Incidental Mutation 'R1560:Gpr158'
ID 170532
Institutional Source Beutler Lab
Gene Symbol Gpr158
Ensembl Gene ENSMUSG00000045967
Gene Name G protein-coupled receptor 158
Synonyms 5330427M13Rik
MMRRC Submission 039599-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1560 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 21372378-21835355 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21831125 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 742 (K742E)
Ref Sequence ENSEMBL: ENSMUSP00000049708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055946]
AlphaFold Q8C419
Predicted Effect probably damaging
Transcript: ENSMUST00000055946
AA Change: K742E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000049708
Gene: ENSMUSG00000045967
AA Change: K742E

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 110 125 N/A INTRINSIC
SCOP:d1edmb_ 313 359 5e-4 SMART
Blast:EGF 318 365 2e-27 BLAST
Pfam:7tm_3 426 669 1.2e-35 PFAM
low complexity region 840 863 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik A G 7: 41,275,466 (GRCm39) T390A probably benign Het
Adamts8 T A 9: 30,867,963 (GRCm39) C596S probably damaging Het
Avl9 T A 6: 56,702,113 (GRCm39) Y89* probably null Het
Cacna1e G A 1: 154,296,850 (GRCm39) R18* probably null Het
Cacng2 A G 15: 77,897,518 (GRCm39) F97S probably benign Het
Calu A G 6: 29,361,657 (GRCm39) D107G probably benign Het
Capns2 G A 8: 93,628,771 (GRCm39) R220Q probably damaging Het
Catsperb C T 12: 101,591,985 (GRCm39) T1105I probably benign Het
Cep350 T C 1: 155,804,825 (GRCm39) N753D possibly damaging Het
D6Ertd527e C G 6: 87,088,506 (GRCm39) T223S unknown Het
Dnah5 G T 15: 28,420,149 (GRCm39) V3816F probably damaging Het
Dzip3 T C 16: 48,771,903 (GRCm39) probably null Het
Ep400 A T 5: 110,818,972 (GRCm39) probably null Het
Epb41l2 T A 10: 25,371,334 (GRCm39) probably null Het
Fetub T C 16: 22,758,117 (GRCm39) V300A probably benign Het
Gabrb3 A T 7: 57,466,043 (GRCm39) M308L probably damaging Het
Galnt16 A T 12: 80,648,566 (GRCm39) D546V possibly damaging Het
Gimap8 G T 6: 48,633,068 (GRCm39) G296W probably damaging Het
Hmbs T C 9: 44,248,657 (GRCm39) H72R possibly damaging Het
Krt16 A G 11: 100,137,475 (GRCm39) I410T probably damaging Het
Lamb3 G A 1: 193,021,710 (GRCm39) A971T probably benign Het
Lilra6 A C 7: 3,914,407 (GRCm39) probably null Het
Mroh7 A T 4: 106,568,451 (GRCm39) M418K possibly damaging Het
Myh11 T A 16: 14,044,484 (GRCm39) K640* probably null Het
Nsd1 T A 13: 55,394,533 (GRCm39) C711* probably null Het
Or1j17 T A 2: 36,578,155 (GRCm39) L47Q probably damaging Het
Or2ak5 A T 11: 58,611,513 (GRCm39) Y120* probably null Het
Or3a10 A G 11: 73,935,441 (GRCm39) S220P probably damaging Het
Or4c111 T C 2: 88,843,550 (GRCm39) Y286C probably damaging Het
Otop3 A T 11: 115,235,289 (GRCm39) H307L possibly damaging Het
Plekhm3 T C 1: 64,976,976 (GRCm39) T165A probably benign Het
Poldip3 G A 15: 83,022,527 (GRCm39) R86W probably damaging Het
Rif1 A T 2: 52,001,143 (GRCm39) R1532S probably damaging Het
Sf3b1 C G 1: 55,058,554 (GRCm39) E12Q possibly damaging Het
Slc27a6 T A 18: 58,712,904 (GRCm39) L242* probably null Het
Spata45 T C 1: 190,772,017 (GRCm39) S80P probably benign Het
Taf4 A G 2: 179,577,746 (GRCm39) V525A probably benign Het
Tbck A G 3: 132,543,809 (GRCm39) T887A probably damaging Het
Tnrc6c C T 11: 117,650,463 (GRCm39) T1571I probably damaging Het
Trim38 A G 13: 23,966,685 (GRCm39) Y44C probably benign Het
