Mutagenetix > Incidental Mutation

Incidental Mutation 'R0058:Triml2'

16963

Institutional Source

Beutler Lab

Gene Symbol

Triml2

Ensembl Gene

ENSMUSG00000091490

Gene Name

tripartite motif family-like 2

Synonyms

EG622117

MMRRC Submission

038352-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

R0058 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

43633578-43646918 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 43638306 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000148196 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000163869] [ENSMUST00000209200] [ENSMUST00000209872] [ENSMUST00000210136]

AlphaFold

E9PW10

Predicted Effect

probably benign
Transcript: ENSMUST00000163869

SMART Domains

Protein: ENSMUSP00000132971
Gene: ENSMUSG00000091490

Domain	Start	End	E-Value	Type
Pfam:zf-B_box	13	51	7e-7	PFAM
PRY	242	294	2.86e-14	SMART
Pfam:SPRY	297	414	2.2e-11	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000209200

Predicted Effect

probably benign
Transcript: ENSMUST00000209872

Predicted Effect

probably benign
Transcript: ENSMUST00000210136

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211228

Coding Region Coverage

1x: 87.4%
3x: 82.9%
10x: 66.9%
20x: 41.4%

Validation Efficiency

85% (62/73)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	A	G	13: 81,330,791 (GRCm39)	V6088A	possibly damaging	Het
Ankrd36	A	G	11: 5,580,691 (GRCm39)		probably benign	Het
Anxa1	A	T	19: 20,361,141 (GRCm39)	Y84N	probably damaging	Het
Arnt2	G	A	7: 83,996,738 (GRCm39)	R63C	probably damaging	Het
Avpr1b	A	G	1: 131,527,524 (GRCm39)	T16A	probably benign	Het
Cables1	A	G	18: 12,056,470 (GRCm39)	E316G	possibly damaging	Het
Cadm1	A	T	9: 47,761,629 (GRCm39)	I427L	probably damaging	Het
Dazap1	T	C	10: 80,097,415 (GRCm39)		probably benign	Het
Dip2b	A	G	15: 100,113,121 (GRCm39)	E1512G	probably benign	Het
Dock1	G	A	7: 134,710,490 (GRCm39)	V1171M	possibly damaging	Het
Dock5	A	T	14: 68,018,485 (GRCm39)	F1230Y	probably benign	Het
Dst	T	C	1: 34,045,305 (GRCm39)	S13P	possibly damaging	Het
Dym	G	A	18: 75,176,243 (GRCm39)	E15K	possibly damaging	Het
Faf1	A	G	4: 109,593,821 (GRCm39)	Q133R	probably benign	Het
Fcer2a	T	C	8: 3,738,111 (GRCm39)		probably benign	Het
Fmo2	A	T	1: 162,713,893 (GRCm39)	S204R	probably benign	Het
Ghitm	A	G	14: 36,853,549 (GRCm39)	L97P	probably damaging	Het
Gins4	A	G	8: 23,719,526 (GRCm39)		probably benign	Het
Gm10573	G	A	4: 121,754,005 (GRCm39)			Het
Golga3	T	A	5: 110,350,643 (GRCm39)	F766Y	possibly damaging	Het
Hapln1	T	C	13: 89,755,997 (GRCm39)	I267T	probably benign	Het
Helz	A	T	11: 107,563,384 (GRCm39)		probably benign	Het
Igll1	A	T	16: 16,681,740 (GRCm39)	V5E	probably benign	Het
Kif16b	A	G	2: 142,699,225 (GRCm39)		probably null	Het
Limk1	A	T	5: 134,688,725 (GRCm39)	W507R	probably damaging	Het
Marf1	C	T	16: 13,960,398 (GRCm39)	A549T	probably damaging	Het
Mtif3	C	A	5: 146,893,731 (GRCm39)	V159F	probably benign	Het
Ncoa7	T	A	10: 30,523,537 (GRCm39)	D887V	probably damaging	Het
Pkd1	G	C	17: 24,783,677 (GRCm39)	A162P	probably benign	Het
Plce1	A	G	19: 38,513,628 (GRCm39)	D309G	possibly damaging	Het
Plk4	T	C	3: 40,760,307 (GRCm39)	V401A	probably benign	Het
Prrc2c	C	T	1: 162,526,453 (GRCm39)	V253I	unknown	Het
Ranbp2	T	A	10: 58,316,353 (GRCm39)	S2358T	probably damaging	Het
Setd2	T	A	9: 110,423,494 (GRCm39)	V2183E	probably damaging	Het
Sgsm1	T	A	5: 113,432,953 (GRCm39)	S232C	probably damaging	Het
Skint6	A	T	4: 112,904,012 (GRCm39)		probably benign	Het
Slc15a2	A	G	16: 36,574,909 (GRCm39)	I531T	probably benign	Het
Slc36a1	C	T	11: 55,112,820 (GRCm39)		probably benign	Het
Sptan1	T	C	2: 29,883,708 (GRCm39)		probably null	Het
Tex15	C	T	8: 34,071,530 (GRCm39)		probably benign	Het
Tlr9	T	G	9: 106,102,164 (GRCm39)	L485R	possibly damaging	Het
Tmem207	A	G	16: 26,343,579 (GRCm39)		probably benign	Het
Tspear	T	C	10: 77,705,465 (GRCm39)	F288L	probably benign	Het
Zfp644	A	T	5: 106,784,869 (GRCm39)	S559R	possibly damaging	Het

