Incidental Mutation 'R0096:Tektl1'
ID 16863
Institutional Source Beutler Lab
Gene Symbol Tektl1
Ensembl Gene ENSMUSG00000078442
Gene Name tektin like 1
Synonyms Ccdc105, 4931413A09Rik
MMRRC Submission 038382-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R0096 (G1)
Quality Score
Status Validated
Chromosome 10
Chromosomal Location 78582760-78588899 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 78584539 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 328 (I328L)
Ref Sequence ENSEMBL: ENSMUSP00000101022 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105383]
AlphaFold Q9D4K7
Predicted Effect probably benign
Transcript: ENSMUST00000105383
AA Change: I328L

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000101022
Gene: ENSMUSG00000078442
AA Change: I328L

DomainStartEndE-ValueType
Pfam:Tektin 115 470 1.6e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209307
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210562
Meta Mutation Damage Score 0.0765 question?
Coding Region Coverage
  • 1x: 90.0%
  • 3x: 87.5%
  • 10x: 81.4%
  • 20x: 72.0%
Validation Efficiency 89% (76/85)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405L10Rik A T 8: 106,435,563 (GRCm39) probably null Het
Adamts3 G A 5: 89,849,576 (GRCm39) Q615* probably null Het
Adamtsl3 T A 7: 82,114,907 (GRCm39) probably benign Het
Anks1b T C 10: 89,909,924 (GRCm39) S48P possibly damaging Het
Aoc1l2 A C 6: 48,908,122 (GRCm39) Q374P probably damaging Het
Arhgap42 G T 9: 9,009,314 (GRCm39) N524K probably damaging Het
Arhgef28 T G 13: 98,067,762 (GRCm39) T1388P probably damaging Het
Arid4b T C 13: 14,303,779 (GRCm39) V68A probably benign Het
Bard1 A T 1: 71,092,889 (GRCm39) probably benign Het
BC005537 T C 13: 24,989,923 (GRCm39) F129L probably damaging Het
Capn3 A T 2: 120,333,010 (GRCm39) H592L possibly damaging Het
Cilp A G 9: 65,180,952 (GRCm39) T256A possibly damaging Het
Cpne8 T A 15: 90,384,118 (GRCm39) I481L probably benign Het
Dglucy A T 12: 100,804,910 (GRCm39) I134F possibly damaging Het
Dnai2 A C 11: 114,645,158 (GRCm39) D531A probably benign Het
Dthd1 A T 5: 63,000,383 (GRCm39) R568S possibly damaging Het
Efr3a A G 15: 65,727,290 (GRCm39) N613S probably damaging Het
Ermp1 A G 19: 29,608,788 (GRCm39) Y164H possibly damaging Het
Fbrs C T 7: 127,088,659 (GRCm39) A145V probably damaging Het
Gm9873 A T 2: 168,863,029 (GRCm39) noncoding transcript Het
Grik1 T C 16: 87,831,114 (GRCm39) M219V possibly damaging Het
Gucy1a2 A T 9: 3,758,928 (GRCm39) probably benign Het
Itih5 G A 2: 10,256,189 (GRCm39) R885Q probably benign Het
Kat2a A T 11: 100,597,297 (GRCm39) V625E probably damaging Het
Kdm4c A G 4: 74,275,580 (GRCm39) E752G probably damaging Het
Ksr1 A G 11: 78,929,073 (GRCm39) probably benign Het
Lama1 T A 17: 68,112,408 (GRCm39) F2283I probably benign Het
Luc7l3 A G 11: 94,192,320 (GRCm39) probably benign Het
Map1a A G 2: 121,131,986 (GRCm39) E696G probably damaging Het
Mrps34 A G 17: 25,114,643 (GRCm39) D110G probably damaging Het
Myh11 T A 16: 14,022,231 (GRCm39) K1710M possibly damaging Het
Myo1d A G 11: 80,375,158 (GRCm39) L972P probably damaging Het
Nol4 T G 18: 23,054,915 (GRCm39) T58P possibly damaging Het
Nos1ap T C 1: 170,156,816 (GRCm39) D214G probably damaging Het
Or4c119 A T 2: 88,986,640 (GRCm39) M293K probably benign Het
Pde4dip A C 3: 97,674,783 (GRCm39) D44E probably damaging Het
