Incidental Mutation 'R1559:Daam2'
ID 170520
Institutional Source Beutler Lab
Gene Symbol Daam2
Ensembl Gene ENSMUSG00000040260
Gene Name dishevelled associated activator of morphogenesis 2
Synonyms 2310016D11Rik
MMRRC Submission 039598-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1559 (G1)
Quality Score 210
Status Validated
Chromosome 17
Chromosomal Location 49763050-49871371 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 49803148 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153095 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057610] [ENSMUST00000224595]
AlphaFold Q80U19
Predicted Effect probably benign
Transcript: ENSMUST00000057610
SMART Domains Protein: ENSMUSP00000052085
Gene: ENSMUSG00000040260

DomainStartEndE-ValueType
Drf_GBD 40 228 4.89e-61 SMART
Drf_FH3 231 429 1.19e-73 SMART
Blast:FH2 476 513 4e-10 BLAST
low complexity region 514 534 N/A INTRINSIC
low complexity region 539 576 N/A INTRINSIC
FH2 595 1085 7.36e-99 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000224595
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224954
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226030
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.0%
  • 20x: 84.8%
Validation Efficiency 95% (73/77)
MGI Phenotype PHENOTYPE: Homozygous KO in combination with homozygous Daam1 conditional KO increases the severity of the heart phenotype (abnormal ventricular morphology and pressure) of the Daam1 single KO. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,349,180 (GRCm39) W3585R probably null Het
Ajm1 G T 2: 25,467,043 (GRCm39) S956* probably null Het
Babam1 G C 8: 71,850,424 (GRCm39) E18Q probably damaging Het
Bcan G T 3: 87,901,519 (GRCm39) S394R probably damaging Het
Birc6 T A 17: 74,999,232 (GRCm39) F4653L probably damaging Het
Camsap2 A T 1: 136,209,832 (GRCm39) H559Q probably benign Het
Cars2 G T 8: 11,580,430 (GRCm39) probably null Het
Ccdc93 T A 1: 121,389,712 (GRCm39) probably benign Het
Ccna2 C A 3: 36,624,879 (GRCm39) probably benign Het
Cdc6 T A 11: 98,803,037 (GRCm39) L326I probably damaging Het
Cdh23 A T 10: 60,255,478 (GRCm39) probably benign Het
Cenpe T A 3: 134,976,661 (GRCm39) S2423T probably benign Het
Cftr A G 6: 18,225,936 (GRCm39) M295V probably benign Het
Cxcl2 A G 5: 91,051,871 (GRCm39) H23R probably benign Het
Cyp4a12b A G 4: 115,291,181 (GRCm39) T370A probably damaging Het
Dclk3 T C 9: 111,298,276 (GRCm39) F607L probably damaging Het
Des T G 1: 75,337,230 (GRCm39) S57A probably benign Het
Drd1 A T 13: 54,206,964 (GRCm39) S410T probably damaging Het
Ecm1 G A 3: 95,643,275 (GRCm39) R342C probably damaging Het
Fanci T C 7: 79,082,941 (GRCm39) L639P probably damaging Het
Fancm A G 12: 65,140,463 (GRCm39) E395G probably benign Het
Grik3 A G 4: 125,601,790 (GRCm39) D889G probably benign Het
Heyl A G 4: 123,135,192 (GRCm39) S62G probably damaging Het
Hmox1 C T 8: 75,826,577 (GRCm39) P267L probably damaging Het
Ifi213 A C 1: 173,394,784 (GRCm39) S584A probably benign Het
Il12rb2 G T 6: 67,333,576 (GRCm39) F234L probably benign Het
Il4i1 T A 7: 44,488,811 (GRCm39) S233T probably damaging Het
