Incidental Mutation 'R1498:Fasn'
| ID |
169061 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fasn
|
| Ensembl Gene |
ENSMUSG00000025153 |
| Gene Name |
fatty acid synthase |
| Synonyms |
A630082H08Rik, FAS |
| MMRRC Submission |
039549-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1498 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
120696672-120715373 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 120706245 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 1033
(T1033I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000052872
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055655]
[ENSMUST00000206589]
|
| AlphaFold |
P19096 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055655
AA Change: T1033I
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000052872
Gene: ENSMUSG00000025153
AA Change: T1033I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ketoacyl-synt
|
1 |
239 |
6.8e-73 |
PFAM |
|
Pfam:Ketoacyl-synt_C
|
243 |
360 |
3.7e-38 |
PFAM |
|
Pfam:KAsynt_C_assoc
|
362 |
474 |
8.2e-46 |
PFAM |
|
Pfam:Acyl_transf_1
|
493 |
810 |
9.5e-115 |
PFAM |
|
Pfam:PS-DH
|
853 |
1169 |
9.9e-24 |
PFAM |
|
low complexity region
|
1175 |
1204 |
N/A |
INTRINSIC |
|
Pfam:Methyltransf_12
|
1238 |
1337 |
2e-9 |
PFAM |
|
PKS_ER
|
1532 |
1847 |
1.44e-147 |
SMART |
|
PKS_KR
|
1878 |
2059 |
2.33e-42 |
SMART |
|
Pfam:PP-binding
|
2119 |
2185 |
1.1e-10 |
PFAM |
|
Pfam:Thioesterase
|
2235 |
2494 |
1.6e-62 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000206589
AA Change: T1033I
PolyPhen 2
Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206637
|
| Meta Mutation Damage Score |
0.3822 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.2%
- 20x: 92.6%
|
| Validation Efficiency |
97% (83/86) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted mutation of this locus has implicated its product in embryogenesis as all homozygotes and most heterozygotes die prior to birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acly |
A |
G |
11: 100,374,627 (GRCm39) |
S799P |
probably benign |
Het |
| Acvr1b |
T |
C |
15: 101,091,891 (GRCm39) |
F57S |
probably benign |
Het |
| Adamts5 |
T |
A |
16: 85,696,990 (GRCm39) |
T56S |
possibly damaging |
Het |
| Adrb2 |
T |
C |
18: 62,312,004 (GRCm39) |
T274A |
probably damaging |
Het |
| Agr3 |
A |
T |
12: 35,984,379 (GRCm39) |
|
probably null |
Het |
| Ankrd6 |
A |
G |
4: 32,810,289 (GRCm39) |
M405T |
probably benign |
Het |
| Aoc1l2 |
A |
G |
6: 48,908,305 (GRCm39) |
H435R |
probably benign |
Het |
| Aqp5 |
T |
C |
15: 99,491,128 (GRCm39) |
I60T |
probably damaging |
Het |
| Arf5 |
G |
T |
6: 28,426,153 (GRCm39) |
R180L |
probably benign |
Het |
| Asap3 |
A |
G |
4: 135,966,505 (GRCm39) |
N528D |
probably benign |
Het |
| Atmin |
G |
A |
8: 117,681,540 (GRCm39) |
E180K |
probably benign |
Het |
| Bcl11a |
A |
T |
11: 24,114,005 (GRCm39) |
E449D |
probably damaging |
Het |
| Cep128 |
A |
T |
12: 91,333,191 (GRCm39) |
F25I |
probably benign |
Het |
| Cfp |
GCAC |
GC |
X: 20,795,905 (GRCm39) |
|
probably null |
Het |
| Chpt1 |
T |
A |
10: 88,312,966 (GRCm39) |
Y282F |
possibly damaging |
Het |
| Cul7 |
A |
G |
17: 46,966,636 (GRCm39) |
D355G |
probably benign |
Het |
| Daxx |
T |
C |
17: 34,131,227 (GRCm39) |
Y385H |
probably damaging |
Het |
| Dnah2 |
A |
C |
11: 69,411,493 (GRCm39) |
|
probably null |
Het |
| Dscc1 |
CTGAATGAAT |
CTGAAT |
15: 54,943,572 (GRCm39) |
|
probably benign |
Het |
| Erc2 |
T |
A |
14: 28,024,855 (GRCm39) |
M578K |
probably benign |
Het |
| Evc |
T |
A |
5: 37,481,044 (GRCm39) |
H267L |
possibly damaging |
Het |
| Exosc10 |
A |
C |
4: 148,666,243 (GRCm39) |
Q837P |
possibly damaging |
Het |
| Fat1 |
C |
A |
8: 45,478,521 (GRCm39) |
Y2522* |
probably null |
Het |
| Fbxw8 |
G |
A |
5: 118,203,850 (GRCm39) |
|
probably benign |
Het |
| Fyn |
A |
G |
10: 39,408,120 (GRCm39) |
D321G |
possibly damaging |
Het |
| Grm6 |
G |
A |
11: 50,748,083 (GRCm39) |
V398M |
probably damaging |
Het |
| Gtpbp1 |
T |
A |
15: 79,603,222 (GRCm39) |
|
probably null |
Het |
| Hnf1a |
A |
G |
5: 115,108,596 (GRCm39) |
V103A |
probably damaging |
Het |
| Hsp90aa1 |
A |
T |
12: 110,662,122 (GRCm39) |
|
