Incidental Mutation 'R0063:Tmem89'
ID 16890
Institutional Source Beutler Lab
Gene Symbol Tmem89
Ensembl Gene ENSMUSG00000025652
Gene Name transmembrane protein 89
Synonyms 1700024B07Rik
MMRRC Submission 038355-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R0063 (G1)
Quality Score
Status Validated
Chromosome 9
Chromosomal Location 108743687-108744631 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108743880 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 60 (N60S)
Ref Sequence ENSEMBL: ENSMUSP00000142016 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026744] [ENSMUST00000098376] [ENSMUST00000192852]
AlphaFold Q9DA04
Predicted Effect probably benign
Transcript: ENSMUST00000026744
AA Change: N60S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000026744
Gene: ENSMUSG00000025652
AA Change: N60S

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:TMEM89 23 47 6.3e-16 PFAM
Pfam:TMEM89 46 166 1.1e-62 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000098376
SMART Domains Protein: ENSMUSP00000095979
Gene: ENSMUSG00000023259

DomainStartEndE-ValueType
Pfam:Sulfate_transp 69 458 4.4e-113 PFAM
low complexity region 471 484 N/A INTRINSIC
PDB:3LLO|A 489 546 2e-16 PDB
low complexity region 554 593 N/A INTRINSIC
low complexity region 638 650 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000191404
Predicted Effect probably benign
Transcript: ENSMUST00000192852
AA Change: N60S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000142016
Gene: ENSMUSG00000025652
AA Change: N60S

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:TMEM89 23 47 1.8e-15 PFAM
Pfam:TMEM89 45 118 1.3e-37 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 89.1%
  • 3x: 86.1%
  • 10x: 78.0%
  • 20x: 64.7%
Validation Efficiency 99% (86/87)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik C T 16: 4,678,912 (GRCm39) R245* probably null Het
4930563I02Rik T A 14: 60,333,477 (GRCm39) probably benign Het
Acss1 T C 2: 150,469,212 (GRCm39) T435A probably damaging Het
Aoc2 T A 11: 101,216,897 (GRCm39) S327T probably damaging Het
Arid5a T A 1: 36,357,645 (GRCm39) Y252N probably damaging Het
AU040320 T C 4: 126,733,465 (GRCm39) Y662H probably damaging Het
Bcam C T 7: 19,500,773 (GRCm39) V134I probably benign Het
Btbd16 A T 7: 130,424,896 (GRCm39) T426S probably benign Het
Cap2 T C 13: 46,791,508 (GRCm39) probably benign Het
Capn8 T A 1: 182,429,677 (GRCm39) D299E probably damaging Het
Cdipt G A 7: 126,578,772 (GRCm39) V160I probably benign Het
Cyb5r3 T C 15: 83,046,137 (GRCm39) T60A probably benign Het
Dazl T C 17: 152,705,859 (NCBIm37) T212A probably damaging Het
Dgkb T G 12: 38,654,112 (GRCm39) S744A probably benign Het
Dock2 T A 11: 34,647,111 (GRCm39) probably null Het
Ece2 A G 16: 20,461,067 (GRCm39) T442A probably benign Het
Elapor2 T C 5: 9,490,709 (GRCm39) probably benign Het
Emid1 A T 11: 5,139,704 (GRCm38) probably benign Het
Eml3 C A 19: 8,915,842 (GRCm39) A644D probably damaging Het
Foxp1 A G 6: 98,921,684 (GRCm39) probably benign Het
Ints8 T C 4: 11,252,857 (GRCm39) N75S probably damaging Het
Irs1 T A 1: 82,266,580 (GRCm39) E545D probably damaging Het
Lama3 T C 18: 12,661,762 (GRCm39) probably benign Het
Nat8f2 A T 6: 85,844,815 (GRCm39) S182R possibly damaging Het
Nrcam G T 12: 44,596,811 (GRCm39) V343F possibly damaging Het
Pdk2 T C 11: 94,923,306 (GRCm39) H106R probably benign Het
Pkhd1 G A 1: 20,282,174 (GRCm39) T2889I probably benign Het
Pkhd1l1 T A 15: 44,392,633 (GRCm39) L1656H probably damaging Het
Plxna2 A T 1: 194,327,247 (GRCm39) T394S probably benign Het
Pnpla8 T A 12: 44,329,615 (GRCm39) C56S probably damaging Het
Prdm8 G T 5: 98,332,453 (GRCm39) R118L probably damaging Het
Prkce T C 17: 86,789,539 (GRCm39) probably benign Het
Ptprk T A 10: 28,139,763 (GRCm39) Y163N probably damaging Het
Rbbp8 T A 18: 11,867,614 (GRCm39) probably benign Het
Sephs1 A G 2: 4,904,371 (GRCm39) T250A probably benign Het
Slc2a2 T C 3: 28,771,589 (GRCm39) M173T probably damaging Het
Slc2a8 T A 2: 32,870,011 (GRCm39) probably null Het
Tmem131 C T 1: 36,858,209 (GRCm39) V713I probably benign Het
Trio G T 15: 27,881,523 (GRCm39) probably benign Het
Tulp2 T C 7: 45,170,284 (GRCm39) probably benign Het
Uggt2 A G 14: 119,244,542 (GRCm39) probably benign Het
Vwa8 A G 14: 79,401,656 (GRCm39) probably benign Het
Xirp2 A G 2: 67,339,427 (GRCm39) D556G probably damaging Het
Xrn1 T C 9: 95,851,588 (GRCm39) L202P probably damaging Het
Zfp354a A T 11: 50,960,398 (GRCm39) H203L probably damaging Het
Other mutations in Tmem89
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0060:Tmem89 UTSW 9 108,744,485 (GRCm39) missense probably damaging 1.00
R0060:Tmem89 UTSW 9 108,744,485 (GRCm39) missense probably damaging 1.00
R0063:Tmem89 UTSW 9 108,743,880 (GRCm39) missense probably benign 0.00
R2447:Tmem89 UTSW 9 108,743,868 (GRCm39) missense probably damaging 0.98
R4778:Tmem89 UTSW 9 108,744,443 (GRCm39) missense probably damaging 0.98
R4906:Tmem89 UTSW 9 108,743,829 (GRCm39) unclassified probably benign
R5529:Tmem89 UTSW 9 108,744,545 (GRCm39) missense probably damaging 0.98
R8676:Tmem89 UTSW 9 108,744,095 (GRCm39) missense unknown
R9095:Tmem89 UTSW 9 108,743,729 (GRCm39) missense unknown
Posted On 2013-01-20