Pip4k2a G A 2: 18,893,850 (GRCm39) probably benign Het
Prmt8 T A 6: 127,709,590 (GRCm39) probably benign Het
Pygl A T 12: 70,237,940 (GRCm39) probably benign Het
Ralgapa1 T C 12: 55,786,290 (GRCm39) D643G probably damaging Het
Sdk2 A G 11: 113,793,970 (GRCm39) probably benign Het
Skint5 A T 4: 113,454,965 (GRCm39) probably benign Het
Slc27a6 T C 18: 58,731,829 (GRCm39) probably benign Het
Spata46 C T 1: 170,139,603 (GRCm39) Q201* probably null Het
Sptbn1 A T 11: 30,064,739 (GRCm39) V1920E probably damaging Het
Sycp2 G T 2: 178,045,528 (GRCm39) Q31K probably damaging Het
Taf6l A G 19: 8,755,881 (GRCm39) F256L probably benign Het
Trf A G 9: 103,099,358 (GRCm39) F300L probably damaging Het
Vmn2r105 A G 17: 20,447,741 (GRCm39) F361S possibly damaging Het
Vmn2r79 A G 7: 86,686,527 (GRCm39) Y636C probably damaging Het
Wdr59 T C 8: 112,231,005 (GRCm39) N68D probably damaging Het
Other mutations in Tektl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00858:Tektl1 APN 10 78,586,403 (GRCm39) missense probably damaging 1.00
IGL01632:Tektl1 APN 10 78,584,536 (GRCm39) missense probably benign 0.01
IGL02473:Tektl1 APN 10 78,586,428 (GRCm39) missense probably benign 0.05
IGL02606:Tektl1 APN 10 78,584,300 (GRCm39) missense probably benign 0.01
IGL03356:Tektl1 APN 10 78,582,966 (GRCm39) missense possibly damaging 0.52
R0096:Tektl1 UTSW 10 78,584,539 (GRCm39) missense probably benign 0.01
R0666:Tektl1 UTSW 10 78,586,381 (GRCm39) missense probably benign 0.04
R1756:Tektl1 UTSW 10 78,583,031 (GRCm39) missense probably damaging 0.96
R1757:Tektl1 UTSW 10 78,583,058 (GRCm39) missense probably benign 0.02
R1765:Tektl1 UTSW 10 78,584,502 (GRCm39) missense probably benign 0.21
R1956:Tektl1 UTSW 10 78,586,373 (GRCm39) critical splice donor site probably null
R2305:Tektl1 UTSW 10 78,584,336 (GRCm39) missense probably damaging 1.00
R3802:Tektl1 UTSW 10 78,584,314 (GRCm39) missense probably damaging 1.00
R3845:Tektl1 UTSW 10 78,584,532 (GRCm39) missense probably benign
R4023:Tektl1 UTSW 10 78,588,727 (GRCm39) missense probably benign 0.03
R4808:Tektl1 UTSW 10 78,588,698 (GRCm39) missense probably benign 0.02
R4812:Tektl1 UTSW 10 78,585,050 (GRCm39) missense probably benign 0.01
R5391:Tektl1 UTSW 10 78,588,688 (GRCm39) nonsense probably null
R5434:Tektl1 UTSW 10 78,584,484 (GRCm39) nonsense probably null
R6382:Tektl1 UTSW 10 78,588,675 (GRCm39) missense possibly damaging 0.90
R6743:Tektl1 UTSW 10 78,588,726 (GRCm39) missense probably benign 0.01
R6749:Tektl1 UTSW 10 78,588,672 (GRCm39) missense possibly damaging 0.95
R7177:Tektl1 UTSW 10 78,588,324 (GRCm39) missense probably damaging 1.00
R8158:Tektl1 UTSW 10 78,584,509 (GRCm39) missense probably benign 0.01
R8504:Tektl1 UTSW 10 78,586,463 (GRCm39) missense probably damaging 1.00
R8504:Tektl1 UTSW 10 78,585,038 (GRCm39) missense probably benign 0.00
R8558:Tektl1 UTSW 10 78,583,035 (GRCm39) missense probably damaging 1.00
R8806:Tektl1 UTSW 10 78,588,306 (GRCm39) missense probably damaging 1.00
R8925:Tektl1 UTSW 10 78,588,258 (GRCm39) missense probably damaging 1.00
R8927:Tektl1 UTSW 10 78,588,258 (GRCm39) missense probably damaging 1.00
R9285:Tektl1 UTSW 10 78,588,234 (GRCm39) splice site probably benign
R9407:Tektl1 UTSW 10 78,583,128 (GRCm39) missense probably damaging 0.99
X0057:Tektl1 UTSW 10 78,586,375 (GRCm39) missense probably null 1.00
Posted On 2013-01-20