Incidental Mutation 'R1553:Zfp616'
ID 170100
Institutional Source Beutler Lab
Gene Symbol Zfp616
Ensembl Gene ENSMUSG00000069476
Gene Name zinc finger protein 616
Synonyms Gm12330
MMRRC Submission 039592-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1553 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 73960781-73978118 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 73974744 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 429 (I429F)
Ref Sequence ENSEMBL: ENSMUSP00000104103 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074813] [ENSMUST00000108463] [ENSMUST00000116546] [ENSMUST00000178159]
AlphaFold J3QN14
Predicted Effect probably benign
Transcript: ENSMUST00000074813
SMART Domains Protein: ENSMUSP00000074365
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000108463
AA Change: I429F

PolyPhen 2 Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000104103
Gene: ENSMUSG00000069476
AA Change: I429F

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
low complexity region 249 258 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000116546
SMART Domains Protein: ENSMUSP00000112245
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137407
Predicted Effect unknown
Transcript: ENSMUST00000178159
AA Change: I338F
SMART Domains Protein: ENSMUSP00000136549
Gene: ENSMUSG00000069476
AA Change: I338F

DomainStartEndE-ValueType
internal_repeat_1 125 447 7.61e-6 PROSPERO
ZnF_C2H2 452 474 3.11e-2 SMART
ZnF_C2H2 509 531 2.61e-4 SMART
ZnF_C2H2 537 559 1.47e-3 SMART
ZnF_C2H2 565 587 5.21e-4 SMART
ZnF_C2H2 593 615 1.22e-4 SMART
ZnF_C2H2 621 643 2.57e-3 SMART
ZnF_C2H2 649 671 9.22e-5 SMART
ZnF_C2H2 677 699 5.9e-3 SMART
ZnF_C2H2 705 727 4.94e-5 SMART
ZnF_C2H2 733 755 8.34e-3 SMART
ZnF_C2H2 761 783 1.6e-4 SMART
ZnF_C2H2 789 811 6.88e-4 SMART
ZnF_C2H2 817 839 1.6e-4 SMART
ZnF_C2H2 845 867 1.3e-4 SMART
ZnF_C2H2 873 895 7.37e-4 SMART
ZnF_C2H2 901 923 1.6e-4 SMART
ZnF_C2H2 929 951 1.3e-4 SMART
ZnF_C2H2 957 979 3.95e-4 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 92.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb8 G T 5: 24,613,748 (GRCm39) A649S probably damaging Het
Adam6a T A 12: 113,508,835 (GRCm39) C403S probably damaging Het
Adgrg3 T C 8: 95,766,896 (GRCm39) F417S possibly damaging Het
Ago1 T C 4: 126,334,194 (GRCm39) E439G probably damaging Het
Alox15 A G 11: 70,240,458 (GRCm39) V241A possibly damaging Het
Arhgap6 A G X: 168,048,480 (GRCm39) H566R probably damaging Het
Asap1 A T 15: 64,024,701 (GRCm39) F345I probably benign Het
Atp1b2 A G 11: 69,493,678 (GRCm39) Y134H probably damaging Het
Atp8b3 G A 10: 80,368,376 (GRCm39) T199M probably damaging Het
Calb1 A T 4: 15,895,656 (GRCm39) S115C probably damaging Het
Ccdc68 A T 18: 70,073,192 (GRCm39) I47F probably damaging Het
Cdc42bpa A T 1: 179,921,540 (GRCm39) N560I probably benign Het
Cdhr3 T C 12: 33,092,370 (GRCm39) D747G probably benign Het
Cdk5rap1 T G 2: 154,194,171 (GRCm39) N378T probably damaging Het
Chil4 T G 3: 106,111,006 (GRCm39) N296T probably benign Het
Cryaa G A 17: 31,898,533 (GRCm39) V87I probably damaging Het
Csk G A 9: 57,538,225 (GRCm39) L28F probably damaging Het
Cspp1 A G 1: 10,156,122 (GRCm39) N444D possibly damaging Het