Other mutations in Triml2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01534:Triml2	APN	8	43,640,660 (GRCm39)	missense	probably benign	0.00
IGL01919:Triml2	APN	8	43,643,349 (GRCm39)	missense	probably damaging	1.00
IGL03382:Triml2	APN	8	43,646,776 (GRCm39)	missense	probably benign	0.00
R0025:Triml2	UTSW	8	43,638,469 (GRCm39)	missense	probably benign	0.00
R0058:Triml2	UTSW	8	43,638,306 (GRCm39)	splice site	probably benign
R0180:Triml2	UTSW	8	43,643,346 (GRCm39)	missense	probably benign	0.14
R1671:Triml2	UTSW	8	43,636,780 (GRCm39)	missense	possibly damaging	0.88
R2143:Triml2	UTSW	8	43,646,548 (GRCm39)	missense	probably damaging	1.00
R2210:Triml2	UTSW	8	43,636,397 (GRCm39)	missense	probably damaging	1.00
R3156:Triml2	UTSW	8	43,640,716 (GRCm39)	missense	probably benign	0.10
R3902:Triml2	UTSW	8	43,643,397 (GRCm39)	missense	probably benign	0.03
R4981:Triml2	UTSW	8	43,640,717 (GRCm39)	missense	probably benign	0.10
R6125:Triml2	UTSW	8	43,640,659 (GRCm39)	missense	probably benign	0.02
R6478:Triml2	UTSW	8	43,638,165 (GRCm39)	splice site	probably null
R6994:Triml2	UTSW	8	43,643,115 (GRCm39)	missense	possibly damaging	0.57
R7037:Triml2	UTSW	8	43,646,573 (GRCm39)	missense	probably damaging	1.00
R7113:Triml2	UTSW	8	43,636,370 (GRCm39)	missense	probably benign	0.01
R7660:Triml2	UTSW	8	43,646,357 (GRCm39)	missense	probably damaging	1.00
R7683:Triml2	UTSW	8	43,638,325 (GRCm39)	missense	probably damaging	0.99
R7971:Triml2	UTSW	8	43,643,313 (GRCm39)	missense	probably damaging	0.99
RF011:Triml2	UTSW	8	43,636,201 (GRCm39)	start gained	probably benign

Posted On

2013-01-20