Itga4 A G 2: 79,146,032 (GRCm39) S745G probably benign Het
Kalrn T A 16: 33,830,918 (GRCm39) I734F possibly damaging Het
Klk1b16 T C 7: 43,790,425 (GRCm39) I200T probably benign Het
Lrrc4c T A 2: 97,461,117 (GRCm39) M581K probably benign Het
M6pr A T 6: 122,292,033 (GRCm39) I122L probably benign Het
Magi3 T C 3: 103,954,169 (GRCm39) probably benign Het
Mybpc2 T G 7: 44,163,111 (GRCm39) T480P probably benign Het
Or14c44 T C 7: 86,061,575 (GRCm39) S43P probably benign Het
Or1j17 A G 2: 36,578,770 (GRCm39) Y252C probably damaging Het
Or51ab3 A T 7: 103,201,372 (GRCm39) I127F possibly damaging Het
Or8g23 T C 9: 38,971,437 (GRCm39) N175S probably benign Het
Pcx T A 19: 4,669,114 (GRCm39) I704N probably damaging Het
Pde3a G T 6: 141,404,824 (GRCm39) A350S probably damaging Het
Ppox A T 1: 171,107,580 (GRCm39) probably benign Het
Prb1a T A 6: 132,185,507 (GRCm39) Y42F unknown Het
Rsph4a T A 10: 33,785,727 (GRCm39) V546E probably damaging Het
Saxo4 T C 19: 10,458,770 (GRCm39) T87A probably benign Het
Sf3b1 C G 1: 55,058,554 (GRCm39) E12Q possibly damaging Het
Sh3tc1 A G 5: 35,860,693 (GRCm39) probably null Het
Slc22a2 T C 17: 12,803,298 (GRCm39) F44S probably damaging Het
Slco6c1 T A 1: 97,026,223 (GRCm39) D334V probably damaging Het
Smim19 T C 8: 22,953,352 (GRCm39) D105G probably damaging Het
Smpdl3a A G 10: 57,683,588 (GRCm39) T233A probably damaging Het
St8sia5 G A 18: 77,299,460 (GRCm39) probably null Het
Stk32a C A 18: 43,376,149 (GRCm39) Q73K probably benign Het
Tmem129 G T 5: 33,815,100 (GRCm39) probably null Het
Traf3ip3 A T 1: 192,860,599 (GRCm39) L441Q probably damaging Het
Ttn C T 2: 76,731,305 (GRCm39) probably benign Het
Unc45b T C 11: 82,808,672 (GRCm39) S253P possibly damaging Het
Vars2 A G 17: 35,977,150 (GRCm39) probably benign Het
Vmn2r51 C T 7: 9,836,372 (GRCm39) M136I possibly damaging Het
Vmn2r51 A G 7: 9,836,373 (GRCm39) M136T possibly damaging Het
Zfp595 T C 13: 67,465,127 (GRCm39) I379V possibly damaging Het
Other mutations in Daam2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02150:Daam2 APN 17 49,797,332 (GRCm39) missense possibly damaging 0.82
IGL02373:Daam2 APN 17 49,780,408 (GRCm39) missense probably damaging 1.00
IGL02626:Daam2 APN 17 49,797,282 (GRCm39) missense possibly damaging 0.46
IGL02793:Daam2 APN 17 49,771,056 (GRCm39) missense probably damaging 1.00
IGL02861:Daam2 APN 17 49,776,455 (GRCm39) missense probably damaging 1.00
IGL02875:Daam2 APN 17 49,771,056 (GRCm39) missense probably damaging 1.00
IGL03370:Daam2 APN 17 49,793,529 (GRCm39) missense probably benign 0.19
R0145:Daam2 UTSW 17 49,787,806 (GRCm39) missense probably benign
R0310:Daam2 UTSW 17 49,770,952 (GRCm39) critical splice donor site probably null
R0362:Daam2 UTSW 17 49,787,813 (GRCm39) splice site probably null
R0423:Daam2 UTSW 17 49,776,449 (GRCm39) nonsense probably null
R0883:Daam2 UTSW 17 49,805,911 (GRCm39) utr 5 prime probably benign
R0928:Daam2 UTSW 17 49,795,255 (GRCm39) missense probably benign 0.30
R1444:Daam2 UTSW 17 49,787,779 (GRCm39) missense possibly damaging 0.89