Tsg101 A T 7: 46,542,208 (GRCm39) probably null Het
Tsku T A 7: 98,002,151 (GRCm39) D60V probably damaging Het
Ttc28 G A 5: 111,373,543 (GRCm39) S962N probably damaging Het
Upf1 G A 8: 70,791,092 (GRCm39) P550L probably damaging Het
Vipr2 A G 12: 116,058,401 (GRCm39) D106G probably benign Het
Vps13c T C 9: 67,843,745 (GRCm39) probably null Het
Washc4 T C 10: 83,391,973 (GRCm39) Y220H probably damaging Het
Wdr81 C T 11: 75,342,449 (GRCm39) W939* probably null Het
Zfp512b T C 2: 181,230,472 (GRCm39) T473A probably benign Het
Other mutations in Gpr158
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Gpr158 APN 2 21,373,494 (GRCm39) missense probably damaging 1.00
IGL00469:Gpr158 APN 2 21,751,606 (GRCm39) splice site probably benign
IGL00706:Gpr158 APN 2 21,751,584 (GRCm39) missense probably damaging 1.00
IGL00780:Gpr158 APN 2 21,831,629 (GRCm39) nonsense probably null
IGL00885:Gpr158 APN 2 21,653,832 (GRCm39) missense probably damaging 1.00
IGL01339:Gpr158 APN 2 21,373,842 (GRCm39) missense possibly damaging 0.73
IGL01368:Gpr158 APN 2 21,831,909 (GRCm39) missense probably damaging 1.00
IGL02141:Gpr158 APN 2 21,788,101 (GRCm39) missense probably damaging 0.99
IGL02455:Gpr158 APN 2 21,373,511 (GRCm39) missense probably benign 0.00
IGL02554:Gpr158 APN 2 21,831,407 (GRCm39) missense probably benign
IGL02681:Gpr158 APN 2 21,820,441 (GRCm39) missense probably damaging 1.00
IGL02752:Gpr158 APN 2 21,831,638 (GRCm39) missense possibly damaging 0.95
IGL02756:Gpr158 APN 2 21,831,890 (GRCm39) missense possibly damaging 0.47
IGL03181:Gpr158 APN 2 21,787,972 (GRCm39) missense probably benign 0.02
IGL03258:Gpr158 APN 2 21,830,085 (GRCm39) missense probably damaging 1.00
IGL03386:Gpr158 APN 2 21,831,057 (GRCm39) missense probably damaging 1.00
PIT4810001:Gpr158 UTSW 2 21,831,682 (GRCm39) missense probably benign 0.01
R0071:Gpr158 UTSW 2 21,815,479 (GRCm39) missense probably benign 0.08
R0081:Gpr158 UTSW 2 21,831,528 (GRCm39) missense probably damaging 1.00
R0528:Gpr158 UTSW 2 21,830,019 (GRCm39) missense probably damaging 1.00
R0560:Gpr158 UTSW 2 21,830,085 (GRCm39) missense probably damaging 1.00
R0603:Gpr158 UTSW 2 21,820,480 (GRCm39) missense possibly damaging 0.67
R1561:Gpr158 UTSW 2 21,820,505 (GRCm39) splice site probably null
R1609:Gpr158 UTSW 2 21,788,104 (GRCm39) missense possibly damaging 0.61
R1741:Gpr158 UTSW 2 21,832,359 (GRCm39) missense probably benign 0.00
R1827:Gpr158 UTSW 2 21,832,129 (GRCm39) missense probably benign
R1854:Gpr158 UTSW 2 21,373,935 (GRCm39) missense probably damaging 1.00
R1871:Gpr158 UTSW 2 21,820,426 (GRCm39) missense probably damaging 1.00
R2151:Gpr158 UTSW 2 21,832,325 (GRCm39) missense possibly damaging 0.82
R2273:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R2275:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R3004:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R3151:Gpr158 UTSW 2 21,581,771 (GRCm39) missense possibly damaging 0.68
R3943:Gpr158 UTSW 2 21,373,370 (GRCm39) missense possibly damaging 0.65
R4238:Gpr158 UTSW 2 21,373,362 (GRCm39) missense probably damaging 1.00
R4379:Gpr158 UTSW 2 21,830,025 (GRCm39) missense probably damaging 1.00
R4381:Gpr158 UTSW 2 21,832,403 (GRCm39) missense probably damaging 1.00
R4464:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4467:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4496:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4506:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4530:Gpr158 UTSW 2 21,373,811 (GRCm39) missense probably benign 0.03
