Incidental Mutation 'R1500:Jag1'
ID 169158
Institutional Source Beutler Lab
Gene Symbol Jag1
Ensembl Gene ENSMUSG00000027276
Gene Name jagged 1
Synonyms Serrate-1, ABE2, Gsfabe2, Ozz, Headturner, Htu
MMRRC Submission 039551-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1500 (G1)
Quality Score 182
Status Validated
Chromosome 2
Chromosomal Location 136923371-136958440 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 136957558 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 51 (N51K)
Ref Sequence ENSEMBL: ENSMUSP00000028735 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028735]
AlphaFold Q9QXX0
Predicted Effect possibly damaging
Transcript: ENSMUST00000028735
AA Change: N51K

PolyPhen 2 Score 0.821 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000028735
Gene: ENSMUSG00000027276
AA Change: N51K

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
Pfam:MNNL 31 109 2.8e-31 PFAM
DSL 167 229 1.85e-37 SMART
EGF 233 263 1.66e1 SMART
EGF 264 294 2.25e1 SMART
EGF_CA 296 334 4.42e-7 SMART
EGF 339 372 2.64e-5 SMART
EGF_CA 374 410 2.89e-11 SMART
EGF_CA 412 448 2.8e-9 SMART
EGF_CA 450 485 2.31e-10 SMART
EGF_CA 487 523 1.69e-12 SMART
EGF_CA 525 561 4.19e-8 SMART
EGF 577 627 2.16e-1 SMART
EGF_CA 629 665 2.56e-12 SMART
EGF_CA 667 703 6.91e-9 SMART
EGF 708 741 5.88e-3 SMART
EGF 747 780 9.62e-8 SMART
EGF_CA 782 818 3.59e-7 SMART
EGF_CA 820 856 3.81e-11 SMART
VWC 863 930 4.79e-16 SMART
transmembrane domain 1069 1091 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.7%
  • 20x: 87.1%
Validation Efficiency 95% (81/85)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants exhibit extensive hemorrhaging and die prior to embryonic day 11.5, while heterozygotes exhibit defects of the eye. Heterozygotes for missense mutations have inner ear abnormalities. Other mutant mice display abnormal head movements. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg1 A G 17: 31,330,253 (GRCm39) D518G probably benign Het
Acaca T A 11: 84,184,810 (GRCm39) D96E probably benign Het
Actbl2 G A 13: 111,391,854 (GRCm39) R63Q probably damaging Het
Adamts6 T A 13: 104,449,389 (GRCm39) H266Q probably damaging Het
Aff4 T C 11: 53,263,205 (GRCm39) V75A probably benign Het
Ank2 A G 3: 126,726,631 (GRCm39) S888P probably benign Het
Ano7 T C 1: 93,325,050 (GRCm39) F534S probably damaging Het
Arhgef6 T C X: 56,383,922 (GRCm39) M5V probably benign Het
Bcam T A 7: 19,492,889 (GRCm39) D484V possibly damaging Het
Bltp2 C A 11: 78,174,958 (GRCm39) Q1698K possibly damaging Het
Ccdc88a T C 11: 29,432,713 (GRCm39) Y1240H probably benign Het
Cfh T C 1: 140,028,614 (GRCm39) Y500C probably damaging Het
Chd1l G A 3: 97,490,121 (GRCm39) A478V probably benign Het
Dnah1 T C 14: 31,038,715 (GRCm39) D122G probably benign Het
Dnah11 A T 12: 117,976,564 (GRCm39) probably null Het
Dnah17 T C 11: 117,991,879 (GRCm39) K1230E probably benign Het
Dync1h1 G A 12: 110,602,943 (GRCm39) E2195K probably benign Het
E330020D12Rik A T 1: 153,284,125 (GRCm39) noncoding transcript Het
Ece2 T C 16: 20,462,992 (GRCm39) L639P probably damaging Het
Epha3 A T 16: 63,416,025 (GRCm39) V658E probably benign Het
Erbb2 C T 11: 98,319,804 (GRCm39) T632I probably damaging Het