R1733:Daam2 UTSW 17 49,797,231 (GRCm39) missense possibly damaging 0.60
R1919:Daam2 UTSW 17 49,792,485 (GRCm39) missense probably benign 0.00
R1930:Daam2 UTSW 17 49,769,241 (GRCm39) splice site probably null
R1968:Daam2 UTSW 17 49,790,088 (GRCm39) missense probably damaging 1.00
R2520:Daam2 UTSW 17 49,787,785 (GRCm39) nonsense probably null
R3004:Daam2 UTSW 17 49,767,682 (GRCm39) missense probably damaging 0.98
R3726:Daam2 UTSW 17 49,776,766 (GRCm39) missense probably damaging 1.00
R3854:Daam2 UTSW 17 49,765,624 (GRCm39) missense probably benign
R4833:Daam2 UTSW 17 49,797,173 (GRCm39) missense possibly damaging 0.91
R4878:Daam2 UTSW 17 49,767,738 (GRCm39) missense probably damaging 1.00
R5015:Daam2 UTSW 17 49,783,550 (GRCm39) missense probably damaging 1.00
R5106:Daam2 UTSW 17 49,783,489 (GRCm39) missense probably damaging 1.00
R5184:Daam2 UTSW 17 49,801,419 (GRCm39) missense possibly damaging 0.50
R5419:Daam2 UTSW 17 49,787,782 (GRCm39) missense possibly damaging 0.95
R5529:Daam2 UTSW 17 49,766,085 (GRCm39) missense probably benign
R5974:Daam2 UTSW 17 49,771,501 (GRCm39) missense probably damaging 1.00
R5979:Daam2 UTSW 17 49,766,232 (GRCm39) missense possibly damaging 0.47
R6032:Daam2 UTSW 17 49,793,525 (GRCm39) missense probably damaging 1.00
R6032:Daam2 UTSW 17 49,793,525 (GRCm39) missense probably damaging 1.00
R6050:Daam2 UTSW 17 49,793,530 (GRCm39) missense possibly damaging 0.78
R6180:Daam2 UTSW 17 49,776,694 (GRCm39) missense probably damaging 0.99
R6225:Daam2 UTSW 17 49,801,467 (GRCm39) missense probably damaging 0.98
R6385:Daam2 UTSW 17 49,770,964 (GRCm39) missense probably damaging 1.00
R6426:Daam2 UTSW 17 49,776,404 (GRCm39) missense probably damaging 1.00
R6427:Daam2 UTSW 17 49,776,404 (GRCm39) missense probably damaging 1.00
R6428:Daam2 UTSW 17 49,776,404 (GRCm39) missense probably damaging 1.00
R6539:Daam2 UTSW 17 49,776,739 (GRCm39) missense probably damaging 1.00
R7090:Daam2 UTSW 17 49,789,973 (GRCm39) missense probably damaging 0.99
R7108:Daam2 UTSW 17 49,767,702 (GRCm39) missense probably damaging 1.00
R7487:Daam2 UTSW 17 49,793,510 (GRCm39) missense probably benign 0.03
R7599:Daam2 UTSW 17 49,787,755 (GRCm39) nonsense probably null
R7763:Daam2 UTSW 17 49,797,050 (GRCm39) missense probably benign 0.04
R8039:Daam2 UTSW 17 49,771,566 (GRCm39) missense probably damaging 1.00
R8700:Daam2 UTSW 17 49,803,180 (GRCm39) missense probably damaging 1.00
R9000:Daam2 UTSW 17 49,769,197 (GRCm39) missense probably damaging 1.00
R9286:Daam2 UTSW 17 49,786,922 (GRCm39) missense possibly damaging 0.63
R9508:Daam2 UTSW 17 49,765,618 (GRCm39) missense probably damaging 1.00
R9621:Daam2 UTSW 17 49,780,332 (GRCm39) missense probably damaging 1.00
V1662:Daam2 UTSW 17 49,771,629 (GRCm39) missense possibly damaging 0.85
Z1177:Daam2 UTSW 17 49,796,044 (GRCm39) missense probably damaging 1.00
Z1177:Daam2 UTSW 17 49,771,648 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CGCGCAGGTATATTGTGTGAAATGCTA -3'
(R):5'- CGTTGGGAAGAGGAAGCTGGACT -3'

Sequencing Primer
(F):5'- acaacctcacatccctttcc -3'
(R):5'- CTCTCTGGGAGAAATATCATAGGC -3'
Posted On 2014-04-13