Cyp2j8 A G 4: 96,363,794 (GRCm39) Y290H probably benign Het
Eps8l1 A T 7: 4,480,448 (GRCm39) D563V probably damaging Het
Fam111a A T 19: 12,564,682 (GRCm39) S144C possibly damaging Het
Fam135a A T 1: 24,060,951 (GRCm39) S1145R probably damaging Het
Fpr2 T A 17: 18,113,856 (GRCm39) V284D possibly damaging Het
Furin A G 7: 80,048,340 (GRCm39) probably null Het
Gatd1 T C 7: 140,989,806 (GRCm39) T135A probably benign Het
Gdf3 A G 6: 122,586,724 (GRCm39) S68P probably benign Het
Gm6871 T C 7: 41,195,822 (GRCm39) H305R probably benign Het
Grip1 A G 10: 119,890,756 (GRCm39) S917G probably damaging Het
Hdac10 T A 15: 89,009,718 (GRCm39) E388V possibly damaging Het
Hectd1 T C 12: 51,820,661 (GRCm39) N1176S probably damaging Het
Hectd4 A G 5: 121,487,322 (GRCm39) D3439G probably benign Het
Kcna4 T C 2: 107,127,032 (GRCm39) Y589H probably benign Het
Kcnk5 A T 14: 20,192,462 (GRCm39) L233Q probably damaging Het
Kcnt1 T C 2: 25,790,397 (GRCm39) I453T probably damaging Het
Kifc3 A G 8: 95,833,170 (GRCm39) I440T possibly damaging Het
Krt10 C A 11: 99,276,806 (GRCm39) G40* probably null Het
Lce1i A T 3: 92,685,102 (GRCm39) C25S unknown Het
Met A G 6: 17,491,460 (GRCm39) N74S probably benign Het
Naa35 G A 13: 59,766,093 (GRCm39) probably null Het
Naalad2 T C 9: 18,289,965 (GRCm39) N221S probably benign Het
Nolc1 AGCG AGCGGCG 19: 46,069,814 (GRCm39) probably benign Het
Nsmf T C 2: 24,950,271 (GRCm39) V181A probably damaging Het
Nwd2 T A 5: 63,957,848 (GRCm39) S393T probably benign Het
Or12j3 T A 7: 139,952,951 (GRCm39) T191S probably damaging Het
Or2d3c A T 7: 106,526,201 (GRCm39) V155E possibly damaging Het
Or51a6 T A 7: 102,604,425 (GRCm39) I128L possibly damaging Het
Papola T A 12: 105,786,669 (GRCm39) S453R probably benign Het
Paqr9 A G 9: 95,442,262 (GRCm39) N84S probably damaging Het
Pde5a T C 3: 122,572,585 (GRCm39) V290A probably benign Het
Prf1 T C 10: 61,138,948 (GRCm39) V302A probably damaging Het
Psg18 T C 7: 18,087,406 (GRCm39) Y84C probably benign Het
Rasgrf2 C T 13: 92,038,783 (GRCm39) R1021H probably damaging Het
Rnf114 G T 2: 167,354,522 (GRCm39) R201L possibly damaging Het
Rp1l1 A G 14: 64,269,343 (GRCm39) E1643G probably benign Het
Scg3 T A 9: 75,576,586 (GRCm39) E263V probably null Het
Scn2a C T 2: 65,544,180 (GRCm39) R854* probably null Het
Setdb2 T C 14: 59,654,934 (GRCm39) K319E probably benign Het
Stub1 A T 17: 26,051,097 (GRCm39) V95E probably damaging Het
Tas2r140 T A 6: 133,032,471 (GRCm39) N96Y probably damaging Het
Tecta T A 9: 42,259,482 (GRCm39) D1467V probably damaging Het
Tenm3 T A 8: 48,689,456 (GRCm39) T2044S probably damaging Het
Tlr2 T A 3: 83,744,770 (GRCm39) M438L probably benign Het
Tmem179 T C 12: 112,471,094 (GRCm39) Y106C probably benign Het
Tspan7 A G X: 10,451,854 (GRCm39) H187R probably benign Het
Ttn T C 2: 76,757,619 (GRCm39) D3332G probably damaging Het
Upp2 T C 2: 58,680,152 (GRCm39) F326S probably damaging Het
Usp2 T A 9: 44,003,452 (GRCm39) D224E probably damaging Het
Vmn1r5 T A 6: 56,962,483 (GRCm39) F53I probably benign Het
Wapl T A 14: 34,451,147 (GRCm39) L727H probably damaging Het
Wipf1 T C 2: 73,267,870 (GRCm39) D176G possibly damaging Het
