Incidental Mutation 'R1551:Htr6'
ID 169907
Institutional Source Beutler Lab
Gene Symbol Htr6
Ensembl Gene ENSMUSG00000028747
Gene Name 5-hydroxytryptamine (serotonin) receptor 6
Synonyms 5-HT6
MMRRC Submission 039590-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R1551 (G1)
Quality Score 199
Status Not validated
Chromosome 4
Chromosomal Location 138788419-138802881 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 138801776 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 99 (C99*)
Ref Sequence ENSEMBL: ENSMUSP00000101428 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068036] [ENSMUST00000105802]
AlphaFold Q9R1C8
Predicted Effect probably null
Transcript: ENSMUST00000068036
AA Change: C99*
SMART Domains Protein: ENSMUSP00000068333
Gene: ENSMUSG00000028747
AA Change: C99*

DomainStartEndE-ValueType
low complexity region 13 32 N/A INTRINSIC
Pfam:7tm_1 43 322 4.6e-63 PFAM
low complexity region 364 378 N/A INTRINSIC
low complexity region 380 391 N/A INTRINSIC
low complexity region 404 416 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000105802
AA Change: C99*
SMART Domains Protein: ENSMUSP00000101428
Gene: ENSMUSG00000028747
AA Change: C99*

DomainStartEndE-ValueType
low complexity region 13 32 N/A INTRINSIC
Pfam:7tm_1 43 322 1.9e-72 PFAM
low complexity region 364 378 N/A INTRINSIC
low complexity region 380 391 N/A INTRINSIC
low complexity region 404 416 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210295
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.0%
  • 20x: 83.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
PHENOTYPE: Male mice homozygous for some disruptions in this gene display decreased body size. Mice homozygous for a different null allele display decreased sensitivity to alcohol induced behavioral responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A G 7: 119,918,101 (GRCm39) I1534M probably benign Het
Acad11 G A 9: 104,003,785 (GRCm39) A626T probably damaging Het
Akap9 T A 5: 4,119,174 (GRCm39) N3560K probably benign Het
Aldh3a2 C T 11: 61,144,470 (GRCm39) V363I probably benign Het
Anks1b A G 10: 89,912,843 (GRCm39) T289A probably benign Het
Atp11a A G 8: 12,862,340 (GRCm39) N64S probably damaging Het
Atp11c T C X: 59,282,072 (GRCm39) probably null Het
Cd101 T C 3: 100,919,329 (GRCm39) H591R probably damaging Het
Cd36 C T 5: 18,002,120 (GRCm39) V294I probably benign Het
Cfap47 C A X: 78,532,251 (GRCm39) L842F probably damaging Het
Cgref1 T C 5: 31,090,929 (GRCm39) E295G probably benign Het
Cit A G 5: 116,083,901 (GRCm39) M787V probably benign Het
Clcn6 G A 4: 148,097,235 (GRCm39) P611S possibly damaging Het
Clec12a A C 6: 129,327,384 (GRCm39) M1L probably damaging Het
Cmtm6 C T 9: 114,575,573 (GRCm39) R161W probably damaging Het
Colec10 G T 15: 54,325,658 (GRCm39) V163L probably damaging Het
Coq8b A G 7: 26,956,907 (GRCm39) Y520C probably damaging Het
Ctsll3 C A 13: 60,948,821 (GRCm39) E45* probably null Het
Dsg3 A G 18: 20,669,975 (GRCm39) E663G possibly damaging Het
Dst G A 1: 34,231,293 (GRCm39) R2962H probably benign Het
Etnk2 T C 1: 133,300,995 (GRCm39) I254T probably damaging Het
Fbxo36 T C 1: 84,858,835 (GRCm39) I40T probably damaging Het
Fgd2 G A 17: 29,597,383 (GRCm39) V568M probably damaging Het
Fmn1 T C 2: 113,356,207 (GRCm39) Y883H possibly damaging Het
Fpr-rs4 A T 17: 18,242,589 (GRCm39) T199S possibly damaging Het
Gm12789 A G 4: 101,846,131 (GRCm39) K131E probably benign Het
Gm17641 C A 3: 68,777,448 (GRCm39) silent Het
Gm6665 G T 18: 31,953,340 (GRCm39) R43S probably damaging Het
Gzmc T A 14: 56,470,203 (GRCm39) H98L probably damaging Het