Erc2 A G 14: 27,993,617 (GRCm39) T883A probably damaging Het
Extl2 T C 3: 115,820,789 (GRCm39) V198A probably benign Het
Fktn G T 4: 53,735,065 (GRCm39) M234I probably benign Het
Ggt7 A G 2: 155,340,966 (GRCm39) S400P probably benign Het
Gldc A C 19: 30,091,225 (GRCm39) V790G possibly damaging Het
Gm14496 A C 2: 181,633,026 (GRCm39) Q3P probably benign Het
H2-D1 G A 17: 35,482,564 (GRCm39) E95K probably benign Het
Ikzf3 T C 11: 98,409,521 (GRCm39) E14G probably benign Het
Khdrbs3 A G 15: 68,800,635 (GRCm39) D14G possibly damaging Het
Krt84 A G 15: 101,438,659 (GRCm39) V276A probably damaging Het
Lamb1 T C 12: 31,348,948 (GRCm39) I660T possibly damaging Het
Lcmt2 A T 2: 120,970,488 (GRCm39) S198R probably benign Het
Lcn6 G A 2: 25,567,131 (GRCm39) R44H probably benign Het
Lrfn5 A T 12: 61,886,527 (GRCm39) H105L probably damaging Het
Lrit1 G A 14: 36,784,091 (GRCm39) R473K probably benign Het
Marchf1 A G 8: 66,921,042 (GRCm39) T495A probably damaging Het
Marveld3 T G 8: 110,675,174 (GRCm39) probably null Het
Mbd3 T C 10: 80,230,420 (GRCm39) D160G possibly damaging Het
Mrc2 T G 11: 105,238,551 (GRCm39) C1233G probably damaging Het
Ms4a13 T G 19: 11,161,225 (GRCm39) T105P probably damaging Het
Mtbp T C 15: 55,480,951 (GRCm39) Y306H probably damaging Het
Muc3a T C 5: 137,244,958 (GRCm39) probably benign Het
Myo1g T A 11: 6,470,811 (GRCm39) Y15F probably benign Het
Nae1 A T 8: 105,250,216 (GRCm39) Y226N probably benign Het
Nlrp9a A G 7: 26,267,316 (GRCm39) S715G probably benign Het
Or1j10 A T 2: 36,267,633 (GRCm39) M282L probably benign Het
Or2ag17 T C 7: 106,390,028 (GRCm39) Y60C probably damaging Het
Or4s2b T A 2: 88,508,219 (GRCm39) S7T possibly damaging Het
Or7g26 A T 9: 19,230,612 (GRCm39) S267C probably damaging Het
Or8g55 G T 9: 39,784,707 (GRCm39) M45I probably benign Het
Pex5l T C 3: 33,069,129 (GRCm39) T123A probably damaging Het
Pip5kl1 A T 2: 32,466,691 (GRCm39) N62I probably benign Het
Pkhd1l1 T C 15: 44,408,890 (GRCm39) V2459A probably damaging Het
Prb1a T A 6: 132,184,439 (GRCm39) Q398L unknown Het
Prkab2 T C 3: 97,571,263 (GRCm39) L165S probably damaging Het
Prl3d2 C G 13: 27,305,689 (GRCm39) probably benign Het
Ptdss1 G A 13: 67,143,472 (GRCm39) G435D probably benign Het
Qrfpr A G 3: 36,236,729 (GRCm39) L224P probably damaging Het
Rasl2-9 C T 7: 5,128,441 (GRCm39) W163* probably null Het
Rgs5 A G 1: 169,517,983 (GRCm39) probably null Het
Rnf19b T C 4: 128,972,754 (GRCm39) L255P probably damaging Het
Rp9 A C 9: 22,368,751 (GRCm39) N69K probably damaging Het
Sh3bp4 G T 1: 89,073,210 (GRCm39) S686I probably damaging Het
Shfl AGAGGAGGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGAGGAGGA 9: 20,785,013 (GRCm39) probably benign Het
Spp2 C A 1: 88,340,015 (GRCm39) Q5K possibly damaging Het
Svep1 C T 4: 58,070,239 (GRCm39) G2516R probably damaging Het
Syncrip A C 9: 88,361,949 (GRCm39) S55R probably damaging Het
Tacc3 T C 5: 33,818,652 (GRCm39) L29P probably damaging Het
Tex15 A G 8: 34,065,120 (GRCm39) T1517A probably damaging Het
Tmem140 A G 6: 34,849,660 (GRCm39) M59V probably benign Het
Ttn G T 2: 76,575,872 (GRCm39) A25007E probably damaging Het
Ubr2 T C 17: 47,297,615 (GRCm39) T253A possibly damaging Het
