Incidental Mutation 'R1500:Myo1g'
ID 169193
Institutional Source Beutler Lab
Gene Symbol Myo1g
Ensembl Gene ENSMUSG00000020437
Gene Name myosin IG
Synonyms E430002D17Rik
MMRRC Submission 039551-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1500 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 6456548-6470960 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 6470811 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 15 (Y15F)
Ref Sequence ENSEMBL: ENSMUSP00000003459 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003459] [ENSMUST00000134489] [ENSMUST00000144725] [ENSMUST00000146536]
AlphaFold Q5SUA5
Predicted Effect probably benign
Transcript: ENSMUST00000003459
AA Change: Y15F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000003459
Gene: ENSMUSG00000020437
AA Change: Y15F

DomainStartEndE-ValueType
MYSc 9 714 N/A SMART
IQ 715 737 2.79e0 SMART
Pfam:Myosin_TH1 821 1024 2.8e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124818
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129570
Predicted Effect probably benign
Transcript: ENSMUST00000134489
SMART Domains Protein: ENSMUSP00000122356
Gene: ENSMUSG00000020437

DomainStartEndE-ValueType
Pfam:Myosin_head 51 99 5.9e-15 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000144725
AA Change: Y15F
SMART Domains Protein: ENSMUSP00000120975
Gene: ENSMUSG00000020437
AA Change: Y15F

DomainStartEndE-ValueType
Blast:MYSc 9 43 8e-14 BLAST
low complexity region 48 60 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000146536
AA Change: Y15F
SMART Domains Protein: ENSMUSP00000122438
Gene: ENSMUSG00000020437
AA Change: Y15F