Hecw1 T A 13: 14,491,528 (GRCm39) E75V probably damaging Het
Herc2 G T 7: 55,796,417 (GRCm39) V1930L probably benign Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Lgals2 C T 15: 78,736,511 (GRCm39) M16I probably benign Het
Lrrc8c A G 5: 105,756,090 (GRCm39) N622D probably damaging Het
Myo15a A T 11: 60,383,791 (GRCm39) I1613F possibly damaging Het
Oacyl C T 18: 65,875,280 (GRCm39) R455C probably benign Het
Or13c25 A T 4: 52,911,397 (GRCm39) Y132* probably null Het
Or5ac21 T A 16: 59,123,766 (GRCm39) N84K probably benign Het
Or5bh3 T C X: 49,098,872 (GRCm39) T81A possibly damaging Het
Orm3 A G 4: 63,275,146 (GRCm39) probably null Het
Phf2 G C 13: 48,985,579 (GRCm39) T67S unknown Het
Phf2 A G 13: 48,957,079 (GRCm39) L1096P probably damaging Het
Pigt T C 2: 164,349,323 (GRCm39) V542A probably damaging Het
Pnpla7 T C 2: 24,937,720 (GRCm39) F992L probably benign Het
Ppp2r5e C G 12: 75,516,341 (GRCm39) A239P probably damaging Het
Pramel11 A G 4: 143,622,263 (GRCm39) M364T probably benign Het
Prmt7 A G 8: 106,964,014 (GRCm39) T303A probably benign Het
Prpf4b A T 13: 35,078,426 (GRCm39) I679F possibly damaging Het
Psd4 T A 2: 24,293,292 (GRCm39) M719K probably benign Het
Ranbp9 A T 13: 43,578,593 (GRCm39) M160K probably benign Het
Rfc1 A G 5: 65,434,706 (GRCm39) Y687H probably damaging Het
Rimbp2 T C 5: 128,883,423 (GRCm39) K119R probably damaging Het
Rnf113a1 T C X: 36,455,046 (GRCm39) M1T probably null Het
Rnf40 A C 7: 127,195,506 (GRCm39) K511Q possibly damaging Het
Ryr2 T A 13: 11,800,029 (GRCm39) probably null Het
Scrib A T 15: 75,937,011 (GRCm39) V365E probably damaging Het
Slc6a17 A G 3: 107,379,443 (GRCm39) V575A possibly damaging Het
Spta1 A G 1: 174,067,732 (GRCm39) N2053S possibly damaging Het
Ssbp2 G A 13: 91,790,511 (GRCm39) probably null Het
Stab1 G T 14: 30,882,456 (GRCm39) N460K probably benign Het
Tbc1d9 T A 8: 83,992,787 (GRCm39) C964S probably benign Het
Tmed11 A G 5: 108,927,680 (GRCm39) probably null Het
Tmem191 C A 16: 17,095,984 (GRCm39) R285S probably damaging Het
Tpr T C 1: 150,312,552 (GRCm39) S1917P probably benign Het
Vill A T 9: 118,892,440 (GRCm39) H357L probably benign Het
Vmn1r229 A G 17: 21,035,051 (GRCm39) T99A probably benign Het
Vmn2r14 A G 5: 109,369,283 (GRCm39) S97P probably damaging Het
Wasf2 G T 4: 132,917,483 (GRCm39) R194L unknown Het
Other mutations in Htr6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02859:Htr6 APN 4 138,801,745 (GRCm39) missense probably damaging 1.00
IGL03093:Htr6 APN 4 138,789,080 (GRCm39) missense probably damaging 1.00
R0179:Htr6 UTSW 4 138,789,437 (GRCm39) missense probably damaging 1.00
R0415:Htr6 UTSW 4 138,789,392 (GRCm39) missense possibly damaging 0.53
R1631:Htr6 UTSW 4 138,788,804 (GRCm39) missense probably benign 0.12
R2181:Htr6 UTSW 4 138,801,736 (GRCm39) missense probably damaging 1.00
R4404:Htr6 UTSW 4 138,789,513 (GRCm39) missense probably benign 0.03
R5310:Htr6 UTSW 4 138,788,977 (GRCm39) missense probably damaging 0.99
R5604:Htr6 UTSW 4 138,788,814 (GRCm39) missense probably benign 0.00
R5768:Htr6 UTSW 4 138,789,015 (GRCm39) missense probably damaging 0.99
R7833:Htr6 UTSW 4 138,789,142 (GRCm39) missense probably damaging 1.00
R8395:Htr6 UTSW 4 138,789,078 (GRCm39) missense possibly damaging 0.81
R9139:Htr6 UTSW 4 138,789,501 (GRCm39) missense possibly damaging 0.89
R9623:Htr6 UTSW 4 138,801,750 (GRCm39) missense probably damaging 1.00
R9661:Htr6 UTSW 4 138,801,963 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCTTTGCCCAGTTCATGCCAG -3'
(R):5'- AAGAACCCTGTTTTGCCACCTACTC -3'

Sequencing Primer
(F):5'- CAGTTCATGCCAGCCCAG -3'
(R):5'- ACCTACTCCTCTGAGGTGCAG -3'
Posted On 2014-04-13