Unc80 C T 1: 66,560,740 (GRCm39) H823Y possibly damaging Het
Usp38 A G 8: 81,722,399 (GRCm39) L374P probably damaging Het
Vmn1r42 T A 6: 89,822,483 (GRCm39) I29L probably benign Het
Vmn2r94 C T 17: 18,477,242 (GRCm39) V390M probably benign Het
Vmp1 A G 11: 86,552,026 (GRCm39) Y113H possibly damaging Het
Wdr20 T C 12: 110,760,464 (GRCm39) M450T probably benign Het
Ylpm1 T C 12: 85,061,770 (GRCm39) V557A unknown Het
Zpld1 T C 16: 55,053,935 (GRCm39) N286D probably damaging Het
Other mutations in Jag1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Jag1 APN 2 136,927,952 (GRCm39) critical splice acceptor site probably null
IGL00912:Jag1 APN 2 136,957,493 (GRCm39) missense probably damaging 1.00
IGL01104:Jag1 APN 2 136,926,298 (GRCm39) missense probably benign 0.40
IGL01529:Jag1 APN 2 136,926,897 (GRCm39) missense probably damaging 0.99
IGL01578:Jag1 APN 2 136,941,971 (GRCm39) splice site probably benign
IGL01720:Jag1 APN 2 136,929,023 (GRCm39) missense probably damaging 1.00
IGL01809:Jag1 APN 2 136,957,404 (GRCm39) missense probably damaging 1.00
IGL02402:Jag1 APN 2 136,927,858 (GRCm39) missense possibly damaging 0.79
IGL02434:Jag1 APN 2 136,929,075 (GRCm39) missense probably benign 0.01
IGL02543:Jag1 APN 2 136,933,867 (GRCm39) splice site probably benign
IGL02650:Jag1 APN 2 136,957,505 (GRCm39) missense possibly damaging 0.95
IGL03010:Jag1 APN 2 136,935,118 (GRCm39) splice site probably benign
IGL03102:Jag1 APN 2 136,926,608 (GRCm39) missense probably benign 0.00
Grenville UTSW 2 136,929,062 (GRCm39) missense probably damaging 1.00
PIT4651001:Jag1 UTSW 2 136,943,617 (GRCm39) missense probably damaging 1.00
R0227:Jag1 UTSW 2 136,957,538 (GRCm39) missense probably benign
R0306:Jag1 UTSW 2 136,927,855 (GRCm39) missense probably damaging 1.00
R0325:Jag1 UTSW 2 136,937,365 (GRCm39) critical splice donor site probably null
R0594:Jag1 UTSW 2 136,929,000 (GRCm39) missense probably damaging 0.99
R0838:Jag1 UTSW 2 136,935,198 (GRCm39) missense probably damaging 0.98
R0879:Jag1 UTSW 2 136,942,001 (GRCm39) missense possibly damaging 0.80
R0900:Jag1 UTSW 2 136,932,802 (GRCm39) frame shift probably null
R0972:Jag1 UTSW 2 136,925,371 (GRCm39) missense possibly damaging 0.64
R1083:Jag1 UTSW 2 136,938,152 (GRCm39) missense probably damaging 0.99
R1182:Jag1 UTSW 2 136,933,409 (GRCm39) missense probably benign 0.36
R1292:Jag1 UTSW 2 136,925,393 (GRCm39) missense possibly damaging 0.79
R1464:Jag1 UTSW 2 136,957,568 (GRCm39) missense probably damaging 0.98
R1464:Jag1 UTSW 2 136,957,568 (GRCm39) missense probably damaging 0.98
R1936:Jag1 UTSW 2 136,925,393 (GRCm39) missense possibly damaging 0.79
R1937:Jag1 UTSW 2 136,925,393 (GRCm39) missense possibly damaging 0.79
R1939:Jag1 UTSW 2 136,925,393 (GRCm39) missense possibly damaging 0.79
R1998:Jag1 UTSW 2 136,932,858 (GRCm39) missense probably damaging 1.00
R2019:Jag1 UTSW 2 136,926,599 (GRCm39) missense probably benign 0.37
R2213:Jag1 UTSW 2 136,931,812 (GRCm39) missense probably benign 0.01
R2300:Jag1 UTSW 2 136,938,235 (GRCm39) missense probably damaging 1.00
R2484:Jag1 UTSW 2 136,926,620 (GRCm39) missense possibly damaging 0.86