R4646:Gpr158 UTSW 2 21,831,864 (GRCm39) missense probably benign
R4798:Gpr158 UTSW 2 21,787,993 (GRCm39) missense probably damaging 1.00
R4882:Gpr158 UTSW 2 21,830,059 (GRCm39) missense probably damaging 0.98
R4943:Gpr158 UTSW 2 21,831,968 (GRCm39) missense probably damaging 1.00
R5334:Gpr158 UTSW 2 21,832,316 (GRCm39) missense probably benign 0.01
R5560:Gpr158 UTSW 2 21,831,101 (GRCm39) missense possibly damaging 0.67
R5600:Gpr158 UTSW 2 21,832,046 (GRCm39) missense probably benign
R5637:Gpr158 UTSW 2 21,788,083 (GRCm39) missense probably benign 0.00
R5701:Gpr158 UTSW 2 21,751,520 (GRCm39) missense probably damaging 1.00
R5744:Gpr158 UTSW 2 21,373,331 (GRCm39) missense probably damaging 1.00
R5911:Gpr158 UTSW 2 21,373,932 (GRCm39) missense possibly damaging 0.95
R5991:Gpr158 UTSW 2 21,373,319 (GRCm39) missense probably damaging 0.99
R6200:Gpr158 UTSW 2 21,404,227 (GRCm39) missense probably damaging 0.97
R6306:Gpr158 UTSW 2 21,820,422 (GRCm39) missense possibly damaging 0.84
R6324:Gpr158 UTSW 2 21,815,365 (GRCm39) missense probably damaging 1.00
R6384:Gpr158 UTSW 2 21,831,099 (GRCm39) missense probably damaging 1.00
R6698:Gpr158 UTSW 2 21,831,921 (GRCm39) missense probably damaging 1.00
R6997:Gpr158 UTSW 2 21,653,802 (GRCm39) missense possibly damaging 0.46
R7086:Gpr158 UTSW 2 21,831,386 (GRCm39) missense probably benign 0.01
R7175:Gpr158 UTSW 2 21,373,113 (GRCm39) missense probably benign 0.13
R7197:Gpr158 UTSW 2 21,815,412 (GRCm39) missense probably damaging 0.99
R7293:Gpr158 UTSW 2 21,581,750 (GRCm39) missense possibly damaging 0.47
R7427:Gpr158 UTSW 2 21,832,129 (GRCm39) missense probably benign
R7515:Gpr158 UTSW 2 21,373,092 (GRCm39) missense probably damaging 1.00
R7730:Gpr158 UTSW 2 21,831,158 (GRCm39) missense probably damaging 1.00
R8122:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R8311:Gpr158 UTSW 2 21,373,701 (GRCm39) missense probably benign 0.00
R8754:Gpr158 UTSW 2 21,581,693 (GRCm39) missense probably benign 0.00
R8782:Gpr158 UTSW 2 21,404,149 (GRCm39) missense probably damaging 1.00
R8792:Gpr158 UTSW 2 21,558,137 (GRCm39) missense probably damaging 1.00
R8842:Gpr158 UTSW 2 21,581,751 (GRCm39) missense possibly damaging 0.88
R9009:Gpr158 UTSW 2 21,581,760 (GRCm39) missense probably damaging 1.00
R9102:Gpr158 UTSW 2 21,830,078 (GRCm39) missense probably damaging 1.00
R9150:Gpr158 UTSW 2 21,831,251 (GRCm39) missense probably benign 0.17
R9254:Gpr158 UTSW 2 21,373,042 (GRCm39) start gained probably benign
R9317:Gpr158 UTSW 2 21,832,037 (GRCm39) missense probably benign
R9379:Gpr158 UTSW 2 21,373,042 (GRCm39) start gained probably benign
R9428:Gpr158 UTSW 2 21,787,972 (GRCm39) missense probably benign
R9497:Gpr158 UTSW 2 21,831,825 (GRCm39) missense probably benign 0.00
R9667:Gpr158 UTSW 2 21,830,054 (GRCm39) missense probably damaging 0.99
R9681:Gpr158 UTSW 2 21,831,315 (GRCm39) missense probably damaging 0.99
X0062:Gpr158 UTSW 2 21,831,180 (GRCm39) missense probably damaging 1.00
Z1176:Gpr158 UTSW 2 21,815,501 (GRCm39) critical splice donor site probably null
Z1177:Gpr158 UTSW 2 21,832,083 (GRCm39) missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- AAACACCACCGGGCTATTTTCTGTC -3'
(R):5'- CAGCGACTCCAAGGTTGAATTTTCG -3'

Sequencing Primer
(F):5'- GGGCTATTTTCTGTCTGAAACAC -3'
(R):5'- GCAAGCTGCTGGATTCTACAG -3'
Posted On 2014-04-13