 130,230,062 (GRCm39) S17P probably damaging Het
Vps13d A T 4: 144,891,264 (GRCm39) probably benign Het
Zfp532 T A 18: 65,818,698 (GRCm39) S851R probably benign Het
Zfp623 G A 15: 75,819,058 (GRCm39) E5K probably benign Het
Other mutations in Stk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01105:Stk10 APN 11 32,527,740 (GRCm39) missense probably benign 0.33
IGL01285:Stk10 APN 11 32,560,653 (GRCm39) missense possibly damaging 0.91
IGL01983:Stk10 APN 11 32,539,460 (GRCm39) missense probably benign 0.05
IGL03177:Stk10 APN 11 32,564,592 (GRCm39) missense probably damaging 1.00
IGL03183:Stk10 APN 11 32,554,143 (GRCm39) missense possibly damaging 0.50
coquet UTSW 11 32,527,764 (GRCm39) missense
legacy UTSW 11 32,554,166 (GRCm39) nonsense probably null
mignon UTSW 11 32,537,363 (GRCm39) missense probably damaging 1.00
R0481_stk10_383 UTSW 11 32,564,708 (GRCm39) missense probably damaging 1.00
FR4976:Stk10 UTSW 11 32,564,520 (GRCm39) critical splice acceptor site probably benign
R0003:Stk10 UTSW 11 32,539,460 (GRCm39) missense probably benign 0.05
R0008:Stk10 UTSW 11 32,537,305 (GRCm39) splice site probably benign
R0056:Stk10 UTSW 11 32,567,851 (GRCm39) missense possibly damaging 0.95
R0227:Stk10 UTSW 11 32,567,859 (GRCm39) missense probably damaging 1.00
R0440:Stk10 UTSW 11 32,554,190 (GRCm39) missense probably damaging 1.00
R0454:Stk10 UTSW 11 32,546,724 (GRCm39) missense probably damaging 0.99
R0481:Stk10 UTSW 11 32,564,708 (GRCm39) missense probably damaging 1.00
R0504:Stk10 UTSW 11 32,567,882 (GRCm39) missense probably benign 0.04
R0790:Stk10 UTSW 11 32,548,653 (GRCm39) missense probably benign 0.00
R1439:Stk10 UTSW 11 32,567,919 (GRCm39) missense probably damaging 0.98
R1539:Stk10 UTSW 11 32,483,440 (GRCm39) missense possibly damaging 0.85
R1770:Stk10 UTSW 11 32,572,464 (GRCm39) missense possibly damaging 0.94
R4304:Stk10 UTSW 11 32,560,634 (GRCm39) missense probably damaging 0.97
R4430:Stk10 UTSW 11 32,483,552 (GRCm39) missense possibly damaging 0.81
R4702:Stk10 UTSW 11 32,505,172 (GRCm39) missense probably benign 0.28
R4797:Stk10 UTSW 11 32,548,471 (GRCm39) missense probably benign 0.01
R5447:Stk10 UTSW 11 32,554,166 (GRCm39) nonsense probably null
R5801:Stk10 UTSW 11 32,546,748 (GRCm39) missense probably benign 0.01
R5802:Stk10 UTSW 11 32,546,748 (GRCm39) missense probably benign 0.01
R6129:Stk10 UTSW 11 32,565,871 (GRCm39) missense probably damaging 1.00
R6154:Stk10 UTSW 11 32,553,654 (GRCm39) splice site probably null
R6175:Stk10 UTSW 11 32,553,761 (GRCm39) missense possibly damaging 0.46
R6185:Stk10 UTSW 11 32,527,749 (GRCm39) missense probably benign 0.13
R6520:Stk10 UTSW 11 32,538,839 (GRCm39) missense probably damaging 1.00
R6824:Stk10 UTSW 11 32,537,363 (GRCm39) missense probably damaging 1.00
R7259:Stk10 UTSW 11 32,548,497 (GRCm39) missense probably benign 0.00
R7649:Stk10 UTSW 11 32,527,764 (GRCm39) missense
R8331:Stk10 UTSW 11 32,538,928 (GRCm39) missense
R8847:Stk10 UTSW 11 32,539,427 (GRCm39) missense
R9252:Stk10 UTSW 11 32,538,915 (GRCm39) missense
R9367:Stk10 UTSW 11 32,538,878 (GRCm39) missense
X0027:Stk10 UTSW 11 32,537,361 (GRCm39) missense probably benign 0.01
Posted On 2013-01-20