R4179:Jag1 UTSW 2 136,943,578 (GRCm39) missense probably damaging 0.99
R4212:Jag1 UTSW 2 136,926,990 (GRCm39) missense probably benign
R4630:Jag1 UTSW 2 136,927,899 (GRCm39) missense probably damaging 1.00
R4701:Jag1 UTSW 2 136,936,376 (GRCm39) missense probably benign 0.11
R4705:Jag1 UTSW 2 136,938,229 (GRCm39) missense probably damaging 1.00
R4904:Jag1 UTSW 2 136,929,062 (GRCm39) missense probably damaging 1.00
R5050:Jag1 UTSW 2 136,927,074 (GRCm39) missense possibly damaging 0.71
R5288:Jag1 UTSW 2 136,937,464 (GRCm39) missense possibly damaging 0.75
R5367:Jag1 UTSW 2 136,927,014 (GRCm39) missense possibly damaging 0.90
R5385:Jag1 UTSW 2 136,937,464 (GRCm39) missense possibly damaging 0.75
R5386:Jag1 UTSW 2 136,937,464 (GRCm39) missense possibly damaging 0.75
R5430:Jag1 UTSW 2 136,943,626 (GRCm39) missense possibly damaging 0.94
R5472:Jag1 UTSW 2 136,926,915 (GRCm39) missense probably damaging 1.00
R5755:Jag1 UTSW 2 136,930,610 (GRCm39) missense probably damaging 1.00
R5764:Jag1 UTSW 2 136,931,167 (GRCm39) missense probably damaging 1.00
R5804:Jag1 UTSW 2 136,930,124 (GRCm39) missense probably benign 0.01
R6406:Jag1 UTSW 2 136,929,563 (GRCm39) missense probably damaging 1.00
R6503:Jag1 UTSW 2 136,943,549 (GRCm39) missense probably damaging 1.00
R6721:Jag1 UTSW 2 136,936,394 (GRCm39) missense probably benign 0.00
R6826:Jag1 UTSW 2 136,958,095 (GRCm39) critical splice donor site probably null
R7055:Jag1 UTSW 2 136,957,409 (GRCm39) missense probably benign 0.26
R7214:Jag1 UTSW 2 136,948,802 (GRCm39) missense probably benign 0.00
R7359:Jag1 UTSW 2 136,926,226 (GRCm39) missense probably benign
R7422:Jag1 UTSW 2 136,926,975 (GRCm39) missense probably benign
R7919:Jag1 UTSW 2 136,930,366 (GRCm39) missense probably damaging 0.97
R8071:Jag1 UTSW 2 136,943,717 (GRCm39) missense probably benign 0.01
R8768:Jag1 UTSW 2 136,932,708 (GRCm39) intron probably benign
R8768:Jag1 UTSW 2 136,943,521 (GRCm39) missense possibly damaging 0.89
R8898:Jag1 UTSW 2 136,935,175 (GRCm39) missense probably damaging 1.00
R8920:Jag1 UTSW 2 136,931,143 (GRCm39) missense probably benign 0.05
R9060:Jag1 UTSW 2 136,931,204 (GRCm39) missense probably damaging 1.00
R9120:Jag1 UTSW 2 136,930,354 (GRCm39) missense probably benign
R9193:Jag1 UTSW 2 136,931,764 (GRCm39) missense probably null 0.99
R9200:Jag1 UTSW 2 136,929,044 (GRCm39) missense probably benign 0.04
R9241:Jag1 UTSW 2 136,926,507 (GRCm39) missense probably damaging 1.00
R9326:Jag1 UTSW 2 136,931,745 (GRCm39) missense probably benign
R9334:Jag1 UTSW 2 136,943,593 (GRCm39) missense probably damaging 1.00
R9358:Jag1 UTSW 2 136,924,948 (GRCm39) missense probably benign 0.26
R9444:Jag1 UTSW 2 136,936,397 (GRCm39) missense probably damaging 1.00
R9477:Jag1 UTSW 2 136,936,409 (GRCm39) missense probably damaging 1.00
RF016:Jag1 UTSW 2 136,938,176 (GRCm39) missense probably benign 0.01
Z1088:Jag1 UTSW 2 136,927,071 (GRCm39) missense probably benign 0.03
Z1177:Jag1 UTSW 2 136,926,939 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGAAAGGCAGTACGATGCGATTACG -3'
(R):5'- GGCTGGGCAAAATGCGATCATTAC -3'

Sequencing Primer
(F):5'- CTGGCCTTGAGATTGAAGGTG -3'
(R):5'- AATGCGATCATTACGTTCTCACG -3'
Posted On 2014-04-13