probably null |
Het |
| Iqgap2 |
C |
T |
13: 95,783,313 (GRCm39) |
V1288I |
probably benign |
Het |
| Irx5 |
A |
G |
8: 93,086,514 (GRCm39) |
D199G |
probably damaging |
Het |
| Klrh1 |
A |
G |
6: 129,748,703 (GRCm39) |
S105P |
probably damaging |
Het |
| Krt9 |
G |
T |
11: 100,079,195 (GRCm39) |
C732* |
probably null |
Het |
| Lifr |
T |
C |
15: 7,220,099 (GRCm39) |
S910P |
probably damaging |
Het |
| Lrig1 |
G |
A |
6: 94,604,968 (GRCm39) |
A209V |
possibly damaging |
Het |
| Lrrk1 |
T |
A |
7: 65,952,419 (GRCm39) |
R506* |
probably null |
Het |
| Lyst |
T |
A |
13: 13,824,960 (GRCm39) |
I1525K |
possibly damaging |
Het |
| Mad2l1 |
C |
T |
6: 66,516,826 (GRCm39) |
Q173* |
probably null |
Het |
| Mcoln1 |
T |
A |
8: 3,562,861 (GRCm39) |
I524N |
probably damaging |
Het |
| Mmp3 |
A |
T |
9: 7,446,967 (GRCm39) |
D49V |
possibly damaging |
Het |
| Morc3 |
A |
T |
16: 93,650,743 (GRCm39) |
N321I |
probably damaging |
Het |
| Mrpl48 |
T |
C |
7: 100,195,695 (GRCm39) |
|
probably benign |
Het |
| Myo6 |
T |
A |
9: 80,214,961 (GRCm39) |
D1231E |
probably damaging |
Het |
| Nlrc4 |
A |
G |
17: 74,753,408 (GRCm39) |
I325T |
probably benign |
Het |
| Or1j19 |
A |
T |
2: 36,677,358 (GRCm39) |
I274F |
probably damaging |
Het |
| Or2ag17 |
T |
C |
7: 106,389,623 (GRCm39) |
Y195C |
possibly damaging |
Het |
| Or4f61 |
A |
T |
2: 111,922,938 (GRCm39) |
M36K |
probably benign |
Het |
| Or8c16 |
C |
G |
9: 38,130,676 (GRCm39) |
P183A |
probably damaging |
Het |
| Or8k32 |
A |
G |
2: 86,368,902 (GRCm39) |
V117A |
probably benign |
Het |
| Parvg |
T |
A |
15: 84,218,832 (GRCm39) |
S230T |
possibly damaging |
Het |
| Pcca |
T |
C |
14: 122,854,230 (GRCm39) |
I118T |
probably damaging |
Het |
| Pde6a |
A |
G |
18: 61,365,932 (GRCm39) |
N219S |
possibly damaging |
Het |
| Phldb1 |
G |
T |
9: 44,612,915 (GRCm39) |
P935Q |
possibly damaging |
Het |
| Plppr5 |
T |
C |
3: 117,456,261 (GRCm39) |
S261P |
probably damaging |
Het |
| Ppl |
T |
C |
16: 4,922,629 (GRCm39) |
N260S |
probably benign |
Het |
| Ppp1r3e |
A |
T |
14: 55,113,882 (GRCm39) |
H263Q |
probably benign |
Het |
| Ppp3cb |
T |
C |
14: 20,559,567 (GRCm39) |
|
probably null |
Het |
| Ppt2 |
A |
T |
17: 34,842,075 (GRCm39) |
D185E |
probably benign |
Het |
| Prr27 |
A |
T |
5: 87,998,600 (GRCm39) |
|
probably benign |
Het |
| Ptcd3 |
A |
T |
6: 71,870,479 (GRCm39) |
V327E |
probably damaging |
Het |
| Pwwp4a |
G |
T |
X: 72,171,261 (GRCm39) |
G218C |
probably damaging |
Het |
| Rsf1 |
GCG |
GCGACG |
7: 97,229,114 (GRCm39) |
|
probably benign |
Het |
| Rtp1 |
A |
T |
16: 23,249,970 (GRCm39) |
M112L |
probably benign |
Het |
| Slc22a5 |
A |
T |
11: 53,760,140 (GRCm39) |
L392Q |
probably damaging |
Het |
| Slc6a7 |
A |
G |
18: 61,129,764 (GRCm39) |
I614T |
probably benign |
Het |
| Slu7 |
C |
A |
11: 43,329,044 (GRCm39) |
P89T |
possibly damaging |
Het |
| Smarcc2 |
T |
C |
10: 128,318,061 (GRCm39) |
V618A |
probably benign |
Het |
| Sorl1 |
C |
T |
9: 41,952,369 (GRCm39) |
R729Q |
probably damaging |
Het |
| Sptbn2 |
T |
C |
19: 4,794,274 (GRCm39) |
F1493L |
possibly damaging |
Het |
| Sulf1 |
C |
T |
1: 12,918,574 (GRCm39) |
T66I |
probably damaging |
Het |
| Tgtp2 |
A |
G |
11: 48,950,165 (GRCm39) |
Y136H |
probably damaging |
Het |
| Tmem117 |
T |
C |
15: 94,536,242 (GRCm39) |
F92S |
probably damaging |
Het |
| Tmprss9 |
T |
A |
10: 80,730,934 (GRCm39) |
V820E |
probably benign |
Het |
| Tpcn2 |
A |
G |
7: 144,822,648 (GRCm39) |
Y266H |
probably damaging |
Het |
| Trat1 |
A |
G |
16: 48,555,304 (GRCm39) |
S143P |
probably benign |
Het |
| Vmn1r49 |
T |
A |
6: 90,049,298 (GRCm39) |
R235W |
probably damaging |
Het |
| Vmn1r71 |
A |
T |
7: 10,482,575 (GRCm39) |
C38S |
probably benign |
Het |
| Vmn2r6 |
T |
A |
3: 64,463,890 (GRCm39) |
T315S |
probably damaging |
Het |
| Wdr36 |
A |
G |
18: 32,986,021 (GRCm39) |
D575G |
possibly damaging |
Het |
| Zfp292 |
G |
T |
4: 34,805,397 (GRCm39) |
A2549E |
possibly damaging |
Het |
| Zfp354a |
A |
T |
11: 50,961,073 (GRCm39) |
H426L |
probably damaging |
Het |
| Zfp407 |
C |
T |
18: 84,577,898 (GRCm39) |
A1072T |
probably benign |
Het |
| Zfp648 |
T |
A |
1: 154,081,119 (GRCm39) |
I426N |
probably damaging |