DomainStartEndE-ValueType
Blast:MYSc 9 38 2e-13 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156878
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147762
Meta Mutation Damage Score 0.0669 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.7%
  • 20x: 87.1%
Validation Efficiency 95% (81/85)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced B cell spreading, migration and homing and impaired T cell motility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg1 A G 17: 31,330,253 (GRCm39) D518G probably benign Het
Acaca T A 11: 84,184,810 (GRCm39) D96E probably benign Het
Actbl2 G A 13: 111,391,854 (GRCm39) R63Q probably damaging Het
Adamts6 T A 13: 104,449,389 (GRCm39) H266Q probably damaging Het
Aff4 T C 11: 53,263,205 (GRCm39) V75A probably benign Het
Ank2 A G 3: 126,726,631 (GRCm39) S888P probably benign Het
Ano7 T C 1: 93,325,050 (GRCm39) F534S probably damaging Het
Arhgef6 T C X: 56,383,922 (GRCm39) M5V probably benign Het
Bcam T A 7: 19,492,889 (GRCm39) D484V possibly damaging Het
Bltp2 C A 11: 78,174,958 (GRCm39) Q1698K possibly damaging Het
Ccdc88a T C 11: 29,432,713 (GRCm39) Y1240H probably benign Het
Cfh T C 1: 140,028,614 (GRCm39) Y500C probably damaging Het
Chd1l G A 3: 97,490,121 (GRCm39) A478V probably benign Het
Dnah1 T C 14: 31,038,715 (GRCm39) D122G probably benign Het
Dnah11 A T 12: 117,976,564 (GRCm39) probably null Het
Dnah17 T C 11: 117,991,879 (GRCm39) K1230E probably benign Het
Dync1h1 G A 12: 110,602,943 (GRCm39) E2195K probably benign Het
E330020D12Rik A T 1: 153,284,125 (GRCm39) noncoding transcript Het
Ece2 T C 16: 20,462,992 (GRCm39) L639P probably damaging Het
Epha3 A T 16: 63,416,025 (GRCm39) V658E probably benign Het
Erbb2 C T 11: 98,319,804 (GRCm39) T632I probably damaging Het
Erc2 A G 14: 27,993,617 (GRCm39) T883A probably damaging Het
Extl2 T C 3: 115,820,789 (GRCm39) V198A probably benign Het
Fktn G T 4: 53,735,065 (GRCm39) M234I probably benign Het
Ggt7 A G 2: 155,340,966 (GRCm39) S400P probably benign Het
Gldc A C 19: 30,091,225 (GRCm39) V790G possibly damaging Het
Gm14496 A C 2: 181,633,026 (GRCm39) Q3P probably benign Het
H2-D1 G A 17: 35,482,564 (GRCm39) E95K probably benign Het
Ikzf3 T C 11: 98,409,521 (GRCm39) E14G probably benign Het
Jag1 A T 2: 136,957,558 (GRCm39) N51K possibly damaging Het
Khdrbs3 A G 15: 68,800,635 (GRCm39) D14G possibly damaging Het
Krt84 A G 15: 101,438,659 (GRCm39) V276A probably damaging Het
Lamb1 T C 12: 31,348,948 (GRCm39) I660T possibly damaging Het
Lcmt2 A T 2: 120,970,488 (GRCm39) S198R probably benign Het
Lcn6 G A 2: 25,567,131 (GRCm39) R44H probably benign Het
Lrfn5 A T 12: 61,886,527 (GRCm39) H105L probably damaging Het
Lrit1 G A 14: 36,784,091 (GRCm39) R473K probably benign Het
Marchf1 A G 8: 66,921,042 (GRCm39) T495A probably damaging Het
Marveld3 T G 8: 110,675,174 (GRCm39) probably null Het
Mbd3 T C 10: 80,230,420 (GRCm39) D160G possibly damaging Het
Mrc2 T G 11: 105,238,551 (GRCm39) C1233G probably damaging Het
Ms4a13 T G 19: 11,161,225 (GRCm39) T105P probably damaging Het
Mtbp T C 15: 55,480,951 (GRCm39) Y306H probably damaging Het
Muc3a T C 5: 137,244,958 (GRCm39) probably benign Het
Nae1 A T 8: 105,250,216 (GRCm39) Y226N probably benign Het
Nlrp9a A G 7: 26,267,316 (GRCm39) S715G probably benign Het
Or1j10 A T 2: 36,267,633 (GRCm39) M282L probably benign Het
Or2ag17 T C 7: 106,390,028 (GRCm39) Y60C probably damaging Het
Or4s2b T A 2: 88,508,219 (GRCm39) S7T possibly damaging Het
Or7g26 A T 9: 19,230,612 (GRCm39) S267C probably damaging Het
Or8g55 G T 9: 39,784,707 (GRCm39) M45I probably benign Het
Pex5l T C 3: 33,069,129 (GRCm39) T123A probably damaging Het
Pip5kl1 A T 2: 32,466,691 (GRCm39) N62I probably benign Het
Pkhd1l1 T C 15: 44,408,890 (GRCm39) V2459A probably damaging Het
Prb1a T A 6: 132,184,439 (GRCm39) Q398L unknown Het
Prkab2 T C 3: 97,571,263 (GRCm39) L165S probably damaging Het
Prl3d2 C G 13: 27,305,689 (GRCm39) probably benign Het
Ptdss1 G A 13: 67,143,472 (GRCm39) G435D probably benign Het
Qrfpr A G 3: 36,236,729 (GRCm39) L224P probably damaging Het
Rasl2-9 C T 7: 5,128,441 (GRCm39) W163* probably null Het
Rgs5 A G 1: 169,517,983 (GRCm39) probably null Het
Rnf19b T C 4: 128,972,754 (GRCm39) L255P probably damaging Het
Rp9 A C 9: 22,368,751 (GRCm39) N69K probably damaging Het
Sh3bp4 G T 1: 89,073,210 (GRCm39) S686I probably damaging Het
Shfl AGAGGAGGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGAGGAGGA 9: 20,785,013 (GRCm39) probably benign Het
Spp2 C A 1: 88,340,015 (GRCm39) Q5K possibly damaging Het
Svep1 C T 4: 58,070,239 (GRCm39) G2516R probably damaging Het
Syncrip A C 9: 88,361,949 (GRCm39) S55R probably damaging Het
Tacc3 T C 5: 33,818,652 (GRCm39) L29P probably damaging Het
Tex15 A G 8: 34,065,120 (GRCm39) T1517A probably damaging Het
Tmem140 A G 6: 34,849,660 (GRCm39) M59V probably benign Het
Ttn G T 2: 76,575,872 (GRCm39) A25007E probably damaging Het