Xpnpep1 G T 19: 52,994,769 (GRCm39) D243E probably benign Het
Zfyve26 G A 12: 79,334,535 (GRCm39) P161L probably benign Het
Other mutations in Zfp616
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00530:Zfp616 APN 11 73,974,439 (GRCm39) missense probably damaging 0.98
IGL00570:Zfp616 APN 11 73,976,631 (GRCm39) missense probably benign 0.03
IGL00594:Zfp616 APN 11 73,973,789 (GRCm39) missense possibly damaging 0.72
IGL01861:Zfp616 APN 11 73,973,742 (GRCm39) missense possibly damaging 0.53
IGL03022:Zfp616 APN 11 73,973,800 (GRCm39) missense possibly damaging 0.85
R0197:Zfp616 UTSW 11 73,976,500 (GRCm39) missense probably damaging 1.00
R0442:Zfp616 UTSW 11 73,975,321 (GRCm39) missense possibly damaging 0.92
R0497:Zfp616 UTSW 11 73,974,306 (GRCm39) missense probably benign 0.00
R0651:Zfp616 UTSW 11 73,974,555 (GRCm39) nonsense probably null
R0730:Zfp616 UTSW 11 73,975,648 (GRCm39) missense probably damaging 1.00
R0883:Zfp616 UTSW 11 73,976,500 (GRCm39) missense probably damaging 1.00
R0926:Zfp616 UTSW 11 73,976,644 (GRCm39) missense probably benign 0.04
R0940:Zfp616 UTSW 11 73,975,850 (GRCm39) missense probably damaging 1.00
R1068:Zfp616 UTSW 11 73,973,767 (GRCm39) makesense probably null
R1272:Zfp616 UTSW 11 73,976,062 (GRCm39) missense probably benign 0.08
R1446:Zfp616 UTSW 11 73,974,064 (GRCm39) splice site probably null
R1482:Zfp616 UTSW 11 73,974,803 (GRCm39) missense possibly damaging 0.72
R1564:Zfp616 UTSW 11 73,975,548 (GRCm39) missense probably damaging 1.00
R1728:Zfp616 UTSW 11 73,976,597 (GRCm39) missense probably damaging 0.99
R1796:Zfp616 UTSW 11 73,976,671 (GRCm39) missense probably damaging 0.98
R1797:Zfp616 UTSW 11 73,976,105 (GRCm39) nonsense probably null
R1993:Zfp616 UTSW 11 73,975,795 (GRCm39) missense probably benign 0.08
R2026:Zfp616 UTSW 11 73,974,413 (GRCm39) missense possibly damaging 0.86
R2124:Zfp616 UTSW 11 73,973,869 (GRCm39) splice site probably null
R2126:Zfp616 UTSW 11 73,976,229 (GRCm39) missense probably benign 0.08
R2199:Zfp616 UTSW 11 73,975,456 (GRCm39) missense possibly damaging 0.58
R2265:Zfp616 UTSW 11 73,976,289 (GRCm39) missense possibly damaging 0.89
R2404:Zfp616 UTSW 11 73,975,682 (GRCm39) missense probably damaging 1.00
R2508:Zfp616 UTSW 11 73,974,121 (GRCm39) missense probably benign 0.01
R2519:Zfp616 UTSW 11 73,975,094 (GRCm39) nonsense probably null
R3103:Zfp616 UTSW 11 73,962,561 (GRCm39) missense probably benign 0.01
R3611:Zfp616 UTSW 11 73,974,268 (GRCm39) missense possibly damaging 0.53
R3703:Zfp616 UTSW 11 73,974,145 (GRCm39) nonsense probably null
R3744:Zfp616 UTSW 11 73,974,813 (GRCm39) missense probably benign 0.01
R4043:Zfp616 UTSW 11 73,976,108 (GRCm39) missense possibly damaging 0.50
R4273:Zfp616 UTSW 11 73,974,526 (GRCm39) missense probably benign 0.00
R4384:Zfp616 UTSW 11 73,974,005 (GRCm39) missense possibly damaging 0.94
R4469:Zfp616 UTSW 11 73,961,950 (GRCm39) missense probably damaging 0.98
R4560:Zfp616 UTSW 11 73,973,860 (GRCm39) missense probably benign 0.00
R4821:Zfp616 UTSW 11 73,975,033 (GRCm39) missense probably benign 0.41
R4844:Zfp616 UTSW 11 73,975,225 (GRCm39) missense probably benign 0.10
R4948:Zfp616 UTSW 11 73,974,830 (GRCm39) missense possibly damaging 0.72
