Incidental Mutation 'R1556:Or1p1'
ID 170287
Institutional Source Beutler Lab
Gene Symbol Or1p1
Ensembl Gene ENSMUSG00000070374
Gene Name olfactory receptor family 1 subfamily P member 1
Synonyms MOR133-3P, Olfr59, IH3, GA_x6K02T2P1NL-4434429-4435400
MMRRC Submission 039595-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R1556 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 74174562-74180472 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 74179762 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 97 (C97S)
Ref Sequence ENSEMBL: ENSMUSP00000146212 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000143976] [ENSMUST00000205790] [ENSMUST00000206659] [ENSMUST00000214048]
AlphaFold B1ARL3
Predicted Effect probably damaging
Transcript: ENSMUST00000119717
AA Change: C97S

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000112522
Gene: ENSMUSG00000070374
AA Change: C97S

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 2.2e-59 PFAM
Pfam:7tm_1 41 292 3.2e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000143976
AA Change: C97S

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000119877
Gene: ENSMUSG00000070374
AA Change: C97S

DomainStartEndE-ValueType
Pfam:7tm_1 41 237 7.5e-34 PFAM
Pfam:7tm_4 139 237 1.9e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000205790
AA Change: C97S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000206659
AA Change: C97S

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000214048
AA Change: C97S

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.4%
  • 20x: 89.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik T C 8: 73,203,477 (GRCm39) S302P probably damaging Het
Anapc1 T C 2: 128,466,819 (GRCm39) T1626A probably benign Het
Arhgef6 T C X: 56,383,922 (GRCm39) M5V probably benign Het
Arid5a T A 1: 36,359,245 (GRCm39) Y520* probably null Het
Aven G A 2: 112,461,230 (GRCm39) M215I probably damaging Het
Cabyr A G 18: 12,877,837 (GRCm39) D58G probably damaging Het
Ccdc146 A G 5: 21,535,551 (GRCm39) Y168H probably damaging Het
Ccnd2 A T 6: 127,107,363 (GRCm39) S269T probably benign Het
Cd68 T A 11: 69,556,676 (GRCm39) T44S probably damaging Het
Clstn2 A T 9: 97,338,558 (GRCm39) I867N probably benign Het
Cmss1 C T 16: 57,136,560 (GRCm39) R104H probably benign Het
Col6a6 A G 9: 105,586,672 (GRCm39) V1783A possibly damaging Het
Dach2 T C X: 112,208,214 (GRCm39) S31P probably benign Het
Dpp8 T A 9: 64,958,761 (GRCm39) W279R probably damaging Het
Fras1 A T 5: 96,890,921 (GRCm39) I2817F possibly damaging Het
Gabrr3 G A 16: 59,281,763 (GRCm39) D373N probably benign Het
Gdf7 T C 12: 8,351,698 (GRCm39) N79S unknown Het
Gpam A G 19: 55,064,763 (GRCm39) V647A possibly damaging Het
Gpatch1 T C 7: 34,994,776 (GRCm39) T497A probably benign Het
Grin2a A T 16: 9,525,579 (GRCm39) F337L probably benign Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
H2-Aa A T 17: 34,503,390 (GRCm39) V69D possibly damaging Het
H2-M10.5 T C 17: 37,084,205 (GRCm39) Y56H probably damaging Het
Kcnu1 G A 8: 26,351,219 (GRCm39) probably null Het
Krt77 A G 15: 101,769,713 (GRCm39) S386P probably damaging Het
L3mbtl2 T A 15: 81,566,203 (GRCm39) M342K probably benign Het
Ldlrad1 A G 4: 107,075,010 (GRCm39) T186A probably benign Het
Lins1 C A 7: 66,360,385 (GRCm39) C168* probably null Het
Lrrtm3 G A 10: 63,923,928 (GRCm39) T413M probably damaging Het
Macf1 T C 4: 123,348,813 (GRCm39) D4038G probably damaging Het
Mark3 T G 12: 111,594,275 (GRCm39) N308K probably damaging Het
Mdga2 T A 12: 66,597,367 (GRCm39) Y709F possibly damaging Het
Mtus2 T A 5: 148,014,198 (GRCm39) S330R probably benign Het
Or4k15c G A 14: 50,321,916 (GRCm39) A74V possibly damaging Het
Or51a24 T A 7: 103,733,468 (GRCm39) H273L probably benign Het
Or6c76 T C 10: 129,612,242 (GRCm39) V168A probably benign Het
Ovgp1 A G 3: 105,894,068 (GRCm39) probably benign Het
P4ha2 A G 11: 54,015,836 (GRCm39) T408A probably damaging Het
Pcdh8 T G 14: 80,007,843 (GRCm39) D240A probably damaging Het
Pcyt2 T C 11: 120,502,911 (GRCm39) probably null Het