Ubr2 T C 17: 47,297,615 (GRCm39) T253A possibly damaging Het
Unc80 C T 1: 66,560,740 (GRCm39) H823Y possibly damaging Het
Usp38 A G 8: 81,722,399 (GRCm39) L374P probably damaging Het
Vmn1r42 T A 6: 89,822,483 (GRCm39) I29L probably benign Het
Vmn2r94 C T 17: 18,477,242 (GRCm39) V390M probably benign Het
Vmp1 A G 11: 86,552,026 (GRCm39) Y113H possibly damaging Het
Wdr20 T C 12: 110,760,464 (GRCm39) M450T probably benign Het
Ylpm1 T C 12: 85,061,770 (GRCm39) V557A unknown Het
Zpld1 T C 16: 55,053,935 (GRCm39) N286D probably damaging Het
Other mutations in Myo1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Myo1g APN 11 6,465,856 (GRCm39) missense possibly damaging 0.70
IGL01608:Myo1g APN 11 6,466,780 (GRCm39) missense possibly damaging 0.61
IGL01679:Myo1g APN 11 6,468,006 (GRCm39) missense possibly damaging 0.90
IGL01830:Myo1g APN 11 6,464,522 (GRCm39) nonsense probably null
IGL02332:Myo1g APN 11 6,470,766 (GRCm39) missense possibly damaging 0.61
IGL02813:Myo1g APN 11 6,468,743 (GRCm39) makesense probably null
IGL02988:Myo1g APN 11 6,458,183 (GRCm39) splice site probably benign
IGL03178:Myo1g APN 11 6,462,181 (GRCm39) missense probably damaging 1.00
R0004:Myo1g UTSW 11 6,465,901 (GRCm39) missense probably damaging 1.00
R0334:Myo1g UTSW 11 6,461,084 (GRCm39) splice site probably benign
R0513:Myo1g UTSW 11 6,460,203 (GRCm39) missense probably benign 0.00
R0730:Myo1g UTSW 11 6,470,794 (GRCm39) missense probably damaging 1.00
R1054:Myo1g UTSW 11 6,468,987 (GRCm39) missense probably damaging 1.00
R1434:Myo1g UTSW 11 6,459,372 (GRCm39) missense probably benign 0.00
R1513:Myo1g UTSW 11 6,465,140 (GRCm39) missense probably damaging 0.99
R1720:Myo1g UTSW 11 6,462,490 (GRCm39) missense probably benign 0.44
R1774:Myo1g UTSW 11 6,465,988 (GRCm39) missense probably damaging 1.00
R1809:Myo1g UTSW 11 6,462,283 (GRCm39) missense probably benign 0.02
R1957:Myo1g UTSW 11 6,462,159 (GRCm39) critical splice donor site probably null
R1978:Myo1g UTSW 11 6,470,829 (GRCm39) missense possibly damaging 0.53
R2212:Myo1g UTSW 11 6,467,870 (GRCm39) missense possibly damaging 0.88
R2438:Myo1g UTSW 11 6,461,542 (GRCm39) missense probably damaging 1.00
R2566:Myo1g UTSW 11 6,462,539 (GRCm39) critical splice acceptor site probably null
R3158:Myo1g UTSW 11 6,464,527 (GRCm39) missense possibly damaging 0.62
R3159:Myo1g UTSW 11 6,464,527 (GRCm39) missense possibly damaging 0.62
R3413:Myo1g UTSW 11 6,467,870 (GRCm39) missense possibly damaging 0.88
R3816:Myo1g UTSW 11 6,460,926 (GRCm39) missense probably benign 0.02
R3872:Myo1g UTSW 11 6,464,886 (GRCm39) missense possibly damaging 0.94
R3946:Myo1g UTSW 11 6,470,760 (GRCm39) missense possibly damaging 0.89
R4551:Myo1g UTSW 11 6,467,874 (GRCm39) missense probably damaging 1.00
R4625:Myo1g UTSW 11 6,462,240 (GRCm39) missense probably damaging 1.00
R4630:Myo1g UTSW 11 6,469,047 (GRCm39) missense probably damaging 1.00
R4700:Myo1g UTSW 11 6,466,785 (GRCm39) splice site probably null
R4713:Myo1g UTSW 11 6,466,080 (GRCm39) missense probably null 1.00
R4964:Myo1g UTSW 11 6,465,976 (GRCm39) missense probably damaging 1.00
R5183:Myo1g UTSW 11 6,458,243 (GRCm39) missense probably damaging 1.00
R5191:Myo1g UTSW 11 6,465,105 (GRCm39) missense probably benign
R5192:Myo1g UTSW 11 6,464,816 (GRCm39) missense probably damaging 1.00
R5726:Myo1g UTSW 11 6,459,420 (GRCm39) missense probably benign 0.06
R5841:Myo1g UTSW 11 6,457,000 (GRCm39) missense probably benign 0.05
R5942:Myo1g UTSW 11 6,464,888 (GRCm39) missense probably damaging 1.00
R6225:Myo1g UTSW 11 6,469,168 (GRCm39) missense probably damaging 1.00
R6517:Myo1g UTSW 11 6,462,509 (GRCm39) missense probably damaging 0.99
R6563:Myo1g UTSW 11 6,467,146 (GRCm39) missense possibly damaging 0.91
R7214:Myo1g UTSW 11 6,461,055 (GRCm39) missense probably damaging 1.00
R7258:Myo1g UTSW 11 6,459,416 (GRCm39) missense possibly damaging 0.92
R7265:Myo1g UTSW 11 6,460,933 (GRCm39) missense possibly damaging 0.92
R7750:Myo1g UTSW 11 6,464,849 (GRCm39) missense probably damaging 1.00
R8683:Myo1g UTSW 11 6,467,569 (GRCm39) critical splice donor site probably null
R8910:Myo1g UTSW 11 6,468,009 (GRCm39) missense possibly damaging 0.66
R9035:Myo1g UTSW 11 6,464,916 (GRCm39) missense probably damaging 1.00
R9103:Myo1g UTSW 11 6,466,153 (GRCm39) missense possibly damaging 0.88
R9162:Myo1g UTSW 11 6,460,897 (GRCm39) missense probably damaging 0.98
R9487:Myo1g UTSW 11 6,456,913 (GRCm39) missense probably benign
X0017:Myo1g UTSW 11 6,466,077 (GRCm39) critical splice donor site probably null
X0061:Myo1g UTSW 11 6,467,967 (GRCm39) missense probably damaging 1.00
Z1176:Myo1g UTSW 11 6,469,045 (GRCm39) missense probably damaging 1.00
Z1177:Myo1g UTSW 11 6,467,935 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTATGTGTAGCCTTGTCCCCATTC -3'
(R):5'- AGACCCCATCAGGACAGACAGTTAG -3'

Sequencing Primer
(F):5'- ATTCCTGACGATGGGACCAG -3'
(R):5'- ACAGTTAGGCATGGACCTTG -3'
Posted On 2014-04-13