R5007:Zfp616 UTSW 11 73,974,643 (GRCm39) missense possibly damaging 0.96
R5198:Zfp616 UTSW 11 73,974,336 (GRCm39) missense probably benign 0.33
R5344:Zfp616 UTSW 11 73,975,321 (GRCm39) missense possibly damaging 0.92
R5918:Zfp616 UTSW 11 73,974,086 (GRCm39) missense possibly damaging 0.70
R5933:Zfp616 UTSW 11 73,973,952 (GRCm39) missense probably damaging 0.96
R6084:Zfp616 UTSW 11 73,974,672 (GRCm39) nonsense probably null
R6421:Zfp616 UTSW 11 73,974,696 (GRCm39) missense possibly damaging 0.53
R6494:Zfp616 UTSW 11 73,976,018 (GRCm39) missense probably damaging 1.00
R6523:Zfp616 UTSW 11 73,973,968 (GRCm39) missense possibly damaging 0.79
R6849:Zfp616 UTSW 11 73,976,276 (GRCm39) missense possibly damaging 0.70
R6910:Zfp616 UTSW 11 73,975,828 (GRCm39) missense probably damaging 1.00
R7146:Zfp616 UTSW 11 73,976,087 (GRCm39) missense possibly damaging 0.61
R7213:Zfp616 UTSW 11 73,976,689 (GRCm39) missense probably benign 0.05
R7302:Zfp616 UTSW 11 73,976,205 (GRCm39) missense probably benign 0.08
R7391:Zfp616 UTSW 11 73,976,155 (GRCm39) missense probably benign 0.08
R7654:Zfp616 UTSW 11 73,974,013 (GRCm39) missense possibly damaging 0.53
R7877:Zfp616 UTSW 11 73,975,188 (GRCm39) missense probably damaging 1.00
R7889:Zfp616 UTSW 11 73,976,271 (GRCm39) missense probably damaging 1.00
R8022:Zfp616 UTSW 11 73,974,894 (GRCm39) missense probably benign
R8061:Zfp616 UTSW 11 73,974,340 (GRCm39) missense possibly damaging 0.96
R8212:Zfp616 UTSW 11 73,976,569 (GRCm39) missense probably damaging 0.96
R8335:Zfp616 UTSW 11 73,974,726 (GRCm39) nonsense probably null
R8361:Zfp616 UTSW 11 73,975,476 (GRCm39) missense probably damaging 0.98
R8486:Zfp616 UTSW 11 73,974,909 (GRCm39) missense probably benign 0.18
R8695:Zfp616 UTSW 11 73,975,710 (GRCm39) missense probably benign 0.45
R8808:Zfp616 UTSW 11 73,976,523 (GRCm39) missense probably damaging 1.00
R9022:Zfp616 UTSW 11 73,976,539 (GRCm39) missense probably damaging 1.00
R9126:Zfp616 UTSW 11 73,976,280 (GRCm39) missense probably damaging 1.00
R9164:Zfp616 UTSW 11 73,975,825 (GRCm39) missense probably damaging 1.00
R9293:Zfp616 UTSW 11 73,974,744 (GRCm39) missense possibly damaging 0.53
R9421:Zfp616 UTSW 11 73,974,331 (GRCm39) missense possibly damaging 0.72
R9512:Zfp616 UTSW 11 73,975,936 (GRCm39) missense probably damaging 1.00
R9529:Zfp616 UTSW 11 73,976,596 (GRCm39) missense possibly damaging 0.90
R9529:Zfp616 UTSW 11 73,975,660 (GRCm39) missense probably damaging 1.00
R9606:Zfp616 UTSW 11 73,976,220 (GRCm39) missense probably damaging 1.00
R9708:Zfp616 UTSW 11 73,976,283 (GRCm39) missense probably damaging 1.00
R9788:Zfp616 UTSW 11 73,975,276 (GRCm39) missense probably damaging 0.99
Z1176:Zfp616 UTSW 11 73,976,467 (GRCm39) missense possibly damaging 0.90
Z1176:Zfp616 UTSW 11 73,974,045 (GRCm39) missense possibly damaging 0.72
Z1176:Zfp616 UTSW 11 73,973,859 (GRCm39) missense probably benign
Z1177:Zfp616 UTSW 11 73,975,878 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- AGCAGGATCATACCACATGGAGCC -3'
(R):5'- GCAAAGGACTTGCCACATTGCAC -3'

Sequencing Primer
(F):5'- ATGACTGGCAGGATGACATT -3'
(R):5'- TCCCTCTAGCTTGAAATACCATAAGG -3'
Posted On 2014-04-13