Pecr T A 1: 72,298,542 (GRCm39) I293L probably benign Het
Pogk A G 1: 166,226,402 (GRCm39) V583A possibly damaging Het
Prkg1 T C 19: 30,602,143 (GRCm39) K371R probably benign Het
Psmd2 T A 16: 20,474,335 (GRCm39) M297K possibly damaging Het
Rgs12 A G 5: 35,196,626 (GRCm39) R769G possibly damaging Het
Sgtb T A 13: 104,276,284 (GRCm39) N237K probably damaging Het
Sh3bgrl2 T C 9: 83,476,751 (GRCm39) V91A probably damaging Het
Slc4a1ap G A 5: 31,691,554 (GRCm39) probably null Het
Slc4a7 T C 14: 14,778,872 (GRCm38) V940A probably benign Het
Tep1 T C 14: 51,090,499 (GRCm39) T740A probably benign Het
Tnk2 G T 16: 32,489,737 (GRCm39) probably null Het
Trpv2 A G 11: 62,483,059 (GRCm39) Y450C probably damaging Het
Tut7 T C 13: 59,948,054 (GRCm39) T354A probably benign Het
Tvp23a A T 16: 10,264,862 (GRCm39) D16E probably damaging Het
Twnk T C 19: 44,997,850 (GRCm39) F460L possibly damaging Het
Unc80 C T 1: 66,560,740 (GRCm39) H823Y possibly damaging Het
Urb2 T C 8: 124,757,356 (GRCm39) L1021P probably damaging Het
Vps13c T C 9: 67,837,993 (GRCm39) Y1848H probably damaging Het
Vwa8 T G 14: 79,324,121 (GRCm39) N1141K probably benign Het
Yipf3 A G 17: 46,561,793 (GRCm39) Y200C probably damaging Het
Zbtb38 A G 9: 96,569,044 (GRCm39) V680A probably benign Het
Znrf3 T C 11: 5,231,347 (GRCm39) E722G probably benign Het
Zzef1 T A 11: 72,806,059 (GRCm39) L2665H probably damaging Het
Other mutations in Or1p1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Or1p1 APN 11 74,179,952 (GRCm39) missense probably damaging 1.00
IGL00337:Or1p1 APN 11 74,180,213 (GRCm39) missense probably damaging 0.97
IGL01307:Or1p1 APN 11 74,180,254 (GRCm39) missense possibly damaging 0.88
IGL01488:Or1p1 APN 11 74,179,514 (GRCm39) missense probably damaging 1.00
IGL02583:Or1p1 APN 11 74,180,330 (GRCm39) missense probably damaging 1.00
IGL02839:Or1p1 APN 11 74,180,196 (GRCm39) nonsense probably null
IGL02996:Or1p1 APN 11 74,179,991 (GRCm39) missense probably benign 0.08
R0013:Or1p1 UTSW 11 74,179,877 (GRCm39) missense possibly damaging 0.88
R0077:Or1p1 UTSW 11 74,179,501 (GRCm39) missense probably benign 0.00
R0078:Or1p1 UTSW 11 74,180,092 (GRCm39) missense probably damaging 1.00
R0734:Or1p1 UTSW 11 74,179,772 (GRCm39) missense probably damaging 1.00
R1033:Or1p1 UTSW 11 74,179,492 (GRCm39) missense probably damaging 0.99
R1721:Or1p1 UTSW 11 74,180,126 (GRCm39) missense probably damaging 1.00
R1737:Or1p1 UTSW 11 74,179,637 (GRCm39) missense probably damaging 1.00
R1848:Or1p1 UTSW 11 74,180,039 (GRCm39) missense probably damaging 0.99
R1881:Or1p1 UTSW 11 74,179,492 (GRCm39) missense probably benign 0.08
R2057:Or1p1 UTSW 11 74,179,652 (GRCm39) missense probably damaging 1.00
R2107:Or1p1 UTSW 11 74,180,216 (GRCm39) missense probably damaging 1.00
R4399:Or1p1 UTSW 11 74,179,682 (GRCm39) missense probably damaging 1.00
R4633:Or1p1 UTSW 11 74,180,120 (GRCm39) missense probably benign 0.00
R5593:Or1p1 UTSW 11 74,179,618 (GRCm39) missense possibly damaging 0.65
R5988:Or1p1 UTSW 11 74,179,679 (GRCm39) missense probably benign
R6104:Or1p1 UTSW 11 74,180,192 (GRCm39) missense probably damaging 1.00
R7436:Or1p1 UTSW 11 74,179,511 (GRCm39) missense possibly damaging 0.84
R7506:Or1p1 UTSW 11 74,179,949 (GRCm39) missense possibly damaging 0.96
R7769:Or1p1 UTSW 11 74,179,589 (GRCm39) missense probably damaging 1.00
R8247:Or1p1 UTSW 11 74,180,315 (GRCm39) missense noncoding transcript
R8709:Or1p1 UTSW 11 74,180,054 (GRCm39) missense possibly damaging 0.76
R8900:Or1p1 UTSW 11 74,180,413 (GRCm39) missense probably damaging 0.98
R9010:Or1p1 UTSW 11 74,180,305 (GRCm39) missense probably damaging 1.00
R9147:Or1p1 UTSW 11 74,180,169 (GRCm39) missense probably damaging 0.97
R9148:Or1p1 UTSW 11 74,180,169 (GRCm39) missense probably damaging 0.97
R9719:Or1p1 UTSW 11 74,180,146 (GRCm39) missense probably damaging 0.97
Z1088:Or1p1 UTSW 11 74,179,661 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCAGACCAGCACCTTTGAGTTCC -3'
(R):5'- CCAACAGGCTGTCACTAAGAGTGAG -3'

Sequencing Primer
(F):5'- cacatcctcttcctggtcttc -3'
(R):5'- TGTCACTAAGAGTGAGCAGCG -3'
Posted On 2014-04-13