Het |
| Zfp87 |
T |
C |
13: 74,520,736 (GRCm39) |
N114S |
probably benign |
Het |
|
| Other mutations in Fasn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00468:Fasn
|
APN |
11 |
120,711,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Fasn
|
APN |
11 |
120,708,055 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01131:Fasn
|
APN |
11 |
120,705,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01603:Fasn
|
APN |
11 |
120,706,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01606:Fasn
|
APN |
11 |
120,699,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01897:Fasn
|
APN |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Fasn
|
APN |
11 |
120,710,975 (GRCm39) |
splice site |
probably benign |
|
|
IGL01987:Fasn
|
APN |
11 |
120,708,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02103:Fasn
|
APN |
11 |
120,702,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Fasn
|
APN |
11 |
120,698,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02294:Fasn
|
APN |
11 |
120,701,102 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02336:Fasn
|
APN |
11 |
120,704,562 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02417:Fasn
|
APN |
11 |
120,711,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02452:Fasn
|
APN |
11 |
120,699,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Fasn
|
APN |
11 |
120,699,892 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02724:Fasn
|
APN |
11 |
120,700,659 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02862:Fasn
|
APN |
11 |
120,709,805 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02947:Fasn
|
APN |
11 |
120,706,502 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03025:Fasn
|
APN |
11 |
120,708,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03131:Fasn
|
APN |
11 |
120,701,550 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03157:Fasn
|
APN |
11 |
120,698,735 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03182:Fasn
|
APN |
11 |
120,703,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03370:Fasn
|
APN |
11 |
120,703,621 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
BB007:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
BB017:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0243:Fasn
|
UTSW |
11 |
120,706,141 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0304:Fasn
|
UTSW |
11 |
120,710,762 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0389:Fasn
|
UTSW |
11 |
120,707,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0449:Fasn
|
UTSW |
11 |
120,701,894 (GRCm39) |
missense |
probably benign |
|
|
R0626:Fasn
|
UTSW |
11 |
120,702,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1037:Fasn
|
UTSW |
11 |
120,700,277 (GRCm39) |
missense |
probably benign |
|
|
R1061:Fasn
|
UTSW |
11 |
120,713,008 (GRCm39) |
splice site |
probably null |
|
|
R1109:Fasn
|
UTSW |
11 |
120,703,150 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1552:Fasn
|
UTSW |
11 |
120,709,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Fasn
|
UTSW |
11 |
120,704,075 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1624:Fasn
|
UTSW |
11 |
120,703,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Fasn
|
UTSW |
11 |
120,707,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1826:Fasn
|
UTSW |
11 |
120,699,325 (GRCm39) |
splice site |
probably benign |
|
|
R1846:Fasn
|
UTSW |
11 |
120,704,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2298:Fasn
|
UTSW |
11 |
120,704,642 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2513:Fasn
|
UTSW |
11 |
120,705,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3002:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3154:Fasn
|
UTSW |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3434:Fasn
|
UTSW |
11 |
120,713,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4794:Fasn
|
UTSW |
11 |
120,702,121 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4840:Fasn
|
UTSW |
11 |
120,703,885 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4863:Fasn
|
UTSW |
11 |
120,699,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4876:Fasn
|
UTSW |
11 |
120,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4915:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4916:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4918:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4936:Fasn
|
UTSW |
11 |
120,706,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Fasn
|
UTSW |
11 |
120,702,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5092:Fasn
|
UTSW |
11 |
120,705,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Fasn
|
UTSW |
11 |
120,702,217 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5175:Fasn
|
UTSW |
11 |
120,707,195 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5183:Fasn
|
UTSW |
11 |
120,699,708 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5506:Fasn
|
UTSW |
11 |
120,700,336 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5557:Fasn
|
UTSW |
11 |
120,703,252 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5614:Fasn
|
UTSW |
11 |
120,704,154 (GRCm39) |
missense |
probably benign |
|
|
R5728:Fasn
|
UTSW |
11 |
120,704,339 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5838:Fasn
|
UTSW |
11 |
120,706,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5959:Fasn
|
UTSW |
11 |
120,699,390 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6029:Fasn
|
UTSW |
11 |
120,711,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6134:Fasn
|
UTSW |
11 |
120,713,012 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6335:Fasn
|
UTSW |
11 |
120,706,185 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6452:Fasn
|
UTSW |
11 |
120,706,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6627:Fasn
|
UTSW |
11 |
120,709,753 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6742:Fasn
|
UTSW |
11 |
120,701,279 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6767:Fasn
|
UTSW |
11 |
120,708,313 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6927:Fasn
|
UTSW |
11 |
120,699,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6976:Fasn
|
UTSW |
11 |
120,710,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Fasn
|
UTSW |
11 |
120,710,946 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7157:Fasn
|
UTSW |
11 |
120,701,291 (GRCm39) |
nonsense |
probably null |
|
|
R7373:Fasn
|
UTSW |
11 |
120,704,802 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7575:Fasn
|
UTSW |
11 |
120,703,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7652:Fasn
|
UTSW |
11 |
120,707,154 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7670:Fasn
|
UTSW |
11 |
120,704,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Fasn
|
UTSW |
11 |
120,700,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7930:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R8007:Fasn
|
UTSW |
11 |
120,700,353 (GRCm39) |
missense |
probably benign |
|
|
R8012:Fasn
|
UTSW |
11 |
120,702,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8185:Fasn
|
UTSW |
11 |
120,702,969 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8557:Fasn
|
UTSW |
11 |
120,706,610 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8711:Fasn
|
UTSW |
11 |
120,709,944 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8772:Fasn
|
UTSW |
11 |
120,711,362 (GRCm39) |
missense |
probably benign |
|
|
R8856:Fasn
|
UTSW |
11 |
120,708,979 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8875:Fasn
|
UTSW |
11 |
120,703,224 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9071:Fasn
|
UTSW |
11 |
120,708,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9153:Fasn
|
UTSW |
11 |
120,706,496 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9238:Fasn
|
UTSW |
11 |
120,705,871 (GRCm39) |
missense |
probably benign |
|
|
R9249:Fasn
|
UTSW |
11 |
120,703,915 (GRCm39) |
missense |
probably benign |
|
|
R9345:Fasn
|
UTSW |
11 |
120,706,735 (GRCm39) |
missense |
probably benign |
0.22 |
|
X0067:Fasn
|
UTSW |
11 |
120,707,129 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Fasn
|
UTSW |
11 |
120,706,297 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGATGTGGATACCACCAGAGACC -3'
(R):5'- GTCAGTGAGCATGACTGCCAGAAG -3'
Sequencing Primer
(F):5'- TTGTCACATCAGCCACTATGGAG -3'
(R):5'- TGACTGCCAGAAGCCATGTC -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation